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Interleukin 35 Regulatory B Cells.

Abstract：

:B lymphocytes play a central role in host immunity. They orchestrate humoral immune responses that modulate activities of other immune cells and produce neutralizing antibodies that confer lasting immunity to infectious diseases including smallpox, measles and poliomyelitis. In addition to these traditional functions is the recent recognition that B cells also play critical role in maintaining peripheral tolerance and suppressing the development or severity of autoimmune diseases. Their immune suppressive function is attributed to relatively rare populations of regulatory B cells (Bregs) that produce anti-inflammatory cytokines including interleukin 10 (IL-10), IL-35 and transforming growth factor-β. The IL-35-producing B cell (i35-Breg) is the newest Breg subset described. i35-Bregs suppress central nervous system autoimmune diseases by inducing infectious tolerance whereby conventional B cells acquire regulatory functions that suppress pathogenic Th17 responses. In this review, we discuss immunobiology of i35-Breg cell, i35-Breg therapies for autoimmune diseases and potential therapeutic strategies for depleting i35-Bregs that suppress immune responses against pathogens and tumor cells.

journal_name

J Mol Biol

journal_title

Journal of molecular biology

authors

Choi JK,Egwuagu CE

doi

10.1016/j.jmb.2020.07.019

subject

Has Abstract

pub_date

2021-01-08 00:00:00

pages

166607

issue

1

eissn

0022-2836

issn

1089-8638

pii

S0022-2836(20)30474-5

journal_volume

433

pub_type

杂志文章,评审

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