Abstract：
:Ammonia toxicity to respiratory system in pig faming is of particular concern, but the molecular mechanism remains still unclear. The present study was devoted to assess the impacts of the ammonia exposure on the lung tissues based on a pig study using 80 ppm ammonia exposing to piglets for different days. The histology analysis revealed ammonia exposure induced lung injury and inflammatory response, as indicated by epithelial-mesenchymal transition (EMT), significant thickening of alveolar septa, infiltration of inflammatory cells and excessive mucus production. The transcriptome analysis revealed many more up-regulated genes in exposure groups when compared with the control group, and these genes were significantly enriched in the GO term of extracellular exosome, proteolysis, and regulation of circadian rhythm. The study discovered the induction of seven genes (CRY2, CIART, CREM, NR1D1, NR1D2, PER1 and PER3) that encode repressors of circadian clock. One gene (ARNTL) that encodes activator of circadian clock was down-regulated after ammonia exposure. The results of this study suggest that ammonia exposure disturbed the pulmonary circadian clock gene expression, which may establish new evidence for further understanding the toxicity of ammonia to lungs.
journal_name
Ecotoxicol Environ Safjournal_title
Ecotoxicology and environmental safetyauthors
Wang X,Wang M,Chen S,Wei B,Gao Y,Huang L,Liu C,Huang T,Yu M,Zhao SH,Li Xdoi
10.1016/j.ecoenv.2020.111050subject
Has Abstractpub_date
2020-12-01 00:00:00pages
111050eissn
0147-6513issn
1090-2414pii
S0147-6513(20)30889-7journal_volume
205pub_type
杂志文章abstract：:Several metabolic systems in Eisenia foetida competent to achieve an intracellular Cr(VI) reduction are described. Evidence that earthworms act as effective scavengers of hexavalent chromium from the environment is also provided. Results suggest that E. foetida may play an important role during occasional Cr(VI) pollu...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/0147-6513(91)90011-d
更新日期：1991-02-01 00:00:00
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/0147-6513(90)90003-n
更新日期：1990-12-01 00:00:00
abstract：:Decabromodiphenyl ether (BDE-209) is widely used as a flame retardant in many products like electronic equipments, plastics, furniture and textiles. BDE-209, a thyroid hormones (THs)-disrupting chemical, affects male reproductive health through altered THs status in mouse model. The present study was designed in conti...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2020.111783
更新日期：2021-02-01 00:00:00
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2018.06.085
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2015.01.019
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2019.109917
更新日期：2020-02-01 00:00:00
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2014.04.001
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2012.09.016
更新日期：2012-12-01 00:00:00
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2019.06.034
更新日期：2019-10-15 00:00:00
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2020.111341
更新日期：2020-12-15 00:00:00
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2020.111846
更新日期：2021-03-01 00:00:00
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2020.110348
更新日期：2020-04-15 00:00:00
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2011.11.029
更新日期：2012-04-01 00:00:00
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2017.07.019
更新日期：2017-11-01 00:00:00
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journal_title：Ecotoxicology and environmental safety
pub_type： 评论,信件
doi：10.1016/j.ecoenv.2015.06.026
更新日期：2015-10-01 00:00:00
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2020.111670
更新日期：2021-01-15 00:00:00
abstract：:The effects of the insecticidal Cry1Ab protein from Bacillus thuringiensis (Bt) on the nematode, Caenorhabditis elegans, were studied with soil from experimental fields cultivated with transgenic Bt corn (MON810) and with trypsinized Cry1Ab protein expressed in Escherichia coli. The content of Cry1Ab protein was above...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2007.10.017
更新日期：2008-06-01 00:00:00
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1006/eesa.1996.1498
更新日期：1997-03-01 00:00:00
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2015.07.037
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1006/eesa.1994.1010
更新日期：1994-02-01 00:00:00
abstract：:Lead (Pb) is a heavy metal environmental pollutant that can cause functional damage and anemia of immune organs. More and more evidence indicate that the toxicity of lead was related to apoptosis driven by oxidative stress and endoplasmic reticulum stress. This article mainly discusses the protective effect and mechan...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2021.111917
更新日期：2021-01-22 00:00:00
abstract：:Environmental exposure to melamine has been associated with early renal injury in urolithiasis patients even when urinary concentrations of melamine are low. The aim of this study was to derive a benchmark dose (BMD) for melamine for urolithiasis patients. To do this, one-spot urine sample from 309 participants was ob...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2020.110741
更新日期：2020-09-01 00:00:00
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2018.10.079
更新日期：2019-01-30 00:00:00
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2017.10.066
更新日期：2018-03-01 00:00:00
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
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更新日期：2011-01-01 00:00:00
abstract：:More research about branch order-specific accumulation of toxic ions in root systems is needed to know root branch-related responses in growth and physiology. In this study, we used Populus deltoides females and males as a model to detect sex-specific differences in physiology, biochemistry, ultrastructure of absorbin...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
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更新日期：2020-06-01 00:00:00
abstract：:The study evaluated contamination of fish by mercury in two important Czech water reservoirs, Orlík and Kamýk, which receive water from the whole watershed of Otava and Vltava rivers. Contamination of these reservoirs reflects the situation in southern and western Bohemia. Six environmentally representative sites were...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1006/eesa.1999.1783
更新日期：1999-07-01 00:00:00
abstract：:Charles Foster male and female rats were exposed only once to 3.52 and 35.32 ppm doses of methyl isocyanate in separate experiments for 10 min each in an acute toxicity study, while in subacute toxicity experiments, they were exposed to 0.212, 0.265, and 0.349 ppm doses for 30 min daily, for 6 days, by inhalation. Cli...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
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