当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Application of subject-specific adaptive mechanical loading for bone healing in a mouse tail vertebral defect.

Application of subject-specific adaptive mechanical loading for bone healing in a mouse tail vertebral defect.

Abstract：

:Methods to repair bone defects arising from trauma, resection, or disease, continue to be sought after. Cyclic mechanical loading is well established to influence bone (re)modelling activity, in which bone formation and resorption are correlated to micro-scale strain. Based on this, the application of mechanical stimulation across a bone defect could improve healing. However, if ignoring the mechanical integrity of defected bone, loading regimes have a high potential to either cause damage or be ineffective. This study explores real-time finite element (rtFE) methods that use three-dimensional structural analyses from micro-computed tomography images to estimate effective peak cyclic loads in a subject-specific and time-dependent manner. It demonstrates the concept in a cyclically loaded mouse caudal vertebral bone defect model. Using rtFE analysis combined with adaptive mechanical loading, mouse bone healing was significantly improved over non-loaded controls, with no incidence of vertebral fractures. Such rtFE-driven adaptive loading regimes demonstrated here could be relevant to clinical bone defect healing scenarios, where mechanical loading can become patient-specific and more efficacious. This is achieved by accounting for initial bone defect conditions and spatio-temporal healing, both being factors that are always unique to the patient.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Malhotra A,Walle M,Paul GR,Kuhn GA,Müller R

doi

10.1038/s41598-021-81132-8

subject

Has Abstract

pub_date

2021-01-21 00:00:00

pages

1861

issue

1

issn

2045-2322

pii

10.1038/s41598-021-81132-8

journal_volume

11

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Prediction of infarction volume and infarction growth rate in acute ischemic stroke.

    abstract：:The prediction of infarction volume after stroke onset depends on the shape of the growth dynamics of the infarction. To understand growth patterns that predict lesion volume changes, we studied currently available models described in literature and compared the models with Adaptive Neuro-Fuzzy Inference System [ANFIS...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-08044-4

    authors： Kamran S,Akhtar N,Alboudi A,Kamran K,Ahmad A,Inshasi J,Salam A,Shuaib A,Qidwai U

    更新日期：2017-08-08 00:00:00

  • Metabolomic effects of the colonization of Medicago truncatula by the facultative endophyte Arthrobacter agilis UMCV2 in a foliar inoculation system.

    abstract：:Biofertilizer production and application for sustainable agriculture is already a reality. The methods for biofertilizers delivery in crop fields are diverse. Although foliar spray is gaining wide acceptance, little is known about the influence that the biochemical features of leaves have on the microbial colonization...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-65314-4

    authors： Ramírez-Ordorica A,Valencia-Cantero E,Flores-Cortez I,Carrillo-Rayas MT,Elizarraraz-Anaya MIC,Montero-Vargas J,Winkler R,Macías-Rodríguez L

    更新日期：2020-05-21 00:00:00

  • Anthrapyrazolone analogues intercept inflammatory JNK signals to moderate endotoxin induced septic shock.

    abstract：:Severe sepsis or septic shock is one of the rising causes for mortality worldwide representing nearly 10% of intensive care unit admissions. Susceptibility to sepsis is identified to be mediated by innate pattern recognition receptors and responsive signaling pathways of the host. The c-Jun N-terminal Kinase (JNK)-med...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep07214

    authors： Prasad KD,Trinath J,Biswas A,Sekar K,Balaji KN,Guru Row TN

    更新日期：2014-11-27 00:00:00

  • In situ response of Antarctic under-ice primary producers to experimentally altered pH.

    abstract：:Elevated atmospheric CO2 concentrations are contributing to ocean acidification (reduced seawater pH and carbonate concentrations), with potentially major ramifications for marine ecosystems and their functioning. Using a novel in situ experiment we examined impacts of reduced seawater pH on Antarctic sea ice-associat...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-42329-0

    authors： Cummings VJ,Barr NG,Budd RG,Marriott PM,Safi KA,Lohrer AM

    更新日期：2019-04-15 00:00:00

  • Potential causal associations between vitamin D and uric acid: Bidirectional mediation analysis.

    abstract：:Vitamin D deficiency, a major public-health worldwide, is associated with hyperuricemia but casual association is questioned. The study was conducted to determine potential causal associations between 25-hydroxy vitamin D (25(OH)D) and uric acid (UA). A cross-sectional study of the Electricity Generating Authority of ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep14528

    authors： Thakkinstian A,Anothaisintawee T,Chailurkit L,Ratanachaiwong W,Yamwong S,Sritara P,Ongphiphadhanakul B

    更新日期：2015-09-29 00:00:00

  • Extracellular microvesicles and invadopodia mediate non-overlapping modes of tumor cell invasion.

    abstract：:Tumor cell invasion requires the molecular and physical adaptation of both the cell and its microenvironment. Here we show that tumor cells are able to switch between the use of microvesicles and invadopodia to facilitate invasion through the extracellular matrix. Invadopodia formation accompanies the mesenchymal mode...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep14748

    authors： Sedgwick AE,Clancy JW,Olivia Balmert M,D'Souza-Schorey C

    更新日期：2015-10-13 00:00:00

  • A Fluorometric Method of Measuring Carboxypeptidase Activities for Angiotensin II and Apelin-13.

    abstract：:Degradation of the biologically potent octapeptide angiotensin Ang II-(1-8) is mediated by the activities of several peptidases. The conversion of Ang II to the septapeptide Ang-(1-7) is of particular interest as the latter also confers organ protection. The conversion is catalyzed by angiotensin-converting enzyme 2 a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep45473

    authors： Liu P,Wysocki J,Serfozo P,Ye M,Souma T,Batlle D,Jin J

    更新日期：2017-04-05 00:00:00

  • Genetic markers and continuity of healthy metabolic status: Tehran cardio-metabolic genetic study (TCGS).

    abstract：:Obese individuals can be categorized as "healthy obese" (MHO) and "unhealthy obese" (MUO) based on the presence or absence of metabolic abnormality. This study sets out to assess potential genetic causes behind persistence of healthy metabolic status in individuals categorized as "healthy obese". This study was conduc...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-70627-5

    authors： Gharooi Ahangar O,Javanrouh N,Daneshpour MS,Barzin M,Valizadeh M,Azizi F,Hosseinpanah F

    更新日期：2020-08-12 00:00:00

  • Decrease of mRNA Editing after Spinal Cord Injury is Caused by Down-regulation of ADAR2 that is Triggered by Inflammatory Response.

    abstract：:We recently showed that spinal cord injury (SCI) leads to a decrease in mRNA editing of serotonin receptor 2C (5-HT2CR) contributing to post-SCI spasticity. Here we study post-SCI mRNA editing and global gene expression using massively parallel sequencing. Evidence is presented that the decrease in 5-HT2CR editing is ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep12615

    authors： Di Narzo AF,Kozlenkov A,Ge Y,Zhang B,Sanelli L,May Z,Li Y,Fouad K,Cardozo C,Koonin EV,Bennett DJ,Dracheva S

    更新日期：2015-07-30 00:00:00

  • Characterizing the conformational landscape of MDM2-binding p53 peptides using Molecular Dynamics simulations.

    abstract：:The conformational landscapes of p53 peptide variants and phage derived peptide (12/1) variants, all known to bind to MDM2, are studied using hamiltonian replica exchange molecular dynamics simulations. Complementing earlier observations, the current study suggests that the p53 peptides largely follow the 'conformatio...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-15930-4

    authors： Yadahalli S,Li J,Lane DP,Gosavi S,Verma CS

    更新日期：2017-11-15 00:00:00

  • Establishment and characterization of patient-derived tumor xenograft using gastroscopic biopsies in gastric cancer.

    abstract：:The patient-derived tumor xenograft (PDTX) model has become the most realistic model for preclinical studies. PDTX models of gastric cancer using surgical tissues are reported occasionally; however, the PDTX models using gastroscopic biopsies, which are best for evaluating new drugs, are unreported. In our study, a to...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep08542

    authors： Zhu Y,Tian T,Li Z,Tang Z,Wang L,Wu J,Li Y,Dong B,Li Y,Li N,Zou J,Gao J,Shen L

    更新日期：2015-02-25 00:00:00

  • Eruptive Spitz nevus, a striking example of benign metastasis.

    abstract：:Metastasis is generally considered a characteristic of malignant tumors. Herein, we describe a patient with more than one hundred discrete Spitz nevi scattered all over her skin. Molecular analysis from three of the lesions identified a ROS1 fusion oncogene with identical genomic breakpoints, indicating that the nevi ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-73264-0

    authors： Raghavan SS,Kapler ES,Dinges MM,Bastian BC,Yeh I

    更新日期：2020-10-01 00:00:00

  • Mitochondrial ribosomal proteins involved in tellurite resistance in yeast Saccharomyces cerevisiae.

    abstract：:A considerable body of evidence links together mitochondrial dysfunctions, toxic action of metalloid oxyanions, and system and neurodegenerative disorders. In this study we have used the model yeast Saccharomyces cerevisiae to investigate the genetic determinants associated with tellurite resistance/sensitivity. Nitro...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-30479-6

    authors： Pontieri P,Hartings H,Di Salvo M,Massardo DR,De Stefano M,Pizzolante G,Romano R,Troisi J,Del Giudice A,Alifano P,Del Giudice L

    更新日期：2018-08-13 00:00:00

  • Genetic engineering of parthenocarpic tomato plants using transient SlIAA9 knockdown by novel tissue-specific promoters.

    abstract：:Parthenocarpy is the development of an ovary into a seedless fruit without pollination. The ubiquitous downregulation of SlIAA9 induces not only parthenocarpic fruit formation but also an abnormal vegetative phenotype. To make parthenocarpic transgenic tomato plants without unwanted phenotypes, we found two genes, nam...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-55400-7

    authors： Kim JS,Ezura K,Lee J,Ariizumi T,Ezura H

    更新日期：2019-12-11 00:00:00

  • Deglycosylation of Tropheryma whipplei biofilm and discrepancies between diagnostic results during Whipple's disease progression.

    abstract：:Whipple's disease is a systemic infectious disease associated with the bacterium Tropheryma whipplei. Numerous reports have presented puzzling discrepancies between diagnosis methods. We addressed this confusion using fluorescent in situ hybridization and immunofluorescence assays to evaluate 34 duodenal biopsies and ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep23883

    authors： Audoly G,Fenollar F,Lagier JC,Lepidi H,Raoult D

    更新日期：2016-03-30 00:00:00

  • Brain activity sustaining the modulation of pain by empathetic comments.

    abstract：:Empathetic verbal feedback from others has been shown to alleviate the intensity of experimental pain. To investigate the brain changes associated with this effect, we conducted 3T-fMRI measurements in 30 healthy subjects who received painful thermal stimuli on their left hand while overhearing empathetic, neutral or ...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章

    doi：10.1038/s41598-019-44879-9

    authors： Fauchon C,Faillenot I,Quesada C,Meunier D,Chouchou F,Garcia-Larrea L,Peyron R

    更新日期：2019-06-10 00:00:00

  • Anomalous Near-Surface Low-Salinity Pulses off the Central Oregon Coast.

    abstract：:From mid-May to August 2011, extreme runoff in the Columbia River ranged from 14,000 to over 17,000 m(3)/s, more than two standard deviations above the mean for this period. The extreme runoff was the direct result of both melting of anomalously high snowpack and rainfall associated with the 2010-2011 La Niña. The eff...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep17145

    authors： Mazzini PL,Risien CM,Barth JA,Pierce SD,Erofeev A,Dever EP,Kosro PM,Levine MD,Shearman RK,Vardaro MF

    更新日期：2015-11-26 00:00:00

  • Internal Extractive Electrospray Ionization Mass Spectrometry for Quantitative Determination of Fluoroquinolones Captured by Magnetic Molecularly Imprinted Polymers from Raw Milk.

    abstract：:Antibiotics contamination in food products is of increasing concern due to their potential threat on human health. Herein solid-phase extraction based on magnetic molecularly imprinted polymers coupled with internal extractive electrospray ionization mass spectrometry (MMIPs-SPE-iEESI-MS) was designed for the quantita...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-15202-1

    authors： Zhang H,Kou W,Bibi A,Jia Q,Su R,Chen H,Huang K

    更新日期：2017-11-07 00:00:00

  • Detection of antibiotics synthetized in microfluidic picolitre-droplets by various actinobacteria.

    abstract：:The natural bacterial diversity is regarded as a treasure trove for natural products. However, accessing complex cell mixtures derived from environmental samples in standardized high-throughput screenings is challenging. Here, we present a droplet-based microfluidic platform for ultrahigh-throughput screenings able to...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-31263-2

    authors： Mahler L,Wink K,Beulig RJ,Scherlach K,Tovar M,Zang E,Martin K,Hertweck C,Belder D,Roth M

    更新日期：2018-08-30 00:00:00

  • Scattering of spoof surface plasmon polaritons in defect-rich THz waveguides.

    abstract：:We report on the first observation of 'Spoof' Surface Plasmon Polariton (SPP) scattering from surface defects on metal-coated 3D printed, corrugated THz waveguiding surfaces. Surface defects, a result of the printing process, are shown to assist the direct coupling of the incident free-space radiation into a spoof SPP...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-42412-6

    authors： Klein AK,Basden A,Hammler J,Tyas L,Cooke M,Balocco C,Zeze D,Girkin JM,Gallant A

    更新日期：2019-04-18 00:00:00

  • Structural Evolution of Hydrothermally Derived Reduced Graphene Oxide.

    abstract：:Hydrothermal reduction is a promising approach for graphene oxide (GO) reduction since it is environmentally friendly, simple, and cost effective. We present a detailed study of structural changes occurring in graphene oxide during the reduction process. The correlations between the interlayer spacing, chemical states...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-25194-1

    authors： Huang HH,De Silva KKH,Kumara GRA,Yoshimura M

    更新日期：2018-05-01 00:00:00

  • Genome-wide assessment of gene-by-smoking interactions in COPD.

    abstract：:Cigarette smoke exposure is a major risk factor in chronic obstructive pulmonary disease (COPD) and its interactions with genetic variants could affect lung function. However, few gene-smoking interactions have been reported. In this report, we evaluated the effects of gene-smoking interactions on lung function using ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-27463-5

    authors： Park B,Koo SM,An J,Lee M,Kang HY,Qiao D,Cho MH,Sung J,Silverman EK,Yang HJ,Won S

    更新日期：2018-06-18 00:00:00

  • Stress-induced tunneling nanotubes support treatment adaptation in prostate cancer.

    abstract：:Tunneling nanotubes (TNTs) are actin-based membranous structures bridging distant cells for intercellular communication. We define roles for TNTs in stress adaptation and treatment resistance in prostate cancer (PCa). Androgen receptor (AR) blockade and metabolic stress induce TNTs, but not in normal prostatic epithel...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-44346-5

    authors： Kretschmer A,Zhang F,Somasekharan SP,Tse C,Leachman L,Gleave A,Li B,Asmaro I,Huang T,Kotula L,Sorensen PH,Gleave ME

    更新日期：2019-05-24 00:00:00

  • Forms and Lability of Phosphorus in Algae and Aquatic Macrophytes Characterized by Solution 31P NMR Coupled with Enzymatic Hydrolysis.

    abstract：:Solution Phosphorus-31 nuclear magnetic resonance (31P NMR) spectroscopy coupled with enzymatic hydrolysis (EH) with commercially available phosphatases was used to characterize phosphorus (P) compounds in extracts of the dominant aquatic macrophytes and algae in a eutrophic lake. Total extractable organic P (Po) conc...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep37164

    authors： Feng W,Zhu Y,Wu F,He Z,Zhang C,Giesy JP

    更新日期：2016-11-16 00:00:00

  • Immune interconnectivity of anatomically distant tumors as a potential mediator of systemic responses to local therapy.

    abstract：:Complex interactions occur between tumor and host immune system at each site in the metastatic setting, the outcome of which can determine behavior ranging from dormancy to rapid growth. An additional layer of complexity arises from the understanding that cytotoxic T cells can traffic through the host circulatory syst...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-27718-1

    authors： Walker R,Poleszczuk J,Pilon-Thomas S,Kim S,Anderson AARA,Czerniecki BJ,Harrison LB,Moros EG,Enderling H

    更新日期：2018-06-21 00:00:00

  • Bending light via adiabatic optical transition in longitudinally modulated photonic lattices.

    abstract：:Bending light in a controllable way is desired in various applications such as beam steering, navigating and cloaking. Different from the conventional way to bend light by refractive index gradient, transformation optics or special beams through wavefront design such as Airy beams and surface plasmons, we proposed a m...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep15805

    authors： Han B,Xu L,Dou Y,Xu J,Zhang G

    更新日期：2015-10-29 00:00:00

  • Age of Complementary Foods Introduction and Risk of Anemia in Children Aged 4-6 years: A Prospective Birth Cohort in China.

    abstract：:Age of complementary foods introduction is associated with childhood anemia, but the ideal age for the introduction of complementary foods to infants is a continuing topic of debate. We examined the longitudinal association between complementary foods introduction age and risk of anemia in 18,446 children from the Jia...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep44726

    authors： Wang F,Liu H,Wan Y,Li J,Chen Y,Zheng J,Huang T,Li D

    更新日期：2017-03-23 00:00:00

  • TGF-β regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells.

    abstract：:The epithelial-mesenchymal plasticity, in tight association with stemness, contributes to the mammary gland homeostasis, evolution of early neoplastic lesions and cancer dissemination. Focused on cell surfaceome, we used mouse models of pre-neoplastic mammary epithelial and cancer stem cells to reveal the connection b...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-67827-4

    authors： Remšík J,Pícková M,Vacek O,Fedr R,Binó L,Hampl A,Souček K

    更新日期：2020-07-09 00:00:00

  • Maternal depression attenuates newborn vitamin D concentrations in winter-spring: a prospective population-based study.

    abstract：:We aimed to investigate whether the newborns of mothers with maternal depression (MD) had lower vitamin D levels than newborns of non-MD (NMD) mothers and identify the potential mechanism underlying this association. Maternal depressive symptoms in late pregnancy and concentrations of cord blood 25 hydroxyvitamin D (2...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-01778-1

    authors： Zhou QF,Zhang MX,Tong SL,Tao RX,Hao JH,Huang K,Tao FB,Zhu P

    更新日期：2017-05-08 00:00:00

  • RNA sequencing reveals a transcriptomic portrait of human mesenchymal stem cells from bone marrow, adipose tissue, and palatine tonsils.

    abstract：:Human mesenchymal stem cells (MSCs) are adult multipotent cells that have plasticity and inhabit the stroma of diverse tissues. The potential utility of MSCs has been heavily investigated in the fields of regenerative medicine and cell therapy. However, MSCs represent diverse populations that may depend on the tissue ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-16788-2

    authors： Cho KA,Park M,Kim YH,Woo SY,Ryu KH

    更新日期：2017-12-07 00:00:00