PM2.5 induces autophagy-mediated cell apoptosis via PI3K/AKT/mTOR signaling pathway in mice bronchial epithelium cells.

abstract：:The aim of the present study was to investigate the effects of feeder layers composed of various ratios of mouse embryonic fibroblasts (MEFs) and human foreskin fibroblasts (hFFs) on the growth of human embryonic stem cells (hESCs). In addition, the secretion levels of basic fibroblast growth factor (bFGF) by the feed...

journal_title：Experimental and therapeutic medicine

authors： Yang H,Qiu Y,Zeng X,Ding Y,Zeng J,Lu K,Li D

更新日期：2016-06-01 00:00:00

abstract：:The present study evaluated the effects of calcitonin gene-related peptide (CGRP) on bone marrow mesenchymal stem cells (BMMSCs) in vitro and in a rat model of mandibular distraction osteogenesis (MDO). Rat BMMSCs were isolated then treated with CGRP or CGRP antagonist (CGRP8-37). The proliferation and migration abili...

journal_title：Experimental and therapeutic medicine

authors： Jia S,Zhang SJ,Wang XD,Yang ZH,Sun YN,Gupta A,Hou R,Lei DL,Hu KJ,Ye WM,Wang L

更新日期：2019-08-01 00:00:00

abstract：:Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is broadly expressed on the majority of immune cells; however, the biological role of LAIR in solid tumors has yet to be elucidated. In the present study, using immunohistochemical staining analysis, the expression of LAIR-1 in human cervical cancer (HCC) an...

journal_title：Experimental and therapeutic medicine

authors： Wang Y,Zhang X,Miao F,Cao Y,Xue J,Cao Q,Zhang X

更新日期：2016-12-01 00:00:00

abstract：:Tumor-infiltrating lymphocytes (TILs) are produced by resecting tumor tissue and growing and expanding ex vivo large quantities of autologous T cells. Once the TILs are ready for infusion, the patient undergoes a non-myeloablative lympho-depleting course of chemotherapy and subsequent TIL infusion with high-dose bolus...

journal_title：Experimental and therapeutic medicine

authors： Zippel DB,Besser M,Shapira R,Ben-Nun A,Goitein D,Davidson T,Treves AJ,Markel G,Schachter J,Papa MZ

更新日期：2012-05-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a rare but highly aggressive type of malignancy. MicroRNA (miR)-25 has been demonstrated to be involved in the genesis of numerous cancer types. The aim of the present study was to investigate the prognostic value and functional role of miR-25 in CCA. The expression of miR-25 was determined...

journal_title：Experimental and therapeutic medicine

authors： Liu H,Ma L,Wang J

更新日期：2019-10-01 00:00:00

abstract：:The hyper-IgM syndromes (HIGMs) are a group of primary immune deficiency diseases characterized by a normal or elevated serum level of IgM and low or absent serum levels of IgG, IgA and IgE. Here, we report a case of X-linked HIGM with a new CD40L gene mutation presenting with eosinophilia. The patient experienced rec...

journal_title：Experimental and therapeutic medicine

authors： Guo LI,Chen BO,Xu B,Lu M,Ning B,Chen Z

更新日期：2015-04-01 00:00:00

abstract：:Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is an acute event characterized by the worsening of a patient's respiratory symptoms. To the best of our knowledge, few studies have investigated the computed tomography (CT) manifestation of AECOPD. Thus, the aim of the present study was to examine ...

journal_title：Experimental and therapeutic medicine

authors： Cheng T,Wan H,Cheng Q,Guo YI,Qian Y,Fan L,Feng Y,Song Y,Zhou M,Li Q,Shi G,Huang S

更新日期：2016-02-01 00:00:00

abstract：:The aim of this study was to analyze the techniques for intraocular lens (IOL) implantation in patients with coloboma of the iris. A retrospective cohort study was used to analyze the degree of iris coloboma and the characteristics of the crystalline lens in 56 patients with iris coloboma. The patients with a lesser d...

journal_title：Experimental and therapeutic medicine

authors： Li J,Li Y,Hu Z,Kong L

更新日期：2014-06-01 00:00:00

abstract：:The aim of the present study was to investigate whether the co-injection of hyaluronic acid (HA) and corticosteroids (CS) was superior to HA alone in the treatment of knee OA. A total of 120 participants with symptomatic knee OA were recruited and formed the intention-to-treat population for a 6-month follow-up. In th...

journal_title：Experimental and therapeutic medicine

authors： Wang SZ,Wu DY,Chang Q,Guo YD,Wang C,Fan WM

更新日期：2018-09-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) with variant translocations is rare. The patient of the present case report, a 2-year-old male with a microgranular variant of APL carrying der(17) ins(17;15) translocation, exhibited fever and epistaxis. The complete blood count showed marked leukocytosis with 72% atypical promyeloc...

journal_title：Experimental and therapeutic medicine

authors： Guan H,Liu J,Guo X,Wu C,Yu H

更新日期：2015-09-01 00:00:00

abstract：:The aim of the present study was to evaluate the diagnostic value of interferon-γ release assays for the detection of active tuberculosis (ATB) in patients previously vaccinated with Bacillus Calmette-Guérin (BCG). In total, 540 patients underwent the T-SPOT.TB test, including 295 patients with active pulmonary TB (PT...

journal_title：Experimental and therapeutic medicine

authors： Yan L,Xiao H,Han M,Zhang Q

更新日期：2015-07-01 00:00:00

abstract：:Eyelid conditioning, including delay eyelid conditioning and trace eyelid conditioning, has been used extensively to study neural structures and mechanisms of learning and memory as a form of associative learning. In the present study, microcurrent electrical stimulation was used to stimulate the medial prefrontal cor...

journal_title：Experimental and therapeutic medicine

authors： Zheng YJ,Dong YC,Zhu C,Zhao MS

更新日期：2016-03-01 00:00:00

abstract：:Vascular calcification, characterized by the active deposition of calcium phosphate in the vascular walls, is commonly observed in aging, diabetes mellitus and chronic kidney disease. This process is mediated by different cell types, including vascular stem/progenitor cells. The anti-aging protein klotho may act as an...

journal_title：Experimental and therapeutic medicine

authors： Yu L,Li M

更新日期：2020-12-01 00:00:00

abstract：:The present study was designed to observe the initiation of mitophagy in tumor cells after ultrasound treatment in the presence of curcumin under transmission electron microscopy. Nasopharyngeal carcinoma CNE2 cells were incubated with 10 μM curcumin and then exposed to ultrasound for 8 sec at an intensity of 0.46 W/c...

journal_title：Experimental and therapeutic medicine

authors： Wang X,Leung AW,Luo J,Xu C

更新日期：2012-01-01 00:00:00

abstract：:The aim of the present study was to investigate the correlation between the protein expression of A-kinase anchor protein 95 (AKAP95), cyclin D3 and AKT with pathological indicators in lung cancer tissues. Immunohistochemistry was used to detect the protein expression levels of the proteins in 51 lung cancer tissue sa...

journal_title：Experimental and therapeutic medicine

authors： Yu X,Yuan Y,Zhi X,Teng B,Chen X,Huang Q,Chen Y,Guan Z,Zhang Y

更新日期：2015-09-01 00:00:00

abstract：:Environmental exposure, including a high-fat diet (HFD), contributes to the high prevalence of colorectal cancer by changing the composition of the intestinal microbiota. However, data examining the interaction between dietary habits and intestinal microbiota of the Chinese population is sparse. We assessed dietary ha...

journal_title：Experimental and therapeutic medicine

authors： Qian L,Gao R,Hong L,Pan C,Li H,Huang J,Qin H

更新日期：2018-08-01 00:00:00

abstract：:To investigate the pharmacological mechanism of Guizhi Fuling Wan (GFW) in the treatment of uterine fibroids, a network pharmacology approach was used. Information on GFW compounds was collected from traditional Chinese medicine (TCM) databases, and input into PharmMapper to identify the compound targets. Genes associ...

journal_title：Experimental and therapeutic medicine

authors： Zeng L,Yang K,Liu H,Zhang G

更新日期：2017-11-01 00:00:00

abstract：:Clinical efficacy of metoprolol combined with irbesartan and hydrochlorothiazide and non-invasive ventilator in the emergency treatment of patients with severe heart failure (HF) was investigated. A retrospective analysis of the medical records of 124 patients with severe HF admitted to Binzhou Medical University Hosp...

journal_title：Experimental and therapeutic medicine

authors： Zhang F,Zhou G,Guo L,Lu F,Zhou G

更新日期：2018-12-01 00:00:00

abstract：:Tools to define the active ingredients and flavors of Traditional Chinese Medicines (TCMs) are limited by long analysis times, complex sample preparation and a lack of multiplexed analysis. The aim of the present study was to optimize and validate an electronic tongue (E-tongue) methodology to analyze the bitterness o...

journal_title：Experimental and therapeutic medicine

authors： Li X,Gao X,Liu R,Wang J,Wu Z,Zhang L,Li H,Gui X,Kang B,Shi J

更新日期：2016-11-01 00:00:00

abstract：:Schwann cell proliferation and differentiation is critical for the remyelination of injured peripheral nerves. Ferulic acid (FA) is a widely used antioxidant agent with neuroprotective properties. However, the potentially beneficial effects of FA on Schwann cells are unknown. Therefore, the present study was designed ...

journal_title：Experimental and therapeutic medicine

authors： Zhu X,Li K,Guo X,Wang J,Xiang Y

更新日期：2016-09-01 00:00:00

abstract：:Neuropathic pain (NP) is a common clinical chronic pain with very complex mechanisms. This study explored the function of activated Wnt signaling pathway in NP. A rat model of chronic constriction injury (CCI) was established. Different doses of IWP-2, a Wnt signal inhibitor, were intrathecally injected to observe the...

journal_title：Experimental and therapeutic medicine

authors： Zhao Y,Yang Z

更新日期：2018-10-01 00:00:00

abstract：:Central venous catheter is one of the most commonly used vascular therapies in patients receiving hemodialysis and vascular perforation is a rare but serious complication. The present study reports on a case of a 64-year-old female who developed massive hemothorax and hemorrhagic shock after long-term dialysis due to ...

journal_title：Experimental and therapeutic medicine

authors： Zhou CZ,Liu KC,Wang P,Ren W,Lv WF

更新日期：2019-10-01 00:00:00

abstract：:The aim of the present study was to investigate the function of microRNA-146b on myocardial infarction and the mechanism. An MTT assay, Annexin V/propidium iodide (PI) apoptosis assay, ELISA kits, western blot analysis and a caspase-3/8 activity assay were used to measure cell growth, vascular apoptosis inflammatory f...

journal_title：Experimental and therapeutic medicine

authors： Zhao L,Yang XR,Han X

更新日期：2019-02-01 00:00:00

abstract：:Bacterial infection is a key factor in airway inflammation. The present study describes the time-dependent changes in the leukocyte counts and cytokine levels of the bronchoalveolar lavage fluid (BALF) following subacute airway inflammation induced by lipopolysaccharide (LPS), a major component of the outer membranes ...

journal_title：Experimental and therapeutic medicine

authors： Liu L,Chen L,Wang Y,Yang H,Chen Y,Xu X,Zhou H,Jiang F,Li T,Wang J

更新日期：2012-12-01 00:00:00

abstract：:The present prospective, randomized, double-blinded, controlled study aimed to investigate the efficacy and safety of dexmedetomidine (DEX) combined with butorphanol for patient-controlled intravenous analgesia (PCIA) following total laparoscopic hysterectomy. A total of 88 patients undergoing total laparoscopic hyste...

journal_title：Experimental and therapeutic medicine

authors： Du J,Li JW,Jin J,Shi CX,Ma JH

更新日期：2018-11-01 00:00:00

abstract：:Cardiac inhibition due to burn injury and anesthetics have been documented previously. However, little is known about their combined effects on cardiac function. The aim of the present study was to observe the effects of a ketamine/xylazine (K/X) combination on the cardiac function of rats with severe scalds and compa...

journal_title：Experimental and therapeutic medicine

authors： Feng Y,Chai J,Chu W,Ma L,Zhang P,Duan H

更新日期：2013-09-01 00:00:00

abstract：:The present study aimed to determine the expression of microRNA (miRNA or miR)-145 in hypertrophic scars at the tissue and cellular levels, and to investigate its biological functions and mechanism of action. A total of 36 patients who were diagnosed with hypertrophic scar were included in the present study. Reverse t...

journal_title：Experimental and therapeutic medicine

authors： Wang S,Li C,Yu Y,Qiao J

更新日期：2019-11-01 00:00:00

abstract：:Alcohol use disorder (AUD) is a primary, chronic and relapsing disease of brain reward, motivation and memory, which is associated with several comorbidities, including major depression and post-traumatic stress disorder. It has been revealed that Ibudilast (IBUD), a dual inhibitor of phosphodiesterase-4 and -10 and o...

journal_title：Experimental and therapeutic medicine

authors： Petralia MC,Mazzon E,Mangano K,Fagone P,Di Marco R,Falzone L,Basile MS,Nicoletti F,Cavalli E

更新日期：2020-03-01 00:00:00

abstract：:The clinical efficacy of minimally invasive lumbar interbody fusion via the intervertebral foramen combined with ozone (O3) therapy for the treatment of L3-L4 central-type lumbar disc herniation was explored. We recruited patients with sciatica who attended our hospital between July 2013 and October 2015 and underwent...

journal_title：Experimental and therapeutic medicine

authors： Wang Y,Sun H,Qin S

更新日期：2017-02-01 00:00:00

abstract：:The effects of recombinant human growth hormone (rhGH) in the treatment of dwarfism and the relationship between insulin-like growth factor (IGF)-1, IGF-binding protein (IGFBP)-3 and thyroid hormone were examined in the present study. For this purpose, 66 patients diagnosed with dwarfism were selected retrospectively,...

journal_title：Experimental and therapeutic medicine

authors： Ren S,Nie Y,Wang A

更新日期：2016-12-01 00:00:00