Abstract:
:Telomeres play an important role in maintaining chromosomal integrity. With each cell division, telomeres are shortened and leukocyte telomere length (LTL) has therefore been considered a marker for biological age. LTL is associated with various lifetime stressors and health-related outcomes. Transgenerational effects have been implicated in newborns, with maternal stress, depression, and anxiety predicting shorter telomere length at birth, possibly reflecting the intrauterine growth environment. Previous studies, with relatively small sample sizes, have reported an effect of maternal stress, BMI, and depression during pregnancy on the LTL of newborns. Here, we attempted to replicate previous findings on prenatal stress and newborn LTL in a sample of 1405 infants using a qPCR-based method. In addition, previous research has been expanded by studying the relationship between maternal sleep quality and LTL. Maternal prenatal stress, anxiety, depression, BMI, and self-reported sleep quality were evaluated with self-reported questionnaires. Despite sufficient power to detect similar or even considerably smaller effects than those previously reported in the literature, we were unable to replicate the previous correlation between maternal stress, anxiety, depression, or sleep with LTL. We discuss several possible reasons for the discrepancies between our findings and those previously described.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ämmälä AJ,Vitikainen EIK,Hovatta I,Paavonen J,Saarenpää-Heikkilä O,Kylliäinen A,Pölkki P,Porkka-Heiskanen T,Paunio Tdoi
10.1038/s41598-020-71000-2subject
Has Abstractpub_date
2020-08-19 00:00:00pages
13986issue
1issn
2045-2322pii
10.1038/s41598-020-71000-2journal_volume
10pub_type
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