The effect of amino acids on the temperature sensitive phenotype of the mammalian leucyl-tRNA synthetase mutant tsHl and its revertants.

abstract：:Cells transformed by murine sarcoma viruses (MSV) produce and release into their tissue culture media several polypeptide growth stimulating factors. One of these has been partially purified using Bio-Gel P-60 column chromatography followed by DEAE-cellulose chromatography. This growth factor was assigned the name sar...

journal_title：Journal of cellular physiology

authors： De Larco JE,Todaro GJ

更新日期：1980-02-01 00:00:00

abstract：:Hybridization analysis of mRNA with a cDNA probe for human sucrase-isomaltase, pulse-chase experiments with L-[35S]-methionine followed by SDS-PAGE, and immunofluorescence detection of sucrase-isomaltase were used to analyze the level(s) at which forskolin interferes with the expression of the enzyme in Caco-2 cells i...

journal_title：Journal of cellular physiology

authors： Rousset M,Chantret I,Darmoul D,Trugnan G,Sapin C,Green F,Swallow D,Zweibaum A

更新日期：1989-12-01 00:00:00

abstract：:A new system for studying growth of normal human mammary epithelial cells in an in vivo environment using athymic nude mice is described. Human mammary epithelial cells dissociated from reduction mammoplasty specimens were embedded within collagen gels and subsequently transplanted subcutaneously into nude mice. Histo...

journal_title：Journal of cellular physiology

authors： Popnikolov NK,Yang J,Guzman RC,Swanson SM,Thordarson G,Collins G,Talamantes F,Nandi S

更新日期：1995-04-01 00:00:00

abstract：:Production of inflammatory cytokines plays important roles in the response against tissue injury and in host defense. Alterations in the production of inflammatory cytokines may cause local or systemic inflammatory imbalance, culminating in organ failure or lethal systemic inflammation. The cholinergic anti-inflammato...

journal_title：Journal of cellular physiology

authors： Pereira MR,Leite PE

更新日期：2016-09-01 00:00:00

abstract：:Incubation of isolated rat soleus and EDL muscles in the presence of 10 mM leucine resulted in a decreased proteolytic rate as measured by the release of tyrosine into the incubation medium. The effect of this branched-chain amino acid (BCAA) is associated with a decreased activity of the lysosomal proteases and a dec...

journal_title：Journal of cellular physiology

authors： Busquets S,Alvarez B,Llovera M,Agell N,López-Soriano FJ,Argilés JM

更新日期：2000-09-01 00:00:00

abstract：:Proteasome inhibitors represent a promising therapy for the treatment of relapsed and/or refractory multiple myeloma, a disease that is concomitant with osteolysis and enhanced osteoclast formation. While blockade of the proteosome pathway has been recently shown to influence osteoclast formation and function, the pre...

journal_title：Journal of cellular physiology

authors： Ang E,Pavlos NJ,Rea SL,Qi M,Chai T,Walsh JP,Ratajczak T,Zheng MH,Xu J

更新日期：2009-08-01 00:00:00

abstract：:Macrophages and many chemokines are closely associated with the adipogenic differentiation of bone marrow mesenchymal stem cells (MSCs), but their roles in adipogenesis and the underlying mechanisms are not fully understood. Here, we first investigated the influence of macrophages on the differentiation of MSCs in vit...

journal_title：Journal of cellular physiology

authors： Cao D,Ma F,Ouyang S,Liu Z,Li Y,Wu J

更新日期：2019-06-01 00:00:00

abstract：:Several studies have shown that interleukin-4 (IL-4) down-regulates synthesis of prostaglandin E2 (PGE2). We evaluated the mechanisms for this suppression in human alveolar macrophages (HAMs). Normal HAMs were obtained from healthy nonsmoking volunteers. The cells either remained unstimulated, or were exposed to 10 mi...

journal_title：Journal of cellular physiology

authors： Yano T,Hopkins HA,Hempel SL,Monick M,Hunninghake GW

更新日期：1995-10-01 00:00:00

abstract：:We recently reported that peptidoglycan (PGN), a cell wall component of the Gram-positive bacterium, induces NF-κB activation and microglia activation. However, PGN-regulated AP-1 activation and cytokine expression in microglia remains unclear. This study investigated how PGN influences the signaling pathway involved ...

journal_title：Journal of cellular physiology

authors： Lin HY,Tang CH,Chen JH,Chuang JY,Huang SM,Tan TW,Lai CH,Lu DY

更新日期：2011-06-01 00:00:00

abstract：:Tight junctions govern the paracellular permeability of endothelial and epithelial cells. Aberrations of tight junction function are an early and key event during the vascular spread of cancer and inflammation. This study sought to determine the role of estrogen in the regulation of tight junctions and expression of m...

journal_title：Journal of cellular physiology

authors： Ye L,Martin TA,Parr C,Harrison GM,Mansel RE,Jiang WG

更新日期：2003-08-01 00:00:00

abstract：:Even though the involvement of intracellular Ca(2+) Ca(i)(2+) in hematopoiesis has been previously demonstrated, the relationship between Ca(i)(2+) signaling and cytokine-induced intracellular pathways remains poorly understood. Herein, the molecular mechanisms integrating Ca(2+) signaling with the extracellular signa...

journal_title：Journal of cellular physiology

authors： Leon CM,Barbosa CM,Justo GZ,Borelli P,Resende JD Jr,de Oliveira JS,Ferreira AT,Paredes-Gamero EJ

更新日期：2011-07-01 00:00:00

abstract：:Matrix metalloproteinase-9 (MMP-9) is implicated in the invasion and metastasis of breast cancer cells. We investigated the modulatory effects of nitric oxide (NO) on the 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced MMP-9 expression in MCF-7 cells. Different chemical NO donors inhibited the extracellular content...

journal_title：Journal of cellular physiology

authors： Jespersen C,Doller A,Akool el-S,Bachmann M,Müller R,Gutwein P,Mühl H,Pfeilschifter J,Eberhardt W

更新日期：2009-05-01 00:00:00

abstract：:Regulation of lipid synthesis from acetate in human diploid fibroblast cultures has been studied at various passage levels and at different stages of cell growth. When cultures were transferred to lipid free medium, a stimulation of [14C]acetate incorporation into lipid occurred within three to six hours after removal...

journal_title：Journal of cellular physiology

authors： Howard BV,Howard WJ,Kefalides NA

更新日期：1976-10-01 00:00:00

abstract：:Minute virus of mice (MVM), a non-defective parvovirus, has been shown to infect cultures of non-pluripotent differentiated teratocarcinoma-derived cells, but pluripotent (and "nullipotent") embryonal carcinoma cells derived from the same teratocarcinoma resist MVN infection. Somatic cell hybrids between an embryonal ...

journal_title：Journal of cellular physiology

authors： Miller RA,Ward DC,Ruddle FH

更新日期：1977-06-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common malignancies and is a serious threat to people's health worldwide. The prognosis of advanced HCC is dim if left untreated. In the clinic, the treatment options for advanced HCC include surgery, radiotherapy, transcatheter arterial chemoembolization, and so forth...

journal_title：Journal of cellular physiology

authors： Zhu J,Yin T,Xu Y,Lu XJ

更新日期：2019-08-01 00:00:00

abstract：:The serum-free medium conditioned by the human colon cancer cell line HT-29 contains insulin-like growth factors (IGF) that are entirely complexed to binding proteins (IGF-BP). Gel filtration in acid conditions of the cell-conditioned medium permits separation of IGF-BP from two molecular forms of IGF of 15,000 and 7,...

journal_title：Journal of cellular physiology

authors： Culouscou JM,Remacle-Bonnet M,Garrouste F,Fantini J,Marvaldi J,Pommier G

更新日期：1990-06-01 00:00:00

abstract：:The basis of the well-known decline in cell proliferation with increasing passage number of human diploid fibroblast-like cell cultures is not known. It has been found that DNA synthesis was deficient in the remaining but still proliferating cells, but when appropriate corrections reflecting the remaining dividing cel...

journal_title：Journal of cellular physiology

authors： Collins JM,Chu AK

更新日期：1990-04-01 00:00:00

abstract：:Protein sorting through vesicular compartments is highly regulated to maintain the integrity and signaling of intracellular organelles in eukaryotic cells. Sorting Nexin-2 (SNX2) is involved in protein sorting in the trans-Golgi network, endosome, and/or lysosome compartments, with loss of function leading to defect i...

journal_title：Journal of cellular physiology

authors： Abdul-Ghani M,Hartman KL,Ngsee JK

更新日期：2005-07-01 00:00:00

abstract：:The growth-regulated vimentin gene contains a functional double AP-1 binding site formed by two nearly perfect inverted repeats. We present evidence for down-regulation of vimentin expression by the retinoic acid receptor (RAR) in two mesodermally derived cell types. By mutation analysis we prove that the double conse...

journal_title：Journal of cellular physiology

authors： Van de Klundert FA,Jansen HJ,Bloemendal H

更新日期：1995-07-01 00:00:00

abstract：:Myeloid cells, including granulocytes and monocyte/macrophages, are important in disease-associated inflammatory reactions. These cells come from a common progenitor, the promyelocyte. The human promyelocytic cell line, HL-60, can be induced to terminally differentiate into granulocytes or monocyte/ macrophages in a c...

journal_title：Journal of cellular physiology

authors： Brent LH,Rubenstein B,Gong QH,Wieland SJ

更新日期：1996-07-01 00:00:00

abstract：:The effects of pulsatile and steady fluid flow on the mRNA levels of proto-oncogenes c-fos, c-jun, and c-myc in cultured human umbilical vein endothelial cells (HUVEC) were investigated. c-fos mRNA levels in stationary cultures were very low. A 1 Hz pulsatile flow with an average shear stress of 16 dynes/cm2 induced a...

journal_title：Journal of cellular physiology

authors： Hsieh HJ,Li NQ,Frangos JA

更新日期：1993-01-01 00:00:00

abstract：:The purpose of this study was to delineate the traffic patterns of EGF and EGF receptors (EGFR) in primary cultured acinar epithelial cells from rabbit lacrimal glands. Uptake of [(125)I]-EGF exhibited saturable and non-saturable, temperature-dependent components, suggesting both receptor-mediated and fluid phase endo...

journal_title：Journal of cellular physiology

authors： Xie J,Qian L,Wang Y,Rose CM,Yang T,Nakamura T,Hamm-Alvarez SF,Mircheff AK

更新日期：2004-04-01 00:00:00

abstract：:Aberrant proliferation of vascular smooth muscle cells (VSMC) is a critical contributor to the pathogenesis of atherosclerosis (AS). Our previous studies have demonstrated that apelin-13/APJ confers a proliferative response in VSMC, however, its underlying mechanism remains elusive. In this study, we aimed to investig...

journal_title：Journal of cellular physiology

authors： He L,Zhou Q,Huang Z,Xu J,Zhou H,Lv D,Lu L,Huang S,Tang M,Zhong J,Chen JX,Luo X,Li L,Chen L

更新日期：2019-06-01 00:00:00

abstract：:Many mammalian SWI/SNF complexes use Brahma-related gene 1 (Brg1) as a catalytic subunit to remodel nucleosomes for transcription regulation. In several mesenchymal cells and tissues, expression of a defective Brg1 protein negates the normal activity of the SWI/SNF complex and delays or blocks differentiation. To inve...

journal_title：Journal of cellular physiology

authors： Vradii D,Wagner S,Doan DN,Nickerson JA,Montecino M,Lian JB,Stein JL,van Wijnen AJ,Imbalzano AN,Stein GS

更新日期：2006-01-01 00:00:00

abstract：:Ascorbic acid induces apoptosis, autophagy, and necrotic cell death in cancer cells. We investigated the mechanisms by which ascorbic acid induces death in laryngeal squamous cell carcinoma Hep2 cells. Ascorbic acid markedly reduced cell viability and induced death without caspase activation and an increase in cytochr...

journal_title：Journal of cellular physiology

authors： Baek MW,Cho HS,Kim SH,Kim WJ,Jung JY

更新日期：2017-02-01 00:00:00

abstract：:Evidence is emerging that long noncoding RNAs (lncRNAs) play vital roles in tumorigenesis. LncRNA gastric cancer-associated transcript 3 (GACAT3) is reported to participate in the development of breast cancer, colorectal cancer, nonsmall cell lung cancer, and gastric cancer. However, whether it is implicated in glioma...

journal_title：Journal of cellular physiology

authors： Pan B,Zhao M,Xu L

更新日期：2019-06-01 00:00:00

abstract：:Nowadays, fat tissue transplantation is widely used in regenerative and reconstructive surgery. However, a shared method of lipoaspirate handling for ensuring a good quality fat transplant has not yet been established. The study was to identify a method to recover from the lipoaspirate samples the highest number of hu...

journal_title：Journal of cellular physiology

authors： Palumbo P,Miconi G,Cinque B,La Torre C,Lombardi F,Zoccali G,Orsini G,Leocata P,Giuliani M,Cifone MG

更新日期：2015-08-01 00:00:00

abstract：:Ebp1, an ErbB-3 binding protein, inhibits the proliferation and induces the differentiation of human breast cancer cells. The mechanisms of these effects are unknown. Rb, the product of the retinoblastoma gene, is an important modulator of cell cycle progression and cellular differentiation. We report that Rb is a bin...

journal_title：Journal of cellular physiology

authors： Xia X,Cheng A,Lessor T,Zhang Y,Hamburger AW

更新日期：2001-05-01 00:00:00

abstract：:Skeletal muscle dysfunction contributes to exercise limitation in COPD. In this study cigarette smoke exposure was hypothesized to increase expression of the inflammatory cytokine, TNF-alpha, thereby suppressing PGC-1alpha, and hence affecting down stream molecules that regulate oxygen transport and muscle function. F...

journal_title：Journal of cellular physiology

authors： Tang K,Wagner PD,Breen EC

更新日期：2010-02-01 00:00:00

abstract：:Nicotinamide adenine dinucleotide phosphate [NAD(P)H] oxidase complex has been shown to be involved in the process of glucose-stimulated insulin secretion (GSIS). In this study, we examined the effect of palmitic acid on superoxide production and insulin secretion by rat pancreatic islets and the mechanism involved. R...

journal_title：Journal of cellular physiology

authors： Graciano MF,Santos LR,Curi R,Carpinelli AR

更新日期：2011-04-01 00:00:00