Abstract:
:Amyotrophic lateral sclerosis (ALS) is among the severe neuro degenerative diseases that lack widely available effective treatments. As the disease progresses, patients lose the control of voluntary muscles. Although the neuronal degeneration is the cause of this disease, the failure mechanism is still unknown. In order to seek genetic mechanisms that initiate and progress ALS, the association of microRNA (miRNA) expression with this disease was considered. Serum miRNAs from healthy controls, sporadic ALS (sALS), familial ALS (fALS) and ALS mutation carriers were investigated. Principal component analysis (PCA)-based unsupervised feature extraction (FE) was applied to these serum miRNA profiles. As a result, we predict miRNAs that can discriminate patients from healthy controls with high accuracy. Thus, these miRNAs can be potential prognosis miRNA biomarkers for ALS.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Taguchi YH,Wang Hdoi
10.3390/ijms19051318subject
Has Abstractpub_date
2018-04-28 00:00:00issue
5issn
1422-0067pii
ijms19051318journal_volume
19pub_type
杂志文章abstract::Oral mucositis is the most frequently occurring early side effect of head-and-neck cancer radiotherapy. Systemic dermatan sulfate (DS) treatment revealed a significant radioprotective potential in a preclinical model of oral mucositis. This study was initiated to elucidate the mechanistic effects of DS in the same mod...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19061684
更新日期:2018-06-06 00:00:00
abstract::There is a complex collection of neuroendocrine function during the postpartum period. Prolactin (PRL) released by suckling stimulus and its PRL receptors (PRL-R) in the central nervous system (CNS) are involved in hyporesponsiveness of the hypothalamic-pituitary-adrenal (HPA) axis in lactating mammals including roden...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18071370
更新日期:2017-06-27 00:00:00
abstract::Cannabidiol (CBD) is known for its vasorelaxant (including in the human pulmonary artery), anti-proliferative and anti-inflammatory properties. The aim of our study was to examine the potential preventive effect of chronic CBD administration (10 mg/kg/day for three weeks) on monocrotaline (MCT)-induced pulmonary hyper...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21197077
更新日期:2020-09-25 00:00:00
abstract::MicroRNAs (miRNAs) act as negative regulators of gene expression in the cytoplasm. Previous studies have identified the presence of miRNAs in the nucleus. Here we study human breast cancer-derived cell-lines (MCF-7 and MDA-MB-231) and a non-tumorigenic cell-line (MCF-10A) and compare their miRNA sequences at the splic...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21218132
更新日期:2020-10-30 00:00:00
abstract::Platelet-released growth factor (PRGF) is a thrombocyte concentrate lysate which, like its clinically equivalent variations (e.g., Vivostat PRF® (platelet-rich fibrin)), is known to support the healing of chronic and hard-to-heal wounds. However, studies on the effect of PRGF on keratinocytes remain scarce. This study...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21124404
更新日期:2020-06-20 00:00:00
abstract::Postmenopausal females display a chronic inflammatory phenotype with higher levels of circulating pro-inflammatory cytokines. Furthermore, the inflammatory response to injury may be altered under estrogen-deficiency, because it was shown previously that estrogen-deficient mice displayed increased levels of the inflamm...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19072070
更新日期:2018-07-16 00:00:00
abstract::Trihelix transcription factors are thought to feature a typical DNA-binding trihelix (helix-loop-helix-loop-helix) domain that binds specifically to the GT motif, a light-responsive DNA element. Members of the trihelix family are known to function in a number of processes in plants. Here, we characterize 20 trihelix f...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17020198
更新日期:2016-02-02 00:00:00
abstract::Mitochondria are involved either directly or indirectly in oncogenesis and the alteration of metabolism in cancer cells. Cancer cells contain large numbers of abnormal mitochondria and produce large amounts of reactive oxygen species (ROS). Oxidative stress is caused by an imbalance between the production of ROS and t...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms12107163
更新日期:2011-01-01 00:00:00
abstract::Peanut samples were irradiated (0.0, 5.2, 7.2 or 10.0 kGy), stored for a year (room temperature) and examined every three months. Mycotoxic fungi (MF) were detected in non-irradiated blanched peanuts. A dose of 5.2 kGy was found suitable to prevent MF growth in blanched samples. No MF was detected in in-shell peanuts,...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms130910935
更新日期:2012-01-01 00:00:00
abstract::Androgens have been known to inhibit cutaneous wound healing in men and male mice. However, in children with major burn injuries, a synthetic androgen was reported clinically to improve wound healing. The aim of this study is to investigate the role of dihydrotestosterone (DHT) as a new therapeutic approach in treatin...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21176231
更新日期:2020-08-28 00:00:00
abstract::The transmembrane protein cytochrome c oxidase (CcO) is the terminal oxidase in the respiratory chain of many aerobic organisms and catalyzes the reduction of dioxygen to water. This process maintains an electrochemical proton gradient across the membrane hosting the oxidase. CcO is a well-established model enzyme in ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21196981
更新日期:2020-09-23 00:00:00
abstract::The proteasome is a validated target of cancer therapeutics. Inhibition of proteasome activity results in the activation of the unfolded protein response (UPR) characterized by phosphorylation of eukaryotic initiation factor 2α (eIF2α), global translational arrest, and increased expression of the proapoptotic CHOP (C/...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21134757
更新日期:2020-07-04 00:00:00
abstract::Research on the protein folding problem differentiates the protein folding process with respect to the duration of this process. The current structure encoded in sequence dogma seems to be clearly justified, especially in the case of proteins referred to as fast-folding, ultra-fast-folding or downhill. In the present ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21207632
更新日期:2020-10-15 00:00:00
abstract:BACKGROUND:Patients with breast cancer-the deadliest cancer among women-are at constant risk of developing metastasis. Oxidative stress and hypoxia are common feature of tumor cells that can proliferate even in a resultant metabolic acidosis. Despite the low extracellular pH, intracellular pH of tumor cells remains rel...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18040170
更新日期:2017-03-23 00:00:00
abstract::Lung cancer is the most common cancer worldwide. Disappointingly, despite great effort in encouraging screening or, at least, a close surveillance of high-risk individuals, most of lung cancers are diagnosed when already surgically unresectable because of local advancement or metastasis. In these cases, the treatment ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18071374
更新日期:2017-06-27 00:00:00
abstract::Chronic liver disease is generally widespread, and a test for screening fibrotic subjects in a large population is needed. The ability of Wisteria floribunda agglutinin-positive mac-2 binding protein (WFA+-M2BP) to detect significant fibrosis was investigated in health checkup subjects in this research. Of 2021 health...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22010040
更新日期:2020-12-22 00:00:00
abstract::The mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in regulating cell growth, proliferation, and life span. mTOR signaling is a central regulator of autophagy by modulating multiple aspects of the autophagy process, such as initiation, process, and termination through controlling the acti...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20030728
更新日期:2019-02-08 00:00:00
abstract::A new anticancer ligustrazine derivative, 3β-hydroxyolea-12-en-28-oic acid- 3,5,6-trimethylpyrazin-2-methylester (T-OA, C38H58O3N2), was previously reported. It was synthesized via conjugating hepatoprotective and anticancer ingredients of traditional Chinese medicine. We found that T-OA exerted its anticancer activit...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms160716401
更新日期:2015-07-17 00:00:00
abstract::Increasing evidence suggests that the gut microbiota plays vital roles in metabolic diseases. Polygonatum odoratum extract alleviates hyperglycemia and hyperlipidemia, but the underlying mechanism remains unclear. This study investigated the effects of P. odoratum polysaccharides (POPs) on high-fat diet (HFD)-induced ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19113587
更新日期:2018-11-13 00:00:00
abstract::Syntenin is an adaptor-like molecule that has two adjacent tandem postsynaptic density protein 95/Discs large protein/Zonula occludens 1 (PDZ) domains. The PDZ domains of syntenin recognize multiple peptide motifs with low to moderate affinity. Many reports have indicated interactions between syntenin and a plethora o...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20174171
更新日期:2019-08-26 00:00:00
abstract::Glioblastoma multiforme (GBM) is the most common type of primary and malignant tumor occurring in the adult central nervous system. GBM often invades surrounding regions of the brain during its early stages, making successful treatment difficult. Osthole, an active constituent isolated from the dried C. monnieri fruit...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms15033889
更新日期:2014-03-04 00:00:00
abstract::Dietary NaCl depletion increases Na+ and Cl- absorption in the colon, but the mechanisms are not fully understood. So far, we reported that the expression of claudin-7 (CLDN7), a tight junction (TJ) protein, was upregulated in the mice fed with NaCl-depleted diets, but the regulatory mechanism has not been clarified. ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21041442
更新日期:2020-02-20 00:00:00
abstract::In the present study, we evaluated tumor-infiltrating lymphocytes (TILs) and blood regulatory T lymphocyte (Tregs, CD4+/CD25+/FoxP3+) expression in bladder cancer patients. The number of CD4+, CD8+, CD25+, FoxP3+ and CD20+ TILs was analyzed in association with clinico-pathomorphological features. In more advanced meta...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17030285
更新日期:2016-02-25 00:00:00
abstract:PURPOSE:to evaluate the role of whole brain radiotherapy (WBRT) and radiation boost (RB) for 208 patients recursive partitioning analysis (RPA) II with 1 or 2 brain metastases (BM) at a single institution. METHODS AND MATERIALS:the dose of WBRT was 30 Gy (10 fractions of 3 Gy). One hundred thirty-two patients (63.5%) ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms15057554
更新日期:2014-05-02 00:00:00
abstract::Deubiquitinases (DUBs) play a critical role in ubiquitin-directed signaling by catalytically removing the ubiquitin from substrate proteins. Ubiquitin-specific protease 15 (USP15), a member of the largest subfamily of cysteine protease DUBs, contains two conservative cysteine (Cys) and histidine (His) boxes. USP15 har...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18030483
更新日期:2017-02-24 00:00:00
abstract::The p38α mitogen-activated protein kinase (MAPK) has become an attractive target for the treatment of many diseases such as rheumatoid arthritis, inflammatory bowel disease and Crohn's disease. In this paper, 3D-QSAR and molecular docking studies were performed on 59 p38α MAPK inhibitors. Comparative molecular field a...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms11093357
更新日期:2010-09-17 00:00:00
abstract::Many nutrients are absorbed via Na+ cotransport systems, and therefore it is predicted that nutrient absorption mechanisms require a large amount of luminal Na+. It is thought that Na+ diffuses back into the lumen via paracellular pathways to support Na+ cotransport absorption. However, direct experimental evidence in...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21020376
更新日期:2020-01-07 00:00:00
abstract::Reduced forms of ascorbate (AsA) and glutathione (GSH) are among the most important non-enzymatic foliar antioxidants in maize (Zea mays L.). The survey was aimed to evaluate impact of bird cherry-oat aphid (Rhopalosiphum padi L.) or grain aphid (Sitobion avenae F.) herbivory on expression of genes related to ascorbat...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17030268
更新日期:2016-02-23 00:00:00
abstract::Since myeloproliferative neoplasms (MPN) pose a significant risk for vascular and thrombotic complications, cytoreductive therapies, such as hydroxyurea (HU), interferon (IFN) inhibitors, and Janus kinase (JAK) inhibitors are recommended for patients at high risk. However, these agents also place patients at increased...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21113900
更新日期:2020-05-30 00:00:00
abstract::An affinity-viscometry-based micro-sensor probe for continuous glucose monitoring was investigated with respect to its suitability for bioprocesses. The sensor operates with glucose and dextran competing as binding partner for concanavalin A, while the viscosity of the assay scales with glucose concentration. Changes ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18061235
更新日期:2017-06-08 00:00:00