2-Nitropropane induces DNA repair synthesis in rat hepatocytes in vitro and in vivo.

abstract：:Two mutagenic compounds have been isolated and purified from commercial beef extract. These two compounds have chemical, chromatographic, spectroscopic and biological behavior indistinguishable from those of the two known mutagens 2-amino-3-methyl-imidazo-[4,5-f]-quinoline and 2-amino-3,8-dimethyl-imidazo-[4,5-f]-quin...

journal_title：Carcinogenesis

authors： Turesky RJ,Wishnok JS,Tannenbaum SR,Pfund RA,Buchi GH

更新日期：1983-01-01 00:00:00

abstract：:Apurinic/apyrimidinic endonuclease/redox effector factor-1 (APE/Ref-1) is a multifunctional protein involved both in DNA base excision repair and redox regulation. Studies have suggested that abnormal Ref-1 levels and/or activities are associated with tumor progression and sensitivities to treatment, but no direct evi...

journal_title：Carcinogenesis

authors： Yang S,Misner BJ,Chiu RJ,Meyskens FL Jr

更新日期：2007-11-01 00:00:00

abstract：:3,3'-Diindolylmethane (DIM), an indole derivative produced on consumption of broccoli and other cruciferous vegetables, has been shown to have multiple anticancer effects in both in vivo and in vitro models. The present study was carried out to clarify the mechanism of DIM's antiangiogenic activity. We found that DIM ...

journal_title：Carcinogenesis

authors： Chang X,Firestone GL,Bjeldanes LF

更新日期：2006-03-01 00:00:00

abstract：:Cryptic deletions at chromosome 6q are common cytogenetic abnormalities in T-cell lymphoblastic leukemia/lymphoma (T-LBL), but the target genes have not been formally identified. Our results build on detection of specific chromosomal losses in a mouse model of γ-radiation-induced T-LBLs and provide interesting clues f...

journal_title：Carcinogenesis

authors： López-Nieva P,Vaquero C,Fernández-Navarro P,González-Sánchez L,Villa-Morales M,Santos J,Esteller M,Fernández-Piqueras J

更新日期：2012-02-01 00:00:00

abstract：:The extracellular matrix (ECM) is known to play an active role in numerous biological processes such as differentiation, apoptosis and cancer. Extensive alterations of epithelial basement membranes and of interstitial ECM are known to occur during the progression of most invasive carcinomas. Collagen, which represents...

journal_title：Carcinogenesis

authors： Pucci-Minafra I,Andriolo M,Basiricò L,Alessandro R,Luparello C,Buccellato C,Garbelli R,Minafra S

更新日期：1998-04-01 00:00:00

abstract：:O(6)-alkylguanine-DNA alkyltransferase (AGT) is a suicide protein that corrects DNA damage by alkylating agents and may also serve to activate environmental carcinogens. We expressed human wild-type and two active mutant AGTs in bacteria that lack endogenous AGT and are also defective in nucleotide excision repair, to...

journal_title：Carcinogenesis

authors： Abril N,Luque-Romero FL,Christians FC,Encell LP,Loeb LA,Pueyo C

更新日期：1999-11-01 00:00:00

abstract：:p90 Ribosomal S6 kinase (RSK) 4 is a serine-threonine kinase that belongs to the p90RSK family. RSK4 has been proposed as a tumor suppressor gene, related with anti-invasive activity, inhibition of the RAS-mitogen-activated protein kinase (MAPK) pathway and induction of senescence. Despite the related findings, little...

journal_title：Carcinogenesis

authors： López-Vicente L,Pons B,Coch L,Teixidó C,Hernández-Losa J,Armengol G,Ramon Y Cajal S

更新日期：2011-04-01 00:00:00

abstract：:We employed cDNA microarray analysis to identify, in mammary adenocarcinomas induced by 7,12-dimethylbenz[a] anthracene (DMBA) in the rat, target genes as potential biomarkers for cancer chemoprevention by 1,4-phenylenebis(methylene)selenocyanate (p-XSC). Confirmation of selected genes was conducted by reverse transcr...

journal_title：Carcinogenesis

authors： El-Bayoumy K,Narayanan BA,Desai DH,Narayanan NK,Pittman B,Amin SG,Schwartz J,Nixon DW

更新日期：2003-09-01 00:00:00

abstract：:The effect of the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was studied using an immortalized human bronchial epithelial cell line, BEAS-2B, both in vivo and in vitro. The in vivo model consisted of tracheas reconstituted with an epithelium of BEAS-2B cells xenotransplanted into athymic nude mice. Int...

journal_title：Carcinogenesis

authors： Bonfil RD,Momiki S,Fridman R,Reich R,Reddel R,Harris CC,Klein-Szanto A

更新日期：1989-12-01 00:00:00

abstract：:Extensive tumorigenicity studies in rodents revealed that dibenzo[a,l]pyrene (DB[a,l]P) is the most potent carcinogen among all polycyclic aromatic hydrocarbons (PAHs) tested so far. The structure of the genotoxic metabolite(s) responsible for this exceptional carcinogenicity is unknown. The fjord-region syn- and anti...

journal_title：Carcinogenesis

authors： Luch A,Glatt H,Platt KL,Oesch F,Seidel A

更新日期：1994-11-01 00:00:00

abstract：:We examined the genotypes of two polymorphic genes involved in the detoxification of several mutagenic and carcinogenic compounds in relation to tobacco smoking-associated urinary mutagenicity. The genes studied were the glutathione S-transferase-encoding GSTM1 gene and acetyltransferase-encoding NAT2 gene. Smokers wi...

journal_title：Carcinogenesis

authors： Hirvonen A,Nylund L,Kociba P,Husgafvel-Pursiainen K,Vainio H

更新日期：1994-05-01 00:00:00

abstract：:The extent to which N-acetylbenzidine and N,N'-diacetylbenzidine are formed may influence benzidine-induced carcinogenesis. This study compared the formation of these metabolites by rat and human liver slices. The relationship between the NAT2 genotype and the formation of these acetylated products was also evaluated ...

journal_title：Carcinogenesis

authors： Lakshmi VM,Bell DA,Watson MA,Zenser TV,Davis BB

更新日期：1995-07-01 00:00:00

abstract：:Untreated and Aroclor 1254-pretreated male Wistar rats were given a single dose of 1.0 mg/kg body weight of randomly tritium-labelled 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (3H-PhIP) by oral intubation. Urine and faeces were collected at 24, 48 and 72 hours after dosing, and total radioactivity determined. A...

journal_title：Carcinogenesis

authors： Dragsted LO,Frandsen H,Reistad R,Alexander J,Larsen JC

更新日期：1995-11-01 00:00:00

abstract：:DNA-methyltransferase-3B (DNMT3B) plays an important role in the generation of aberrant methylation in carcinogenesis. Polymorphisms and haplotypes of the DNMT3B gene may influence DNMT3B activity on DNA methylation, thereby modulating the susceptibility to lung cancer. To test this hypothesis, we investigated the ass...

journal_title：Carcinogenesis

authors： Lee SJ,Jeon HS,Jang JS,Park SH,Lee GY,Lee BH,Kim CH,Kang YM,Lee WK,Kam S,Park RW,Kim IS,Cho YL,Jung TH,Park JY

更新日期：2005-02-01 00:00:00

abstract：:Recent studies have proposed that exposure to ultraviolet radiation (UVR) protects against development of some internal cancers including that in prostate. This effect may be mediated by UVR-induced cutaneous synthesis of vitamin D. It is also proposed that ability to pigment in response to UVR will influence suscepti...

journal_title：Carcinogenesis

authors： Bodiwala D,Luscombe CJ,French ME,Liu S,Saxby MF,Jones PW,Ramachandran S,Fryer AA,Strange RC

更新日期：2003-04-01 00:00:00

abstract：:Debrisoquine hydroxylase activity has been attributed to CYP2D6 and poor metabolizers of debrisoquine have a reduced relative risk of developing aggressive bladder cancer. Production of a proximate carcinogen could occur in liver or bladder mucosa. However, it is not known if CYP2D6 is expressed in human bladder mucos...

journal_title：Carcinogenesis

authors： Romkes-Sparks M,Mnuskin A,Chern HD,Persad R,Fleming C,Sibley GN,Smith P,Wilkinson GR,Branch RA

更新日期：1994-09-01 00:00:00

abstract：:The identification of primary molecular targets of cancer-preventive phytochemicals is essential for a comprehensive understanding of their mechanism of action. In the present study, we investigated the chemopreventive effects and molecular targets of acacetin, a flavonoid found in Robinia p seudoacacia, also known as...

journal_title：Carcinogenesis

authors： Jung SK,Kim JE,Lee SY,Lee MH,Byun S,Kim YA,Lim TG,Reddy K,Huang Z,Bode AM,Lee HJ,Lee KW,Dong Z

更新日期：2014-01-01 00:00:00

abstract：:Zinc has been shown to be accumulated in N-methyl-N-nitrosourea (MNU)-induced rat mammary tumors. Zinc is required for cell proliferation and tumorigenesis is characterized by dysregulation of cell proliferation. An accumulation of zinc in mammary tumors perhaps indicates a reliance on zinc to sustain tumor growth. Li...

journal_title：Carcinogenesis

authors： Lee S,Simpson M,Nimmo M,Xu Z

更新日期：2004-10-01 00:00:00

abstract：:Poly(ADP-ribose) (polymer) is enzymatically synthesized on nuclear proteins in response to DNA strand breaks. NAD+ is the substrate for this reaction, which is catalyzed by poly(ADP-ribose)polymerase. This post-translational modification occurs in response to DNA strand breaks and is thought to play an important role ...

journal_title：Carcinogenesis

authors： Rawling JM,Driscoll ER,Poirier GG,Kirkland JB

更新日期：1993-12-01 00:00:00

abstract：:The reactive metabolites of the carcinogenic N-acetyl-2-aminofluorene (AAF) form adducts with the guanine base of DNA. The fluorescence emission characteristics of N-(deoxy-guanosin-8-yl)-N-acetyl-2-aminofluorene (dGuo-C8-AAF), N-(deoxyguanosin-8-yl)-2-aminofluorene (dGuo-C8-AF) and the two N7 = C8 imidazole ring-open...

journal_title：Carcinogenesis

authors： van Houte LP,Retèl J,Westra JG,van Grondelle R

更新日期：1990-04-01 00:00:00

abstract：:The rat liver microsomal metabolism of 3-deutero-6-nitrobenzo(a)pyrene ([3-2H]6-NO2-BaP) was studied. The metabolites were separated by h.p.l.c. The 500 MHz 1H n.m.r. spectral analysis of the metabolites indicated that the 3-hydroxy-6-NO2-BaP and 6-NO2-BaP-3,9-hydroquinone each retained 33% of the deuterium label at t...

journal_title：Carcinogenesis

authors： Chou MW,Evans FE,Yang SK,Fu PP

更新日期：1983-01-01 00:00:00

abstract：:The modulating effects of dietary feeding of two xanthophylls, astaxanthin (AX) and canthaxanthin (CX) during the postinitiation phase on colon carcinogenesis initiated with azoxymethane (AOM) were investigated in male F344 rats. Animals were initiated with AOM by weekly s.c. injections of 15 mg/kg body wt for 3 weeks...

journal_title：Carcinogenesis

authors： Tanaka T,Kawamori T,Ohnishi M,Makita H,Mori H,Satoh K,Hara A

更新日期：1995-12-01 00:00:00

abstract：:Liver metastases develop in more than half of the patients with colorectal cancer (CRC) and are associated with a poor prognosis. The factors influencing liver metastasis of CRC are poorly characterized, but this information is urgently needed. We have now discovered that small extracellular vesicles (sEVs; exosomes) ...

journal_title：Carcinogenesis

authors： Shao Y,Chen T,Zheng X,Yang S,Xu K,Chen X,Xu F,Wang L,Shen Y,Wang T,Zhang M,Hu W,Ye C,Yu X,Shao J,Zheng S

更新日期：2018-12-13 00:00:00

abstract：:The effect of changing the format of administration as well as the total dose of the promoting agent phenobarbital (PB) on the development of altered hepatic foci (AHF) was determined in an initiation-promotion protocol with female rats fed the purified AIN-76 diet. Effects on the total number of AHF and the volume pe...

journal_title：Carcinogenesis

authors： Xu YD,Dragan YP,Young T,Pitot HC

更新日期：1991-06-01 00:00:00

abstract：:Treatment of human skin fibroblasts in early S-phase with (+-)7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene (BPDE-I) results in more extensive modification of early replicating DNA than parental DNA. We have investigated the effects of benzamide (BZ) and 3-aminobenzamide (3-ABZ), i...

journal_title：Carcinogenesis

authors： Kurian P,Kumari HL,Milo GE

更新日期：1992-03-01 00:00:00

abstract：:Women who carry the BRCA mutation are at high lifetime risk of breast cancer, but there is no consensus regarding an effective and safe chemoprevention strategy. A large body of evidence suggests that 3,3-diindolylmethane (DIM), a dimer of indole-3-carbinol found in cruciferous vegetables, can potentially prevent carc...

journal_title：Carcinogenesis

authors： Yerushalmi R,Bargil S,Ber Y,Ozlavo R,Sivan T,Rapson Y,Pomerantz A,Tsoref D,Sharon E,Caspi O,Grubsrein A,Margel D

更新日期：2020-10-15 00:00:00

abstract：:Epidemiological investigations suggest that chronic lung inflammation increases lung cancer risk. Pharmacologic and genetic evidence in mouse models indicates that lipid mediators released during pulmonary inflammation enhance lung tumor formation. Cytosolic phospholipase A2 (cPLA2) catalyzes arachidonic acid (AA) rel...

journal_title：Carcinogenesis

authors： Meyer AM,Dwyer-Nield LD,Hurteau GJ,Keith RL,O'Leary E,You M,Bonventre JV,Nemenoff RA,Malkinson AM

更新日期：2004-08-01 00:00:00

abstract：:Trabectedin is a marine-derived antineoplastic drug. Besides targeting the cancer cells, trabectedin has a peculiar activity on the tumor microenvironment with marked effects on the vasculature and the immune response. Because a favorable microenvironment is a key factor in the progression of cutaneous melanoma, we hy...

journal_title：Carcinogenesis

authors： Carminati L,Pinessi D,Borsotti P,Minoli L,Giavazzi R,D'Incalci M,Belotti D,Taraboletti G

更新日期：2019-04-29 00:00:00

abstract：:In two separate in vivo studies, ethionine was evaluated for carcinogenic activity in mice. In the first study, DL-ethionine was fed in a chow diet at 0 (controls), 0.1 (low dose, LD) and 0.25% (high dose, HD) concentrations to the following groups of mice (30 animals/group): Swiss Webster CD-1 females, BALB/c males, ...

journal_title：Carcinogenesis

authors： Hoover KL,Hyde CL,Wenk ML,Poirier LA

更新日期：1986-07-01 00:00:00

abstract：:Propylene oxide, a widely used monofunctional alkylating agent, has been shown to be genotoxic in in vitro test systems and induces tumors in the nasal tissues of experimental animals. Propylene oxide, like related alkylating agents, forms several different adducts with DNA bases, but predominantly at the 7-position o...

journal_title：Carcinogenesis

authors： Plna K,Nilsson R,Koskinen M,Segerbäck D

更新日期：1999-10-01 00:00:00