Role of antibody response helper factors in immunosuppressive effects of friend leukemia virus.

Abstract:

:The primary antibody response of BALB/c splenocytes to sheep erythrocytes in vitro was suppressed by infection with Friend leukemia virus (FLV), with the response capacity decreasing with increasing duration of infection. The acquisition of normal antibody responses was amplified by macrophage-produced antibody response helper factor(s). FLV-infected mice were treated with bacterial lipopolysaccharide to induce the release of these helper factors into the serum. Similar to the loss of antibody response capacity by their splenocytes, the FLV-infected mice progressively lost the ability to produce helper factors in response to lipopolysaccharide. In vitro cultures of FLV-infected cells also showed a depressed ability to produce helper factor activity both spontaneously and in response to lipopolysaccharide stimulation. The reconstitution of normal levels of exogenous helper factors to FLV-infected splenocytes restored the antibody response to normal or even elevated levels. These studies indicate that the mechanism for suppression of antibody responses by FLV involves the depression of antibody response helper factor production.

journal_name

Infect Immun

journal_title

Infection and immunity

authors

Butler RC,Frier JM,Chapekar MS,Graham MO,Friedman H

doi

10.1128/IAI.39.3.1260-1264.1983

subject

Has Abstract

pub_date

1983-03-01 00:00:00

pages

1260-4

issue

3

eissn

0019-9567

issn

1098-5522

journal_volume

39

pub_type

杂志文章
  • Electron microscope study of experimental enteric adenovirus infection in mice.

    abstract::Using fluorescent antibody techniques (FA) and light microscopy (LM) and electron microscopy (EM), this paper describes the morphological features of the ileum in the DK1 mouse orally challenged with adenovirus K87. At the peak of infection, virus is easily identified by FA in the epithelium of the villi and crypts of...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.13.2.569-580.1976

    authors: Takeuchi A,Hashimoto K

    更新日期:1976-02-01 00:00:00

  • Association of bacterial carbohydrate-specific cold agglutinin antibody production with immunization by group C, group B type III, and Streptococcus pneumoniae type XIV streptococcal vaccines.

    abstract::Rabbits immunized with group B type III, group C, and Streptococcus pneumoniae type XIV streptococcal vaccines developed autoantibodies reactive with autologous and isologous erythrocytes and human O-positive erythrocytes at reduced temperatures. The cold agglutinin antibodies were present in both the immunoglobulin M...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.41.1.205-213.1983

    authors: Colling RG,Pearson TC,Brown JC

    更新日期:1983-07-01 00:00:00

  • CD4+ T cells and antibody are required for optimal major outer membrane protein vaccine-induced immunity to Chlamydia muridarum genital infection.

    abstract::Despite effective antimicrobial chemotherapy, control of Chlamydia trachomatis urogenital infection will likely require a vaccine. We have assessed the protective effect of an outer membrane protein-based vaccine by using a murine model of chlamydial genital infection. Female mice were first vaccinated with Chlamydia ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00622-10

    authors: Farris CM,Morrison SG,Morrison RP

    更新日期:2010-10-01 00:00:00

  • Macrophage Polarization during Murine Lyme Borreliosis.

    abstract::Infection of C3H mice with Borrelia burgdorferi, the causative agent of Lyme disease, reliably produces an infectious arthritis and carditis that peak around 3 weeks postinfection and then spontaneously resolve. Macrophage polarization has been suggested to drive inflammation, the clearance of bacteria, and tissue rep...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00369-15

    authors: Lasky CE,Olson RM,Brown CR

    更新日期:2015-07-01 00:00:00

  • A constitutively active variant of the quorum-sensing regulator LuxO affects protease production and biofilm formation in Vibrio cholerae.

    abstract::Vibrio cholerae normally inhabits aquatic habitats but can cause a severe diarrheal illness in humans. Its arsenal of virulence factors includes a secreted hemagglutinin (HA) protease. An HA protease-deficient mutant of V. cholerae was isolated and designated E7946 mpc. E7946 mpc was found to contain a point mutation ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/iai.71.5.2571-2576.2003

    authors: Vance RE,Zhu J,Mekalanos JJ

    更新日期:2003-05-01 00:00:00

  • Toxic shock syndrome-associated staphylococcal and streptococcal pyrogenic toxins are potent inducers of tumor necrosis factor production.

    abstract::Toxic shock syndrome-associated staphylococcal and streptococcal exotoxins were tested for an ability to induce the production of tumor necrosis factor (TNF). Staphylococcal enterotoxins B and C1, along with streptococcal pyrogenic exotoxin A, all induced TNF production in a dose-dependent manner, with production peak...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.57.1.291-294.1989

    authors: Fast DJ,Schlievert PM,Nelson RD

    更新日期:1989-01-01 00:00:00

  • Extracellular phospholipase A2 and lysophospholipase produced by Vibrio vulnificus.

    abstract::Phospholipase A2 and lysophospholipase activities were detected in the culture supernatant fluids of a virulent strain of Vibrio vulnificus. The phospholipase A2 was inactivated by heating at 56 degrees C for 30 min, had an apparent molecular weight of greater than or equal to 80,000 (estimated by gel filtration with ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.45.2.458-463.1984

    authors: Testa J,Daniel LW,Kreger AS

    更新日期:1984-08-01 00:00:00

  • Microbial amyloids induce interleukin 17A (IL-17A) and IL-22 responses via Toll-like receptor 2 activation in the intestinal mucosa.

    abstract::The Toll-like receptor 2 (TLR2)/TLR1 receptor complex responds to amyloid fibrils, a common component of biofilm material produced by members of the phyla Firmicutes, Bacteroidetes, and Proteobacteria. To determine whether this TLR2/TLR1 ligand stimulates inflammatory responses when bacteria enter intestinal tissue, w...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00911-12

    authors: Nishimori JH,Newman TN,Oppong GO,Rapsinski GJ,Yen JH,Biesecker SG,Wilson RP,Butler BP,Winter MG,Tsolis RM,Ganea D,Tükel Ç

    更新日期:2012-12-01 00:00:00

  • Ultrastructural and immunological aspects of the phagocytosis of Trypanosoma brucei by mouse peritoneal macrophages.

    abstract::Trypanosome-activated mouse peritoneal macrophages phagocytized and digested Trypanosoma brucei in vitro and in vivo, but in the absence of specific antiserum and complement the degree of phagocytosis was minimal. Ultrastructurally, the parasites attached to the macrophage by their flagella, and ingestion proceeded fl...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.19.3.972-982.1978

    authors: Stevens DR,Moulton JE

    更新日期:1978-03-01 00:00:00

  • Association and dissociation of Escherichia coli heat-stable enterotoxin from rat brush border membrane receptors.

    abstract::Escherichia coli heat-stable enterotoxin (ST) binds to receptors on rat intestinal cells and brush border membranes (BBM). We devised experiments to examine the reversibility of ST binding. We found that both 125I-labeled ST and native ST were spontaneously dissociable from the BBM receptor. Radiolabeled ST bound to B...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.55.2.329-334.1987

    authors: Cohen MB,Thompson MR,Overmann GJ,Giannella RA

    更新日期:1987-02-01 00:00:00

  • Production and partial characterization of a Vibrio fluvialis cytotoxin.

    abstract::Conditions are described for the production of an extracellular cytotoxin or CHO cell-killing factor by Vibrio fluvialis, a recently recognized enteric pathogen. The cell-killing factor was ammonium sulfate precipitable, heat labile, and inactivated by proteases, and had an isoelectric point (estimated by sucrose dens...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.46.3.773-777.1984

    authors: Wall VW,Kreger AS,Richardson SH

    更新日期:1984-12-01 00:00:00

  • Identification of Mannheimia haemolytica adhesins involved in binding to bovine bronchial epithelial cells.

    abstract::Mannheimia haemolytica, a commensal organism of the upper respiratory tract in cattle, is the principal bacterial pathogen associated with the bovine respiratory disease complex. Adherence to the respiratory mucosa is a crucial event in its pathogenesis. However, the bacterial components that contribute to this proces...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00312-08

    authors: Kisiela DI,Czuprynski CJ

    更新日期:2009-01-01 00:00:00

  • Cell surface hydrophobicity of pigmented and nonpigmented clinical Serratia marcescens strains.

    abstract::The cell surface hydrophobicity of 10 pigmented and 4 nonpigmented clinical Serratia marcescens strains was studied, based on the ability of the strains to adhere to hydrocarbons and to polystyrene. The cell surface hydrophobicity depended greatly on growth temperature; all of the strains tested were adherent followin...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.51.3.932-935.1986

    authors: Rosenberg M,Blumberger Y,Judes H,Bar-Ness R,Rubinstein E,Mazor Y

    更新日期:1986-03-01 00:00:00

  • Experimental otitis media after nasal inoculation of Streptococcus pneumoniae and influenza A virus in chinchillas.

    abstract::Otitis media developed in 67% of chinchillas inoculated intranasally with type 7 Streptococcus pneumoniae and influenza A virus. Only 4% of chinchillas inoculated with influenza alone and 21% of chinchillas inoculated with S. pneumoniae alone developed otitis media. Among the chinchillas that developed otitis media af...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:

    authors: Giebink GS,Berzins IK,Marker SC,Schiffman G

    更新日期:1980-11-01 00:00:00

  • Experimental infection of newly weaned pigs with human and porcine strains of Serpulina pilosicoli.

    abstract::Cultures of Serpulina pilosicoli 95/1000, isolated from a pig with porcine intestinal spirochetosis (PIS), and S. pilosicoli WesB, isolated from an Aboriginal child with diarrhea, were used to infect 5-week-old newly weaned pigs. Four of 12 pigs infected with strain 95/1000 and 2 of 12 pigs infected with strain WesB b...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.64.11.4648-4654.1996

    authors: Trott DJ,Huxtable CR,Hampson DJ

    更新日期:1996-11-01 00:00:00

  • Serum antibodies from malaria-exposed people recognize conserved epitopes formed by the two epidermal growth factor motifs of MSP1(19), the carboxy-terminal fragment of the major merozoite surface protein of Plasmodium falciparum.

    abstract::The major merozoite surface protein of Plasmodium falciparum (PfMSP1) is a candidate antigen for a malaria vaccine. A 19-kDa C-terminal processing product of PfMSP1 (PfMSP1(19)) is composed of two domains sharing a cysteine-rich motif with epidermal growth factor (EGF) and is the target of monoclonal antibodies which ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.63.2.456-466.1995

    authors: Egan AF,Chappel JA,Burghaus PA,Morris JS,McBride JS,Holder AA,Kaslow DC,Riley EM

    更新日期:1995-02-01 00:00:00

  • A hemagglutinin of uropathogenic Escherichia coli recognizes the Dr blood group antigen.

    abstract::A receptor moiety and blood group substance recognized by the O75X adhesin was studied. Well-defined erythrocytes representing different blood group systems and bacterial derivatives carrying plasmid pBJN406 encoding the adhesin were used in a direct hemagglutination assay. We showed that Dr blood group antigen, a com...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.56.5.1057-1060.1988

    authors: Nowicki B,Moulds J,Hull R,Hull S

    更新日期:1988-05-01 00:00:00

  • Masking of β(1-3)-glucan in the cell wall of Candida albicans from detection by innate immune cells depends on phosphatidylserine.

    abstract::The virulence of Candida albicans in a mouse model of invasive candidiasis is dependent on the phospholipids phosphatidylserine (PS) and phosphatidylethanolamine (PE). Disruption of the PS synthase gene CHO1 (i.e., cho1Δ/Δ) eliminates PS and blocks the de novo pathway for PE biosynthesis. In addition, the cho1Δ/Δ muta...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.01612-14

    authors: Davis SE,Hopke A,Minkin SC Jr,Montedonico AE,Wheeler RT,Reynolds TB

    更新日期:2014-10-01 00:00:00

  • Role of Porphyromonas gingivalis protease activity in colonization of oral surfaces.

    abstract::Cysteine proteases, including Arg-gingipain of Porphyromonas gingivalis, have been implicated as important virulence factors in periodontal diseases. These enzymes are also involved in the hemagglutinating activity of the organisms. In order to determine the role of proteases in the colonization of the gingival margin...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.64.10.4067-4073.1996

    authors: Tokuda M,Duncan M,Cho MI,Kuramitsu HK

    更新日期:1996-10-01 00:00:00

  • The repeat-in-toxin family member TosA mediates adherence of uropathogenic Escherichia coli and survival during bacteremia.

    abstract::Uropathogenic Escherichia coli (UPEC) is responsible for the majority of uncomplicated urinary tract infections (UTI) and represents the most common bacterial infection in adults. UPEC utilizes a wide range of virulence factors to colonize the host, including the novel repeat-in-toxin (RTX) protein TosA, which is spec...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.05713-11

    authors: Vigil PD,Wiles TJ,Engstrom MD,Prasov L,Mulvey MA,Mobley HL

    更新日期:2012-02-01 00:00:00

  • Heparin protects human endothelial cells infected by Rickettsia rickettsii.

    abstract::Routine culture of endothelial cells currently includes the use of heparin, which significantly reduces cell doubling time and increases cell population size. Heparin protects cultured arterial endothelial cells from damage by toxic oxygen metabolites produced by the action of xanthine and xanthine oxidase. Because of...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.59.12.4505-4510.1991

    authors: Silverman DJ,Santucci LA,Sekeyova Z

    更新日期:1991-12-01 00:00:00

  • Natural and immune antibodies for Vibrio fetus in serum and secretions of cattle.

    abstract::Naturally occurring antibodies for Vibrio fetus with whole-cell and O antigen specificities were detected in sera of mature cattle by means of the agglutination and indirect immunofluorescence reactions. O antibodies occurred in each of 21 sera examined, and whole-cell antibodies, in lower concentrations, occurred in ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.5.5.728-733.1972

    authors: Duncan JR,Wilkie BN,Winter AJ

    更新日期:1972-05-01 00:00:00

  • Oxygen consumption by trachea organ cultures infected with Mycoplasma pneumoniae.

    abstract::Hamster trachea organ cultres were shown to consume measurable amounts of oxygen when incubated in a closed micro-chamber. Several simple and complex media were evaluated, and the optimal system involved incubating 2 to 4 mg of tracheal tissue in Tyrodes balanced salt solution at 37 C for 60 min, with oxygen activity ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.12.3.544-549.1975

    authors: Gabridge MG

    更新日期:1975-09-01 00:00:00

  • Survival of Staphylococcus epidermidis in Fibroblasts and Osteoblasts.

    abstract::Staphylococcus epidermidis is a leading cause of infections associated with indwelling medical devices, including prosthetic joint infection. While biofilm formation is assumed to be the main mechanism underlying the chronic infections S. epidermidis causes, we hypothesized that S. epidermidis also evades immune killi...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00237-18

    authors: Perez K,Patel R

    更新日期:2018-09-21 00:00:00

  • Protection against syphilis correlates with specificity of antibodies to the variable regions of Treponema pallidum repeat protein K.

    abstract::Syphilis has been recognized as a disease since the late 1400s, yet there is no practical vaccine available. One impediment to the development of a vaccine is the lack of understanding of multiple reinfections in humans despite the development of robust immune responses during the first episode. It has been shown that...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/iai.71.10.5605-5612.2003

    authors: Morgan CA,Lukehart SA,Van Voorhis WC

    更新日期:2003-10-01 00:00:00

  • Demonstration of a new type of immunoglobulin G receptor in Streptococcus zooepidemicus strains.

    abstract::Forty-seven bacterial strains representing four different group C streptococcal species were tested for binding of human and bovine immunoglobulin G (IgG) subclasses. Specific binding sites for IgG were found in all bacterial species studied. The four species included differed, however, in their capacities to interact...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.27.3.808-816.1980

    authors: Myhre EB,Kronvall G

    更新日期:1980-03-01 00:00:00

  • Central role for interleukin-4 in regulating nitric oxide-mediated inhibition of T-cell proliferation and gamma interferon production in schistosomiasis.

    abstract::Schistosoma mansoni-infected wild-type (WT) mice develop a Th2 response and chronic disease. In contrast, infected interleukin-4 double-deficient (IL-4(-/-)) mice develop a Th1-like response and an acute, lethal syndrome. Disease severity in these animals correlates with excessive and prolonged production of nitric ox...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/iai.70.1.177-184.2002

    authors: Patton EA,La Flamme AC,Pedras-Vasoncelos JA,Pearce EJ

    更新日期:2002-01-01 00:00:00

  • Effect of methylamine and monodansylcadaverine on the susceptibility of McCoy cells to Chlamydia trachomatis infection.

    abstract::We used inhibitors of receptor-mediated endocytosis to study the mechanisms of infectivity, especially the uptake mechanism, of Chlamydia trachomatis for cultured cells. The effect of methylamine and monodansylcadaverine on the different stages of the chlamydial growth cycle in McCoy cells was examined. There was a do...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.40.2.534-541.1983

    authors: Söderlund G,Kihlström E

    更新日期:1983-05-01 00:00:00

  • The SrtA Sortase of Streptococcus agalactiae is required for cell wall anchoring of proteins containing the LPXTG motif, for adhesion to epithelial cells, and for colonization of the mouse intestine.

    abstract::Streptococcus agalactiae (group B streptococcus [GBS]) is the leading cause of neonatal pneumonia, sepsis, and meningitis. An in silico genome analysis indicated that GBS strain NEM316 encodes 35 proteins containing an LPXTG motif which are thought to be covalently linked to the peptidoglycan by an enzyme called sorta...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.73.6.3342-3350.2005

    authors: Lalioui L,Pellegrini E,Dramsi S,Baptista M,Bourgeois N,Doucet-Populaire F,Rusniok C,Zouine M,Glaser P,Kunst F,Poyart C,Trieu-Cuot P

    更新日期:2005-06-01 00:00:00

  • Polymorphism in the aerobactin-cloacin DF13 receptor genes from an enteroinvasive strain of Escherichia coli and pColV-K30 is associated only with a decrease in cloacin susceptibility.

    abstract::We have cloned chromosomal genes mediating the aerobactin iron transport system from the enteroinvasive strain Escherichia coli 978-77. The physical map of the region spanning the siderophore biosynthesis genes and the upstream portion of the receptor gene in strain 978-77-derived clones was identical to the correspon...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.59.1.357-364.1991

    authors: Marolda CL,Valvano MA,Crosa JH

    更新日期:1991-01-01 00:00:00