当前位置： SCI文献检索 > ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY期刊下所有文献 > Is there a link between hypospadias and organochlorine exposure in East Greenland sledge dogs (Canis familiaris)?

Is there a link between hypospadias and organochlorine exposure in East Greenland sledge dogs (Canis familiaris)?

Abstract：

:In a clinical survey on East Greenland male sledge dogs (Canis familiaris), one dog exhibited malformation of the external genital organs. The clinically in situ examination of the sledge dog revealed a rare congenital malformation of the urethra and penis corresponding to severe perineal and penile hypospadias. The testes showed spermiogenesis and no sign of true hermaphroditism. We did not have the opportunity to examine the dam for endocrine organ pathology or tumours. But, based on organochlorine data in ringed seal (Phoca hispida) blubber and information from the owners, the potential in uteri OC exposure of the sledge dog was estimated to 320 microg/day which correspond to 128 pg TEQ/kg/day. This is 32-128-folds above WHO guidelines and threshold levels for teratogen and reproductive effects. We suggest that the congenital malformation was due to endocrine organ pathology/tumours of the dam, enzyme/receptor defects (mutation) in the pup or in uteri exposure to environmental xenoestrogens.

journal_name

Ecotoxicol Environ Saf

journal_title

Ecotoxicology and environmental safety

authors

Sonne C,Dietz R,Born EW,Leifsson PS,Andersen S

doi

10.1016/j.ecoenv.2007.09.008

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

391-5

issue

3

eissn

0147-6513

issn

1090-2414

pii

S0147-6513(07)00229-1

journal_volume

69

pub_type

杂志文章

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