Abstract：
BACKGROUND:The role of bone and tissue banking is well known to meet the ever-growing need of bone and soft tissue allografts. Strict guidelines have been established to ensure high standard and minimize complications related to bone transplantation. METHODS:The Bone Bank in King Faisal Specialist Hospital and Research Centre (KFSH&RC), affiliated with the Saudi Council of Organ Transplantation, was inaugurated in 2010, and it has since been an integral part of the KFSH&RC organ retrieval team. The bank has a very strict regulations which were described. RESULTS:Between January 2010 and January 2020, there were 143 multi-organ donors (mean age: 36 years, range: 24-55 years). The total number of allografts used was 2191 which were utilized in 1047 patients. CONCLUSIONS:In this paper, we present our 10-year experience of administrative structure, donor and recipient testing protocols, allograft retrieval, processing procedures, and the internal audit safety arrangements. The utilization of allografts in various pathologies such as revision joint replacement, spine surgery, and tumor surgery is discussed with our results over a 10-year period.
journal_name
Cell Tissue Bankjournal_title
Cell and tissue bankingauthors
Ilyas I,Al-Rabiah AM,Alhussainan TS,Alrumaih HA,Fallatah AB,Alsakran SA,Al-Mohrej OAdoi
10.1007/s10561-020-09868-7subject
Has Abstractpub_date
2020-10-04 00:00:00eissn
1389-9333issn
1573-6814pii
10.1007/s10561-020-09868-7pub_type
杂志文章abstract：:The purpose of the present research was: 1. To investigate the opportunity of application of allogen osteoplastic materials such as Lioplast, received in Samara Tissue Bank of Samara State Medical University. 2. To work out a new technique of producing lyophilized allogen osteoplastic materials, such as Lioplast, with...
journal_title：Cell and tissue banking
pub_type： 杂志文章
doi：10.1007/s10561-004-7254-3
更新日期：2005-01-01 00:00:00
abstract：:Delivering the promise of personalised medicine is the challenge that the current generation of scientists face. The variations in human physiology and disease are considerable, and designing appropriate strategies to deliver what has been promised will require access to tissue from a large number of volunteers. The N...
journal_title：Cell and tissue banking
pub_type： 杂志文章
doi：10.1007/s10561-010-9212-6
更新日期：2011-02-01 00:00:00
abstract：:Tissue banking is started in Thailand in 1979 at the Department of Orthopaedic Surgery, Siriraj Hospital, Bangkok. At that time tissues produced were freeze-dried bone allografts which were sterilized by ethylene oxide. In 1984, the freeze-dried tissue allograft project received an award from the National Research Cou...
journal_title：Cell and tissue banking
pub_type： 杂志文章
doi：10.1023/A:1026542730541
更新日期：2000-01-01 00:00:00
abstract：:Whilst some of the assays used for serological screening of post-mortem blood samples from deceased tissue donors in some countries have been specifically validated by the manufacturer for this purpose, a significant number of those currently in use globally have not. Although specificity has previously been considere...
journal_title：Cell and tissue banking
pub_type： 杂志文章
doi：10.1007/s10561-010-9175-7
更新日期：2011-05-01 00:00:00
abstract：:A limited number of grafts produced in one batch is the main constrain to validate radiation sterilization dose of amnion and bone grafts according to ISO standard. The validation experiments done were according to ISO 13409 with a slight modification in sampling method. The experiments were carried out three times by...
journal_title：Cell and tissue banking
pub_type： 杂志文章
doi：10.1023/A:1010129720363
更新日期：2000-01-01 00:00:00
abstract：:Stem cell therapy is in constant need of new cell sources to conceive regenerative medicine approaches for diseases that are still without therapy. Scientists drew the attention toward amniotic membrane and amniotic fluid stem cells, since these sources possess many advantages: first of all as cells can be extracted f...
journal_title：Cell and tissue banking
pub_type： 杂志文章,评审
doi：10.1007/s10561-014-9428-y
更新日期：2014-06-01 00:00:00
abstract：:Demineralized freeze-dried bone allograft (DFDBA) has been used extensively in periodontal therapy. Questions have been raised however, about the osteogenic potential of the variety of grafts available. In India the cost factor is another important consideration. The aim of this study therefore was to evaluate the cli...
journal_title：Cell and tissue banking
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10561-014-9481-6
更新日期：2015-09-01 00:00:00
abstract：:Homograft or allograft tissue has been available for use as replacement for diseased valves or reconstruction of major vessels for decades. However, with respect to replacement of diseased valvular tissue the search for the ideal valve still continues. In this review we will discuss the clinical indications, surgical ...
journal_title：Cell and tissue banking
pub_type： 杂志文章,评审
doi：10.1007/s10561-006-9009-9
更新日期：2006-01-01 00:00:00
abstract：:The use of glycosaminoglycans (GAGs) as the second macromolecular component with collagen for the membrane preparation is based on the idea to create a biodegradable scaffold for new tissue. A hybrid collagen/hyaluronan membrane with specific bubble macrostructure was designed to serve as a synthetic dermal substitute...
journal_title：Cell and tissue banking
pub_type： 杂志文章
doi：10.1023/a:1010181925236
更新日期：2000-01-01 00:00:00
abstract：:Recently Bulgarian Bone Marrow Donors Registry (BBMDR) has been established and since August 2005 it has been a member of Bone Marrow Donors Worldwide. Currently the number of healthy donors included in the BBMDR is relatively low. All donors included in the BBMDR are typed for HLA-A, -B, -DRB loci. Phylogenetic analy...
journal_title：Cell and tissue banking
pub_type： 杂志文章
doi：10.1007/s10561-007-9046-z
更新日期：2008-12-01 00:00:00
abstract：:The aim of this study is to evaluate the beneficial effect of Myoinositol (MYO) supplement in freezing media on the post thaw sperm quality. Semen samples from 40 normozoospermic men were divided into two aliquots and frozen with simple or 2 mg/mL MYO supplemented freezing medium. Post thaw process including, computer...
journal_title：Cell and tissue banking
pub_type： 杂志文章
doi：10.1007/s10561-018-9731-0
更新日期：2019-03-01 00:00:00
abstract：:National Blood Service (NBS) Tissue Services (TS) operates living donor and deceased donor tissue banking programmes. The living bone donor programme operates in collaboration with 91 orthopaedic departments across the country and collects bone donations, in the form of surgically removed femoral heads (FHs), from ove...
journal_title：Cell and tissue banking
pub_type： 杂志文章
doi：10.1007/s10561-005-2362-2
更新日期：2006-01-01 00:00:00
abstract：:The aim of this study is to set up a standardized and reproducible method to determine the potency (= stem cell content) of human conjunctival cell cultures by means of immunofluorescence-based analyses. This will help the development of new Advanced Therapy Medicinal Products (ATMPs) to use in future cell therapy cli...
journal_title：Cell and tissue banking
pub_type： 杂志文章
doi：10.1007/s10561-020-09874-9
更新日期：2020-10-13 00:00:00
abstract：:Cell manufacturing for clinical applications is a unique form of biologics manufacturing that relies on maintenance of stringent work practices designed to ensure product consistency and prevent contamination by microorganisms or by another patient's cells. More extensive, prolonged laboratory processes involve greate...
journal_title：Cell and tissue banking
pub_type： 杂志文章,评审
doi：10.1007/s10561-011-9276-y
更新日期：2012-12-01 00:00:00
abstract：:This is a report of a workshop held on the establishment of human research tissue banking which was held in Levi, Finland 21-24 March 2002. There were 21 participants from 7 European countries. This meeting was attended by representatives from academia, research tissue banks and from the Biotech and Pharmaceutical Ind...
journal_title：Cell and tissue banking
pub_type： 杂志文章
doi：10.1023/A:1022811232250
更新日期：2002-01-01 00:00:00
abstract：:Most protocols to cryopreserve ovarian tissue utilize the permeable cryoprotective agents (CPAs) in 1.5 M concentration. However the issues related to the ability to use higher concentrations of CPAs have remained open. The research aim was to assess the efficiency of media containing osmotically active sugars (sucros...
journal_title：Cell and tissue banking
pub_type： 杂志文章
doi：10.1007/s10561-017-9623-8
更新日期：2018-03-01 00:00:00
abstract：:Current regulatory requirements demand an in-depth understanding and validation of protocols used in tissue banking. The aim of this work was to characterize the quality of split thickness skin allografts cryopreserved or manufactured using highly concentrated solutions of glycerol (50, 85 or 98%), where tissue water ...
journal_title：Cell and tissue banking
pub_type： 杂志文章
doi：10.1007/s10561-018-9694-1
更新日期：2018-06-01 00:00:00
abstract：:Injured nerves cannot regenerate on their own, and a lack of engraftable human nerves has been a major obstacle in cell-based therapies for regenerating damaged nerves. A monolayer culture approach to obtain adherent neural stem cells from human embryonic stem cells (hESC-NSCs) was established, and the greatest number...
journal_title：Cell and tissue banking
pub_type： 杂志文章
doi：10.1007/s10561-020-09816-5
更新日期：2020-06-01 00:00:00
abstract：:Recovered human and animal tissues are used extensively in surgery for wound repair and reconstruction. In preparation for the validation of chemical disinfection and radiation sterilization processes, studies were performed on the development and validation of quantitative bioburden recovery methods for human bone an...
journal_title：Cell and tissue banking
pub_type： 杂志文章
doi：10.1007/s10561-010-9238-9
更新日期：2012-03-01 00:00:00
abstract：:The Central Tissue Bank in Warsaw was established in 1963 and since then ionising radiation has been routinely applied to sterilise tissue grafts. Connective tissue grafts such as bone, cartilage, tendons, sclera, pericardium, skin, acellular dermis and amnion irradiated with a dose of 35 kGy in a (60)Co source and/or...
journal_title：Cell and tissue banking
pub_type： 杂志文章,评审
doi：10.1007/s10561-005-0338-x
更新日期：2005-01-01 00:00:00
abstract：:The viscoelastic and inertial properties of the arterial wall are responsible for the arterial functional role in the cardiovascular system. Cryopreservation is widely used to preserve blood vessels for vascular reconstruction but it is controversially suspected to affect the dynamic behaviour of these allografts. The...
journal_title：Cell and tissue banking
pub_type： 杂志文章
doi：10.1007/s10561-005-0655-0
更新日期：2006-01-01 00:00:00
abstract：:In order to guarantee the required level of quality for our Bone &Tissue Banking, we evaluated a new CE marked container (CELLFLEX MacoPharma), for packing, transport, processing and storage of bones for therapeutic use. The use of CE marked containers is mandatory for organ and tissue containers (Medical Device Direc...
journal_title：Cell and tissue banking
pub_type： 杂志文章
doi：10.1007/s10561-004-1090-3
更新日期：2004-01-01 00:00:00
abstract：:Despite a plethora of studies on overall attitudes related to organ donation in a health care setting, little is known as to whether or not medical students at various levels of undergraduate training have distinctive attitudes towards donation. The purpose of this study was to analyze attitudes of first- and sixth-ye...
journal_title：Cell and tissue banking
pub_type： 杂志文章
doi：10.1007/s10561-014-9491-4
更新日期：2015-09-01 00:00:00
abstract：:There are controversial reports about cardiac differentiation potential of mesenchymal stem cells (MSCs), and there is still no well-defined protocol for the induction of cardiac differentiation. The effects of retinoic acid (RA) and dimethyl sulfoxide (DMSO) on the proliferation and differentiation of human fetal liv...
journal_title：Cell and tissue banking
pub_type： 杂志文章
doi：10.1007/s10561-015-9514-9
更新日期：2016-03-01 00:00:00
abstract：:A tympano-ossicular tissue bank complying with European Union regulations on human allografts is feasible and critical to assure that the patient receives tissue which is safe, individually checked and prepared in a suitable environment. The transcranial procurement technique has become the standard approach to procur...
journal_title：Cell and tissue banking
pub_type： 杂志文章
doi：10.1007/s10561-012-9344-y
更新日期：2013-09-01 00:00:00
abstract：:Decellularised tissue allografts have been used in reconstructive surgical applications and transplantation for many years. Some of the current methods of sterilisation have a detrimental effect on the tissue graft structure and function. The anti-microbial activity of cupric ions and hydrogen peroxide (H2O2) are well...
journal_title：Cell and tissue banking
pub_type： 杂志文章
doi：10.1007/s10561-017-9660-3
更新日期：2017-12-01 00:00:00
abstract：:Revision surgery of joint replacements is increasing and raises the demand for allograft bone since restoration of bone stock is crucial for longevity of implants. Proceedings of bone grafts influence the biological and mechanic properties differently. This study examines the effect of thermodisinfection on mechanic p...
journal_title：Cell and tissue banking
pub_type： 杂志文章
doi：10.1007/s10561-016-9567-4
更新日期：2016-09-01 00:00:00
abstract：:Good manufacturing practices guidelines require safer and standardized cell substrates especially for those cell therapy products to treat ocular diseases where fibroblasts are used as feeder layers. However, if these are unavailable for stem cells culturing, murine fibroblasts are regularly used, raising critical iss...
journal_title：Cell and tissue banking
pub_type： 杂志文章
doi：10.1007/s10561-012-9325-1
更新日期：2013-06-01 00:00:00
abstract：:Cerebral ischemic injury as the main manifestation of stroke can occur in stroke patients (70-80%). Nowadays, the main therapeutic strategy used for ischemic brain injury treatment aims to achieve reperfusion, neuroprotection, and neurorecovery. Also, angiogenesis as a therapeutic approach maybe represents a promising...
journal_title：Cell and tissue banking
pub_type： 杂志文章,评审
doi：10.1007/s10561-020-09885-6
更新日期：2020-11-24 00:00:00
abstract：:The regulatory framework of tissue banking introduces a number of requirements for monitoring cleanrooms for processing tissue or cell grafts. Although a number of requirements were clearly defined, some requirements are open for interpretation. This study aims to contribute to the interpretation of GMP or GTP guideli...
journal_title：Cell and tissue banking
pub_type： 杂志文章
doi：10.1007/s10561-012-9355-8
更新日期：2013-12-01 00:00:00
