Abstract：
:In colonic biopsies of 33 patients with acute colitis caused by campylobacter, salmonella, or shigella immunoglobulin containing cells were determined quantitatively using an indirect immunoperoxidase technique and morphometry with a graphic tablet. The findings were compared with those of 10 patients without histological abnormalities, 10 patients with Crohn's disease of the colon, and 10 patients with ulcerative colitis. Biopsies of patients with acute infectious colitis had increased numbers of IgA containing cells and to a lesser extent IgM containing cells but not IgG containing cells compared with controls. Compared with the patients with active chronic idiopathic inflammatory bowel disease the patients with acute colitis showed significantly lower relative and absolute numbers of IgG containing cells. We therefore conclude that quantitative assessment of immunoglobulin containing cells in colonic biopsies may be useful in the differential diagnosis of acute infectious colitis and chronic idiopathic inflammatory bowel disease.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
van Spreeuwel JP,Lindeman J,Meijer CJdoi
10.1136/jcp.38.7.774subject
Has Abstractpub_date
1985-07-01 00:00:00pages
774-7issue
7eissn
0021-9746issn
1472-4146journal_volume
38pub_type
杂志文章abstract：AIMS:To evaluate the effect of microwave irradiation on the staining quality of a range of commonly used primary antibodies in archival, formalin fixed, paraffin wax embedded material, with emphasis on antibodies that have previously worked successfully only on frozen tissue. METHODS:Immunocytochemistry (streptavidin-...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.47.5.448
更新日期：1994-05-01 00:00:00
abstract：AIMS:The JAK2 V617F mutation is highly recurrent in many of the myeloproliferative neoplasms, a molecular variant that can be easily detected using sensitive and minimally invasive techniques. Given the ease of JAK2 V617F testing, this test may be improperly requested for the purposes of patient 'screening' and to opti...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jclinpath-2018-205527
更新日期：2019-02-01 00:00:00
abstract：:A male patient with a 17 year history of intractable ulcerative colitis of the entire type was treated by total proctocolectomy. Colonoscopy before surgery did not identify dysplasia. Histological examination of the resected colorectum revealed that, in addition to chronic inflammatory infiltrates, there were 21 areas...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.56.12.963
更新日期：2003-12-01 00:00:00
abstract：:A locally developed, computer-based clinical chemistry laboratory system has been in operation since 1970. This utilises a Digital Equipment Co Ltd PDP 12 and an interconnected PDP 8/F computer. Details are presented of the performance and quality control techniques incorporated into the system. Laboratory performance...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.32.2.100
更新日期：1979-02-01 00:00:00
abstract：:A system is described for the maintenance of cumulative haematology records for selected patients using a laboratory minicomputer with limited storage capacity. Records are indexed by the patient's name and location since, as in the majority of hospital laboratories, there is no unique numbering scheme which covers al...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.30.4.356
更新日期：1977-04-01 00:00:00
abstract：:A unique case of a metastatic non-desmoplastic sarcomatoid malignant melanoma in an axillary lymph node showing smooth muscle differentiation in a 54 year old woman is described. The tumour cells exhibited alpha-smooth muscle actin, HHF-35 and desmin positivity but were negative for S100 protein and HMB-45. Ultrastruc...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.49.11.950
更新日期：1996-11-01 00:00:00
abstract：:A patient with megaloblastic anaemia due to nutritional folate deficiency is described. Partial villous atrophy and malabsorption of xylose showed progressive improvement to normal with folic acid therapy. ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.24.2.131
更新日期：1971-03-01 00:00:00
abstract：:In a case of atypical mucin-producing bronchial carcinoid in a 40-year-old man covert metastases were present at the time of lobectomy and were revealed at necropsy--a feature highlighting the malignant potential of the atypical carcinoid. ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.31.12.1218
更新日期：1978-12-01 00:00:00
abstract：AIMS:Hypomethylating agents (HMAs) exhibit clinical efficacy in patients with myelodysplastic syndromes (MDS) and myelodysplastic/myeloproliferative neoplasms (MDS/MPN). This study was performed to assess residual disease status by flow cytometry immunophenotyping (FCI) methods in patients with MDS or MDS/MPN treated w...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jclinpath-2016-203715
更新日期：2016-04-15 00:00:00
abstract：:An automated technique is described which is capable of detecting sickle-cell haemoglobin and differentiating the sickle-cell trait from sickle-cell anaemia. The method is based upon the Itano solubility test and utilizes Technicon equipment. ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.25.4.330
更新日期：1972-04-01 00:00:00
abstract：:Melanocytes in melanocytic naevi and melanomas can display great variation. The presence of nuclear pseudoinclusions (NPI) is said to be useful in the histological and cytological differential diagnosis of malignant melanoma. The prevalence and characteristics of NPI in a series of 493 naevi and 50 melanomas are descr...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.48.7.676
更新日期：1995-07-01 00:00:00
abstract：AIMS:To investigate the morphological and histopathological associations between an individual pit seen on stereomicroscopy or magnifying colonoscopy and an individual crypt seen in histological sections; and to examine these associations in colorectal tumours. METHODS:Fourteen thousand and twenty three cases were exa...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.47.10.880
更新日期：1994-10-01 00:00:00
abstract：:Normal haemoglobin is a tetramer molecule, consisting of two α and β haemoglobin chains. Haemoglobinopathies occur when abnormalities in these proteins are present. More than 1000 naturally occurring human haemoglobin variants with single amino acid substitution throughout the molecule have been identified and can be ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章,评审
doi：10.1136/jclinpath-2018-205616
更新日期：2019-07-01 00:00:00
abstract：:Visual differential counts were examined for efficiency, cost effectiveness, and staff acceptability within our laboratory. A comparison with the Hemalog D system was attempted. The advantages and disadvantages of each system are enumerated and discussed in the context of a large general hospital. ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.33.11.1114
更新日期：1980-11-01 00:00:00
abstract：AIMS:To investigate the histopathological changes in the livers of patients undergoing cholecystectomy and to relate these changes to the underlying biliary tract pathology. METHODS:Liver changes in 67 patients undergoing cholecystectomy were investigated. Sixty three had gall stones, one cholesterolosis only, and the...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.47.5.457
更新日期：1994-05-01 00:00:00
abstract：:A rare case of adult onset Langerhans' cell histiocytosis associated with dysgerminoma in a 35 year old Chinese woman is reported. The patient had a history of dysgerminoma of left ovary 15 years previously and had undergone surgery followed by radiotherapy and an uneventful recovery. She presented again in March 1994...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.48.10.963
更新日期：1995-10-01 00:00:00
abstract：AIMS:To study whether differences in eradication rates of antibiotics may be explained by differences in secretion of antibiotics in gastric juice. METHODS:A single intravenous dose of either ampicillin 500 mg, erythromycin 500 mg, or metronidazole 500 mg was administered to four healthy Helicobacter pylori negative v...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.45.3.225
更新日期：1992-03-01 00:00:00
abstract：:Statistical tables including 50 and 95 percentile ranges are presented of the combined kidney weights compared with body weight, crown-rump length, and gestation age of foetuses and newborn children, and also a table of kidney weights related to post-natal age. The importance of relating kidney weight to more than one...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.13.6.490
更新日期：1960-11-01 00:00:00
abstract：AIMS:PCR amplicon-based next-generation sequencing (NGS) panels are increasingly used for clinical diagnostic assays. Amplification bias is a well-known limitation of PCR amplicon-based approaches. We sought to characterise lower-performance amplicons in an off-the-shelf NGS panel (TruSight Myeloid Sequencing Panel) fo...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jclinpath-2015-203580
更新日期：2016-09-01 00:00:00
abstract：:Results of blood culture examination using the radiometric (Bactec-460) system for one year showed no overall improvement compared with those of the previous three years when a manual system with early blind subculture was used. The isolates from the manual system were available more often on solid media, 24 hours ear...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.38.10.1146
更新日期：1985-10-01 00:00:00
abstract：:Haemoglobin (Hb) Bonn is a newly described benign Hb variant that causes falsely depressed oxygen saturation as measured by pulse oximetry. It was found to be associated with mild haemolysis. Since its first report in a German family, no further cases have been documented in the literature. We report the first Chinese...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.2010.078147
更新日期：2010-10-01 00:00:00
abstract：:In a retrospective study of the records of 160 necropsies it was found that, according to the clinical and gross necropsy findings, no clinically important abnormality would have been anticipated in 46% of the tissue samples. The estimated annual cost of processing this material alone was pounds 10,500, including the ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.40.4.459
更新日期：1987-04-01 00:00:00
abstract：:Temporal changes in gastric antibody response were investigated in 113 (51 men, 62 women) patients with confirmed pernicious anaemia. Their ages ranged from 31-92 years (mean (SD 13.2) 66). At diagnosis, parietal cell antibody and intrinsic factor antibody were detected in 90.9% and 39.1% of all patients, respectively...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.42.10.1092
更新日期：1989-10-01 00:00:00
abstract：:Isolates of Campylobacter jejuni, C coli, C fetus and C laridis were tested for agglutination reactions with a panel of five lectins: Arachis hypogaea, Bauhinia purpurea, Solanum tuberosum, Triticum vulgaris and Wisteria floribunda. Twenty three patterns of agglutination (lectin types) were recorded among 376 isolates...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.43.11.957
更新日期：1990-11-01 00:00:00
abstract：AIMS:Dysfunctional prothrombin residue Arg596 associated mutation has been found to precipitate venous thromboembolism (VTE). In the current study we investigated the prevalence of Arg596 associated mutations in Chinese patients with VTE and explored the functional impact of Arg596Gln mutation on coagulation function i...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jclinpath-2017-204888
更新日期：2018-07-01 00:00:00
abstract：:The effect of radiotherapy on normal buccal mucosa was investigated using the quantitative techniques of cytomorphology (measurement of nuclear and cytoplasmic area) and DNA cytophotometry. These techniques were applied to smears obtained before, during, and after irradiation. Nuclear area and cytoplasmic area increas...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.42.9.940
更新日期：1989-09-01 00:00:00
abstract：AIMS:Although the autopsy is still the gold standard for quality assessment of clinical diagnoses, autopsy rates have been declining over the last decades to <10%. The aim of this study was to investigate the value of autopsies in the high-tech medicine era by determining the frequency of discrepancies between clinical...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jclinpath-2013-202122
更新日期：2014-06-01 00:00:00
abstract：:Phyllodes tumours (PTs) of the breast are true biphasic neoplasms within which interactions between the epithelium and stroma are critical for tumour development and progression. Despite numerous studies reporting the results of ancillary marker investigations in PTs, the current histological grading systems remain un...
journal_title：Journal of clinical pathology
pub_type： 杂志文章,评审
doi：10.1136/jclinpath-2012-201082
更新日期：2013-06-01 00:00:00
abstract：:A case of coexistent acute myeloid leukaemia and sarcoidosis is reported. This was complicated by recurrent pulmonary haemorrhage during reinduction and consolidation chemotherapy. A review of published papers on malignancy and sarcoidosis, in particular acute leukaemia is given. The outcome of most cases of acute leu...
journal_title：Journal of clinical pathology
pub_type： 杂志文章,评审
doi：10.1136/jcp.47.7.672
更新日期：1994-07-01 00:00:00
abstract：:A study has been made of 523 strains of staphylococci on the basis of biological properties, phage typing, and serology. The value of serology in the identification of pathogenic staphylococci has been assessed. ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.23.4.370
更新日期：1970-05-01 00:00:00
