Abstract:
:Temporal patterning of neural progenitors leads to the sequential production of diverse neurons. To understand how extrinsic cues influence intrinsic temporal programs, we studied Drosophila mushroom body progenitors (neuroblasts) that sequentially produce only three neuronal types: γ, then α'β', followed by αβ. Opposing gradients of two RNA-binding proteins Imp and Syp comprise the intrinsic temporal program. Extrinsic activin signaling regulates the production of α'β' neurons but whether it affects the intrinsic temporal program was not known. We show that the activin ligand Myoglianin from glia regulates the temporal factor Imp in mushroom body neuroblasts. Neuroblasts missing the activin receptor Baboon have a delayed intrinsic program as Imp is higher than normal during the α'β' temporal window, causing the loss of α'β' neurons, a decrease in αβ neurons, and a likely increase in γ neurons, without affecting the overall number of neurons produced. Our results illustrate that an extrinsic cue modifies an intrinsic temporal program to increase neuronal diversity.
journal_name
Elifejournal_title
eLifeauthors
Rossi AM,Desplan Cdoi
10.7554/eLife.58880subject
Has Abstractpub_date
2020-07-06 00:00:00issn
2050-084Xpii
58880journal_volume
9pub_type
杂志文章相关文献
eLife文献大全abstract::Humans are motivated to seek information from their environment. How the brain motivates this behavior is unknown. One speculation is that the brain employs neuromodulatory systems implicated in primary reward-seeking, in particular dopamine, to instruct information-seeking. However, there has been no causal test for ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.59152
更新日期:2020-12-02 00:00:00
abstract::Though neurotransmitters are essential elements in neuronal signal transduction, techniques for in vivo analysis are still limited. Here, we describe an organic electrochemical transistor array (OECT-array) technique for monitoring catecholamine neurotransmitters (CA-NTs) in rat brains. The OECT-array is an active sen...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.50345
更新日期:2020-02-11 00:00:00
abstract::Over the past century, soybean oil (SBO) consumption in the United States increased dramatically. The main SBO fatty acid, linoleic acid (18:2), inhibits in vitro the growth of lactobacilli, beneficial members of the small intestinal microbiota. Human-associated lactobacilli have declined in prevalence in Western micr...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.32581
更新日期:2018-03-27 00:00:00
abstract::Homologous recombination (HR)-mediated repair of DNA double-strand break (DSB)s is restricted to the post-replicative phases of the cell cycle. Initiation of HR in the G1 phase blocks non-homologous end joining (NHEJ) impairing DSB repair. Completion of HR in G1 cells can lead to the loss-of-heterozygosity (LOH), whic...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.02445
更新日期:2014-04-30 00:00:00
abstract::Metabolic network rewiring is the rerouting of metabolism through the use of alternate enzymes to adjust pathway flux and accomplish specific anabolic or catabolic objectives. Here, we report the first characterization of two parallel pathways for the breakdown of the short chain fatty acid propionate in Caenorhabditi...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.17670
更新日期:2016-07-06 00:00:00
abstract::The brain has an impressive ability to withstand neural damage. Diseases that kill neurons can go unnoticed for years, and incomplete brain lesions or silencing of neurons often fail to produce any behavioral effect. How does the brain compensate for such damage, and what are the limits of this compensation? We propos...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.12454
更新日期:2016-12-09 00:00:00
abstract::The gut microbiota of patients recently diagnosed with rheumatoid arthritis is enriched in microbes belonging to the Prevotella genus. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.01608
更新日期:2013-11-05 00:00:00
abstract::The new open-access journal eLife has launched, making its first content available in PubMed Central. In addition to publishing science of the highest quality, the journal aims to improve both the peer-review process and the presentation of new research results. ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.00270
更新日期:2012-10-15 00:00:00
abstract::Learning more about the cells that enable parasitic worms called schistosomes to reproduce inside snails could lead to new treatments that prevent these parasites from being transmitted to humans. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.01115
更新日期:2013-07-30 00:00:00
abstract::TCF/LEF factors are ancient context-dependent enhancer-binding proteins that are activated by β-catenin following Wnt signaling. They control embryonic development and adult stem cell compartments, and their dysregulation often causes cancer. β-catenin-dependent transcription relies on the NPF motif of Pygo proteins. ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.09073
更新日期:2015-08-27 00:00:00
abstract::Ki-67 and RepoMan have key roles during mitotic exit. Previously, we showed that Ki-67 organizes the mitotic chromosome periphery and recruits protein phosphatase 1 (PP1) to chromatin at anaphase onset, in a similar manner as RepoMan (Booth et al., 2014). Here we show how Ki-67 and RepoMan form mitotic exit phosphatas...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.16539
更新日期:2016-08-30 00:00:00
abstract::To improve chemical cross-linking of proteins coupled with mass spectrometry (CXMS), we developed a lysine-targeted enrichable cross-linker containing a biotin tag for affinity purification, a chemical cleavage site to separate cross-linked peptides away from biotin after enrichment, and a spacer arm that can be label...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.12509
更新日期:2016-03-08 00:00:00
abstract::Stem cells are maintained in a specialized microenvironment called niche but the nature of stem cell niche remains poorly defined in many systems. Here we demonstrate that intestinal epithelium-derived BMP serves as a niche signal for intestinal stem cell (ISC) self-renewal in Drosophila adult midgut. We find that BMP...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.01857
更新日期:2014-03-11 00:00:00
abstract::Numerous brain regions have been shown to have neural correlates of gradually accumulating evidence for decision-making, but the causal roles of these regions in decisions driven by accumulation of evidence have yet to be determined. Here, in rats performing an auditory evidence accumulation task, we inactivated the f...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.05457
更新日期:2015-04-14 00:00:00
abstract::Vitamin B12 (cobalamin) is the most complex B-type vitamin and is synthetized exclusively in a limited number of prokaryotes. Its biologically active variants contain rare organometallic bonds, which are used by enzymes in a variety of central metabolic pathways such as L-methionine synthesis and ribonucleotide reduct...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.35828
更新日期:2018-05-29 00:00:00
abstract::Bacteria of the genus Shigella cause shigellosis, a severe gastrointestinal disease that is a major cause of diarrhea-associated mortality in humans. Mice are highly resistant to Shigella and the lack of a tractable physiological model of shigellosis has impeded our understanding of this important human disease. Here,...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.59022
更新日期:2020-10-19 00:00:00
abstract::During inflammation, serum amyloid A proteins transport retinol to infected tissues. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.04246
更新日期:2014-09-02 00:00:00
abstract::TMEM16A is a ligand-gated anion channel that is activated by intracellular Ca2+. This channel comprises two independent pores and closely apposed Ca2+ binding sites that are contained within each subunit of a homodimeric protein. Previously we characterized the influence of positively charged pore-lining residues on a...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.39122
更新日期:2018-10-12 00:00:00
abstract::The rhythm generating network for breathing must continuously adjust to changing metabolic and behavioral demands. Here, we examined network-based mechanisms in the mouse preBötzinger complex using substance P, a potent excitatory modulator of breathing frequency and stability, as a tool to dissect network properties ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.51350
更新日期:2019-12-05 00:00:00
abstract::The dynamic tyrosination-detyrosination cycle of α-tubulin regulates microtubule functions. Perturbation of this cycle impairs mitosis, neural physiology, and cardiomyocyte contraction. The carboxypeptidases vasohibins 1 and 2 (VASH1 and VASH2), in complex with the small vasohibin-binding protein (SVBP), mediate α-tub...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.58157
更新日期:2020-08-10 00:00:00
abstract::Cytoplasmic dyneins are motor proteins in the AAA+ superfamily that transport cellular cargos toward microtubule minus-ends. Recently, ciliobrevins were reported as selective cell-permeable inhibitors of cytoplasmic dyneins. As is often true for first-in-class inhibitors, the use of ciliobrevins has in part been limit...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.25174
更新日期:2017-05-19 00:00:00
abstract::Previously, we showed that serum and monocytes from patients with CF exhibit an enhanced NLRP3-inflammasome signature with increased IL-18, IL-1β, caspase-1 activity and ASC speck release (Scambler et al. eLife 2019). Here we show that CFTR modulators down regulate this exaggerated proinflammatory response following L...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.54556
更新日期:2020-03-02 00:00:00
abstract::Mutations in PROP1 are the most common cause of hypopituitarism in humans; therefore, unraveling its mechanism of action is highly relevant from a therapeutic perspective. Our current understanding of the role of PROP1 in the pituitary gland is limited to the repression and activation of the pituitary transcription fa...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.14470
更新日期:2016-06-28 00:00:00
abstract::To effectively interact with their environment, humans must often select actions from multiple incompatible options. Existing theories propose that during motoric response-conflict, inappropriate motor activity is actively (and perhaps non-selectively) suppressed by an inhibitory fronto-basal ganglia mechanism. We her...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.42959
更新日期:2019-05-07 00:00:00
abstract::Using a clever combination of genetic and biochemical tools researchers have shown that a transcription factor called USF1 has a central role in determining how mutations of the Clock gene manifest themselves in the behaviour of different mouse strains. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.00659
更新日期:2013-04-09 00:00:00
abstract::Animals and humans replay neural patterns encoding trajectories through their environment, both whilst they solve decision-making tasks and during rest. Both on-task and off-task replay are believed to contribute to flexible decision making, though how their relative contributions differ remains unclear. We investigat...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.56911
更新日期:2020-06-17 00:00:00
abstract::We previously showed in Drosophila melanogaster embryos that low-affinity Ultrabithorax (Ubx)-responsive shavenbaby (svb) enhancers drive expression using localized transcriptional environments and that active svb enhancers on different chromosomes tended to colocalize (Tsai et al., 2017). Here, we test the hypothesis...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.45325
更新日期:2019-07-11 00:00:00
abstract::Cranial neural crest (CNC) cells give rise to bone, cartilage, tendons, and ligaments of the vertebrate craniofacial musculoskeletal complex, as well as regulate mesoderm-derived craniofacial muscle development through cell-cell interactions. Using the mouse soft palate as a model, we performed an unbiased single-cell...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.62387
更新日期:2021-01-22 00:00:00
abstract::Ageing is characterised by cellular senescence, leading to imbalanced tissue maintenance, cell death and compromised organ function. This is first observed in the thymus, the primary lymphoid organ that generates and selects T cells. However, the molecular and cellular mechanisms underpinning these ageing processes re...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.56221
更新日期:2020-08-25 00:00:00
abstract::The restoration of homeostasis after tissue damage relies on proper spatial-temporal control of damage-induced apoptosis and compensatory proliferation. In Drosophila imaginal discs these processes are coordinated by the stress response pathway JNK. We demonstrate that JNK signaling induces a dose-dependent extension ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.41036
更新日期:2019-02-08 00:00:00