Distribution and accumulation of [2,3-14C]acrylonitrile in rat after single injection.

Abstract:

:The distribution and accumulation of acrylonitrile after the single i.p. injection of [2,3-14C]acrylonitrile were examined by whole-body autoradiography and by the determination of 14C radioactivities in several tissues and subcellular fractions after a whole-body perfusion. 14C Radioactivity was seen strongly in blood, particularly in red blood cells, and in several tissues including lung, liver, and kidney. Longer retention of radioactivity in brain and muscle was observed. At the subcellular level a relatively high specific radioactivity was seen in cytosol fractions of the brain, liver, and kidney.

journal_name

Ecotoxicol Environ Saf

authors

Sato M,Hirasawa F,Ogata M,Takizawa Y,Kojima H,Yoshida T

doi

10.1016/0147-6513(82)90030-6

subject

Has Abstract

pub_date

1982-10-01 00:00:00

pages

489-94

issue

5

eissn

0147-6513

issn

1090-2414

pii

0147-6513(82)90030-6

journal_volume

6

pub_type

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