The MgcRacGAP SxIP motif tethers Centralspindlin to microtubule plus ends in Xenopus laevis.

abstract：:Prion diseases are fatal transmissible neurodegenerative disorders characterized by the accumulation of an abnormally folded isoform of the cellular prion protein (PrP(C)) denoted PrP(Sc). Recently, wild-type and pathogenic PrP mutants have been shown to be degraded by the endoplasmic reticulum-associated degradation ...

journal_title：Journal of cell science

authors： Mangé A,Crozet C,Lehmann S,Béranger F

更新日期：2004-05-01 00:00:00

abstract：:Vertebrate nuclear lamins form a multigene family with developmentally controlled expression. In contrast, invertebrates have long been thought to contain only a single lamin, which in Drosophila is the well-characterized lamin Dm0. Recently, however, a Drosophila cDNA clone (pG-IF) has been identified that codes for ...

journal_title：Journal of cell science

authors： Riemer D,Stuurman N,Berrios M,Hunter C,Fisher PA,Weber K

更新日期：1995-10-01 00:00:00

abstract：:Schizosaccharomyces pombe cells divide by medial fission throughout contraction of an actomyosin ring and deposition of a multilayered division septum that must be cleaved to release the two daughter cells. Although many studies have focused on the actomoysin ring and septum assembly, little information is available c...

journal_title：Journal of cell science

authors： Martín-Cuadrado AB,Dueñas E,Sipiczki M,Vázquez de Aldana CR,del Rey F

更新日期：2003-05-01 00:00:00

abstract：:The structural events in the stigma and transmitting tissue of Petunia hybrida pistils that accompany compatible and incompatible intraspecific pollinations have been investigated in detail, together with the changes in reserve levels that also take place at this time. Many of these phenomena may be explained in terms...

journal_title：Journal of cell science

authors： Herrero M,Dickinson HG

更新日期：1979-04-01 00:00:00

abstract：:Pregnancy-associated plasma protein A2 (PAPP-A2, also known as pappalysin-2) is a large metalloproteinase that is known to be required for normal postnatal growth and bone development in mice. We here report the detection of zebrafish papp-a2 mRNA in the chordamesoderm, notochord and lower jaw of zebrafish (Danio reri...

journal_title：Journal of cell science

authors： Kjaer-Sorensen K,Engholm DH,Jepsen MR,Morch MG,Weyer K,Hefting LL,Skov LL,Laursen LS,Oxvig C

更新日期：2014-12-01 00:00:00

abstract：:Molecular mechanisms of chemotactic response are highly conserved among many eukaryotic cells including human leukocytes and Dictyostelium discoideum cells. The cells can sense the differences in chemoattractant concentration across the cell body and respond by extending pseudopods from the cell side facing to a highe...

journal_title：Journal of cell science

authors： Matsuoka S,Iijima M,Watanabe TM,Kuwayama H,Yanagida T,Devreotes PN,Ueda M

更新日期：2006-03-15 00:00:00

abstract：:Cue1p is an N-terminally anchored endoplasmic reticulum (ER) protein essential for the activity of the two major yeast RING finger ubiquitin ligases (E3s) implicated in ER-associated degradation (ERAD). Cue1p contains a CUE domain, which for several proteins is known to bind ubiquitin. We now establish that the CUE do...

journal_title：Journal of cell science

authors： Kostova Z,Mariano J,Scholz S,Koenig C,Weissman AM

更新日期：2009-05-01 00:00:00

abstract：:Chromatin is no longer considered to be a static structural framework for packaging DNA within the nucleus but is instead believed to be an interactive component of DNA metabolism. The ordered assembly of chromatin produces a nucleoprotein template capable of epigenetically regulating the expression and maintenance of...

journal_title：Journal of cell science

authors： Ridgway P,Almouzni G

更新日期：2000-08-01 00:00:00

abstract：:During the interphase to metaphase transition, microtubules are destabilized by a cdc2 kinase-dependent phosphorylation event. This destabilization is due to a dramatic increase in the rate at which each growing microtubule starts to shrink (catastrophe rate). In principle, this could be brought about by lowering the ...

journal_title：Journal of cell science

authors： Faruki S,Dorée M,Karsenti E

更新日期：1992-01-01 00:00:00

abstract：:We have shown previously, by fluorescent antibody staining, that desmosomal antigens are widely distributed in the tissues of vertebrate animals. Furthermore, we have demonstrated mutual desmosome formation between cells derived from man, cow, dog, chicken and frog. In this paper we have studied the components of desm...

journal_title：Journal of cell science

authors： Suhrbier A,Garrod D

更新日期：1986-03-01 00:00:00

abstract：:The tetrapeptide N-Acetyl-Seryl-Aspartyl-Lysyl-Proline (AcSDKP) is a natural regulator of hematopoietic stem cell proliferation. The present study was aimed at investigating the presence and the role of AcSDKP in rat testis. Specific immunoreactivity was always observed in the interstitial tissue at all stages of test...

journal_title：Journal of cell science

authors： Stéphan J,Melaine N,Ezan E,Hakovirta H,Maddocks S,Toppari J,Garnier D,Wdzieczak-Bakala J,Jégou B

更新日期：2000-01-01 00:00:00

abstract：:Most secretory proteins travel through a well-documented conventional secretion pathway involving the endoplasmic reticulum (ER) and the Golgi complex. However, recently, it has been shown that a significant number of proteins reach the plasma membrane or extracellular space via unconventional routes. Unconventional p...

journal_title：Journal of cell science

authors： Kim J,Gee HY,Lee MG

更新日期：2018-06-25 00:00:00

abstract：:Glomerular mesangial cells (MCs) are central to the pathogenesis of progressive glomeruli-associated renal diseases. However, molecular mechanisms underlying changes in MC functions still remain poorly understood. Here, we show that in MCs, the urokinase-type plasminogen activator (uPA) induces, via its specific recep...

journal_title：Journal of cell science

authors： Shushakova N,Tkachuk N,Dangers M,Tkachuk S,Park JK,Hashimoto K,Haller H,Dumler I

更新日期：2005-06-15 00:00:00

abstract：:ARVCF is a novel Armadillo repeat domain protein that is closely related to the catenin p120(ctn). Using new ARVCF monoclonal antibodies, we have found that ARVCF associates with E-cadherin and competes with p120 for interaction with the E-cadherin juxtamembrane domain. ARVCF also localized to the nucleus in some cell...

journal_title：Journal of cell science

authors： Mariner DJ,Wang J,Reynolds AB

更新日期：2000-04-01 00:00:00

abstract：:Microinjected GTP gamma S revealed three distinct steps in the exocytic transport of the temperature sensitive glycoprotein of vesicular stomatitis virus (ts-O45-G) from the ER to the cell surface in intact Vero cells. While COPII dependent export of ts-O45-G from the ER is blocked in cells injected with recombinant p...

journal_title：Journal of cell science

authors： Pepperkok R,Lowe M,Burke B,Kreis TE

更新日期：1998-07-01 00:00:00

abstract：:The conjugation junction of Tetrahymena is the specialized site where plasma membrane fusion occurs between two cells of complementary mating types. The junction is constructed through a series of cooperative interactions and morphogenetic steps. A contact-mediated interaction between free-swimming, sexually mature an...

journal_title：Journal of cell science

authors： Wolfe J

更新日期：1985-02-01 00:00:00

abstract：:The Sar1 GTPase controls coat assembly on coat protein complex II (COPII)-coated vesicles, which mediate protein transport from the endoplasmic reticulum (ER) to the Golgi. The GTP-bound form of Sar1, activated by the ER-localized guanine nucleotide exchange factor (GEF) Sec12, associates with the ER membrane. GTP hyd...

journal_title：Journal of cell science

authors： Kurokawa K,Suda Y,Nakano A

更新日期：2016-09-01 00:00:00

abstract：:The nonclaret disjunctional (ncd) protein is a kinesin-related microtubule motor protein that is encoded at the claret locus in Drosophila and is required for proper chromosome distribution in meiosis and early mitosis. The protein contains a region with 41% amino acid sequence identity to kinesin heavy chain, but tra...

journal_title：Journal of cell science

authors： Chandra R,Endow SA,Salmon ED

更新日期：1993-03-01 00:00:00

abstract：:NADH:ubiquinone oxidoreductases catalyse the first step within the diverse pathways of mitochondrial NADH oxidation. In addition to the energy-conserving form commonly called complex I, fungi and plants contain much simpler alternative NADH:ubiquinone oxido-reductases that catalyze the same reaction but do not translo...

journal_title：Journal of cell science

authors： Kerscher SJ,Okun JG,Brandt U

更新日期：1999-07-01 00:00:00

abstract：:In many cells, the endoplasmic reticulum (ER) contains segregated smooth and rough domains, but the mechanism of this segregation is unclear. Here, we used a HeLa cell line, inducibly expressing a GFP fusion protein [GFP-b(5)tail] anchored to the ER membrane, as a tool to investigate factors influencing ER organisatio...

journal_title：Journal of cell science

authors： Sprocati T,Ronchi P,Raimondi A,Francolini M,Borgese N

更新日期：2006-08-01 00:00:00

abstract：:Diversity of cell lineages within glandular organs is generated postnatally by differentiation of committed progenitor cells. Fundamental regulatory aspects of this process are not understood. The mouse submandibular salivary gland (SSG) served as model to assess the role of epidermal growth factor (EGF) receptor sign...

journal_title：Journal of cell science

authors： Durban EM,Nagpala PG,Barreto PD,Durban E

更新日期：1995-06-01 00:00:00

abstract：:Ran is an abundant GTPase of the Ras superfamily that is highly conserved in eukaryotes. In interphase cells, Ran is mainly nuclear and thought to be predominantly GTP-bound, but it is also present in the cytoplasm, probably GDP-bound. This asymmetric distribution plays an important role in directing nucleocytoplasmic...

journal_title：Journal of cell science

authors： Zhang C,Hughes M,Clarke PR

更新日期：1999-07-01 00:00:00

abstract：:Primary cilia are conserved organelles that play crucial roles as mechano- and chemosensors, as well as transducing signaling cascades. Consequently, ciliary dysfunction results in a broad range of phenotypes: the ciliopathies. Bardet-Biedl syndrome (BBS), a model ciliopathy, is caused by mutations in 16 known genes. ...

journal_title：Journal of cell science

authors： Gascue C,Tan PL,Cardenas-Rodriguez M,Libisch G,Fernandez-Calero T,Liu YP,Astrada S,Robello C,Naya H,Katsanis N,Badano JL

更新日期：2012-01-15 00:00:00

abstract：:Lysosomal cysteine proteases from mammalian cells and plants are regulated by endogenous tight-binding inhibitors from the cystatin superfamily. The presence of cystatin-like inhibitors in lower eukaryotes such as protozoan parasites has not yet been demonstrated, although these cells express large quantities of cyste...

journal_title：Journal of cell science

authors： Monteiro AC,Abrahamson M,Lima AP,Vannier-Santos MA,Scharfstein J

更新日期：2001-11-01 00:00:00

abstract：:The regulation of mitochondrial dynamics by the GTPase OPA1, which is located at the inner mitochondrial membrane, is crucial for adapting mitochondrial function and preserving cellular health. OPA1 governs the delicate balance between fusion and fission in the dynamic mitochondrial network. A disturbance of this bala...

journal_title：Journal of cell science

authors： MacVicar T,Langer T

更新日期：2016-06-15 00:00:00

abstract：:The microtubule-associated protein tau is a developmentally regulated family of neuronal phosphoproteins that promotes the assembly and stabilization of microtubules. The carboxy-terminal half of the protein contains three copies of an imperfectly repeated sequence; this region has been found to bind microtubules in v...

journal_title：Journal of cell science

authors： Lee G,Rook SL

更新日期：1992-06-01 00:00:00

abstract：:The existence of two forms of the chromosome passenger complex (CPC) in the mammalian oocyte has meant that its role in female meiosis has remained unclear. Here we use loss- and gain-of function approaches to assess the meiotic functions of one of the shared components of these complexes, INCENP, and of the variable ...

journal_title：Journal of cell science

authors： Sharif B,Na J,Lykke-Hartmann K,McLaughlin SH,Laue E,Glover DM,Zernicka-Goetz M

更新日期：2010-12-15 00:00:00

abstract：:Alix is a cytosolic protein in mammalian cells that was originally identified on the basis of its association with pro-apoptotic signaling. More recent evidence has established that Alix has a hand in regulating other cellular mechanisms, including endocytic membrane trafficking and cell adhesion. Although Alix appear...

journal_title：Journal of cell science

authors： Odorizzi G

更新日期：2006-08-01 00:00:00

abstract：:Drosophila melanogaster Suppressor of Under-Replication (SuUR) gene encodes a protein that modulates replicative properties of heterochromatin in endocycles of polytene cells. The SuUR mutation abolishes underreplication of intercalary heterochromatin and results in partial underreplication of pericentric heterochroma...

journal_title：Journal of cell science

authors： Pindyurin AV,Moorman C,de Wit E,Belyakin SN,Belyaeva ES,Christophides GK,Kafatos FC,van Steensel B,Zhimulev IF

更新日期：2007-07-15 00:00:00

abstract：:BMP-dependent patterning in the Drosophila melanogaster wing imaginal disc serves as a paradigm to understand how morphogens specify cell fates. The observed profile of the transcriptional response to the graded signal of BMP relies upon two counter-active gradients of pMad and Brinker (Brk). This patterning model is ...

journal_title：Journal of cell science

authors： Ziv O,Finkelstein R,Suissa Y,Dinur T,Deshpande G,Gerlitz O

更新日期：2012-12-01 00:00:00