Abstract:
:Athletes, clinicians, and practitioners are increasingly interested in the proposed performance and therapeutic benefits of nutritional ketosis (NK). NK is best operationally defined as a nutritionally induced metabolic state resulting in blood β-hydroxybutyrate concentrations of ≥0.5 mM. Most tissues readily metabolize ketone bodies (KBs), and KBs in turn regulate metabolism and signaling in both a systemic and tissue-specific manner. During fasting, starvation, or ketogenic diets, endogenous synthesis of KBs is amplified resulting in a state of NK. Orally administered exogenous ketone supplements rapidly elevate circulating KBs and produce a similar, but far from identical, metabolic state. NK results in a number of convergent features regardless of endogenous or exogenous induction; however, important differences also are observed. The implications of NK across health, disease, and performance is rapidly becoming more evident, thus acknowledging the convergent and divergent features of NK is critical for fully understanding the potential utility of this metabolic state.
journal_name
Curr Sports Med Repjournal_title
Current sports medicine reportsauthors
Poff AM,Koutnik AP,Egan Bdoi
10.1249/JSR.0000000000000732subject
Has Abstractpub_date
2020-07-01 00:00:00pages
251-259issue
7eissn
1537-890Xissn
1537-8918pii
00149619-202007000-00004journal_volume
19pub_type
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