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Tumor-associated mutations of rat mitochondrial transfer RNA genes.

Abstract：

:Mitochondrial DNA is a sensitive target of chemical carcinogens (Backer and Weinstein (1980) Science 209, 297-299), suggesting that mutations of the mitochondrial genome occur in tumor cells. We examined this point by comparing mitochondrial DNA sequences in four rat tumors with those of normal rat liver. Some novel mutations found in the tRNA genes of tumor mitochondria were as follows: nucleotides deletions in the aminoacyl-acceptor stem of the tRNATyr gene or in the anticodon stem of the tRNATrp gene and insertions in the "YpsiC" loop of the tRNACys gene. These structures are extraordinary compared with those of the tRNA genes of other mammals, indicating that these mutations are each associated with a corresponding tumor.

journal_name

Nucleic Acids Res

journal_title

Nucleic acids research

authors

Taira M,Yoshida E,Kobayashi M,Yaginuma K,Koike K

doi

10.1093/nar/11.6.1635

subject

Has Abstract

pub_date

1983-03-25 00:00:00

pages

1635-43

issue

6

eissn

0305-1048

issn

1362-4962

journal_volume

11

pub_type

杂志文章

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