Chromosomal control of mating activity in Drosophila pseudoobscura.

abstract：:T-cell tumors are characterized by inversions or translocations of chromosome 14. The breakpoints of these karyotypic abnormalities occur in chromosome bands 14q11 and 14q32--the same bands in which the T-cell receptor (TCR) alpha-chain and immunoglobulin heavy chain genes have been mapped, respectively. Patients with...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baer R,Heppell A,Taylor AM,Rabbitts PH,Boullier B,Rabbitts TH

更新日期：1987-12-01 00:00:00

abstract：:A mutant strain deficient in RNase T was isolated and used to study the role of this enzyme in Escherichia coli. Strains lacking as much as 70% of RNase T activity, alone or in combination with the absence of other RNases, display normal growth properties. However, in cca strains, which lack tRNA nucleotidyltransferas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deutscher MP,Marlor CW,Zaniewski R

更新日期：1985-10-01 00:00:00

abstract：:In normal adult rats anesthetized with urethane, intravenous injections of beta-endorphin (30--150 micrograms kg-1) induced a transient fall of blood pressure followed by a small hypertension and a prolonged hypotension. Prior administration of naloxone completely blocked these effects, whereas naloxone, given 1 hr af...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lemaire I,Tseng R,Lemaire S

更新日期：1978-12-01 00:00:00

abstract：:We report a general mass spectrometric approach for the rapid identification and characterization of proteins isolated by preparative two-dimensional polyacrylamide gel electrophoresis. This method possesses the inherent power to detect and structurally characterize covalent modifications. Absolute sensitivities of ma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clauser KR,Hall SC,Smith DM,Webb JW,Andrews LE,Tran HM,Epstein LB,Burlingame AL

更新日期：1995-05-23 00:00:00

abstract：:Acetyl-CoA synthase from Clostridium thermoaceticum (ACS(Ct)) is an alpha(2)beta(2) tetramer containing two novel Ni-X-Fe(4)S(4) active sites (the A and C clusters) and a standard Fe(4)S(4) cluster (the B cluster). The acsA and acsB genes encoding the enzyme were cloned into Escherichia coli strain JM109 and overexpre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Loke HK,Bennett GN,Lindahl PA

更新日期：2000-11-07 00:00:00

abstract：:Computational and biochemical studies implicate the blue-light sensor cryptochrome (CRY) as an endogenous light-dependent magnetosensor enabling migratory birds to navigate using the Earth's magnetic field. Validation of such a mechanism has been hampered by the absence of structures of vertebrate CRYs that have funct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zoltowski BD,Chelliah Y,Wickramaratne A,Jarocha L,Karki N,Xu W,Mouritsen H,Hore PJ,Hibbs RE,Green CB,Takahashi JS

更新日期：2019-09-24 00:00:00

abstract：:The interaction between the ribosomal-stalk protein L7/12 (L12) and initiation factor 2 (IF2) is essential for rapid subunit association, but the underlying mechanism is unknown. Here, we have characterized the L12-IF2 interaction on Escherichia coli ribosomes using site-directed mutagenesis, fast kinetics, and molecu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ge X,Mandava CS,Lind C,Åqvist J,Sanyal S

更新日期：2018-05-01 00:00:00

abstract：:Platelets are best known for their vasoprotective responses to injury and inflammation. Here, we have asked whether they also support vascular integrity when neither injury nor inflammation is present. Changes in vascular barrier function in dermal and meningeal vessels were measured in real time in mouse models using...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gupta S,Konradt C,Corken A,Ware J,Nieswandt B,Di Paola J,Yu M,Wang D,Nieman MT,Whiteheart SW,Brass LF

更新日期：2020-09-29 00:00:00

abstract：:Xenopus oocytes express a gene encoding bovine rhodopsin as well as its SP6 RNA polymerase-derived transcripts and total retinal mRNA. The opsin produced is in unglycosylated (30 kDa) and two glycosylated (35 kDa and 41 kDa) forms. Incubation of the cells expressing the above proteins with 11-cis-retinal generates rho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khorana HG,Knox BE,Nasi E,Swanson R,Thompson DA

更新日期：1988-11-01 00:00:00

abstract：:Turbulence is an important determinant of phytoplankton physiology, often leading to cell stress and damage. Turbulence affects phytoplankton migration both by transporting cells and by triggering switches in migratory behavior, whereby vertically migrating cells can actively invert their direction of migration upon e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carrara F,Sengupta A,Behrendt L,Vardi A,Stocker R

更新日期：2021-02-02 00:00:00

abstract：:Cell-based or pharmacological approaches for promoting tendon repair are currently not available because the molecular mechanisms of tendon development and healing are not well understood. Although analysis of knockout mice provides many critical insights, small animals such as mice have some limitations. In particula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suzuki H,Ito Y,Shinohara M,Yamashita S,Ichinose S,Kishida A,Oyaizu T,Kayama T,Nakamichi R,Koda N,Yagishita K,Lotz MK,Okawa A,Asahara H

更新日期：2016-07-12 00:00:00

abstract：:The protein kinase A stimulator cAMP can potentiate the ability of progestins to induce the transactivation function of the human progesterone receptor (hPR). We questioned in the present study whether cAMP could functionally cooperate with the progestin antagonist RU486. In T47D human breast cancer cells, RU486 behav...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beck CA,Weigel NL,Moyer ML,Nordeen SK,Edwards DP

更新日期：1993-05-15 00:00:00

abstract：:Understanding the relationship between the structural and functional organization of the human brain is one of the most important goals of neuroscience. Individual variability in brain structure means that it is essential to obtain this information from the same subject. To date, this has been almost impossible. Even ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walters NB,Egan GF,Kril JJ,Kean M,Waley P,Jenkinson M,Watson JD

更新日期：2003-03-04 00:00:00

abstract：:Information concerning the dynamics of river meandering is embedded in their planforms. Here, we focus on how bend skewing varies with increasing sinuosity, and how flow direction is embedded in bend skewing. It has often been thought that upstream-skewed bends are dominant within a sufficiently long reach. These bend...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo X,Chen D,Parker G

更新日期：2019-11-19 00:00:00

abstract：:It has long been recognized that a suite of proteins exists in coral skeletons that is critical for the oriented precipitation of calcium carbonate crystals, yet these proteins remain poorly characterized. Using liquid chromatography-tandem mass spectrometry analysis of proteins extracted from the cell-free skeleton o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Drake JL,Mass T,Haramaty L,Zelzion E,Bhattacharya D,Falkowski PG

更新日期：2013-03-05 00:00:00

abstract：:Using a comprehensive transcriptome analysis, a Z chromosome-linked chicken homolog of hemogen (cHEMGN) was identified and shown to be specifically involved in testis differentiation in early chicken embryos. Hemogen [Hemgn in mice, EDAG (erythroid differentiation-associated gene protein) in humans] was recently chara...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakata T,Ishiguro M,Aduma N,Izumi H,Kuroiwa A

更新日期：2013-02-26 00:00:00

abstract：:When propagated on arl strains (a subclass of Escherichia coli hyper-rec mutants), lambda "Red-" duplication phages accumulated an enhanced potential for recombination. The physical properties of the recombinogenic phages thus obtained ("Arl-" phages) were similar to those of phages grown on arl+ bacteria. However, Ar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hays JB,Korba BE

更新日期：1979-12-01 00:00:00

abstract：:RNA-binding motif protein 4 (RBM4) plays a regulatory role in alternative splicing of precursor mRNA. We show here that cell stress such as arsenite exposure induces phosphorylation of RBM4 at serine 309 and also drives its cytoplasmic accumulation and targeting to stress granule via the MKK(3/6)-p38 signaling pathway...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin JC,Hsu M,Tarn WY

更新日期：2007-02-13 00:00:00

abstract：:Ionizing radiation (IR) induces a variety of DNA lesions among which DNA double-strand breaks (DSBs) are the biologically most significant. It is currently unclear if DSB repair is equally efficient after low and high doses. Here, we use gamma-H2AX, phospho-ATM (pATM), and 53BP1 foci analysis to monitor DSB repair. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grudzenski S,Raths A,Conrad S,Rübe CE,Löbrich M

更新日期：2010-08-10 00:00:00

abstract：:We explored the feasibility of designing retroviral vectors that can target human breast cancer cells with characteristic receptors via ligand-receptor interaction. The ecotropic Moloney murine leukemia virus envelope was modified by insertion of sequences encoding human heregulin. Ecotropic virus, which normally does...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Han X,Kasahara N,Kan YW

更新日期：1995-10-10 00:00:00

abstract：:We outline a theory to quantify the interplay of entropic and selective forces on nucleotide organization and apply it to the genomes of single-stranded RNA viruses. We quantify these forces as intensive variables that can easily be compared between sequences, outline a computationally efficient transfer-matrix method...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greenbaum BD,Cocco S,Levine AJ,Monasson R

更新日期：2014-04-01 00:00:00

abstract：:The cellular replicative DNA polymerases cannot initiate DNA synthesis without a priming 3' OH. During DNA replication, this is supplied in the context of a short RNA primer molecule synthesized by DNA primase. The primase of archaea and eukaryotes, despite having varying subunit compositions, share sequence and struc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan J,Holzer S,Pellegrini L,Bell SD

更新日期：2018-06-26 00:00:00

abstract：:We have determined the nucleotide sequences of cDNAs encoding the precursor of the beta subunit of rat lutropin, a polypeptide hormone that regulates gonadal function, including the development of gametes and the production of steroid sex hormones. The cDNAs were prepared from poly(A)+ RNA derived from the pituitary g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chin WW,Godine JE,Klein DR,Chang AS,Tan LK,Habener JF

更新日期：1983-08-01 00:00:00

abstract：:Mutations in genes that encode components of the phosphatidyl-inositol 3-kinase (PI3-kinase) signaling pathway are common in human cancer. The recent discovery of nonrandom somatic mutations in the PIK3CA gene of many human tumors suggests an oncogenic role for the mutated enzyme. We have determined the growth-regulat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kang S,Bader AG,Vogt PK

更新日期：2005-01-18 00:00:00

abstract：:Chromosome region 11p15.5 harbors unidentified genes involved in neoplasms and in the genetic disease Beckwith-Wiedemann syndrome. The genetic analysis of a 170-kb region at 11p15.5 between loci D11S601 and D11S679 resulted in the identification of six transcriptional units. Three genes, hNAP2, CDKN1C, and KVLQT1, are...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwienbacher C,Sabbioni S,Campi M,Veronese A,Bernardi G,Menegatti A,Hatada I,Mukai T,Ohashi H,Barbanti-Brodano G,Croce CM,Negrini M

更新日期：1998-03-31 00:00:00

abstract：:Advances in direct radiocarbon dating of Neanderthal and anatomically modern human (AMH) fossils and the development of archaeostratigraphic chronologies now allow refined regional models for Neanderthal-AMH coexistence. In addition, they allow us to explore the issue of late Neanderthal survival in regions of Western...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pinhasi R,Higham TF,Golovanova LV,Doronichev VB

更新日期：2011-05-24 00:00:00

abstract：:Although much of the brain's functional organization is genetically predetermined, it appears that some noninnate functions can come to depend on dedicated and segregated neural tissue. In this paper, we describe a series of experiments that have investigated the neural development and organization of one such noninna...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Polk TA,Farah MJ

更新日期：1998-02-03 00:00:00

abstract：:Rett syndrome is a severe neurodevelopmental disorder caused by mutations in the methyl-CpG binding protein gene (MECP2). MeCP2 is a methyl-cytosine binding protein that is proposed to function as a transcriptional repressor. However, multiple gene expression studies comparing wild-type and MeCP2-deficient neurons hav...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kinde B,Wu DY,Greenberg ME,Gabel HW

更新日期：2016-12-27 00:00:00

abstract：:Voltage gating of hyperpolarization-activated cation (HCN) channels is potentiated by direct binding of cAMP to a cytoplasmic cAMP-sensing domain (CSD). When unliganded, the CSD inhibits hyperpolarization-dependent opening of the HCN channel gate; cAMP binding relieves this autoinhibition so that opening becomes more ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wicks NL,Wong T,Sun J,Madden Z,Young EC

更新日期：2011-01-11 00:00:00

abstract：:Triglyceridemic response to a standard oral fat meal was determined in 28 healthy subjects and related to the levels of several lipids, lipoproteins, and apolipoproteins in the post-absorptive plasma. A fatty test meal was administered orally, and postprandial plasma triglyceride levels were determined. In the fasting...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patsch JR,Karlin JB,Scott LW,Smith LC,Gotto AM Jr

更新日期：1983-03-01 00:00:00