Abstract:
BACKGROUND:Little is known about the change in prevalence of comorbidities during the disease course of people with multiple sclerosis (MS) and whether the prevalences vary by MS onset type. OBJECTIVE:To calculate the change in prevalence of comorbidities between symptom onset and the time of study, to compare the prevalences of comorbidities with those in the Australian population at the time of study and to examine onset-type differences. METHODS:Comorbidity data from 1518 participants of the Australian MS Longitudinal Study and Australian population comparator data (2014-2015 National Health Survey) were used. The change in prevalence between time points and prevalence ratios (PR) at the time of study (crude, age and sex adjusted, and stratified by onset type) was calculated. RESULTS:Comorbidities were common, and those with the largest increases in prevalence between MS symptom onset and the time of study were depression (+ 26.9%), anxiety (+ 23.1%), hypertension (+ 21.9%), elevated cholesterol (+ 16.3%), osteoarthritis (+ 17.1%), eye diseases (+ 11.6%), osteoporosis (+ 10.9%) and cancer (+ 10.3%). Compared to the general population and after age and sex adjustment, participants had a significantly higher prevalence for 14/19 comorbidities at the time of study. The associations were strongest for anaemia, cancer (both PR > 4.00), anxiety, depression, migraine (all PR > 3.00), psoriasis and epilepsy (both PR > 2.00). No significant differences were seen by onset type. CONCLUSION:Comorbidities are common at MS symptom onset and increase with MS duration. Having MS may thus contribute to accrual of comorbidities. This emphasises the importance of optimal screening for and management of comorbidities in early MS and throughout the disease course.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Lo LMP,Taylor BV,Winzenberg T,Palmer AJ,Blizzard L,van der Mei Idoi
10.1007/s00415-020-10194-xsubject
Has Abstractpub_date
2020-09-03 00:00:00eissn
0340-5354issn
1432-1459pii
10.1007/s00415-020-10194-xpub_type
杂志文章abstract::We investigated the muscle strength and motor unit (MU) territory of five patients with postpolio syndrome (PPS), six stable patients with prior poliomyelitis, and five healthy volunteers. The MU territory was assessed by measuring amplitudes of motor unit potentials (MUPs) recorded by the macro EMG technique. The inv...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00920572
更新日期:1994-12-01 00:00:00
abstract::Small fibre neuropathy (SFN) has been demonstrated in sarcoidosis. However, a systematic analysis of neuropathic pain and autonomic symptoms, key features of SFN, has not been performed. Clinimetric evaluation of pain and autonomic symptoms using the neuropathic pain scale (NPS) and the modified Composite Autonomic Sy...
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abstract::Clinical diagnosis of amyotrophic lateral sclerosis (ALS) in patients presenting with cramps and fasciculations may not be evident at the first consultation. Sequential reviews, clinical and neurophysiological, form an important part of clinical practice in such cases. Recent attempts to delineate a more benign group ...
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更新日期:2011-04-01 00:00:00
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doi:10.1007/s00415-016-8156-6
更新日期:2016-08-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章,评审
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更新日期:2006-12-01 00:00:00
abstract:OBJECTIVE:To investigate the efficacy of acupuncture on stroke recovery compared to an inert placebo. DESIGN:Placebo-controlled, randomised, clinical trial. SETTING:Post-stroke rehabilitation wards in five NHS hospitals in the UK. SUBJECTS:Patients between 4 and 10 days after their first stroke. INTERVENTIONS AND O...
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2008-06-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00313744
更新日期:1981-01-01 00:00:00
abstract::Levamisole seems to regulate cell-mediated immunity by restoring T-cell function. Since a deficiency of T lymphocytes has been described by various authors in multiple sclerosis patients. Of the 85 patients involved in the trial, evaluation of functional and neurological scores was possible in 54 (32 with placebo and ...
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pub_type: 临床试验,杂志文章
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
doi:10.1007/s00415-005-0963-0
更新日期:2006-02-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00314132
更新日期:1987-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00415-011-6140-8
更新日期:2012-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00415-007-0590-z
更新日期:2007-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s004150050558
更新日期:2000-03-01 00:00:00
abstract::Three patients with postural and intention cerebellar tremor caused by a cerebellar infarction in the superior cerebellar artery distribution were studied; treatment with carbamazepine resulted in marked improvement. ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00328507
更新日期:1989-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF00314752
更新日期:1990-08-01 00:00:00
abstract:BACKGROUND:Gastrointestinal (GI) dysfunction is prevalent in Parkinson's disease (PD). Symptoms are evident throughout the disease course, affect the length of the GI tract and impact on patient quality of life and management. We clarify real-life differences in the frequency and severity of GI symptoms in a cohort of ...
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pub_type: 杂志文章
doi:10.1007/s00415-020-09723-5
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:1975-01-01 00:00:00