S-antigen in the developing retina and pineal gland: a monoclonal antibody study.

abstract：Purpose:The present study investigated retinal glia and choroidal vessels in flatmounts and sections from individuals with clinically diagnosed Stargardt disease (STGD). Methods:Eyes from three donors clinically diagnosed with STGD were obtained through the Foundation Fighting Blindness (FFB). Genetic testing was perf...

journal_title：Investigative ophthalmology & visual science

authors： Edwards MM,Bonilha VL,Bhutto IA,Bell BA,McLeod DS,Hollyfield JG,Lutty GA

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:To investigate whether mucosal immune responses directed against the ubiquitous parasite Toxoplasma gondii can be detected in tears of healthy humans. METHODS:Nonstimulated tears and blood were obtained from 62 healthy humans (mean age, 35 +/- 10 [SD] years). Serum anti-T. gondii immunoglobulin titers were det...

journal_title：Investigative ophthalmology & visual science

authors： Meek B,Klaren VN,van Haeringen NJ,Kijlstra A,Peek R

更新日期：2000-08-01 00:00:00

abstract：:The retinal blood vessels serve for nutrition of the retinal ganglion cells and their axons. This study was undertaken to evaluate the vessel diameter in normal and glaucoma eyes. The calibers of the superior temporal and inferior temporal retinal artery and vein were measured at the optic disc border and at a distanc...

journal_title：Investigative ophthalmology & visual science

authors： Jonas JB,Nguyen XN,Naumann GO

更新日期：1989-07-01 00:00:00

abstract：PURPOSE:To determine the usefulness of polytetrafluoroethylene/polylactide-co-glycolide (PTFE/PLGA) laminate containing dexamethasone in delayed adjustable strabismus surgery. METHODS:A prospective, masked-observer, controlled study was performed in rabbits. Fifty-two rabbit eyes were divided into three groups. After ...

journal_title：Investigative ophthalmology & visual science

authors： Jee JP,Choung HK,Kim CK,Hwang JM

更新日期：2006-06-01 00:00:00

abstract：:Gamma-interferon (G-IFN) exhibits antiproliferative effects, inhibits collagen synthesis by fibroblasts, and may help to regulate the turnover of fibrous tissue. Fibroblasts from Tenon's capsule are cellular components that contribute to unsuccessful glaucoma filtration surgery. Therefore, the authors studied the effe...

journal_title：Investigative ophthalmology & visual science

authors： Latina MA,Belmonte SJ,Park C,Crean E

更新日期：1991-09-01 00:00:00

abstract：Purpose:To characterize intraocular pressure (IOP) dynamics by identifying the sources of transient IOP fluctuations and quantifying the frequency, magnitude, associated cumulative IOP-related mechanical energy, and temporal distribution. Methods:IOP was monitored at 500 Hz for periods of 16 to 451 days in nine normal...

journal_title：Investigative ophthalmology & visual science

authors： Turner DC,Edmiston AM,Zohner YE,Byrne KJ,Seigfreid WP,Girkin CA,Morris JS,Downs JC

更新日期：2019-06-03 00:00:00

abstract：PURPOSE:This study was conducted to determine whether there were significant differences in choroidal thickness, contrast, outer choroidal vessel (OCV), and choroidal-scleral junction (CSJ) visualization in inverted versus upright spectral-domain optical coherence tomography (SD-OCT). METHODS:Images were captured on B...

journal_title：Investigative ophthalmology & visual science

authors： Lin P,Mettu PS,Pomerleau DL,Chiu SJ,Maldonado R,Stinnett S,Toth CA,Farsiu S,Mruthyunjaya P

更新日期：2012-04-06 00:00:00

abstract：PURPOSE:To examine the relationship between retinal vascular geometric parameters with retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GC-IPL) parameters in nonglaucomatous subjects. METHODS:Study subjects were identified from the Singapore Chinese Eye Study (SCES), a population-based survey ...

journal_title：Investigative ophthalmology & visual science

authors： Tham YC,Cheng CY,Zheng Y,Aung T,Wong TY,Cheung CY

更新日期：2013-11-05 00:00:00

abstract：PURPOSE:To compare anterior segment parameters, assessed by anterior segment optical coherence tomography (ASOCT), in subjects categorized as primary angle closure suspect (PACS), primary angle closure (PAC), primary angle closure glaucoma (PACG), and previous acute PAC (APAC); and to identify factors associated with A...

journal_title：Investigative ophthalmology & visual science

authors： Guzman CP,Gong T,Nongpiur ME,Perera SA,How AC,Lee HK,Cheng L,He M,Baskaran M,Aung T

更新日期：2013-08-07 00:00:00

abstract：PURPOSE:To investigate the capacity for rapid saccade adaptation in Williams-Beuren Syndrome (WBS), a genetic neurodevelopmental disorder, in which it has been observed that saccadic accuracy is severely reduced. METHODS:Saccade amplitude modification was elicited by backward steps (30% of target eccentricity) during ...

journal_title：Investigative ophthalmology & visual science

authors： van der Geest JN,Haselen GC,Frens MA

更新日期：2006-04-01 00:00:00

abstract：PURPOSE:Heparanase and VEGF are related closely to angiogenesis in cancer. The purpose of our study was to evaluate the expression and correlation of heparanase and VEGF in hypoxia-induced retinal neovascularization. METHODS:C57BL/6 oxygen-induced retinopathy (OIR) mice and human retinal microvascular endothelial cell...

journal_title：Investigative ophthalmology & visual science

authors： Hu J,Song X,He YQ,Freeman C,Parish CR,Yuan L,Yu H,Tang S

更新日期：2012-10-03 00:00:00

abstract：:PURPOSE. To investigate the anti-inflammatory effect of aminoimidazole carboxamide ribonucleotide (AICAR), an analog of adenosine monophosphate (AMP), in endotoxin-induced uveitis (EIU). METHODS. EIU was induced by subcutaneous injection of lipopolysaccharide (LPS) (200 μg) in Lewis rats. AICAR (50 mg/kg, intraperiton...

journal_title：Investigative ophthalmology & visual science

authors： Suzuki J,Manola A,Murakami Y,Morizane Y,Takeuchi K,Kayama M,Miller JW,Sobrin L,Vavvas DG

更新日期：2011-08-22 00:00:00

abstract：PURPOSE:The authors investigated whether trigeminal sensitization occurs in response to bright light with the retina disconnected from the rest of the central nervous system by optic nerve section. METHODS:In urethane-anesthetized rats, trigeminal reflex blinks were evoked with air puff stimuli directed at the cornea ...

journal_title：Investigative ophthalmology & visual science

authors： Dolgonos S,Ayyala H,Evinger C

更新日期：2011-10-04 00:00:00

abstract：PURPOSE:To determine new referents, or cutoff levels for tear film hyperosmolarity in the diagnosis of keratoconjunctivitis sicca (KCS) and to assess their effectiveness in independent patient groups. METHOD:A meta-analysis was performed on published data for tear osmolarity in samples of normal eyes and various subty...

journal_title：Investigative ophthalmology & visual science

authors： Tomlinson A,Khanal S,Ramaesh K,Diaper C,McFadyen A

更新日期：2006-10-01 00:00:00

abstract：PURPOSE:To investigate the effects of retinoic acid, retinol, and 11-cis retinaldehyde on proliferation, differentiation, and survival of cultured embryonic chick neural retina cells; to describe the metabolic transformations of these retinoids by the cultured cells. METHODS:Retinoids were added to glia-free, low-dens...

journal_title：Investigative ophthalmology & visual science

authors： Stenkamp DL,Gregory JK,Adler R

更新日期：1993-07-01 00:00:00

abstract：PURPOSE:To determine the efficacy and safety of naked plasmid gene therapy to the corneal stroma and epithelium. METHODS:Naked plasmid DNA was injected under pressure into the cornea of mice. The expression of genes coding for beta galactosidase (beta-gal), enhanced green fluorescent protein (EGFP), vascular endotheli...

journal_title：Investigative ophthalmology & visual science

authors： Stechschulte SU,Joussen AM,von Recum HA,Poulaki V,Moromizato Y,Yuan J,D'Amato RJ,Kuo C,Adamis AP

更新日期：2001-08-01 00:00:00

abstract：:A simple method for the culture of human retinal capillary endothelial cells in vitro is described in this report. Through a process of gentle mechanical disruption and sieving, a sufficient yield of retinal microvessels was obtained from one or two human eyes to allow the culture of endothelial cells in abundance. Th...

journal_title：Investigative ophthalmology & visual science

authors： Su T,Gillies MC

更新日期：1992-09-01 00:00:00

abstract：PURPOSE:To investigate whether time outdoors and a range of other activities are associated with change in spherical equivalent (SE) and axial length in Chinese children over a period of 2 years. METHODS:A total of 1997 children aged 12.7 ± 0.5 (10.9-15.6) years in the Anyang Childhood Eye Study (ACES) were examined a...

journal_title：Investigative ophthalmology & visual science

authors： Li SM,Li H,Li SY,Liu LR,Kang MT,Wang YP,Zhang F,Zhan SY,Gopinath B,Mitchell P,Wang N,Anyang Childhood Eye Study Group.

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:To identify the risk factors for having advanced glaucomatous visual field loss on the first visit at three hospital eye services. METHODS:This was a hospital-based, case-control study involving patients newly diagnosed with glaucoma at first visit to one of three ophthalmic departments in the United Kingdom. ...

journal_title：Investigative ophthalmology & visual science

authors： Fraser S,Bunce C,Wormald R

更新日期：1999-09-01 00:00:00

abstract：PURPOSE:Cigarette smoking is the most consistent risk factor for age-related macular degeneration (AMD), especially the choroidal neovascularization (CNV)-mediated exudative type. Dioxins and dioxin-like compounds have various effects on living organisms and are also contained in cigarette smoke. However, the effects o...

journal_title：Investigative ophthalmology & visual science

authors： Takeuchi A,Takeuchi M,Oikawa K,Sonoda KH,Usui Y,Okunuki Y,Takeda A,Oshima Y,Yoshida K,Usui M,Goto H,Kuroda M

更新日期：2009-07-01 00:00:00

abstract：:Congenic mice of the MRL/Mp strain spontaneously develop an autoimmune connective tissue disease that shares immunologic and histopathologic features with the human disorders systemic lupus erythematosus, rheumatoid arthritis, and systemic vasculitis. The autoimmune disorder in these mice is markedly accelerated by th...

journal_title：Investigative ophthalmology & visual science

authors： Jabs DA,Alexander EL,Green WR

更新日期：1985-09-01 00:00:00

abstract：PURPOSE:To evaluate the physiological characteristics of the macula in patients with Vogt-Koyanagi-Harada disease during the convalescent stage with specific reference to the kinetics of foveal cone photopigment regeneration. METHODS:Six eyes of three patients at the convalescent stage of Vogt-Koyanagi-Harada disease ...

journal_title：Investigative ophthalmology & visual science

authors： Okamoto Y,Miyake Y,Horio N,Takakuwa H,Yamamoto E,Terasaki H

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:To characterize the effect of postural IOP elevation and pharmacological IOP lowering on retinal ganglion cell (RGC) function in the DBA/2J mouse model of glaucoma. METHODS:Four groups of DBA/2J mice (3 months old, n = 7; 5 months old, n = 7; 10 months old, n = 7; and 11 months old, n = 8) were anesthetized by...

journal_title：Investigative ophthalmology & visual science

authors： Nagaraju M,Saleh M,Porciatti V

更新日期：2007-10-01 00:00:00

abstract：PURPOSE:In Program K, a new automated kinetic algorithm that we developed, the frequency distributions of the number of patients' response points were obtained for external angles to distinguish normal and abnormal isopters. We also assessed the agreement between the results of Program K and Goldmann manual kinetic per...

journal_title：Investigative ophthalmology & visual science

authors： Hashimoto S,Matsumoto C,Okuyama S,Takada S,Arimura-Koike E,Shimomura Y

更新日期：2015-03-05 00:00:00

abstract：:Paired human donor corneas (age, 73 +/- 12 yr), preserved in organ culture medium, were used to evaluate the effect of human epidermal growth factor (hEGF) on endothelial wound closure rate (WCR), on morphometric parameters (cell size, shape, and density), and on cell division in the wound area. The endothelium of the...

journal_title：Investigative ophthalmology & visual science

authors： Hoppenreijs VP,Pels E,Vrensen GF,Oosting J,Treffers WF

更新日期：1992-05-01 00:00:00

abstract：PURPOSE:We reviewed and illustrated the most optimal retinal structural measurements to make in stem cell clinical trials. METHODS:Optical coherence tomography (OCT) and autofluorescence (AF) imaging were used to evaluate patients with severe visual loss from nonsyndromic and syndromic retinitis pigmentosa (RP), ABCA4...

journal_title：Investigative ophthalmology & visual science

authors： Jacobson SG,Matsui R,Sumaroka A,Cideciyan AV

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:To compare the ability of several machine learning classifiers to predict development of abnormal fields at follow-up in ocular hypertensive (OHT) eyes that had normal visual fields in baseline examination. METHODS:The visual fields of 114 eyes of 114 patients with OHT with four or more visual field tests with...

journal_title：Investigative ophthalmology & visual science

authors： Sample PA,Goldbaum MH,Chan K,Boden C,Lee TW,Vasile C,Boehm AG,Sejnowski T,Johnson CA,Weinreb RN

更新日期：2002-08-01 00:00:00

abstract：Purpose:To refine the Minnesota Grading System (MGS) using definitions from the Age-Related Eye Disease Studies (AREDS) into a nine-step grading scale (MGS-9). Methods:A nine-step grading scale descriptive analysis using three key phenotypic features (total drusen area, increased, and decreased pigmentation) of human ...

journal_title：Investigative ophthalmology & visual science

authors： Olsen TW,Liao A,Robinson HS,Palejwala NV,Sprehe N

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:To investigate if topical treatment of neuroprotectin D1 (NPD1) increases regeneration of functional nerves after lamellar keratectomy. METHODS:An 8-mm stromal dissection was performed in the left eye of each rabbit. The rabbits were treated with NPD1, pigment epithelial-derived factor (PEDF) in combination wi...

journal_title：Investigative ophthalmology & visual science

authors： Cortina MS,He J,Russ T,Bazan NG,Bazan HE

更新日期：2013-06-12 00:00:00

abstract：PURPOSE:The aim of this study was to elucidate the molecular mechanisms that lead to a dominant nuclear cataract in a mouse harboring the Y118D mutation in the alphaA-crystallin gene. METHODS:The physicochemical properties of alpha-crystallin obtained from mouse lenses with the Y118D mutation as well as a recombinant ...

journal_title：Investigative ophthalmology & visual science

authors： Huang Q,Ding L,Phan KB,Cheng C,Xia CH,Gong X,Horwitz J

更新日期：2009-06-01 00:00:00