Abstract：
:DNA methylation (5-mc) is one of the several epigenetic markers, and is generally associated with the inhibition of gene expression. Both hyper and hypo DNA methylation are associated with the diseases. Exposure to fine particles with a diameter of 2.5 μm or less (PM2.5) is a pervasive risk factor for cardiopulmonary mortality, metabolic disorders, cognition damage, and etc.. Recent reports pointed toward that these diseases were associated with the altered DNA methylation level of some specific-gene, potentially suggesting that the DNA methylation alteration was involved in the health hazard derived from the PM2.5 exposure. In this study, we systematically investigated the global DNA methylation level of most tissues, including lung, heart, testis, thymus, spleen, epididymal fat, hippocampus, kidney, live, after short and long term PM2.5 exposure. After acute PM2.5 exposure, the global hypo-methylation in DNA was observed in lung and heart. Notably, after chronic PM2.5 exposure, level of global DNA methylation decreased in most organs which included lung, testis, thymus, spleen, epididymal fat, hippocampus and blood. The present study systematically demonstrated the global DNA methylation changes by PM2.5 exposure, and put forward a possible orientation for further exploring the effects of ambient air particles exposure on the specific organs.
journal_name
Ecotoxicol Environ Safjournal_title
Ecotoxicology and environmental safetyauthors
Li Z,Li N,Guo C,Li X,Qian Y,Wu J,Yang Y,Wei Ydoi
10.1016/j.ecoenv.2019.04.049subject
Has Abstractpub_date
2019-09-15 00:00:00pages
175-181eissn
0147-6513issn
1090-2414pii
S0147-6513(19)30482-8journal_volume
179pub_type
杂志文章abstract：:Herein, crop (vegetables and rice, n = 30), soil (n = 14), dust (n = 12), and PM10 (n = 25) samples were collected to assess the environmental quality of a former e-waste recycling area and evaluate the related health risks. In dust and PM10, the concentrations of heavy metals (Cd, Cu, Ni, Pb, and Zn) were lower than ...
journal_title：Ecotoxicology and environmental safety
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journal_title：Ecotoxicology and environmental safety
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journal_title：Ecotoxicology and environmental safety
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journal_title：Ecotoxicology and environmental safety
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journal_title：Ecotoxicology and environmental safety
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journal_title：Ecotoxicology and environmental safety
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章,评审
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更新日期：1991-08-01 00:00:00
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2019.01.119
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章,评审
doi：10.1016/j.ecoenv.2018.03.089
更新日期：2018-08-15 00:00:00
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2018.04.071
更新日期：2018-09-30 00:00:00
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2011.05.010
更新日期：2011-09-01 00:00:00
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2018.08.070
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2019.04.090
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2014.07.029
更新日期：2014-11-01 00:00:00
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
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journal_title：Ecotoxicology and environmental safety
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abstract：:A basic theory of nonspecific toxicity has been developed using bioconcentration as a basis and applying kinetic relationships developed in previous work. This approach has involved calculation of the critical volume fraction and critical concentration in lipid tissue of fish for a variety of organic compounds at the ...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/0147-6513(92)90001-j
更新日期：1992-12-01 00:00:00
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
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更新日期：2015-12-01 00:00:00
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
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更新日期：2015-04-01 00:00:00
abstract：:With petroleum exploration and development expanding in the Arctic (AMAP, 2007) there is a need to obtain additional information on the ecotoxicology of Arctic organisms. Here we perform 192 h laboratory exposure experiments on the keystone Arctic zooplankton species, Calanus finmarchicus. We trace the accumulation an...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
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更新日期：2012-04-01 00:00:00
