Abstract:
:Nonylphenol (NP) has been classified as an endocrine-disrupting chemical. In this study, we conducted mysid DNA microarray analysis with which has 2240 oligo DNA probes to observe differential gene expressions in mysid crustacean (Americamysis bahia) exposed to 1, 3, 10 and 30 μg/l of NP for 14 days. As a result, we found 31, 27, 39 and 68 genes were differentially expressed in the respective concentrations. Among these genes, the expressions of five particular genes were regulated in a similar manner at all concentrations of the NP exposure. So, we focused on one gene encoding cuticle protein, and another encoding cuticular protein analogous to peritrophins 1-H precursor. These genes were down-regulated by NP exposure in a dose-dependent manner, and it suggested that they were related in a reduction of the number of molting in mysids. Thus, they might become useful molecular biomarker candidates to evaluate molting inhibition in mysids.
journal_name
Ecotoxicol Environ Safjournal_title
Ecotoxicology and environmental safetyauthors
Uchida M,Hirano M,Ishibashi H,Kobayashi J,Kagami Y,Koyanagi A,Kusano T,Koga M,Arizono Kdoi
10.1016/j.ecoenv.2016.07.037subject
Has Abstractpub_date
2016-11-01 00:00:00pages
360-5eissn
0147-6513issn
1090-2414pii
S0147-6513(16)30296-2journal_volume
133pub_type
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