Ocular axial length in unilateral congenital cataracts and blepharoptosis.

abstract：PURPOSE:The chaperone proteins, α-crystallins, also possess antiapoptotic properties. The purpose of the present study was to investigate whether 19 to 20-mer α-crystallin-derived mini-chaperone peptides (α-crystallin mini-chaperone) are antiapoptotic, and to identify their putative transporters in human fetal RPE (hfR...

journal_title：Investigative ophthalmology & visual science

authors： Sreekumar PG,Chothe P,Sharma KK,Baid R,Kompella U,Spee C,Kannan N,Manh C,Ryan SJ,Ganapathy V,Kannan R,Hinton DR

更新日期：2013-04-17 00:00:00

abstract：PURPOSE:To search for proprioceptive nerve terminals in human ciliary muscle. METHODS:In 48 human donor eyes, histologic and ultrathin sections cut in different planes and wholemounts of the ciliary muscle were studied. Immunohistochemical staining with antibodies against pan-neuronal antigens and antigens reported as...

journal_title：Investigative ophthalmology & visual science

authors： Flügel-Koch C,Neuhuber WL,Kaufman PL,Lütjen-Drecoll E

更新日期：2009-12-01 00:00:00

abstract：:Neodymium: yttrium aluminum garnet (Nd:YAG) laser transscleral cyclophotocoagulation has been shown to be an effective method of lowering intraocular pressure (IOP). Transmission and absorption features of diode laser radiation (810 nm) make these new laser sources suitable for production of transscleral thermal lesio...

journal_title：Investigative ophthalmology & visual science

authors： Brancato R,Leoni G,Trabucchi G,Cappellini A

更新日期：1991-04-01 00:00:00

abstract：PURPOSE:To investigate whether the detection of apoptosing retinal cells (DARC) could detect cells undergoing apoptosis in a laser model of retinal damage. METHODS:Laser lesions were placed, with the use of a frequency-doubled Nd:YAG laser, on the retina in 34 eyes of anesthetized Dark Agouti rats. Lesion size and las...

journal_title：Investigative ophthalmology & visual science

authors： Schmitz-Valckenberg S,Guo L,Maass A,Cheung W,Vugler A,Moss SE,Munro PM,Fitzke FW,Cordeiro MF

更新日期：2008-06-01 00:00:00

abstract：Purpose:To compare cross-sectional choroidal morphology in rhesus macaque and human eyes using enhanced-depth imaging optical coherence tomography (EDI-OCT) and histologic analysis. Methods:Enhanced-depth imaging-OCT images from 25 rhesus macaque and 30 human eyes were evaluated for choriocapillaris and choroidal-scle...

journal_title：Investigative ophthalmology & visual science

authors： Yiu G,Vuong VS,Oltjen S,Cunefare D,Farsiu S,Garzel L,Roberts J,Thomasy SM

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:Protein kinase C α (PKCα) is abundantly expressed in rod bipolar cells (RBCs) in the retina, yet the physiological function of PKCα in these cells is not well understood. To elucidate the role of PKCα in visual processing in the eye, we examined the effect of genetic deletion of PKCα on the ERG and on RBC light...

journal_title：Investigative ophthalmology & visual science

authors： Xiong WH,Pang JJ,Pennesi ME,Duvoisin RM,Wu SM,Morgans CW

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:Retinal nerve fiber (RNFL) thickness and visual field loss data from patients with glaucoma were analyzed in the context of a model, to better understand individual variation in structure versus function. METHODS:Optical coherence tomography (OCT) RNFL thickness and standard automated perimetry (SAP) visual fi...

journal_title：Investigative ophthalmology & visual science

authors： Hood DC,Anderson SC,Wall M,Raza AS,Kardon RH

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:Patients with sickle cell disease have elevated circulating levels of cytokines including tumor necrosis factor (TNF) alpha. TNF-alpha stimulates expression by endothelial cells of adhesion molecules, including vascular cell adhesion molecule (VCAM) 1. Others have demonstrated that VLA-4 (alpha(4)beta(1)), a li...

journal_title：Investigative ophthalmology & visual science

authors： Lutty GA,Taomoto M,Cao J,McLeod DS,Vanderslice P,McIntyre BW,Fabry ME,Nagel RL

更新日期：2001-05-01 00:00:00

abstract：PURPOSE:Imaging studies suggest that the choroidal vasculature may be altered in central serous chorioretinopathy. Little is known, however, about the regulation of ocular blood flow in patients with central serous chorioretinopathy (CSC). The hypothesis for the present study was that choroidal blood flow changes durin...

journal_title：Investigative ophthalmology & visual science

authors： Tittl M,Maar N,Polska E,Weigert G,Stur M,Schmetterer L

更新日期：2005-12-01 00:00:00

abstract：Purpose:Mutations in the retinitis pigmentosa-1-like-1 (RP1L1) gene are the major cause of autosomal dominant occult macular dystrophy (OCMD), while recessive mutations have been linked to autosomal recessive retinitis pigmentosa (arRP). We present the clinical phenotype of a large German OCMD cohort, as well as four R...

journal_title：Investigative ophthalmology & visual science

authors： Zobor D,Zobor G,Hipp S,Baumann B,Weisschuh N,Biskup S,Sliesoraityte I,Zrenner E,Kohl S

更新日期：2018-06-01 00:00:00

abstract：:Recombinant human interferon alpha subtype D (RIFN alpha D) was effective in reducing the shedding of herpes simplex virus type-1 (HSV-1) induced by 6-hydroxydopamine iontophoresis followed by topical epinephrine application in previously infected rabbit corneas. A treatment schedule of RIFN alpha D, two drops QID was...

journal_title：Investigative ophthalmology & visual science

authors： Mayers M,Matli M,Okumoto M,Samy M,Smolin G

更新日期：1985-02-01 00:00:00

abstract：PURPOSE:Strabismic amblyopia is typically associated with several visual deficits, including loss of contrast sensitivity in the amblyopic eye and abnormal binocular vision. Binocular summation ratios (BSRs) are usually assessed by comparing contrast sensitivity for binocular stimuli (sens(BIN)) with that measured in t...

journal_title：Investigative ophthalmology & visual science

authors： Baker DH,Meese TS,Mansouri B,Hess RF

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:To investigate cytokine production by leukocytes in aqueous humor (AH) during corneal graft rejection and nitric oxide (NO) production by macrophages as a potential mediator of graft damage. METHODS:Rats received corneal allotransplants and were killed during acute rejection. Leukocytes in AH that expressed tu...

journal_title：Investigative ophthalmology & visual science

authors： Nicholls SM,Dick AD

更新日期：2008-11-01 00:00:00

abstract：:While using cobalt (Co2+) to block synaptic transmission in an in vitro preparation of chick retina, the authors observed significant changes in the DC electroretinogram (DC ERG). Cobalt (3.0 mM) increased the amplitudes of all three photoreceptor-dependent responses of the retinal pigment epithelium (RPE): the c-wave...

journal_title：Investigative ophthalmology & visual science

authors： Gallemore RP,Steinberg RH

更新日期：1991-11-01 00:00:00

abstract：PURPOSE:Trabecular meshwork (TM) cells appear to sense changes in intraocular pressure (IOP) as mechanical stretching. In response, they make homeostatic corrections in the aqueous humor outflow resistance, partially by increasing extracellular matrix (ECM) turnover initiated by the matrix metalloproteinases. To unders...

journal_title：Investigative ophthalmology & visual science

authors： Vittal V,Rose A,Gregory KE,Kelley MJ,Acott TS

更新日期：2005-08-01 00:00:00

abstract：PURPOSE:The retina of the blind mole rat Spalax ehrenbergi was compared with other vertebrate photosensitive organs in an attempt to correlate its histologic organization with a presumptive nonvisual photoreceptor role. METHODS:The eyes of eight adult animals were analyzed by light and electron microscopy, using conve...

journal_title：Investigative ophthalmology & visual science

authors： Cernuda-Cernuda R,DeGrip WJ,Cooper HM,Nevo E,García-Fernández JM

更新日期：2002-07-01 00:00:00

abstract：PURPOSE:The purpose of this study was to evaluate expression of methyl-CpG-binding protein 2 (MeCP2) in epiretinal membranes from patients with proliferative vitreoretinopathy (PVR) and to investigate effects of inhibition of MeCP2 and DNA methylation on transforming growth factor (TGF)-β-induced retinal pigment epithe...

journal_title：Investigative ophthalmology & visual science

authors： He S,Barron E,Ishikawa K,Nazari Khanamiri H,Spee C,Zhou P,Kase S,Wang Z,Dustin LD,Hinton DR

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:This study investigated multifocal pupillographic objective perimetry (mfPOP) stimuli that target the intrinsic photosensitivity of melanopsin retinal ganglion cells. The diagnostic potential for glaucoma is compared between stimuli biased toward either cone input to these cells or their melanopsin response. M...

journal_title：Investigative ophthalmology & visual science

authors： Carle CF,James AC,Kolic M,Essex RW,Maddess T

更新日期：2015-10-01 00:00:00

abstract：:A recent hypothesis for the cellular mechanism of fluid secretion by lacrimal acini has been based, in part, on the results of subcellular fractionation analyses of lacrimal gland fragments which had been incubated for a brief period in vitro. An important assumption in those studies was that the ion transporters and ...

journal_title：Investigative ophthalmology & visual science

authors： Yiu SC,Wood RL,Mircheff AK

更新日期：1990-11-01 00:00:00

abstract：PURPOSE:To assess the postural stability and gait characteristics of adults with age-related maculopathy (ARM) and to identify the visual factors associated with postural stability and gait in this clinical population. METHODS:Participants included 80 individuals with a range of severity of ARM (mean age, 77.2 years)....

journal_title：Investigative ophthalmology & visual science

authors： Wood JM,Lacherez PF,Black AA,Cole MH,Boon MY,Kerr GK

更新日期：2009-01-01 00:00:00

abstract：Purpose:To determine if variation in anterior lamina cribrosa surface depth (ALCSD) differs between glaucoma patients of African (AD) and European descent (ED). Methods:A total of 178 eyes from 123 glaucoma patients in the African Descent and Glaucoma Evaluation Study (ADAGES) and Diagnostic Innovations in Glaucoma St...

journal_title：Investigative ophthalmology & visual science

authors： Girkin CA,Fazio MA,Bowd C,Medeiros FA,Weinreb RN,Liebmann JM,Proudfoot J,Zangwill LM,Belghith A

更新日期：2019-10-01 00:00:00

abstract：PURPOSE:The growth of ocular neovascularization is regulated by a balance between stimulating and inhibiting growth factors. Somatostatin affects angiogenesis by inhibiting the growth hormone-insulin-like growth factor axis and also has a direct antiproliferative effect on human retinal endothelial cells. The purpose o...

journal_title：Investigative ophthalmology & visual science

authors： Lambooij AC,Kuijpers RW,van Lichtenauer-Kaligis EG,Kliffen M,Baarsma GS,van Hagen PM,Mooy CM

更新日期：2000-07-01 00:00:00

abstract：PURPOSE:The protein RPE65 plays a critical role in retinoid processing in the retinal pigment epithelium (RPE). Previous studies have identified the RPE65 mRNA in salamander cones, but not in rods. The purpose of the present study was to determine whether RPE65 is expressed at the protein level in mammalian cones, as w...

journal_title：Investigative ophthalmology & visual science

authors： Znoiko SL,Crouch RK,Moiseyev G,Ma JX

更新日期：2002-05-01 00:00:00

abstract：Purpose:Recent retrospective clinical studies and animal experiments have suggested that cerebrospinal fluid pressure (CSFP) is important in glaucoma, acting through the translaminar pressure (TLP = IOP - CSFP), which directly affects the optic nerve head. In this study, IOP and intracranial pressure (ICP; a surrogate ...

journal_title：Investigative ophthalmology & visual science

authors： Jasien JV,Samuels BC,Johnston JM,Downs JC

更新日期：2020-10-01 00:00:00

abstract：Purpose:Synucleinopathies such as multiple system atrophy (MSA) and Parkinson's disease are associated with a variety of visual symptoms. Functional and morphological retinal aberrations are therefore supposed to be valuable biomarkers for these neurodegenerative diseases. This study examined the retinal morphology and...

journal_title：Investigative ophthalmology & visual science

authors： Kaehler K,Seitter H,Sandbichler AM,Tschugg B,Obermair GJ,Stefanova N,Koschak A

更新日期：2020-06-03 00:00:00

abstract：:Class II (DR or Ia) alloantigens are potent inducers of cell-mediated immune responses. However, the expression of Class II alloantigens on corneal cells, except for Langerhans cells within the limbal epithelium, has not previously been described. We have induced Ia expression on cultured rabbit corneal endothelial ce...

journal_title：Investigative ophthalmology & visual science

authors： Donnelly JJ,Li WY,Rockey JH,Prendergast RA

更新日期：1985-04-01 00:00:00

abstract：PURPOSE:Lens case hygiene practices are important in maintaining safe contact lens wear. However, the effectiveness of various lens case cleaning practices have not been evaluated and compared. This in vitro study aimed to evaluate and compare the efficacy of cleaning practices that are most commonly carried out by len...

journal_title：Investigative ophthalmology & visual science

authors： Wu YT,Zhu H,Willcox M,Stapleton F

更新日期：2010-12-01 00:00:00

abstract：:Gross correlation coefficient between light-scattering intensity and the optical parameters obtained for 48 sections of eight lenses with nuclear cataracts were evaluated. On the basis of these and other data in the literature, the structural elements, within the lens fiber are identified. These give rise to the optic...

journal_title：Investigative ophthalmology & visual science

authors： Bettelheim FA,Siew EL,Chylack LT Jr

更新日期：1981-03-01 00:00:00

abstract：PURPOSE:To compare accommodative facility in eyes with myopia to that in eyes with emmetropia or hyperopia and to determine whether accommodative facility can be used to predict an association with myopia. METHODS:In the Sydney Myopia Study, year-1 school children (6.7 +/- 0.4 years) were assessed for accommodative fa...

journal_title：Investigative ophthalmology & visual science

authors： Pandian A,Sankaridurg PR,Naduvilath T,O'Leary D,Sweeney DF,Rose K,Mitchell P

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:As efforts to noninvasively measure intracranial pressure (ICP) increase, we thought it important to investigate the timing of retinal venous pulsation in relation to the intraocular and intracranial pressure pulses. METHODS:Neurosurgical patients undergoing continuous direct ICP monitoring had video recording...

journal_title：Investigative ophthalmology & visual science

authors： Morgan WH,Lind CR,Kain S,Fatehee N,Bala A,Yu DY

更新日期：2012-07-10 00:00:00