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Strategies to expand the therapeutic potential of superoxide dismutase by exploiting delivery approaches.

Abstract：

:The overproduction of free radicals can cause oxidative-stress damage to a range of biomolecules, and thus potentially contribute to several pathologies, from neurodegenerative disorders to cardiovascular diseases and metabolic disorders. Endogenous antioxidant enzymes, such as superoxide dismutase (SOD), play an important role in diminishing oxidative stress. SOD supplementation could therefore be an effective preventive strategy to reduce the risk of free-radical overproduction. However, the efficacy of SOD administration is hampered by its rapid clearance. Several different approaches to improve the bioavailability of SOD have been explored in recent decades. This review intends to describe the rationale that underlie the various approaches and chemical strategies that have led to the most recent advances in SOD delivery. This critical description includes SOD conjugates, SOD loaded into particulate carriers (micelles, liposomes, nanoparticles, microparticles) and the most promising and suitable formulations for oral delivery, with a particular emphasis on reports of preclinical/clinical results. Likely future directions are also considered and reported.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Rosa AC,Bruni N,Meineri G,Corsi D,Cavi N,Gastaldi D,Dosio F

doi

10.1016/j.ijbiomac.2020.11.149

subject

Has Abstract

pub_date

2021-01-31 00:00:00

pages

846-865

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(20)35075-3

journal_volume

168

pub_type

杂志文章,评审

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