Abstract:
:Background: We previously reported that the adipokine chemerin, when added exogenously to the isolated rat mesenteric artery, amplified electrical field-stimulated (EFS) contraction. The Chemerin1 antagonist CCX832 alone inhibited EFS-induced contraction in tissues with but not without perivascular adipose tissue (PVAT). These data suggested indirectly that chemerin itself, presumably from the PVAT, facilitated EFS-induced contraction. We created the chemerin KO rat and now test the focused hypothesis that endogenous chemerin amplifies EFS-induced arterial contraction. Methods: The superior mesenteric artery +PVAT from global chemerin WT and KO female rats, with endothelium and sympathetic nerve intact, were mounted into isolated tissue baths for isometric and EFS-induced contraction. Results: CCX832 reduced EFS (2-20 Hz)-induced contraction in tissues from the WT but not KO rats. Consistent with this finding, the magnitude of EFS-induced contraction was lower in the tissues from the KO vs. WT rats, yet the maximum response to the adrenergic stimulus PE was not different among all tissues. Conclusion: These studies support that endogenous chemerin modifies sympathetic nerve-mediated contraction through Chemerin1, an important finding relative in understanding chemerin's role in control of blood pressure.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Flood ED,Watts SWdoi
10.3390/ijms21176392subject
Has Abstractpub_date
2020-09-02 00:00:00issue
17issn
1422-0067pii
ijms21176392journal_volume
21pub_type
杂志文章abstract::The imbalance between cell proliferation and apoptosis can lead to tumor progression, causing oncogenic transformation, abnormal cell proliferation and cell apoptosis suppression. Tea polysaccharide (TPS) is the major bioactive component in green tea, it has showed antioxidant, antitumor and anti-inflammatory bioactiv...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19020506
更新日期:2018-02-08 00:00:00
abstract::Doxorubicin (DOX) is an anthracycline drug with a wide spectrum of antineoplastic activities. However, it causes cardiac cytotoxicity, and this limits its clinical applications. MicroRNA-21 (miR-21) plays a vital role in regulating cell proliferation and apoptosis. While miR-21 is preferentially expressed in adult car...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms160714511
更新日期:2015-06-26 00:00:00
abstract::Hexavalent chromium (Cr(VI)) is a serious environmental pollutant and human toxicant. Mammalian cells are very sensitive to chromate as they lack efficient chromate detoxifying strategy, e.g., chromate-reducing genes that are widely present in prokaryotes. To test whether introduction of prokaryotic chromate-reducing ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms160611892
更新日期:2015-05-26 00:00:00
abstract::Parkinson's disease (PD) is a complex disorder underpinned by both environmental and genetic factors. The latter only began to be understood around two decades ago, but since then great inroads have rapidly been made into deconvoluting the genetic component of PD. In particular, recent large-scale projects such as gen...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21197332
更新日期:2020-10-04 00:00:00
abstract::Cyclin-dependent kinase 5 regulatory subunit 1 (CDK5R1) gene encodes for p35, the main activator of Cyclin-dependent kinase 5 (CDK5). The active p35/CDK5 complex is involved in numerous aspects of brain development and function, and its deregulation is closely associated to Alzheimer's disease (AD) onset and progressi...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19072022
更新日期:2018-07-11 00:00:00
abstract:BACKGROUND:The alkaloid 8-hydroxyquinoline (8HQ) is well-known for various biological activities, including antioxidant effects and especially for the formation of coordination complexes with various transition metals, such as iron, amongst others. Therefore, 8HQ was extensively explored as a promising antineurodegener...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19123917
更新日期:2018-12-07 00:00:00
abstract::A new approach for encoding DNA sequences as input for DNA sequence analysis is proposed using the error correction coding theory of communication engineering. The encoder was designed as a convolutional code model whose generator matrix is designed based on the degeneracy of codons, with a codon treated in the model ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms14048393
更新日期:2013-04-16 00:00:00
abstract::Sclerotinia sclerotiorum (Ss) is a devastating fungal pathogen that causes Sclerotinia stem rot in rapeseed (Brassica napus), and is also detrimental to mulberry and many other crops. A wild mulberry germplasm, Morus laevigata, showed high resistance to Ss, but the molecular basis for the resistance is largely unknown...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21218358
更新日期:2020-11-07 00:00:00
abstract::The olfactory system, composed of the olfactory organs and the olfactory bulb, allows organisms to interact with their environment and through the detection of odor signals. Olfaction mediates behaviors pivotal for survival, such as feeding, mating, social behavior, and danger assessment. The olfactory organs are dire...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20071639
更新日期:2019-04-02 00:00:00
abstract::Polyglutamine diseases, including Huntington's disease and a number of spinocerebellar ataxias, are caused by expanded CAG repeats that are located in translated sequences of individual, functionally-unrelated genes. Only mutant proteins containing polyglutamine expansions have long been thought to be pathogenic, but ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms160818741
更新日期:2015-08-11 00:00:00
abstract::Blood rheology is a key determinant of tissue perfusion at rest and during exercise. The present study investigated the effects of race distance on hematological, blood rheological, and red blood cell (RBC) senescence parameters. Eleven runners participated in the Martigny-Combes à Chamonix 40 km race (MCC, elevation ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21228531
更新日期:2020-11-12 00:00:00
abstract::While necroptosis has been shown to contribute to the pathogenesis of post-infarction heart failure (HF), the role of autophagy remains unclear. Likewise, linkage between these two cell death modalities has not been sufficiently investigated. HF was induced by 60-min left coronary occlusion in adult Wistar rats and he...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21207782
更新日期:2020-10-21 00:00:00
abstract::This study aimed to determine the effect of selected essential oil compounds (EOCs) on the antibacterial activity of β-lactam antibiotics (βLAs) against methicillin-resistant Staphylococcus aureus (MRSA) strains. The following parameters were studied: antibiotic susceptibility testing, detection of mecA gene and evalu...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21197106
更新日期:2020-09-26 00:00:00
abstract::Previously, we developed a novel microRNA (miRNA) delivery system based on bacteriophage MS2 virus-like particles (MS2 VLPs). In this current study, we used this system to transport miR-146a into human peripheral blood mononuclear cells (PBMCs), and demonstrated the inhibition of osteoclastogenesis in precursors. Two ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms16048337
更新日期:2015-04-14 00:00:00
abstract::Photodynamic therapy (PDT) of the thoracic cavity can be performed in conjunction with surgery to treat cancers of the lung and its pleura. However, illumination of the cavity results in tissue exposure to a broad range of fluence rates. In a murine model of intrathoracic PDT, we studied the efficacy of 2-(1-hexyloxye...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17010101
更新日期:2016-01-14 00:00:00
abstract::In the first trimester of pregnancy, placental development involves a wide range of cellular processes. These include trophoblast proliferation, fusion, and differentiation, which are dependent on tight cell cycle control. The intrauterine environment affects placental development, which also includes the trophoblast ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21020468
更新日期:2020-01-11 00:00:00
abstract::Microglia are first-line defense antigen-presenting phagocytes in the central nervous system. Activated microglial cells release pro-inflammatory cytokines and can trigger an oxidative burst. The amino acid glycine exerts anti-inflammatory, immunomodulatory and cytoprotective effects and influences cell volume regulat...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21030804
更新日期:2020-01-26 00:00:00
abstract::Cisplatin is the first-line treatment for different types of solid tumors, such as ovarian, testicular, bladder, cervical, head and neck, lung, and esophageal cancers. The main problem related to its clinical use is the onset of drug resistance. In the last decades, among the studied molecular mechanisms of cisplatin ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21030937
更新日期:2020-01-31 00:00:00
abstract::Sox2 and Oct4 are transcription factors with the characteristics of regulating self-renewal and differentiation of embryonic stem cell. The aim of this study was to detect the expression of Sox2 and Oct4 and analyze their clinical significance in human non-small-cell lung cancer (NSCLC). Expression of Sox2 and Oct4 we...
journal_title:International journal of molecular sciences
pub_type: 临床试验,杂志文章,多中心研究
doi:10.3390/ijms13067663
更新日期:2012-01-01 00:00:00
abstract::To investigate the potential for the utilization of cotton stalk, ammonia hydrothermal treatment was applied to fractionate the samples into aqueous ammonia-soluble and ammonia-insoluble portions. The ammonia-soluble portion was purified to yield lignin fractions. The lignin fractions obtained were characterized by we...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms131115209
更新日期:2012-11-16 00:00:00
abstract::The ankyrin repeat domain 1 (ANKRD1) protein is a cardiac-specific stress-response protein that is part of the muscle ankyrin repeat protein family. ANKRD1 is functionally pleiotropic, playing pivotal roles in transcriptional regulation, sarcomere assembly and mechano-sensing in the heart. Importantly, cardiac ANKRD1 ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18071362
更新日期:2017-06-26 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is among the severe neuro degenerative diseases that lack widely available effective treatments. As the disease progresses, patients lose the control of voluntary muscles. Although the neuronal degeneration is the cause of this disease, the failure mechanism is still unknown. In ord...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19051318
更新日期:2018-04-28 00:00:00
abstract::Scaffolds made of biodegradable biomaterials are widely used to guide bone regeneration. Commonly, in vitro assessment of scaffolds' osteogenesis potential has been performed predominantly in monoculture settings. Hence, this study evaluated the potential of an unstimulated, growth factor-free co-culture system compri...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20051068
更新日期:2019-03-01 00:00:00
abstract::Although not a disease itself, aging represents a risk factor for many aging-related illnesses, including cancer. Numerous causes underlie the increased incidence of malignancies in the elderly, for example, genomic instability and epigenetic alterations that occur at cellular level, which also involve the immune cell...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19123774
更新日期:2018-11-27 00:00:00
abstract::A total of 85 strains of lactic acid bacteria were isolated from corn silage in this study and analyzed in vitro for their cholesterol removal, NPC1L1 protein down-regulation and bile salt deconjugation ability, respectively. Nineteen strains were selected for further analysis for their probiotic potential. Finally, 3...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20092073
更新日期:2019-04-26 00:00:00
abstract::Quorum sensing is an intercellular form of communication that bacteria use to coordinate group behaviors such as biofilm formation and the production of antibiotics and virulence factors. The term quorum sensing was originally coined to describe the mechanism underlying the onset of luminescence production in cultures...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms140816386
更新日期:2013-08-07 00:00:00
abstract::To decrease the cost of bioethanol production, biomass recalcitrance needs to be overcome so that the conversion of biomass to bioethanol becomes more efficient. CO(2) laser irradiation can disrupt the lignocellulosic physical structure and reduce the average size of fiber. Analyses with Fourier transform infrared spe...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms13044141
更新日期:2012-01-01 00:00:00
abstract::Melatonin exerts its actions through membrane MT1/MT2 melatonin receptors, which belong to the super family of G-protein-coupled receptors consisting of the typical seven transmembrane domains. MT1 and MT2 receptors are expressed in various tissues of the body either as single ones or together. A growing literature su...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms140612458
更新日期:2013-06-13 00:00:00
abstract::Ataxia is a common clinical feature in inherited metabolic disorders. There are more than 150 inherited metabolic disorders in patients presenting with ataxia in addition to global developmental delay, encephalopathy episodes, a history of developmental regression, coarse facial features, seizures, and other types of ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21155519
更新日期:2020-08-01 00:00:00
abstract::The insulin signaling (IIS) pathway plays an important role in the metabolism, growth, development, reproduction, and longevity of an organism. As a key member of the IIS pathway, insulin-like growth factor binding proteins (IGFBPs) are widely distributed a family in invertebrates and vertebrates that are critical in ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22031056
更新日期:2021-01-21 00:00:00