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Tissue repair: a critical determinant in CCl4 hepatotoxicity.

Abstract：

:A single antimitotic dose of colchicine administered 24 hr after a single ip dose of CCl4 profoundly enhanced lethality in the adult Sprague-Dawley male rat from < 10% to over > or = 70% within the next 24 hr. These findings suggest that disruption of normal hepatic cellular repair processes is a critical factor affecting the outcome of CCl4 intoxication.

journal_name

Ecotoxicol Environ Saf

journal_title

Ecotoxicology and environmental safety

authors

Calabrese EJ,Leonard DA,Baldwin LA

doi

10.1006/eesa.1994.1010

subject

Has Abstract

pub_date

1994-02-01 00:00:00

pages

105-6

issue

1

eissn

0147-6513

issn

1090-2414

pii

S0147-6513(84)71010-4

journal_volume

27

pub_type

杂志文章

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