Malondialdehyde production by platelets during secondary aggregation.

abstract：:To assess interobserver variability of venography for screening for postoperative deep venous thrombosis (DVT), we used 185 bilateral ascending contrast venograms (366 lower limbs) which were performed using the long-leg film technique, in the frame of a trial of the efficacy of two low-molecular-weight-heparin fracti...

journal_title：Thrombosis and haemostasis

authors： Couson F,Bounameaux C,Didier D,Geiser D,Meyerovitz MF,Schmitt HE,Schneider PA,Bounameaux H

更新日期：1993-10-18 00:00:00

abstract：:East Asian patients have reduced anti-ischemic benefits and increased bleeding risk during antithrombotic therapies compared with Caucasian patients. As potent P2Y12 receptor inhibitors (e.g., ticagrelor and prasugrel) and direct oral anticoagulants are commonly used in current daily practice, the unique risk-benefit ...

journal_title：Thrombosis and haemostasis

authors： Kim HK,Tantry US,Smith SC Jr,Jeong MH,Park SJ,Kim MH,Lim DS,Shin ES,Park DW,Huo Y,Chen SL,Bo Z,Goto S,Kimura T,Yasuda S,Chen WJ,Chan M,Aradi D,Geisler T,Gorog DA,Sibbing D,Lip GYH,Angiolillo DJ,Gurbel PA,J

更新日期：2020-11-10 00:00:00

abstract：:We investigated changes in both thrombin activatable fibrinolysis inhibitor (TAFI) antigen levels and its functional effect on in vitro fibrinolysis in normal pregnancy. 152 pregnant women and 31 women in the immediate postpartum period were studied, with pregnancy divided into 6 windows at 4 weekly intervals. As TAFI...

journal_title：Thrombosis and haemostasis

authors： Mousa HA,Downey C,Alfirevic Z,Toh CH

更新日期：2004-11-01 00:00:00

abstract：:The esterase activity of highly purified human urokinase on Nalpha-acetylglycl-L-lysine methyl ester is strongly inhibited by 1 X 10(-5) to 1 X 10(-2)M Cu++, Hg++, Ni++, Co++, Fe+++, and Mn++ solutions, whereas Na+, K+, Ca++, and Mg++ are weakly effective. This inhibition is parallel with the inhibition of activation ...

journal_title：Thrombosis and haemostasis

authors： Sumi H,Takada Y,Takada A

更新日期：1978-02-28 00:00:00

abstract：:Light to moderate drinking is associated with lower risk of coronary heart (CHD) than non-drinkers. We have examined the relationships between total alcohol intake and type of alcoholic beverage and several potential biological mechanisms. We carried out the study in 3158 men aged 60-79 years drawn from general practi...

journal_title：Thrombosis and haemostasis

authors： Wannamethee SG,Lowe GD,Shaper G,Whincup PH,Rumley A,Walker M,Lennon L

更新日期：2003-12-01 00:00:00

abstract：:Forty-eight patients with acute proximal deep vein thrombosis (DVT) were randomised to intravenous infusions for 4 to 6 days with melagatran, a novel synthetic low molecular weight thrombin inhibitor, or unfractionated heparin adjusted by the activated partial thromboplastin time (APTT). The aim of the study was to in...

journal_title：Thrombosis and haemostasis

authors： Eriksson H,Eriksson UG,Frison L,Hansson PO,Held P,Holmström M,Hägg A,Jonsson T,Lapidus L,Leijd B,Stockelberg D,Säfwenberg U,Taghavi A,Thorsén M

更新日期：1999-03-01 00:00:00

abstract：:In a prospective study, coagulation test results were compared in 137 patients with colorectal cancer (CRC) and 39 subjects with benign colorectal diseases. Prothrombin fragment 1+2 (F1+2), thrombin-antithrombin complex (TAT), and soluble fibrin (SF) were measured in plasma before and after surgery. CRC patients prese...

journal_title：Thrombosis and haemostasis

authors： Iversen LH,Thorlacius-Ussing O

更新日期：2002-03-01 00:00:00

abstract：:We reported previously that plasma fibrinogen was significantly higher in U.S. Caucasians than in Japanese, which may contribute to the higher mortality rate of coronary heart disease in the United States than in Japan. To examine the contribution of genetic variations to the race difference in plasma fibrinogen level...

journal_title：Thrombosis and haemostasis

authors： Iso H,Folsom AR,Winkelmann JC,Koike K,Harada S,Greenberg B,Sato S,Shimamoto T,Iida M,Komachi Y

更新日期：1995-01-01 00:00:00

abstract：:The simultaneous additon of suboptimal concentrations of factor VIII and intact or plasmin-lysed fibrinogen into mixtures of the vitamin K dependent factors, phospholipids, adsorbed bovine serum (supplier to factor V) and calcium, increased the amount of thrombin which was generated three to twenty times over the sum ...

journal_title：Thrombosis and haemostasis

authors： Triantaphyllopoulos DC,Ryan LT

更新日期：1976-04-30 00:00:00

abstract：:Venous oxygen tension (pO2) was measured in discrete samples of blood obtained through the femoral vein of cardiac catheterisation patients before, during and after application of sustained external graduated pressure in the form of compression stockings (T. E. D. Kendall). There was a significant reduction (p less th...

journal_title：Thrombosis and haemostasis

authors： Okoye GC,Evans JH,Beattie J,Lowe GD,Lorimer AR,Forbes CD

更新日期：1984-02-28 00:00:00

abstract：:Activation and signaling of circulating blood and vessel wall cells, as well as their direct adhesive interactions, are critical for the regulation of vascular homeostasis related to vasomotor responses, inflammation, hemostasis, and wound repair. Under conditions of stress, inflammation, or infection the targeting an...

journal_title：Thrombosis and haemostasis

authors： May AE,Neumann FJ,Preissner KT

更新日期：1999-08-01 00:00:00

abstract：:In the past decade understanding of the role of the Rho GTPases RhoA, Rac1 and Cdc42 has been developed from regulatory proteins that regulate specific actin cytoskeletal structures - stress fibers, lamellipodia and filopodia - to complex integrators of cytoskeletal structures that can exert multiple functions dependi...

journal_title：Thrombosis and haemostasis

authors： Beckers CM,van Hinsbergh VW,van Nieuw Amerongen GP

更新日期：2010-01-01 00:00:00

abstract：:The novel fast inhibitor to tissue plasminogen activator in plasma has been determined in 20 healthy non-pregnant women, 48 apparently healthy pregnant women and 136 women with risk pregnancies (preeclampsia, suspected fetal growth retardation, thrombosis or previous history of thrombosis, diabetes and others). In hea...

journal_title：Thrombosis and haemostasis

authors： Wiman B,Csemiczky G,Marsk L,Robbe H

更新日期：1984-10-31 00:00:00

abstract：:The effects of argatroban, a direct thrombin inhibitor, on the International Normalized Ratio (INR), activated partial thromboplastin time (aPTT) and functional factor X during warfarin co-administration were established to provide means to interpret INRs during argatroban/warfarin co-therapy. Twenty-four subjects rec...

journal_title：Thrombosis and haemostasis

authors： Sheth SB,DiCicco RA,Hursting MJ,Montague T,Jorkasky DK

更新日期：2001-03-01 00:00:00

abstract：:Treatment with the direct thrombin inhibitor argatroban (ARG) is often followed by vitamin K-antagonist treatment (VKA). Phenprocoumon (PC) and acenocoumarol (AC) are frequently used in Europe. The standard monitoring test for VKA, pro-thrombin time (PT), is prolonged by direct thrombin inhibitors. Therefore the Inter...

journal_title：Thrombosis and haemostasis

authors： Harder S,Graff J,Klinkhardt U,von Hentig N,Walenga JM,Watanabe H,Osakabe M,Breddin HK

更新日期：2004-06-01 00:00:00

abstract：:The plasma protein beta2-glycoprotein I (beta2-GPI) is a major target of autoantibodies in patients with the antiphospholipid syndrome. To understand the physiological function of beta2-GPI and its potential role in the pathophysiology of the antiphospholipid syndrome, the binding of beta2-GPI to phospholipid membrane...

journal_title：Thrombosis and haemostasis

authors： Harper MF,Hayes PM,Lentz BR,Roubey RA

更新日期：1998-10-01 00:00:00

abstract：:A nutritionally induced obesity model was used to investigate the modulation of fibrinolytic and gelatinolytic activity during the development of adipose tissue. Five week old male mice were fed a standard fat diet (SFD, 13% kcal as fat) or a high fat diet (HFD, 42% kcal as fat) for up to 15 weeks. The HFD resulted in...

journal_title：Thrombosis and haemostasis

authors： Lijnen HR,Maquoi E,Demeulemeester D,Van Hoef B,Collen D

更新日期：2002-08-01 00:00:00

abstract：:The core protein components of the plasminogen activator (PA) system are two plasminogen activators, two plasminogen activator inhibitors and a urokinase type plasminogen activator-specific cell surface receptor. Various types of biological regulation are exerted through the interplay of these components mutually and ...

journal_title：Thrombosis and haemostasis

authors： Nagamine Y,Medcalf RL,Muñoz-Cánoves P

更新日期：2005-04-01 00:00:00

abstract：:DX-9065a is an antithrombin III (AT III)-independent and selective inhibitor of activated blood coagulation factor X (FXa). We evaluated the effects of DX-9065a and warfarin on bleeding time and blood loss in rat tail transection model and on blood loss in hydrochloride (HCl)-induced rat gastrointestinal haemorrhage m...

journal_title：Thrombosis and haemostasis

authors： Tanabe K,Morishima Y,Shibutani T,Terada Y,Hara T,Shinohara Y,Aoyagi K,Kunitada S,Kondo T

更新日期：1999-05-01 00:00:00

abstract：:Plaque rupture underlies most myocardial infarctions. Plaques vulnerable to rupture have thin fibrous caps, an excess of macrophages over vascular smooth muscle cells, large lipid cores, and depletion of collagen and other matrix proteins form the cap and lipid core. Production of matrix metalloproteinases from macrop...

journal_title：Thrombosis and haemostasis

authors： Newby AC,George SJ,Ismail Y,Johnson JL,Sala-Newby GB,Thomas AC

更新日期：2009-06-01 00:00:00

abstract：:A factor VIII inhibitor has been found in a patient with an unusual combination of factor VIII-related properties. The inhibitor is directed specifically against the clotting activity (VIII:C) of the factor VIII complex. It behaves in a similar fashion to high responding inhibitors of factor VIII seen in haemophilia A...

journal_title：Thrombosis and haemostasis

authors： Taylor LD,Dean FL,Tiedemann K,Ekert H

更新日期：1986-04-30 00:00:00

abstract：:Bypassing inhibitors in haemophilia patients is limited to activated (a) Factor(F)VII products. We introduced "FVa activity augmentation" as another bypassing strategy and studied effects of an engineered FVa variant designated superFVa. Procoagulant and clot stabilising properties of superFVa and recombinant human (r...

journal_title：Thrombosis and haemostasis

authors： Bhat V,von Drygalski A,Gale AJ,Griffin JH,Mosnier LO

更新日期：2016-03-01 00:00:00

abstract：:Antiphospholipid antibodies (aPL) have been associated with thrombosis and pregnancy losses in patients diagnosed with antiphospholipid syndrome (APS) and enhance thrombus formation in vivo in mice, but the mechanism of thrombosis by aPL is not completely understood. It has been proposed that aPL may affect endothelia...

journal_title：Thrombosis and haemostasis

authors： Pierangeli SS,Liu X,Espinola R,Olee T,Zhu M,Harris NE,Chen PP

更新日期：2000-09-01 00:00:00

abstract：:The alphaII(b)beta3 integrin and FcgammaRII receptors mediate, respectively, platelet adhesion and spreading on fibrinogen and immunoglobulin (IgG) coated surfaces. Platelet adhesion to fibrinogen resulted in a partial conversion of the faster to the slower migrating (phosphorylated) form of Ca(+2)-sensitive cytosolic...

journal_title：Thrombosis and haemostasis

authors： Haimovich B,Ji P,Ginalis E,Kramer R,Greco R

更新日期：1999-04-01 00:00:00

abstract：:Protein C is an important inhibitor of blood coagulation. We investigated the effect of two polymorphisms within the promoter region of the protein C gene (C/T at position 2405 and A/G at position 2418) on risk of venous thrombosis and on plasma protein C levels. In addition the combined effect of the two polymorphism...

journal_title：Thrombosis and haemostasis

authors： Pomp ER,Doggen CJ,Vos HL,Reitsma PH,Rosendaal FR

更新日期：2009-01-01 00:00:00

abstract：:Induction of procoagulant factors in malignant cells is considered to be the major cause of coagulation disorders in cancer. Thrombomodulin (TM), a negative regulator of coagulation was also found to be expressed in cancer cells. We report here evidence for another anticoagulant, the endothelial cell protein C recepto...

journal_title：Thrombosis and haemostasis

authors： Tsuneyoshi N,Fukudome K,Horiguchi S,Ye X,Matsuzaki M,Toi M,Suzuki K,Kimoto M

更新日期：2001-02-01 00:00:00

abstract：:Sixteen Danish unrelated thrombophilic families with plasma protein S deficiency of type 1 (or III) are currently under investigation in our laboratory for defects in the protein S alpha gene. The present paper describes a part of this work, which deals with the identification and phenotypical presentation of two uniq...

journal_title：Thrombosis and haemostasis

authors： Andersen BD,Lind B,Philips M,Hansen AB,Ingerslev J,Thorsen S

更新日期：1996-08-01 00:00:00

abstract：:Vascular endothelial cells perform many differentiated functions in processes such as angiogenesis, hemostasis, and inflammation. The number of recognized differentiated functions has increased rapidly in recent years, but there may be many more still unrecognized. The purpose of this study is to estimate the fraction...

journal_title：Thrombosis and haemostasis

authors： Rieber AJ,Marr HS,Comer MB,Edgell CJ

更新日期：1993-05-03 00:00:00

abstract：:Recently, numerous studies have suggested an association between factor XII (FXII) deficiency and recurrent pregnancy losses, and between autoantibodies to FXII and recurrent pregnancy losses. Autoantibodies to FXII rather than FXII deficiency may be a risk factor for recurrent pregnancy losses. To know the pathogenes...

journal_title：Thrombosis and haemostasis

authors： Inomo A,Sugi T,Fujita Y,Matsubayashi H,Izumi S,Mikami M

更新日期：2008-02-01 00:00:00

abstract：:Overexpression of plasminogen activator inhibitor-1 (SERPINE1, PAI-1), the major physiological inhibitor of pericellular plasmin generation, is a significant causative factor in the progression of vascular disorders (e.g. arteriosclerosis, thrombosis, perivascular fibrosis) as well as a biomarker and a predictor of ca...

journal_title：Thrombosis and haemostasis

authors： Samarakoon R,Higgins PJ

更新日期：2008-12-01 00:00:00