Abstract:
:The importance of intact host defense mechanisms for successful antimicrobial therapy was investigated in an animal model. Recovery from lobar pneumococcal pneumonia as a result of penicillin therapy was studied in normal rats and in rats treated with cobra venom factor. This factor was used to selectively suppress the phagocytosis of pneumococci as a result of complement depletion. Although complete recovery from the infection occurred in normal rats after appropriate penicillin therapy, this was not the case in cobra venom factor-treated rats. Within the limitations of this study, evidence is presented for loss of antibiotic activity as a consequence of impaired phagocytosis.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Bakker-Woudenberg IA,de Jong-Hoenderop JY,Michel MFdoi
10.1128/IAI.25.1.366-375.1979subject
Has Abstractpub_date
1979-07-01 00:00:00pages
366-75issue
1eissn
0019-9567issn
1098-5522journal_volume
25pub_type
杂志文章abstract::Tritrichomonas foetus is a serious veterinary pathogen, causing bovine trichomoniasis, a sexually transmitted disease leading to infertility and abortion. T. foetus infects the mucosal surfaces of the reproductive tract. Infection with T. foetus leads to apoptotic cell death of bovine vaginal epithelial cells (BVECs) ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.72.7.4151-4158.2004
更新日期:2004-07-01 00:00:00
abstract::We produced anti-idiotype antibodies to antibody to lipid A from Eikenella corrodens. The ALA-1 monoclonal antibody (immunoglobulin M [IgM] isotype), which had already been produced in our laboratory (T. Kato, I. Takazoe, and K. Okuda, Infect. Immun. 57:656-659, 1989), had reacted strongly with lipid A from E. corrode...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.2.416-420.1990
更新日期:1990-02-01 00:00:00
abstract::Lipopolysaccharide (LPS) binding protein (LBP) is an acute-phase protein that enhances the responsiveness of immune cells to LPS by virtue of its capacity to transfer LPS to CD14. To determine the role of LBP in the innate immune response to peritonitis, LBP gene-deficient (LBP(-/-)) and normal wild-type mice were int...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.12.6747-6753.2003
更新日期:2003-12-01 00:00:00
abstract::Salmonellae possess the ability to adhere to and invade macrophages and in so doing trigger a number of intracellular events that are associated with cellular activation. As an initial approach to defining the mechanisms by which invasive salmonellae alter macrophage function, we have explored the impact of Salmonella...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.5.1820-1826.1995
更新日期:1995-05-01 00:00:00
abstract::Studies of mice suggest that pneumococcal proteins, including PspA, pneumolysin, PsaA, and CbpA, are promising vaccine candidates. To determine whether these proteins are good mucosal immunogens in humans, adenoidal lymphocytes from 20 children who had adenoidectomies were isolated and tested by ELISpot for antigen-sp...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.10.5363-5369.2002
更新日期:2002-10-01 00:00:00
abstract::Adherence of erythrocytes infected with Plasmodium falciparum to microvascular endothelial cells (sequestration) is considered to play an important role in parasite virulence and pathogenesis. However, the real importance of sequestration for infection and disease has never been fully assessed. The absence of an appro...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.7.4135-4144.2000
更新日期:2000-07-01 00:00:00
abstract::Borrelia burgdorferi sensu stricto is the major causative agent of Lyme disease in the United States, while B. garinii and B. afzelii are more prevalent in Europe. The highly complex genome of B. burgdorferi is comprised of a linear chromosome and a large number of variably sized linear and circular plasmids. Many pla...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.06326-11
更新日期:2012-04-01 00:00:00
abstract::Mosquitoes are infected with Plasmodium falciparum by taking a blood meal from a gametocyte carrier. Since a mosquito takes a volume of 1 to 2 microl, a blood meal may contain 1 x 10(4) to 3 x 10(4) leukocytes (WBC). The majority of WBC are composed of neutrophils which may phagocytose and kill developing gametes insi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.9.3834-3837.1997
更新日期:1997-09-01 00:00:00
abstract::The adenylate cyclase-hemolysin of Bordetella pertussis consists of a cell-invasive N-terminal adenylate cyclase domain linked to a C-terminal RTX hemolysin containing extensive glycine-rich repeats. The toxin is an essential virulence factor required in the initial stages of infection. Adenylate cyclase-hemolysin was...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.9.3309-3315.1995
更新日期:1995-09-01 00:00:00
abstract::The bactericidal and opsonizing effects of normal human serum on six strains of Salmonella typhimurium LT-2 having different lipopolysaccharide (LPS) composition were demonstrated through five indices. Complement activity in the presence of antibody was important for the opsonization of all six strains and for the bac...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.49.3.647-653.1985
更新日期:1985-09-01 00:00:00
abstract::Human polymorphonuclear leukocytes from normal subjects produced proinflammatory cytokines in response to stimulation with Cryptococcus neoformans yeast cells. The cytokines released after stimulation of neutrophils included interleukin-1beta (IL-1beta), IL-6, IL-8 and tumor necrosis factor alpha. The magnitude of the...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.8.2897-2903.1996
更新日期:1996-08-01 00:00:00
abstract::CS31A is a K88-related capsule-like surface protein that mediates Escherichia coli and Klebsiella pneumoniae adhesion to the human Caco-2 and Intestine-407 cell lines. In this study, we demonstrate that ClpG, the major subunit of CS31A, contains the adhesive domain of the polymerized structure. We mapped this domain w...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.2.609-616.1997
更新日期:1997-02-01 00:00:00
abstract::A number of polymorphonuclear leukocyte (PMN) chemotactic factors derived from complement components have been described. We sought to determine which of these factors accounted for the majority of PMN chemotactic activity in rabbit serum and guinea pig serum treated with preformed immune complexes. Normal rabbit sera...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.1.6.521-525.1970
更新日期:1970-06-01 00:00:00
abstract::Members of the babesial rhoptry-associated protein 1 (RAP-1) family express surface-exposed B-cell epitopes and are candidate antigens for vaccine development. The relationship between rap-1 genomic polymorphism and surface-exposed B-cell epitope expression was analyzed by comparison of biological clones of Mexico str...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.8.3576-3579.1994
更新日期:1994-08-01 00:00:00
abstract::We have recently found that strain B31 infection-immune rabbits are completely protected against homologous challenge with large numbers (>10(6)) of host-adapted Borrelia burgdorferi (HAB) (E. S. Shang, C. I. Champion, X. Wu, J. T. Skare, D. B. Blanco, J. N. Miller, and M. A. Lovett, Infect. Immun. 68:4189-4199, 2000)...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.1.593-598.2001
更新日期:2001-01-01 00:00:00
abstract::The binding of (125)I-labeled S component to rabbit polymorphonuclear leukocytes was found to be concentration dependent and saturable at 37 degrees C. Scatchard analysis of the binding curve gave a straight line, indicating that S component binds to a single population of sites. The dissociation constant, K(D), deriv...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.34.2.362-367.1981
更新日期:1981-11-01 00:00:00
abstract::Rats kept under germfree conditions showed lower specific lysosomal enzyme activities in liver endothelial cells, but not in Kupffer cells. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.33.2.620-622.1981
更新日期:1981-08-01 00:00:00
abstract::Bordetella pertussis is the causative agent of whooping cough, a potentially lethal respiratory disease in children. In immunocompetent individuals, B. pertussis infection elicits an effective adaptive immune response driven by activated CD4(+) T cells. However, live B. pertussis persists in the host for 3 to 4 weeks ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.72.3.1450-1462.2004
更新日期:2004-03-01 00:00:00
abstract::The addition of inhibitors of cell wall biosynthesis to exponential-phase cultures of Streptococcus mutans may do one of three things, depending on the concentrations used: (i) prevent cell division at a time coincident with the onset of chromosome replication, (ii) prevent cell division later in the cell cycle coinci...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.41.1.28-32.1983
更新日期:1983-07-01 00:00:00
abstract::Tissue macrophages are the obligatory host cells for Leishmania donovani, the causative agent of visceral leishmaniasis. In this study we sought to determine whether activated macrophages, as defined by the functional criterion of tumor cell cytotoxicity, were also able to exert a microbicidal effect on ingested L. do...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.33.3.918-926.1981
更新日期:1981-09-01 00:00:00
abstract::Polyprotein allergens are a family of structurally homologous molecules from parasitic nematodes which induce specific immunoglobulin E in infected individuals. We show here that both H-2 and non-H-2 factors determine the ability of mice to generate T- and B-cell responses to the filarial polyprotein allergen (Brugia ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.8.2892-2898.1995
更新日期:1995-08-01 00:00:00
abstract::Immunity to pneumococcal colonization in mice by exposure to live or killed pneumococci has been shown to be antibody independent but dependent on CD4+ T cells. Here we show that intranasal immunization with pneumococcal proteins (pneumococcal surface protein C, adhesin A, and a pneumolysoid) can elicit a similar mech...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00773-07
更新日期:2007-11-01 00:00:00
abstract::The parameters of a persistent-state measles virus infection in BGM/MV cells were examined. The BGM/MV cell line was established by cocultivation of measles virus-infected primary C3H mouse brain cells with a stable line of African green monkey kidney cells (BGM). Initially, a morphologically mixed population of cells...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.11.1.152-158.1975
更新日期:1975-01-01 00:00:00
abstract::Three MudJ prototrophs demonstrated that intracellular replication is a Salmonella virulence trait (K. Y. Leung and B. B. Finlay, Proc. Natl. Acad. Sci. USA, 88:11470-11474, 1991). mutS and mutH are disrupted in mutants 3-11 and 12-23, and ssaQ is disrupted in mutant 17-21. Further analysis revealed that loss of Salmo...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.4.2247-2252.2003
更新日期:2003-04-01 00:00:00
abstract::Escherichia coli hemolysin is considered an important virulence factor in extraintestinal E. coli infections. The present study demonstrates that cultured pulmonary artery endothelial cells are susceptible to attack by low concentrations of E. coli hemolysin (greater than or equal to 0.05 hemolytic units/ml; greater t...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.11.3796-3801.1990
更新日期:1990-11-01 00:00:00
abstract::Unmethylated CpG dinucleotide motifs present in bacterial genomes or synthetic oligodeoxynucleotides (ODNs) serve as strong immunostimulatory agents in mice, monkeys and humans. We determined the adjuvant effect of murine CpG ODN 1826 on the immunogenicity and protective efficacy of the Saccharomyces cerevisiae-expres...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.72.2.949-957.2004
更新日期:2004-02-01 00:00:00
abstract::The role of the spleen in hepatic amoebiasis in hamsters was studied. In hamsters receiving an intrahepatic inoculation of 10(5) trophozoites of axenic Entamoeba histolytica at 7 or 14 days postsplenectomy, the mean weight of metastatic foci increased significantly when compared with sham-splenectomized or intact cont...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.31.2.571-573.1981
更新日期:1981-02-01 00:00:00
abstract::A parasitic protozoan, Leishmania mexicana amazonensis, was previously made resistant to tunicamycin (J.A. Kink and K.-P. Chang, Proc. Natl. Acad. Sci. USA 84:1253-1257, 1987). In the present study, six different tunicamycin-resistant variants were biologically and biochemically compared with their parental wild type ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.7.1692-1700.1987
更新日期:1987-07-01 00:00:00
abstract::A 10-amino-acid repeating sequence of the hemagglutinating portion of Clostridium difficile toxin A has been synthesized and used to produce antisera in rabbits. Antipeptide antibody inhibited toxin A-mediated hemagglutination and neutralized cytotoxic activity. Immunoblot analysis with the antipeptide antibody reveal...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.9.3151-3155.1991
更新日期:1991-09-01 00:00:00
abstract::Blastomyces dermatitidis is a thermally induced dimorphic fungus capable of causing lung and systemic infections in immunocompetent animal hosts. With the publication of genomic sequences from three different strains of B. dermatitidis and the development of RNA interference as a gene-silencing tool, it has become pos...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01328-09
更新日期:2010-06-01 00:00:00