Targeting the Achilles' heel of bacteria: different mechanisms to break down the peptidoglycan cell wall during bacterial warfare.

Abstract:

:Bacteria commonly live in dense polymicrobial communities and compete for scarce resources. Consequently, they employ a diverse array of mechanisms to harm, inhibit and kill their competitors. The cell wall is essential for bacterial survival by providing mechanical strength to resist osmotic stress. Because peptidoglycan is the major component of the cell wall and its synthesis is a complex multi-step pathway that requires the coordinate action of several enzymes, it provides a target for rival bacteria, which have developed a large arsenal of antibacterial molecules to attack the peptidoglycan of competitors. These molecules include antibiotics, bacteriocins and contact-dependent effectors that are either secreted into the medium or directly translocated into a target cell. In this review, we summarize the diversity of these molecules and highlight distinct mechanisms to disrupt the peptidoglycan, giving special attention to molecules that are known or have the potential to be used during interbacterial competitions.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Sibinelli-Sousa S,Hespanhol JT,Bayer-Santos E

doi

10.1128/JB.00478-20

subject

Has Abstract

pub_date

2020-11-02 00:00:00

eissn

0021-9193

issn

1098-5530

pii

JB.00478-20

pub_type

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