Expression of a novel combination of fast and slow troponin T isoforms in rabbit extraocular muscles.

abstract：:Cardiac muscle M-band structures in several mammals (guinea pig, rabbit, rat and cow) and also from three teleosts (plaice, carp and roach), have been studied using electron microscopy and image processing. Axial structure seen in negatively stained isolated myofibrils or negatively stained cryo-sections shows the pre...

journal_title：Journal of muscle research and cell motility

authors： Pask HT,Jones KL,Luther PK,Squire JM

更新日期：1994-12-01 00:00:00

abstract：:Homozygous calsequestrin 2 (CASQ2) point mutations leads to catecholaminergic polymorphic ventricular tachycardia: a common pathogenetic feature appears to be the drastic reduction of mutant CASQ2 in spite of normal transcription. Comparative biochemical analysis of R33Q and D307H knock in mutant mice identifies diffe...

journal_title：Journal of muscle research and cell motility

authors： Valle G,Arad M,Volpe P

更新日期：2020-09-01 00:00:00

abstract：:Guinea-pig soleus muscles were denervated and electrically stimulated for periods of 43 to 66 days. Stimuli were in 1 s bursts of 40 Hz pulses, repeated every 5 min. Other guinea-pigs were denervated for 82 days without stimulation and, in a third group, the soleus muscle was necrotized and allowed to regenerate witho...

journal_title：Journal of muscle research and cell motility

authors： Lewis DM,al-Amood WS,Schmalbruch H

更新日期：1997-10-01 00:00:00

abstract：:ADF/cofilins disassemble the actin filament and contribute to a wide range of actin dynamics. These proteins are regulated by several factors, including phosphorylation, pH and mechanical forces. Although the cofilin-decorated actin filament structure was published recently, the mechanisms of these regulating factors ...

journal_title：Journal of muscle research and cell motility

authors： Narita A

更新日期：2020-03-01 00:00:00

abstract：:Clenbuterol is a beta2-adrenoceptor agonist primarily used for treating bronchospasm and alleviating the symptoms of chronic obstructive pulmonary disease (COPD) in the horse. In other species (rats, mice, sheep, and cattle), chronic high doses of clenbuterol (typically in the milligram per kilogram body weight range)...

journal_title：Journal of muscle research and cell motility

authors： Plant DR,Kearns CF,McKeever KH,Lynch GS

更新日期：2003-01-01 00:00:00

abstract：:The pattern of expression of different types of myosin heavy chains and the development of different generations of muscle cells during foetal life were studied in four bovine muscles with widely varying characteristics, the Masseter, Longissimus thoracis, Cutaneus trunci and Diaphragma. Different complementary techni...

journal_title：Journal of muscle research and cell motility

authors： Picard B,Robelin J,Pons F,Geay Y

更新日期：1994-08-01 00:00:00

abstract：:To explain observed differences in the activation dependence of force redevelopment kinetics between cardiac and skeletal muscle, two numerical models of contractile regulation by Ca2+ were investigated. Ca2+ binding and force production were each modelled as two-state processes with forward and reverse rate constants...

journal_title：Journal of muscle research and cell motility

authors： Hancock WO,Huntsman LL,Gordon AM

更新日期：1997-12-01 00:00:00

abstract：:Myomesin-I (also known as Skelemin) is a approximately 185 kDa protein, which is highly expressed in striated muscle. It contains the prototypic class-I (type-III fibronectin) and class-II (C2-immunoglobulin) motifs. Previous studies have shown the presence of Myomesin-I at the M-line of the sarcomere, where it is tho...

journal_title：Journal of muscle research and cell motility

authors： Reddy KB,Fox JE,Price MG,Kulkarni S,Gupta S,Das B,Smith DM

更新日期：2008-01-01 00:00:00

abstract：:The myosin II motor from Dictyostelium discoideum has been engineered to contain single tryptophan residues at strategic locations to probe movements of switch 1 and switch 2. The tryptophan residue at W501 probes movement of the relay helix and indirectly reports on switch 2 movement. This probe suggests that there i...

journal_title：Journal of muscle research and cell motility

authors： Málnási-Csizmadia A,Dickens JL,Zeng W,Bagshaw CR

更新日期：2005-01-01 00:00:00

abstract：:The giant molecule titin (also called connectin) provides an elastic connection in the I-band between the Z-disk and A-band of striated muscle. This region is assembled in a tissue-specific way by extensive differential splicing events. We have raised monoclonal antibodies against the two N2-line isoforms of titin and...

journal_title：Journal of muscle research and cell motility

authors： Gautel M,Lehtonen E,Pietruschka F

更新日期：1996-08-01 00:00:00

abstract：:Heart disease is a leading cause of death in patients with Duchenne muscular dystrophy (DMD). Patients with DMD lack the protein dystrophin, which is widely expressed in striated muscle. In skeletal muscle, the loss of dystrophin results in dramatically decreased expression of the dystrophin associated glycoprotein co...

journal_title：Journal of muscle research and cell motility

authors： Sharpe KM,Premsukh MD,Townsend D

更新日期：2013-12-01 00:00:00

abstract：:The effects of two amino acids, arginine which has a positively charged side-chain and glutamate which has a negatively charged side-chain on the Ca2+-activation properties of the contractile apparatus were examined in four structurally and functionally different types of skeletal muscle; long- and short-sarcomere fib...

journal_title：Journal of muscle research and cell motility

authors： Jame DW,West JM,Dooley PC,Stephenson DG

更新日期：2004-01-01 00:00:00

abstract：:temporaria (0.9-2.5degrees C) were stimulated to produce a 1 s isometric tetanus at regular intervals until constant mechanical responses were attained. Various degrees of force depression ("fatigue") were produced by decreasing the contraction interval from 30 or 15 min (control to 120, 60, 30 and 15s, respectively. ...

journal_title：Journal of muscle research and cell motility

authors： Edman KA,Mattiazzi AR

更新日期：1981-09-01 00:00:00

abstract：:The ability for muscle to repeatedly generate force is limited by fatigue. The cellular mechanisms behind muscle fatigue are complex and potentially include breakdown at many points along the excitation-contraction pathway. In this paper we construct a mathematical model of the skeletal muscle excitation-contraction p...

journal_title：Journal of muscle research and cell motility

authors： Shorten PR,O'Callaghan P,Davidson JB,Soboleva TK

更新日期：2007-01-01 00:00:00

abstract：:Rotary-shadowed filamin molecules appear as long, highly flexible rods curved into a variety of configurations. The particles observed were 2.7 nm wide but had contour lengths of either 98 nm or 193 nm. The longer particles are probably end-to-end dimers of the shorter but it is not clear how many polypeptide chains t...

journal_title：Journal of muscle research and cell motility

authors： Castellani L,Offer G,Elliott A,O'Brien EJ

更新日期：1981-06-01 00:00:00

abstract：:Reactive oxygen species (ROS) are generated in skeletal muscle both during the rest and contractile activity. Myogenic cells are equipped with antioxidant enzymes, like superoxide dismutase, catalase, glutathione peroxidase, γ-glutamylcysteine synthetase and heme oxygenase-1. These enzymes not only neutralise excessiv...

journal_title：Journal of muscle research and cell motility

authors： Kozakowska M,Pietraszek-Gremplewicz K,Jozkowicz A,Dulak J

更新日期：2015-12-01 00:00:00

abstract：:Secophalloidin (SPH) is known to cause in cardiac myofibrils force without Ca(2+) (half-maximal effect approximately 2 mM) followed by irreversible loss of Ca(2+)-activated force. At maximal Ca(2+) activation, SPH increases force (half-maximal effect < 0.1 mM). We found that SPH at low concentration (0.5 mM) did not c...

journal_title：Journal of muscle research and cell motility

authors： Bukatina AE,Sieck GC,Campbell KB,Belohlavek M

更新日期：2009-01-01 00:00:00

abstract：:This study investigated the effects of the protein kinase A (PKA) inhibitor, H-89, in mechanically-skinned muscle fibres and intact muscle fibres, in order to determine whether PKA phosphorylation is essential for normal excitation-contraction (E-C) coupling. In skinned EDL fibres of the rat, force responses to depola...

journal_title：Journal of muscle research and cell motility

authors： Blazev R,Hussain M,Bakker AJ,Head SI,Lamb GD

更新日期：2001-01-01 00:00:00

abstract：:Long-(SL > 6 microns) and short-sarcomere (SL < 4 microns) fibres were isolated from the claw muscle of the yabby (Cherax destructor) during limb regeneration and at different stages of the moult cycle. Long-sarcomere fibres were more susceptible to the changes resulting from the moult-induced atrophy compared with th...

journal_title：Journal of muscle research and cell motility

authors： West JM,Humphris DC,Stephenson DG

更新日期：1995-06-01 00:00:00

abstract：:In this study the spontaneous activities of prescapular lymph nodes, which were isolated from calves, goats and sheep and mesenteric lymph nodes of guinea-pigs were recorded and analysed in the frequency domain. Stretch-evoked contractions of the mesenteric lymph nodes were also recorded and their frequency characteri...

journal_title：Journal of muscle research and cell motility

authors： Tümer A,Oztürk-Demir N,Basar-Eroğlu C,Noyan A

更新日期：1983-02-01 00:00:00

abstract：:The organization of the principal cytoskeletal components (actin, tubulin and 10 nm filament protein) have been compared by immunofluorescence microscopy in two populations of chick heart fibroblasts, previously shown to be adapted respectively for rapid, directed migration or adhesion and growth. We find that neither...

journal_title：Journal of muscle research and cell motility

authors： Badley RA,Couchman JR,Rees DA

更新日期：1980-03-01 00:00:00

abstract：:Gaps in our understanding of muscle mechanics demonstrate that the current model is incomplete. Increasingly, it appears that a role for titin in active muscle contraction might help to fill these gaps. While such a role for titin is increasingly accepted, the underlying molecular mechanisms remain unclear. The goals ...

journal_title：Journal of muscle research and cell motility

authors： Nishikawa K,Dutta S,DuVall M,Nelson B,Gage MJ,Monroy JA

更新日期：2020-03-01 00:00:00

abstract：:Changes in the isoform patterns of myosin heavy chains (MHC) and Ca2+-ATPase (SERCA) were studied in long-term (72 days) denervated slow-twitch soleus muscles of euthyroid and hyperthyroid rabbits. MHC isoforms were separated electrophoretically. SERCA isoforms were assessed by electrophoretic separation of the trypsi...

journal_title：Journal of muscle research and cell motility

authors： Hämäläinen N,Pette D

更新日期：2001-01-01 00:00:00

abstract：:The in vivo state of assembly of myosin in vertebrate smooth muscle is controversial. In vitro studies on purified smooth muscle myosin show that it is monomeric (10S) under relaxing conditions and filamentous under contraction conditions. Electron microscopic and antibody labelling studies of intact smooth muscles, o...

journal_title：Journal of muscle research and cell motility

authors： Xu JQ,Gillis JM,Craig R

更新日期：1997-06-01 00:00:00

abstract：:Using a variety of techniques, we have demonstrated the presence of at least two fibre types in Limulus median telson levator muscle. By light and electron microscopy, large (2,156 microns 2 mean cross-sectional area) fibres have A-bands of 4.1 microns, one-half I bands of 2.15 microns and Z lines less than or equal t...

journal_title：Journal of muscle research and cell motility

authors： Levine RJ,Davidheiser S,Kelly AM,Kensler RW,Leferovich J,Davies RE

更新日期：1989-02-01 00:00:00

abstract：:We have determined the amino acid sequences of the essential light chains (ELC) and regulatory light chains (RLC) of myosin from two species of clam, Mercenaria mercenaria and Macrocallista nimbosa, using protein chemistry methods. The N-termini of all four proteins were blocked, and sequencing was carried out on vari...

journal_title：Journal of muscle research and cell motility

authors： Barouch WW,Breese KE,Davidoff SA,Leszyk J,Szent-Györgyi AG,Theibert JL,Collins JH

更新日期：1991-08-01 00:00:00

abstract：:Dr. John Gergely passed away on July 26, 2013 after a long and distinguished career. His publications spanned 67 years. He founded the Department of Muscle Research in the Retina Foundation (which later became the Boston Biomedical Research Institute) and served as director for 34 years. Dr. Gergely served on the edit...

journal_title：Journal of muscle research and cell motility

authors： Greaser ML,Potter JD,Thomas DD,Strasburg GM,Lehrer SS,Wang CL,Grabarek Z

更新日期：2013-12-01 00:00:00

abstract：:The trimeric protein AMP-activated protein kinase (AMPK) is an important sensor of energetic status and cellular stress, and mutations in genes encoding two of the regulatory γ subunits cause inherited disorders of either cardiac or skeletal muscle. AMPKγ2 mutations cause hypertrophic cardiomyopathy with glycogen depo...

journal_title：Journal of muscle research and cell motility

authors： Pinter K,Grignani RT,Watkins H,Redwood C

更新日期：2013-12-01 00:00:00

abstract：:Two single mutations, R694N and E45Q, were introduced in the beta isoform of human cardiac myosin to remove permanent salt bridges E45:R694 and E98:R694 in the SH1-SH2 helix of the myosin head. Beta isoform-specific bridges E45:R694 and E98:R694 were discovered in the molecular dynamics simulations of the alpha and be...

journal_title：Journal of muscle research and cell motility

authors： Gargey A,Iragavarapu SB,Grdzelishvili AV,Nesmelov YE

更新日期：2020-09-14 00:00:00

abstract：:The ATP-ADP exchange reaction and its related partial reactions of fragmented sarcoplasmic reticulum from bullfrog skeletal muscle (frog FSR) were investigated and compared with those of rabbit FSR in order to understand the characteristics of calcium-activated ATPase (Ca2+-ATPase) of frog FSR. MgATP and magnesium-fre...

journal_title：Journal of muscle research and cell motility

authors： Ogawa Y,Kurebayashi N

更新日期：1982-03-01 00:00:00