Absence of initiating activity by quercetin in the rat liver.

Abstract:

:Initiating activity of quercetin was tested in rats which were treated with partial hepatectomy and given a liver cancer promoter, phenobarbital. A few intestinal neoplasms were seen but without significant difference in incidence from those in the quercetin-untreated group. Moreover, neither neoplastic nor preneoplastic liver changes were detected in quercetin-treated groups. With hepatocyte primary culture/DNA repair test, quercetin did not produce genotoxicity. The results show that quercetin has no initiating or genotoxic activities in the rat liver.

journal_name

Ecotoxicol Environ Saf

authors

Kato K,Mori H,Tanaka T,Fujii M,Kawai T,Nishikawa A,Takahashi M,Hirono I

doi

10.1016/0147-6513(85)90007-7

subject

Has Abstract

pub_date

1985-08-01 00:00:00

pages

63-9

issue

1

eissn

0147-6513

issn

1090-2414

pii

0147-6513(85)90007-7

journal_volume

10

pub_type

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