Abstract:
:Stability of aromatic phosphoramidates was studied using 2',3'-O-dibenzoyluridine 5'-phosphoramidates and N,2',3'-O-tribenzoylcytidine 5'-phosphate. The effect of dicyclohexylcarbodiimide in this mixture was investigated. Decomposition of the anilidate was slower in the presence of DCC. Substituted anilidates of uridine 5'-phosphate were synthesized and the stability of these amidates in anhydrous pyridine was studied.2'-O-Benzoyluridine 3'-phosphoranilidate and the corresponding beta-naphthylidate were compared in their stabilities in anhydrous pyridine, 50% aqueous pyridine and 80% acetic acid. 2'-O-Benzoyluridine 3'-phosphoro-beta-naphthylidate was used for synthesis of dinucleotides.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Otsuka E,Honda A,Shigyo H,Morioka S,Sugiyama Tdoi
10.1093/nar/1.2.223subject
Has Abstractpub_date
1974-02-01 00:00:00pages
223-34issue
2eissn
0305-1048issn
1362-4962journal_volume
1pub_type
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