Mechanism of cataract formation in alphaA-crystallin Y118D mutation.

abstract：Purpose:The purpose of this study was to investigate the impact of stanniocalcin-1 (STC-1), a photoreceptor-protective glycoprotein, on the development of choroidal neovascularization (CNV) in relation to VEGF and its main receptor (VEGFR2) expression after laser injury. Methods:In rats, CNV was induced by laser photo...

journal_title：Investigative ophthalmology & visual science

authors： Zhao M,Xie W,Tsai SH,Hein TW,Rocke BA,Kuo L,Rosa RH Jr

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:To demonstrate the effect of glaucoma on the optical attenuation coefficient of the retinal nerve fiber layer (RNFL) in Spectral Domain Optical Coherence Tomography (SD-OCT) images. METHODS:We analyzed images of the peripapillary areas in 10 healthy and 30 glaucomatous eyes (mild, moderate, and advanced glauco...

journal_title：Investigative ophthalmology & visual science

authors： van der Schoot J,Vermeer KA,de Boer JF,Lemij HG

更新日期：2012-04-30 00:00:00

abstract：PURPOSE:As efforts to noninvasively measure intracranial pressure (ICP) increase, we thought it important to investigate the timing of retinal venous pulsation in relation to the intraocular and intracranial pressure pulses. METHODS:Neurosurgical patients undergoing continuous direct ICP monitoring had video recording...

journal_title：Investigative ophthalmology & visual science

authors： Morgan WH,Lind CR,Kain S,Fatehee N,Bala A,Yu DY

更新日期：2012-07-10 00:00:00

abstract：PURPOSE:Dynamic color and brightness adaptation are crucial for visual functioning. The effects of glaucoma on retinal ganglion cells (RGCs) could compromise these functions. We have previously used slow dynamic changes of light at moderate intensities to measure the speed and magnitude of subtractive adaptation in RGC...

journal_title：Investigative ophthalmology & visual science

authors： Dul M,Ennis R,Radner S,Lee B,Zaidi Q

更新日期：2015-01-22 00:00:00

abstract：Purpose:Conjunctival squamous cell carcinoma (SCC), a type of ocular surface neoplasia, is primarily treated by surgical resection and topical immuno- or chemotherapy. Metastatic disease may be treated with systemic chemo- or immunotherapy, albeit with variable response. The purpose of this study was to determine wheth...

journal_title：Investigative ophthalmology & visual science

authors： Nagarajan P,El-Hadad C,Gruschkus SK,Ning J,Hudgens CW,Sagiv O,Gross N,Tetzlaff MT,Esmaeli B

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:To determine whether anthocyanin-enriched bilberry extracts modulate pre- or posttranslational levels of oxidative stress defense enzymes heme-oxygenase (HO)-1 and glutathione S-transferase-pi (GST-pi) in cultured human retinal pigment epithelial (RPE) cells. METHODS:Confluent ARPE-19 cells were preincubated w...

journal_title：Investigative ophthalmology & visual science

authors： Milbury PE,Graf B,Curran-Celentano JM,Blumberg JB

更新日期：2007-05-01 00:00:00

abstract：PURPOSE:To examine the distribution of anti-GQ1b, -GT1a, and -GD1b antibody binding in human extraocular muscles (EOMs), axial and limb muscles, and muscle spindles and thereby test the hypothesis that their distinctive ganglioside composition provides the molecular basis for selective involvement of EOMs and muscle sp...

journal_title：Investigative ophthalmology & visual science

authors： Liu JX,Willison HJ,Pedrosa-Domellöf F

更新日期：2009-07-01 00:00:00

abstract：Purpose:To quantify and evaluate macular superficial capillaries and large vessels separately using an optical coherence tomographic angiography (OCTA)-based automatic segmentation algorithm. Methods:In this cross-sectional study, all eyes were scanned using an OCTA device with 3 × 3 mm cube centered on the fovea. Ret...

journal_title：Investigative ophthalmology & visual science

authors： Lei J,Yi E,Suo Y,Chen C,Xu X,Ding W,Abdelfattah NS,Fan X,Lu H

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:T cells play an important role in the pathogenesis of uveitis. Recent studies have indicated that the TNFSF15 gene that encodes the TL1A protein can regulate the differentiation and activation of T cells. TNFSF15 gene polymorphisms have been found to be associated with several autoimmune disorders. A possible a...

journal_title：Investigative ophthalmology & visual science

authors： Li H,Hou S,Yu H,Zheng M,Zhang L,Zhang J,Zhang Q,Cao Q,Yuan G,Kijlstra A,Yang P

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:Hormone diseases induce changes in the lacrimal gland (LG) and ocular surface (OS). Thyroid hormone (TH) induces cell proliferation and lipid metabolism through the activation of TH receptors. The aim of the present study was to evaluate the location and comparative expression of TH receptor beta-1 (Thrb) in LG...

journal_title：Investigative ophthalmology & visual science

authors： Dias AC,Módulo CM,Jorge AG,Braz AM,Jordão AA Jr,Filho RB,de Paula JS,Rocha EM

更新日期：2007-07-01 00:00:00

abstract：PURPOSE:Protein kinase C α (PKCα) is abundantly expressed in rod bipolar cells (RBCs) in the retina, yet the physiological function of PKCα in these cells is not well understood. To elucidate the role of PKCα in visual processing in the eye, we examined the effect of genetic deletion of PKCα on the ERG and on RBC light...

journal_title：Investigative ophthalmology & visual science

authors： Xiong WH,Pang JJ,Pennesi ME,Duvoisin RM,Wu SM,Morgans CW

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:We studied morphologic changes of the retinal vasculature in eyes with central retinal vein occlusion (CRVO) through the use of optical coherence tomography (OCT). METHODS:Major retinal vessels in 35 eyes from 35 consecutive patients with acute CRVO were examined prospectively and longitudinally with sequentia...

journal_title：Investigative ophthalmology & visual science

authors： Muraoka Y,Tsujikawa A,Kumagai K,Akagi-Kurashige Y,Ogino K,Murakami T,Miyamoto K,Yoshimura N

更新日期：2014-01-07 00:00:00

abstract：Purpose:We investigate morphologic and physiologic alterations of ganglion cells (GCs) in a streptozocin (STZ)-induced diabetic mouse model. Methods:Experiments were conducted in flat-mount retinas of mice 3 months after the induction of diabetes. Changes in morphology of four subtypes of GCs (ON-type RGA2 [ON-RGA2], ...

journal_title：Investigative ophthalmology & visual science

authors： Cui RZ,Wang L,Qiao SN,Wang YC,Wang X,Yuan F,Weng SJ,Yang XL,Zhong YM

更新日期：2019-04-01 00:00:00

abstract：PURPOSE:Since central corneal thickness may inversely influence the amount and rate of progression of glaucomatous optic nerve damage and because lamina cribrosa thickness may be of importance in susceptibility to glaucoma, it was the purpose of the present study to evaluate whether central corneal thickness is related...

journal_title：Investigative ophthalmology & visual science

authors： Jonas JB,Holbach L

更新日期：2005-04-01 00:00:00

abstract：PURPOSE:To investigate the role of leukotriene B4 (LTB4) and its receptor BLT1 in the pathogenesis of mouse uveitis. METHODS:Experimental autoimmune uveitis (EAU) was induced in B10RIII mice by immunization of interphotoreceptor retinoid binding protein (IRBP; peptide sequence 161-180) or in C57BL/6 (B6) mice by trans...

journal_title：Investigative ophthalmology & visual science

authors： Liao T,Ke Y,Shao WH,Haribabu B,Kaplan HJ,Sun D,Shao H

更新日期：2006-04-01 00:00:00

abstract：PURPOSE:To assess the diagnostic validity of a fully automated image analysis algorithm of in vivo confocal microscopy images in quantifying corneal subbasal nerves to diagnose diabetic neuropathy. METHODS:One hundred eighty-six patients with type 1 and type 2 diabetes mellitus (T1/T2DM) and 55 age-matched controls un...

journal_title：Investigative ophthalmology & visual science

authors： Petropoulos IN,Alam U,Fadavi H,Marshall A,Asghar O,Dabbah MA,Chen X,Graham J,Ponirakis G,Boulton AJ,Tavakoli M,Malik RA

更新日期：2014-04-03 00:00:00

abstract：PURPOSE:This study was conducted to define whether pigment epithelial-derived growth factor (PEDF), together with docosahexaenoic acid (DHA), enhances the synthesis of neuroprotectin D1 (NPD1) and the regeneration of corneal nerves damaged after surgery. METHODS:Corneal stromal dissection was performed in the left eye...

journal_title：Investigative ophthalmology & visual science

authors： Cortina MS,He J,Li N,Bazan NG,Bazan HE

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:Vision restoration is a fast-approaching reality for some people with profound vision loss. In order to reliably determine treatment efficacy, accurate assessment of baseline residual visual function is critical. The purpose of this study was to compare residual function as detected on Goldman visual field (GVF...

journal_title：Investigative ophthalmology & visual science

authors： Ayton LN,Apollo NV,Varsamidis M,Dimitrov PN,Guymer RH,Luu CD

更新日期：2014-03-06 00:00:00

abstract：PURPOSE:To examine the histologic and ultrastructural changes in Bruch's membrane (BM) in apolipoprotein E deficient [ApoE(-)] mice in comparison with age-matched control animals. METHODS:Two-month-old (group 1) and 8-month-old (group 2) normal control C57BL/6 mice and 2-month-old (group 3) and 8-month-old (group 4) A...

journal_title：Investigative ophthalmology & visual science

authors： Dithmar S,Curcio CA,Le NA,Brown S,Grossniklaus HE

更新日期：2000-07-01 00:00:00

abstract：Purpose:The purpose of this study was to evaluate macular preganglionic function and to verify its relationship with retinal and choroidal morphology in patients with intermediate age-related macular degeneration (iAMD) patients. Methods:All included patients performed multifocal electroretinogram (mfERG) for investig...

journal_title：Investigative ophthalmology & visual science

authors： Parisi V,Ziccardi L,Costanzo E,Tedeschi M,Barbano L,Manca D,Di Renzo A,Giorno P,Varano M,Parravano M

更新日期：2020-05-11 00:00:00

abstract：PURPOSE:To compare action spectra for visual discomfort in the fovea and the parafovea and to determine the effect of macular pigment (MP). METHODS:Visual discomfort thresholds to lights from 440 to 600 nm were obtained for six young (<35 y), visually normal subjects with a wide range of MP densities (0.10-0.71 at 30'...

journal_title：Investigative ophthalmology & visual science

authors： Stringham JM,Snodderly DM

更新日期：2013-09-19 00:00:00

abstract：PURPOSE:To investigate the effects of lomerizine, a Ca2+ antagonist, on the ocular tissue circulation in rabbits and on the circulation in the optic nerve head (ONH) and choroid in healthy volunteers. METHODS:Lomerizine (0.1 [n=10] or 0.3 [n=11] mg/kg) or vehicle solution (n=11) was injected intravenously in urethane-...

journal_title：Investigative ophthalmology & visual science

authors： Tamaki Y,Araie M,Fukaya Y,Nagahara M,Imamura A,Honda M,Obata R,Tomita K

更新日期：2003-11-01 00:00:00

abstract：Purpose:To examine the association between intraocular pressure (IOP) and the prevalence of glaucomatous optic neuropathy (GON) in high myopia. Methods:The hospital-based observational study consisted of patients treated in the Tokyo High Myopia Clinics and for whom fundus photographs and IOP readings were available. ...

journal_title：Investigative ophthalmology & visual science

authors： Jonas JB,Nagaoka N,Fang YX,Weber P,Ohno-Matsui K

更新日期：2017-11-01 00:00:00

abstract：:Lymphocyte cultures were employed to assess the degree of spontaneous and induced chromosomal fragility in retinoblastoma. Sister chromatid exchange (SCEs) were scored in metaphases. Three unilateral, three bilateral, eleven family members and controls were studied. Retinoblastoma (RB) lymphocytes did not exhibit incr...

journal_title：Investigative ophthalmology & visual science

authors： Abramovsky-Kaplan I,Jones IS

更新日期：1984-06-01 00:00:00

abstract：PURPOSE:To characterize the differential expression of intraocular inflammatory cytokines in eyes with branch retinal vein occlusion (BRVO) and to assess their roles as prognostic determinants of BRVO. METHODS:A prospective cohort study of 38 eyes with BRVO. Aqueous humor samples were collected just before the intravi...

journal_title：Investigative ophthalmology & visual science

authors： Kaneda S,Miyazaki D,Sasaki S,Yakura K,Terasaka Y,Miyake K,Ikeda Y,Funakoshi T,Baba T,Yamasaki A,Inoue Y

更新日期：2011-05-06 00:00:00

abstract：PURPOSE:To determine the levels of free UV filters and selected amino acids in cataract lenses compared with normal lenses. METHODS:Indian cataract lenses (n=39) and normal lenses (n=6) were examined by HPLC to quantify levels of UV filter compounds, the UV filter precursor amino acid tryptophan (Trp), as well as tyro...

journal_title：Investigative ophthalmology & visual science

authors： Streete IM,Jamie JF,Truscott RJ

更新日期：2004-11-01 00:00:00

abstract：PURPOSE:AIPL1 mutations cause the severe inherited blindness Leber congenital amaurosis (LCA). The similarity of AIPL1 to tetratricopeptide repeat (TPR) cochaperones that interact with the chaperone Hsp90 and the ability of AIPL1 to suppress the aggregation of NUB1 fragments in a chaperone-like manner suggest that AIPL...

journal_title：Investigative ophthalmology & visual science

authors： Hidalgo-de-Quintana J,Evans RJ,Cheetham ME,van der Spuy J

更新日期：2008-07-01 00:00:00

abstract：PURPOSE:To explore the maximum retinal vasodilation in response to repeated flicker light stimulation in relation to vasospastic propensity in healthy subjects. METHODS:Twenty-four young healthy women were grouped as vasospastic and nonvasospastic, based on their history of cold extremities and on the results of nailf...

journal_title：Investigative ophthalmology & visual science

authors： Gugleta K,Zawinka C,Rickenbacher I,Kochkorov A,Katamay R,Flammer J,Orgul S

更新日期：2006-09-01 00:00:00

abstract：PURPOSE:To evaluate the antilymphangiogenic potential of multi-target tyrosine kinase inhibitor sunitinib in corneal neovascularization (NV). METHODS:Inflammatory corneal NV was induced by thermal cauterization applied in the central cornea of mice, to which sunitinib malate was daily administered by gavage or not. At...

journal_title：Investigative ophthalmology & visual science

authors： Detry B,Blacher S,Erpicum C,Paupert J,Maertens L,Maillard C,Munaut C,Sounni NE,Lambert V,Foidart JM,Rakic JM,Cataldo D,Noël A

更新日期：2013-05-03 00:00:00

abstract：PURPOSE:The purpose of this study was to examine the test-retest repeatability of microperimetric sensitivity at the border of deep scotomas. METHODS:Thirty normal participants underwent two examinations, each on the Macular Integrity Assessment (MAIA) microperimeter and on the MP-1 microperimeter (four examinations i...

journal_title：Investigative ophthalmology & visual science

authors： Wu Z,Jung CJ,Ayton LN,Luu CD,Guymer RH

更新日期：2015-04-01 00:00:00