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Modulatory effect of metal ions on the immune response of fish: in vivo and in vitro influence of MnCl2 on NK activity of carp pronephros cells.

Abstract：

:The in vivo and in vitro influence of MnCl2 on carp pronephros cells was investigated. Increased cytotoxicity against both YAC-1 and P 815 target cells was observed following an intraperitoneal injection of 40, 80, or 120 micrograms MnCl2/g body wt administrated 24 hr prior to the in vitro 51Cr release assay. Similarly, in vitro treatment of carp pronephros cells, at a final concentration of 60 micrograms/culture, resulted in an increase of NK cell activity in both YAC-1 and P 815 target cell lines. However, a significant decrease in this activity was shown with lower doses of MnCl2 (40 and 20 micrograms/culture).

journal_name

Ecotoxicol Environ Saf

journal_title

Ecotoxicology and environmental safety

authors

Ghanmi Z,Rouabhia M,Alifuddin M,Troutaud D,Deschaux P

doi

10.1016/0147-6513(90)90003-n

subject

Has Abstract

pub_date

1990-12-01 00:00:00

pages

241-5

issue

3

eissn

0147-6513

issn

1090-2414

pii

0147-6513(90)90003-N

journal_volume

20

pub_type

杂志文章

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