Abstract:
:Autophagy is fundamental for cell and organismal health. Two types of autophagy are conserved in eukaryotes: macroautophagy and microautophagy. During macroautophagy, autophagosomes deliver cytoplasmic constituents to endosomes or lysosomes, whereas during microautophagy lytic organelles take up cytoplasm directly. While macroautophagy has been investigated extensively, microautophagy has received much less attention. Nonetheless, it has become clear that microautophagy has a broad range of functions in biosynthetic transport, metabolic adaptation, organelle remodeling and quality control. This Review discusses the selective and non-selective microautophagic processes known in yeast, plants and animals. Based on the molecular mechanisms for the uptake of microautophagic cargo into lytic organelles, I propose to distinguish between fission-type microautophagy, which depends on ESCRT proteins, and fusion-type microautophagy, which requires the core autophagy machinery and SNARE proteins. Many questions remain to be explored, but the functional versatility and mechanistic diversity of microautophagy are beginning to emerge.
journal_name
J Cell Scijournal_title
Journal of cell scienceauthors
Schuck Sdoi
10.1242/jcs.246322subject
Has Abstractpub_date
2020-09-09 00:00:00issue
17eissn
0021-9533issn
1477-9137pii
133/17/jcs246322journal_volume
133pub_type
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journal_title:Journal of cell science
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更新日期:2002-10-15 00:00:00
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journal_title:Journal of cell science
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更新日期:2003-08-15 00:00:00
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journal_title:Journal of cell science
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更新日期:1998-12-18 00:00:00
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doi:
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更新日期:2012-10-01 00:00:00
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journal_title:Journal of cell science
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更新日期:2008-07-15 00:00:00
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journal_title:Journal of cell science
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journal_title:Journal of cell science
pub_type: 杂志文章
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journal_title:Journal of cell science
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doi:
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journal_title:Journal of cell science
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journal_title:Journal of cell science
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journal_title:Journal of cell science
pub_type: 杂志文章
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