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Chlorpyrifos induces apoptosis and DNA damage in Drosophila through generation of reactive oxygen species.

Abstract：

:The present study investigated the apoptosis and DNA damage inducing potential of chlorpyrifos (CP) in Drosophila melanogaster. Third instar larvae of Drosophila were treated with different concentrations of CP (0.015-15.0 microg/L) for 2-48 h. Reactive oxygen species (ROS) generation, oxidative stress markers, DNA damage and apoptotic cell death end points were measured in them. A significant increase in DNA damage was concomitant with apoptotic mode of cell death in 15.0 microg/L CP-treated organisms for 24 and 48 h. Depolarization in mitochondrial membrane potential and increased casapase-3 and caspase-9 activities in these organisms indicated both as potential targets of CP. A significant positive correlation was observed among ROS generation, apoptosis and DNA damage. The study suggests that (i) ROS may be involved in inducing apoptosis and DNA damage in the CP-exposed larvae of Drosophila and (ii) D. melanogaster may be used as an alternative in vivo animal model for xenobiotics hazard assessment.

journal_name

Ecotoxicol Environ Saf

journal_title

Ecotoxicology and environmental safety

authors

Gupta SC,Mishra M,Sharma A,Deepak Balaji TG,Kumar R,Mishra RK,Chowdhuri DK

doi

10.1016/j.ecoenv.2010.05.013

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

1415-23

issue

6

eissn

0147-6513

issn

1090-2414

pii

S0147-6513(10)00100-4

journal_volume

73

pub_type

杂志文章

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