Abstract：
:Microgravity is known to affect the organization of the cytoskeleton, cell and nuclear morphology and to elicit differential expression of genes associated with the cytoskeleton, focal adhesions and the extracellular matrix. Although the nucleus is mechanically connected to the cytoskeleton through the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex, the role of this group of proteins in these responses to microgravity has yet to be defined. In our study, we used a simulated microgravity device, a 3-D clinostat (Gravite), to investigate whether the LINC complex mediates cellular responses to the simulated microgravity environment. We show that nuclear shape and differential gene expression are both responsive to simulated microgravity in a LINC-dependent manner and that this response changes with the duration of exposure to simulated microgravity. These LINC-dependent genes likely represent elements normally regulated by the mechanical forces imposed by gravity on Earth.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Neelam S,Richardson B,Barker R,Udave C,Gilroy S,Cameron MJ,Levine HG,Zhang Ydoi
10.3390/ijms21186762subject
Has Abstractpub_date
2020-09-15 00:00:00issue
18issn
1422-0067pii
ijms21186762journal_volume
21pub_type
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