Abstract:
:Cyanobacterial blooms of Microcystis aeruginosa represent a significant risk to the environment and have become a worldwide concern. M. aeruginosa can produce the hepatotoxins microcystins (MCs) with potential for tumor promotion. The present study evaluated the time-dependent effects in the transcription of tumor-related genes in the zebrafish, Danio rerio, exposed to dilutions of a M. aeruginosa lysate containing 3.5 and 54.6 µg L-1 MCs. We used a cultured M. aeruginosa strain, RST 9501, which contains mainly the variant [D-Leu1] MC-LR and originated from the Patos Lagoon Estuary (RS, Brazil). The exposure caused short-term repression of tumor suppressor genes and long-term repression of proto-oncogenes. These responses were more evident for p53 that was repressed with exposure for 6, 24 and 96 h, and fosab and myca that were consistently repressed with exposure for 384 h, when fish were exposed to both M. aeruginosa lysate dilutions, compared to controls (p < 0.05). The suppressor genes, baxa and gadd45α, and the proto-oncogene, junba, were suppressed mainly at 96 h, where both dilutions of the lysate caused repression compared to controls (p < 0.05). The p53 gene was the only gene to be induced; this occurred in fish exposed to lysate containing 3.5 µg L-1 for 384 h. This is the first study to show that M. aeruginosa containing an environmentally relevant concentration of [D-Leu1] MC-LR could cause time-dependent repression of proto-oncogenes and tumor suppressor genes in fish. The results suggest that short-term repression of tumor suppressor genes could participate in the mechanism of tumor promotion caused by M. aeruginosa in fish.
journal_name
Ecotoxicol Environ Safjournal_title
Ecotoxicology and environmental safetyauthors
Fonseca VB,Sopezki MDS,Yunes JS,Zanette Jdoi
10.1016/j.ecoenv.2018.06.007subject
Has Abstractpub_date
2018-10-01 00:00:00pages
729-734eissn
0147-6513issn
1090-2414pii
S0147-6513(18)30498-6journal_volume
161pub_type
杂志文章abstract::This study examined the antioxidant responses of Daphnia magna following exposure to different concentrations of the ionic liquid (IL) 1-octyl-3-methylimidazolium bromide and the 50% LC(50) concentrations of methylimidazolium bromide ILs with different alkyl-chain lengths. Activities of antioxidant defense enzymes (su...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2009.05.002
更新日期:2009-09-01 00:00:00
abstract::The aim of the study was to investigate the subacute toxicity of a polychlorinated naphthalene (PCN) mixture and its effect on cytochrome P-450 levels in rats. The animals were administered PCNs intragastrically in repeated daily doses of 1, 10, and 100 mg/kg. The animals were dissected after 7, 14, or 21 doses. Doses...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2008.07.010
更新日期:2009-02-01 00:00:00
abstract::Chlorpyrifos (CPF) is a worldwide used pesticide that raises concerns from the environmental and human health perspectives. The presence of pesticides such as CPF in edible vegetables has been already reported, but little is known about the effects induced by this pesticide stress on the morphology, oxidative response...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2018.03.005
更新日期:2018-07-30 00:00:00
abstract::Resistance to treatments with Temephos or plant derived oil, Pb-CVO, between a field collected Wild Strain (WS) and a susceptible Laboratory Strain (LS) of Ae. aegypti were measured. The Temephos (0.1mg/L) showed the greatest percentage of mosquito mortality compared to Pb-CVO (1.5mg/L) in LS Ae. aegypti. However, WS ...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2017.01.026
更新日期:2017-05-01 00:00:00
abstract::The objective of this study was to evaluate the chronic lethal and sublethal aquatic toxicity effects associated with the phytoremediation of water contaminated with 2,4,6-trinitrotoluene (TNT) by the wetland plant species Myriophyllum aquaticum (parrot feather). Rotifers (Brachionus calyciflorus) feeding on an algal ...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/s0147-6513(03)00007-1
更新日期:2003-06-01 00:00:00
abstract::This study was conducted with the aim of analyzing persistent organic pollutants i.e., PCBs, PBDEs, DPs and OCPs for sediment samples collected from Mehmood Booti Drain, Lahore, Pakistan that receives higher pollution loads from adjacent waste dumping site. Levels of ∑PCBs, ∑PBDEs, ∑DPs and ∑OCPs ranged between 5.9-62...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2015.11.019
更新日期:2016-03-01 00:00:00
abstract::Questions remain about the effects of rare earth elements (REEs) on reproductive health, and no study has explored in utero exposure to REEs and risk of orofacial clefts (OFCs). We recruited subjects from a case-control study conducted in Shanxi Province, China. Concentrations of fifteen REEs were quantified in umbili...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2020.111284
更新日期:2021-01-01 00:00:00
abstract::Deltamethrin is a commonly used pyrethroid pesticide. Vitamin E is a antioxidant that plays an important role in protecting cells against toxicity by inactivating free radicals generated following pesticides exposure. Therefore, in the present study, it was evaluated whether deltamethrin induced changes on the fatty a...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2012.04.012
更新日期:2012-06-01 00:00:00
abstract::Selenium (Se) is considered a beneficial element to higher plants based on its regulation of antioxidative system under abiotic or biotic stresses. However, the limit of beneficial and toxic physiological effects of Se is very narrow. In the present study, the antioxidant performance, nutritional composition, long-dis...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2020.111016
更新日期:2020-10-15 00:00:00
abstract::Atlantic salmon smolts were exposed to three doses of the fungicide azoxystrobin for 4 days, and physiological blood parameters and transcriptional effects in liver and muscle were evaluated in search for potential negative effects. Azoxystrobin exposure mediated up-regulation of catalase, MAPK1 and IGFBP1 in liver ti...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2010.07.017
更新日期:2010-11-01 00:00:00
abstract::The work is a continuation of two previous studies in which biomarker fatty acids (12 of 56 FA pools) were analysed in Helix pomatia L. after heterogeneous micro-supplementation of Zn and Cu (administered in five micro-doses in the form of salts and EDTA and lysine chelates). This time, peroxidation (PI) and unsaturat...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2017.11.051
更新日期:2018-02-01 00:00:00
abstract::Chaff is a radiofrequency countermeasure released by military aircraft, ships, and vehicles to confuse enemy radar. Chaff consists of aluminum-coated glass fibers ranging in lengths from 0.8 to 0.75 cm and is released in packets of 0.5 to 100 million fibers. The Department of Defense has determined that use of chaff i...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章,评审
doi:10.1006/eesa.2002.2197
更新日期:2002-09-01 00:00:00
abstract::The performance of cornstack based biofilter inoculated with a mixed culture was evaluated for gas phase MEK removal under various operating conditions. Experiments were carried out at different flow rates (0.03-0.12m3h-1) and various initial concentrations (0.2-1.2g-3). A maximum elimination capacity (EC) of 35g-3h-1...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2015.09.016
更新日期:2016-12-01 00:00:00
abstract::Pharmaceutically active compounds (PhACs) recently have been recognized to constitute a health risk for aquatic ecosystems. The major pathways of PhACs to enter the aquatic environment are excretion and discharge of effluents through sewage treatment plants (STPs). The occurrence, bioaccumulation and risk assessment o...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2018.02.052
更新日期:2018-06-15 00:00:00
abstract::Biocidal products represent mixtures that might be released into the environment at application and continuously during service life. Concentration addition (CA) has been proposed as default model to calculate theoretical mixture toxicity. However, the suitability of CA for chronic toxicity towards soil organisms has ...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2018.08.094
更新日期:2018-12-15 00:00:00
abstract::Subalpine wetland is a mercury (Hg) sensitive ecosystem, but there is poor understanding of Hg behavior in this typical wetland. Here, distribution and speciation of Hg in waters of a subalpine wetland (Dajiuhu) in China were investigated, and an initial model of the Hg geochemical cycle in the wetland was established...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2020.111507
更新日期:2021-01-15 00:00:00
abstract::The polychlorobiphenyl (PCB) composition of pine needles of Pinus uncinata from the Pyrenean high mountains has been investigated. Samples from four altitudes (1750, 1950, 2150, and 2250 m above sea level) were collected in March 2002 and June 2002 in a central area near Lake Redon. The observed concentrations were si...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2005.06.005
更新日期:2006-01-01 00:00:00
abstract::Nickel (Ni) is a metal of environmental concern, known to cause toxicity to freshwater organisms by impairing ionoregulation and/or respiratory gas exchange, and by inducing oxidative stress. However, little is known regarding how nickel toxicity is influenced by salinity. In the current study we investigated the sali...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2015.07.019
更新日期:2015-12-01 00:00:00
abstract::Griffon vultures (Gyps fulvus), by virtue of their position at the top of the food chain and as obligate scavengers, are at risk of accumulating and concentrating heavy metals in their tissues and may be more predisposed to their toxic effects. The aim of this study is to investigate heavy metal concentrations in Grif...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2014.12.016
更新日期:2015-03-01 00:00:00
abstract::This paper presents the adaptation of Escherichia coli Gram-negative bacteria to increased concentrations of ionic liquids. Theophylline-based quaternary ammonium salts were used as an example of an ionic liquid that on the one hand includes an anion of natural origin and on the other hand is characterized by amphiphi...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2018.08.048
更新日期:2018-11-30 00:00:00
abstract::The potential of Hydrocotyle vulgaris as an aquatic plant species was evaluated for phytoremediation of C.I. Basic Red 46 (BR46) from nutrient solution. Under the optimized experimental conditions, BR46 was removed up to 95% from incubation medium by H. vulgaris. The ability of the plant in consecutive removal under l...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2013.03.035
更新日期:2013-07-01 00:00:00
abstract::Phytoremediation and bioremediation are site-specific processes, and feasibility studies should be performed as an initial step in scaling-up these processes. Soil microcosms can be a useful tool for investigating the efficiency of remediation alternatives under realistic conditions. In the present study, the degradat...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2011.08.009
更新日期:2011-11-01 00:00:00
abstract::The effects of chlorpyrifos, an organophosphorus insecticide, were examined on the activity of the nervous system enzyme acetylcholinesterase (AChE) in the threeridge mussel Amblema plicata in a 24-day laboratory test. Thirty-six mussels in each of seven treatments (18 mussels per duplicate) were exposed to chlorpyrif...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1006/eesa.2000.2036
更新日期:2001-05-01 00:00:00
abstract::Monitoring the contamination level in aquatic environments and assessing the impact on aquatic life occurs throughout the world. In the present study, an approach based on a combination of biomarkers and the distribution of various industrial and municipal pollutants was used to investigate the effect of aquatic envir...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2018.07.109
更新日期:2018-11-30 00:00:00
abstract:BACKGROUND:Bisphenol A (BPA) is a well-known xenobiotic endocrine disrupting chemical, with estrogenic activity and many other potential biological effects. Although multiple toxicities have been reported for BPA, molecular mechanisms underlying the transgenerational toxic effects of BPA are still underestimated. METH...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2020.111165
更新日期:2020-12-01 00:00:00
abstract::Algae blooms frequently occur in the coastal areas of China, and pose numbers of adverse effects to marine environment. Nitzschia closterium is one of the algal species associated with algae blooms and was selected as the target algae of this work. This study was the first attempt to investigate the effect of carbon s...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2019.03.110
更新日期:2019-08-15 00:00:00
abstract::Lipophilic persistent organic pollutants (POPs) are released from fat reserves during fasting, causing increased blood concentrations. Thus, POPs represent a potential anthropogenic stressor during fasting periods. We analysed the blood of female common eiders (Somateria mollissima) by using agarose gel electrophoresi...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2014.04.020
更新日期:2014-08-01 00:00:00
abstract::The effect of 2,4-dichlorophenoxyacetic (2,4-D) acid in artificial rain at pH 3.3 was examined for young plants of rape (Brassica napus L.) and white mustard (Sinapis alba L.). Plants were treated in a closed simulation chamber system with varying CO2 supply (198-418 ppm). Single or daily showers were applied for 20-3...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/0147-6513(84)90002-2
更新日期:1984-08-01 00:00:00
abstract::Biochar has a significant effect on alleviating acid soil aluminum (Al) toxicity and promoting plant growth. The potential effects of aged biochar (long-term applied biochar in soil) on soil amendment have attracted increasing attention. Here, the effects of biochar and aged biochar were evaluated through a pot experi...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2018.06.010
更新日期:2018-10-01 00:00:00
abstract::Cd(II) is one of the most widespread and toxic heavy metals and seriously threatens plant growth, furthermore negatively affecting human health. For survival from this metal stress, plants always fight with Cd(II) toxicity by themselves or using other external factors. The effects of second metals copper (Cu(II)), zin...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2018.03.055
更新日期:2018-08-15 00:00:00