Abstract:
:Sedentary behaviour is an emerging risk factor for several site-specific cancers. Ovarian cancers are often detected at late disease stages and the role of sedentary behaviour as a modifiable risk factor potentially contributing to ovarian cancer risk has not been extensively examined. We systematically searched relevant databases from inception to February 2020 for eligible publications dealing with sedentary behaviour in relation to ovarian cancer risk. We conducted a systematic review and meta-analysis, calculating summary relative risks (RR) and 95% confidence intervals (CI) using a random-effects model. We calculated the E-Value, a sensitivity analysis for unmeasured confounding. We tested for publication bias and heterogeneity. Seven studies (three prospective cohort studies and four case-control studies) including 2060 ovarian cancer cases were analysed. Comparing highest versus lowest levels of sedentary behaviour, the data indicated a statistically significant increase in the risk of ovarian cancer in relation to prolonged sitting time (RR = 1.29, 95% CI = 1.07-1.57). Sub-analyses of prospective cohort studies (RR = 1.33, 95% CI = 0.92-1.93) and case-control studies (RR = 1.28, 95% CI = 0.98-1.68) showed statistically non-significant results. Sensitivity analysis showed that an unmeasured confounder would need to be related to sedentary behaviour and ovarian cancer with a RR of 1.90 to fully explain away the observed RR of 1.29. Our analyses showed a statistically significant positive association between sedentary behaviour and ovarian cancer risk.
journal_name
Eur J Epidemioljournal_title
European journal of epidemiologyauthors
Biller VS,Leitzmann MF,Sedlmeier AM,Berger FF,Ortmann O,Jochem Cdoi
10.1007/s10654-020-00712-6subject
Has Abstractpub_date
2021-01-25 00:00:00eissn
0393-2990issn
1573-7284pii
10.1007/s10654-020-00712-6pub_type
杂志文章,评审abstract::To estimate the prevalence of infection by hepatitis C virus (HCV) in general practice, and to investigate attitudes to screening for HCV, a specific questionnaire was sent to the sentinel general practitioners (SGPs) of the French Sentinel Network. From the figures reported by SGPs, the number of anti-HCV tests perfo...
journal_title:European journal of epidemiology
pub_type: 杂志文章
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journal_title:European journal of epidemiology
pub_type: 信件
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journal_title:European journal of epidemiology
pub_type: 杂志文章
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abstract:: ...
journal_title:European journal of epidemiology
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pub_type: 杂志文章,meta分析
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journal_title:European journal of epidemiology
pub_type: 杂志文章,评审
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journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/a:1007640424387
更新日期:2000-06-01 00:00:00
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journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF00148927
更新日期:1988-09-01 00:00:00
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journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-012-9683-9
更新日期:2012-05-01 00:00:00
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journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/a:1007635104096
更新日期:2000-02-01 00:00:00
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journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF00146402
更新日期:1988-12-01 00:00:00
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journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF00148915
更新日期:1988-09-01 00:00:00
abstract::The measurement of lifetime prevalence of depression in cross-sectional surveys is biased by recall problems. We estimated it indirectly for two countries using modelling, and quantified the underestimation in the empirical estimate for one. A microsimulation model was used to generate population-based epidemiological...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-004-1009-0
更新日期:2005-01-01 00:00:00
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journal_title:European journal of epidemiology
pub_type: 杂志文章
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journal_title:European journal of epidemiology
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更新日期:1995-04-01 00:00:00
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journal_title:European journal of epidemiology
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pub_type: 信件
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journal_title:European journal of epidemiology
pub_type: 杂志文章,评审
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journal_title:European journal of epidemiology
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pub_type: 杂志文章
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journal_title:European journal of epidemiology
pub_type: 杂志文章
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abstract::The aim of our study was to assess the association between green tea consumption and all-cause and cause-specific mortality in a pooled analysis of eight Japanese population-based cohort studies. Pooled hazard ratios (HR) and 95% confidence intervals (CI), derived from random effects models, were used to evaluate the ...
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pub_type: 杂志文章,meta分析
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journal_title:European journal of epidemiology
pub_type: 杂志文章
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更新日期:2010-03-01 00:00:00