Mercury and heavy metal profiles of maternal and umbilical cord RBCs in Japanese population.

Abstract:

:Mercury (Hg) and other heavy metal profiles, namely, lead (Pb), arsenic (As), cadmium (Cd), and selenium (Se) were investigated in maternal and umbilical cord (cord) red blood cells (RBCs) at parturition in Japanese population. Correlation coefficients of Hg, Pb, As, Cd, and Se between maternal and cord RBCs were 0.91, 0.79, 0.89, 0.31, and 0.76, respectively, and the respective means of cord/maternal RBCs ratios were 1.63, 0.52, 0.62, 0.12, and 1.18. These results indicate that fetal exposure to these metals (excluding Cd) strongly reflected each maternal exposure level. Among these metals, the placental transfer of methylmercury (MeHg) seemed to be extremely high but that of Cd to be limited. Hg showed positive correlations with Se in maternal RBCs but not in cord RBCs, and the Se/Hg molar ratio was lower in the latter, suggesting that the protective effects of Se against MeHg are less expected in fetuses than in mothers.

journal_name

Ecotoxicol Environ Saf

authors

Sakamoto M,Murata K,Kubota M,Nakai K,Satoh H

doi

10.1016/j.ecoenv.2009.09.010

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

1-6

issue

1

eissn

0147-6513

issn

1090-2414

pii

S0147-6513(09)00206-1

journal_volume

73

pub_type

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