Diagnostic utility and therapeutic impact of PET/CT [18F]F-Fluoromethylcholine -Choline in the biochemical recurrence of prostate cancer.

Abstract:

OBJECTIVE:To assess the diagnostic capability of PET/CT with [18F]F-Fluoromethylcholine in prostate cancer (PC) with biochemical recurrence and its therapeutic impact. MATERIAL AND METHODS:We included 108 patients, diagnosed with PC with biochemical criteria for recurrence. A PET/CT Choline scan was performed by dynamic pelvic and whole body study at 60min post-tracer injection. The relationship between the positive studies and the PSA value was analysed by classifying patients into three groups (<1.2/1.2-2/>2ng/ml), and the diagnostic capacity was assessed with respect to pelvic MRI and the impact on the therapeutic decision. RESULTS:The location of recurrence was identified in 85 of 108 patients (78.7%): 34 local, 47 pelvic lymph nodes and 58 distant lesions, including retroperitoneal, mediastinal lymph nodes and distant organ lesions (bone and lung). Second tumors were diagnosed in 4 patients. No significant differences were found in the percentage of positive studies depending on primary treatment. Patients with PSA>2ng/ml showed a higher percentage of disease detection than patients with a lower PSA level, with significant differences (p<0.0001). PET/CT [18F]F-Choline was able to detect local disease, not previously known from MRI, in 29.41% of patients. PET/CT Choline had an impact on therapeutic management in 67 of 108 patients (62%). CONCLUSIONS:PET/CT with [18F]F-Fluoromethylcholine is a useful tool in the detection of locoregional and disseminated disease of PC treated with suspicion of recurrence, providing a change in therapeutic management in 62% of patients.

authors

Sánchez N,Valduvieco I,Ribal MJ,Campos F,Casas F,Nicolau C,Salvador R,Mellado B,Jorcano S,Fuster D,Paredes P

doi

10.1016/j.remn.2020.03.010

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

284-291

issue

5

eissn

2253-654X

issn

2253-8070

pii

S2253-654X(20)30056-1

journal_volume

39

pub_type

杂志文章
  • Incidental pathologic extracardiac uptake of (99m)Tc-tetrofosmin in myocardial perfusion imaging: Importance of patient background evaluation.

    abstract::(99m)Tc-tetrofosmin single photon emission computed tomography ((99m)Tc-tetrofosmin SPECT) has an important role in the assessment of coronary artery disease. Despite being its main indication, this study does not only evaluate myocardial perfusion, but much more. Moreover, during the SPECT acquisition, the field area...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2015.03.005

    authors: González García B,García Vicente AM,Palomar Muñoz A,Poblete García VM,Jiménez Londoño GA,Soriano Castrejón AM

    更新日期:2015-11-01 00:00:00

  • Development of a leakage monitoring system in isolated limb perfusion with portable gamma camera.

    abstract::Isolated limb perfusion (ILP) is a method for treating unresectable lesions of limbs in patients with melanoma or sarcoma by using high doses of tumor necrosis factor alpha and melphalan. These high doses can result in high systemic toxicity if there is a drug leak from the isolated circulation of the limb to the syst...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2020.06.018

    authors: Agudo Martínez A,Calvo Morón C,Cambil Molina T,García Gómez FJ,de la Riva Pérez PA,de la Cruz Merino L,Araji Tiliani O,Terrón León JA,Castro Montaño J

    更新日期:2021-01-01 00:00:00

  • [Implementation of a quality management system according to the UNE-UN-ISO 9001:2008 standard in a nuclear medicine department].

    abstract:OBJECTIVE:To describe the process of implementing a quality management system according to UNE-EN-ISO 9001:2008 standard in a Nuclear Medicine Department. MATERIAL AND METHOD:In February 2008, the committee on internal quality of the Department was established, naming a responsible physician. The general operating pla...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2012.01.004

    authors: Poblete García VM,Talavera Rubio MP,Palomar Muñoz A,Pilkington Woll JP,Cordero García JM,García Vicente AM,Bellón Guardia M,González García B,Cañuelo Merino T,Núñez García A,Peiró Valgañón V,Soriano Castrejón AM

    更新日期:2013-01-01 00:00:00

  • Dual time point 2-deoxy-2-[18F]fluoro-D-glucose PET/CT: nodal staging in locally advanced breast cancer.

    abstract:AIM:To assess dual time point 2-deoxy-2-[(18)F]fluoro-D-glucose (18)(F)FDG PET-CT accuracy in nodal staging and in detection of extra-axillary involvement. MATERIAL AND METHODS:Dual time point [(18)F] FDG PET/CT scan was performed in 75 patients. Visual and semiquantitative assessment of lymph nodes was performed. Sem...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/j.remn.2013.03.005

    authors: García Vicente AM,Soriano Castrejón A,Cruz Mora MÁ,Ortega Ruiperez C,Espinosa Aunión R,León Martín A,González Ageitos A,Van Gómez López O

    更新日期:2014-01-01 00:00:00

  • [Extension study and evaluation of the therapeutic response in a patient with metastatic lung adenocarcinoma using sequential study with ¹⁸F-FDG PET-CT and ¹⁸F-fluoride PET-CT].

    abstract::We report a case of a patient with lung adenocarcinoma and bone and extraosseus metastases studied with (18)F-FDG PET-CT, (99m)Tc-HMDP and (18)F-fluoride PET-CT. It assesses the usefulness of (18)F-FDG PET-CT for initial staging of the disease and monitoring response to therapy. For the study of the sclerotic bone met...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2014.02.004

    authors: Moragas M,Soler M,Riera E,García JR

    更新日期:2015-01-01 00:00:00

  • [Contribution of time of flight and point spread function modeling to the performance characteristics of the PET/CT Biograph mCT scanner].

    abstract:OBJECTIVE:To characterize the performance of the Biograph mCT PET/CT TrueV scanner with time of flight (TOF) and point spread function (PSF) modeling. MATERIAL AND METHODS:The PET/CT scanner combines a 64-slice CT and PET scanner that incorporates in the reconstruction the TOF and PSF information. PET operating charac...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2012.07.001

    authors: Martí-Climent JM,Prieto E,Domínguez-Prado I,García-Velloso MJ,Rodríguez-Fraile M,Arbizu J,Vigil C,Caicedo C,Peñuelas I,Richter JA

    更新日期:2013-01-01 00:00:00

  • Neurolymphomatosis as a late relapse of non-Hodgkin's lymphoma detected by 18F-FDG PET/CT: a case report.

    abstract::Neurolymphomatosis is a rare condition defined as an infiltration of nerves, nerve roots or nervous plexuses by haematological malignancy. Its diagnosis may sometimes be difficult with conventional imaging techniques. This paper aims to emphasize the importance of this entity and the role of (18)F-FDG PET/CT in this i...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2013.03.004

    authors: Kajáry K,Molnár Z,Mikó I,Barsi P,Lengyel Z,Szakáll S Jr

    更新日期:2014-01-01 00:00:00

  • [Findings of the (18)F-FDG PET-CT in a cardiac angiosarcoma complicated by a cardiac rupture].

    abstract::Primary malignant tumors of the heart are a rare condition. The most common type is the cardiac angiosarcoma. The symptoms of this disease are very nonspecific and can be very difficult to diagnose by conventional imaging techniques. We report the case of a male patient with cardiac angiosarcoma who also had a rare co...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2013.04.006

    authors: Santiago-Chinchilla A,Ruiz-Carazo E,Moral-Ruiz A,Testart Dardel N,Martínez-Martínez A,López-Fernández S

    更新日期:2014-07-01 00:00:00

  • [Elaboration of the SPM template for the standardization of SPECT images with 123I-Ioflupane].

    abstract:PURPOSE:Statistical parametric mapping (SPM) is a widely used produced for normalization of functional images. This study has aimed to develop a normalization template of (123)I-Ioflupane SPECT-imaging DaTSCAN(®), GE Healthcare), not available in SPM5, and to validate it compared to other quantification methods. MATER...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2013.02.009

    authors: García-Gómez FJ,García-Solís D,Luis-Simón FJ,Marín-Oyaga VA,Carrillo F,Mir P,Vázquez-Albertino RJ

    更新日期:2013-11-01 00:00:00

  • 99mTc-HMPAO brain SPECT in the monitoring of cerebral vasculitis therapy.

    abstract:OBJECTIVE:The central nervous system (CNS) may be involved in a variety of inflammatory diseases of the blood vessels, generally known as vasculitis. The clinical diagnosis of such involvement in early stages is difficult, since a mild cognitive impairment can be the only symptom. It was hypothesized that brain-perfusi...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2017.10.009

    authors: Frantellizzi V,Morreale M,Pontico M,Francia A,Drudi FM,Farcomeni A,Liberatore M

    更新日期:2018-01-01 00:00:00

  • Characterization and simulation of noise in PET images reconstructed with OSEM: Development of a method for the generation of synthetic images.

    abstract:INTRODUCTION:The goals of the study are to characterize imaging properties in 2D PET images reconstructed with the iterative algorithm ordered-subset expectation maximization (OSEM) and to propose a new method for the generation of synthetic images. MATERIAL AND METHODS:The noise is analyzed in terms of its magnitude,...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2017.10.007

    authors: Castro P,Huerga C,Chamorro P,Garayoa J,Roch M,Pérez L

    更新日期:2018-01-01 00:00:00

  • Study of factors that influence the outcome of 131I treatment in hyperthyroidism secondary to nodular goitre.

    abstract:OBJECTIVE:To assess the outcome after 131I treatment in patients with multinodular (MNG) and nodular toxic goitre (NTG) according to the administered dose and other factors related to the patient, pathology, or previous treatments. MATERIAL AND METHODS:A retrospective study was conducted on 108 patients (67 MNG and 41...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2017.03.010

    authors: Tabuenca-Dopico O,Boente-Varela R,Lamas-Ferreiro JL

    更新日期:2017-01-01 00:00:00

  • Value of the bone scintigraphy in multiple osteochrondromatosis with sarcomatous degeneration.

    abstract::Multiple osteochondromatosis can become malignant in 20% of the cases, this being more common when the lesion is multiple than when it is solitary. A male patient with multiple osteochondromatosis who had several local recurrences of secondary chondrosarcoma and who is still under follow-up by the Nuclear Medicine Dep...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2011.10.011

    authors: Sánchez-Rodríguez V,Medina-Romero F,Gómez Rodríguez-Bethencourt MÁ,González Díaz MA,González Soto MJ,Alarcó Hernández R

    更新日期:2012-09-01 00:00:00

  • [Detection of tumors in the central zone of the prostate with 11C-Choline PET/CT].

    abstract::Prostate tumors originate 68% in the peripheral region and 24% in the transitional region where tumors originating in the central zone are rare (8%). However, diagnosis of the tumors in the central zone is important since they exhibit greater aggressiveness conditioned by their location and different biological behavi...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2013.07.013

    authors: Garcia JR,Soler M,Moragas M,Ponce A,Moreno C,Riera E

    更新日期:2014-03-01 00:00:00

  • Uncommon isolated distant subcutaneous tissue and skeletal muscle metastasis from oesophageal cancer diagnosed by PET/CT (18)F-FDG.

    abstract::Distant soft-tissue metastases (subcutaneous tissues and skeletal muscle) are extremely rare, particularly in oesophageal carcinoma. The case is described of a patient who was treated for oesophageal adenocarcinoma 2.5 years previously. A PET/CT was performed showing metastatic spread due to a solitary focus of increa...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2015.07.005

    authors: Domínguez ML,Rayo JI,Serrano J,Infante JR,García L,Moreno M

    更新日期:2016-01-01 00:00:00

  • The role of brain perfusion SPECT in Moyamoya disease.

    abstract::Moyamoya disease (MMD) is a cerebrovascular disorder involving stenosis of brain vessels. Brain perfusion SPECT in MMD demonstrates impaired perfusion in ischemic areas. We present a 6-year-old boy with MMD. The patient had numbness on the right arm and simultaneous electroencephalography changes while studying arms u...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2012.02.006

    authors: Volkan-Salanci B,Lay Ergün E,Genc Sel Ç,Yalnizoğlu D,Turanli G

    更新日期:2012-07-01 00:00:00

  • Discordance between MRI and bone scan findings in a child with acute complicated osteomyelitis: scintigraphic features that contribute to the early diagnosis.

    abstract::Early diagnosis and prompt treatment of acute osteomyelitis are of paramount importance in children because they can prevent irreversible bone damage. Magnetic resonance imaging (MRI) with its superior spatial resolution and lack of ionizing radiation is routinely preferred over bone scan for this purpose. Increased b...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2013.06.004

    authors: Mpalaris V,Arsos G,Iakovou I,Dalpa E,Karatzas N

    更新日期:2014-03-01 00:00:00

  • Spontaneous intracranial hypotension syndrome: contribution of radioisotope cisternography.

    abstract::Spontaneous intracranial hypotension is a clinical syndrome caused by a loss of cerebrospinal fluid volume, usually secondary to leaking through structural defects of the spinal dura mater. Radioisotope cisternography (RC) can confirm the diagnosis of spontaneous intracranial hypotension, especially in doubtful or aty...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2016.05.005

    authors: Suárez JP,Domínguez ML,Gómez MA,Muñoz JL

    更新日期:2017-01-01 00:00:00

  • Radioguided hepatic resection with 18F-DOPA in a patient with metastatic medullary thyroid carcinoma.

    abstract:INTRODUCTION:Medullary carcinoma accounts for 1-2% of all thyroid malignancies. 13-20% of patients present with distant metastasis, with 45% of the cases affecting the liver. CLINICAL CASE:A 50-year-old woman, diagnosed with medullary thyroid carcinoma, was treated with total thyroidectomy and a modified neck dissecti...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2017.12.003

    authors: López-Gómez J,Medina-Ornelas S,Salazar-Álvarez MA,Álvarez-Bojórquez M,Zaragoza-Cruz N,Melchor-Ruan J,Álvarez-Cano A

    更新日期:2018-01-01 00:00:00

  • Platypnea-orthodeoxia syndrome: Importance of patient position for correct diagnosis at the time of (99m)Tc-MAA injection.

    abstract::A 65-year-old male presented with unexplained hypoxia that became exacerbated by an upright posture (platypnea-orthodeoxia syndrome) secondary to hepatopulmonary syndrome (HPS). A (99m)Tc-macroaggregated albumin pulmonary perfusion scan revealed a right to left shunt of 29% in the sitting position, which had not been ...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2014.12.009

    authors: Fierro Alanis MP,Bastón Rey I,Nieves-Maldonado S,Torre Carballada JA,Domínguez-Muñoz JE,Ruibal Morell Á

    更新日期:2015-07-01 00:00:00

  • 75Se-Homocholic acid taurine scintigraphy (75SeHCAT®), a standard benchmark test in bile acid malabsorption?

    abstract::Chronic diarrhoea due to bile acid malabsorption (BAM) is an underdiagnosed pathology. Different diagnostic tools are available. However, there is currently no consensus on which of these would be the benchmark test or gold standard. This review evaluates the possibility of using 75Se-taurocholic acid (75SeHCAT®) scin...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章,评审

    doi:10.1016/j.remn.2018.12.005

    authors: Baena García A,Partida Palma F,García Martínez S,de Bonilla Candau M,Pajares Vinardell M

    更新日期:2019-01-01 00:00:00

  • 18F-FDG PET/CT in lung cancer. The added value of quantification.

    abstract:OBJECTIVE:To test a software application for the quantification of metabolic heterogeneity and to evaluate its superiority in relation to visual interpretation. To investigate if a quantitative analysis adds information to the interpretation of 18F-FDG-PET/CT. MATERIAL AND METHODS:The study analyzed 215 patients with ...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2017.04.001

    authors: Lapa P,Marques M,Isidoro J,Barata F,Costa G,de Lima JP

    更新日期:2017-01-01 00:00:00

  • False positive in fluorodeoxyglucose-F18 positron emission tomography computed tomography scan of inferior vena cava leiomyoma in patient with a suspected paraganglioma.

    abstract::Leiomyomas are benign tumors derived from smooth muscle tissue that rarely present outside the uterus. These tumors do not usually show FDG uptake. We present the case of a patient with hypertension refractory to treatment and a lesion arising from inferior vena cava, that shows intense FDG uptake in PET/CT scan, sugg...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2019.06.006

    authors: González Jiménez AD,Rodríguez Fernández A,Sánchez Sánchez R,Jaén Águila F,Mediavilla García JD,Llamas Elvira JM

    更新日期:2020-01-01 00:00:00

  • Prognostic importance of 18F-fluorodeoxyglucose uptake by positron emission tomography for stage III non-small cell lung cancer treated with definitive chemoradiotherapy.

    abstract:OBJECTIVES:Survival heterogeneity exists among patients with non-small cell lung cancer (NSCLC), even within the same stage. We aimed to evaluate the prognostic role of pre-treatment maximum standardized uptake value (SUVmax) in patients treated with definitive concurrent chemoradiotherapy for stage III NSCLC. MATERIA...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2019.04.006

    authors: Kanyilmaz G,Benli Yavuz B,Aktan M,Sahin O

    更新日期:2020-01-01 00:00:00

  • Cardiac sympathetic innervation assessed with (123)I-MIBG retains prognostic utility in diabetic patients with severe left ventricular dysfunction evaluated for primary prevention implantable cardioverter-defibrillator.

    abstract:BACKGROUND:Scintigraphy with iodine-123-metaiodobenzylguanidine ((123)I-MIBG) is a non-invasive tool for the assessment of cardiac sympathetic innervation (CSI) that has proven to be an independent predictor of survival. Recent studies have shown that diabetic patients with heart failure (HF) have a higher deterioratio...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2015.08.002

    authors: García-González P,Fabregat-Andrés Ó,Cozar-Santiago P,Sánchez-Jurado R,Estornell-Erill J,Valle-Muñoz A,Quesada-Dorador A,Payá-Serrano R,Ferrer-Rebolleda J,Ridocci-Soriano F

    更新日期:2016-03-01 00:00:00

  • Value of post-therapy 177Lu-PSMA images for accurate interpretation of therapy response with 68Ga-PSMA PET/CT.

    abstract::A 54-year-old man with progressive prostate cancer underwent a 68Ga-PSMA PET/CT, which showed lymph node and bone metastases. After 2-cycles of 177Lu-PSMA therapy, the repeated 68Ga-PSMA PET/CT showed decreased radiotracer uptake in lymph node and bones metastases, but there were new lesions which may be compatible wi...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2017.05.004

    authors: Tuncel M,Telli T

    更新日期:2018-01-01 00:00:00

  • Hospital Radiopharmacy in Argentina during the COVID-19 pandemic. Criteria and rationale for the organization of work.

    abstract::This publication presents criteria and bases for the work organization in the safe practice of Hospital Radiopharmacy, in order to minimize the risk of viral transmission during the COVID-19 pandemic, in a reference facility of the National Energy Commission Atomic of Argentina, while continuing to perform essential s...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2020.08.015

    authors: Rabiller G,Cordoba N,Poch C,Paulo PS,Seijas M,Vazquez MF

    更新日期:2020-01-01 00:00:00

  • Uterine leiomyosarcoma metastatic to thyroid shown by 18F-FDG PET/CT imaging.

    abstract::About one third of focal thyroid uptakes in a fluorodeoxyglucose (FDG) positron emission tomography/computerized tomography (PET/CT) study are malignant, the most frequent histological type being papillary carcinoma. Metastases to the thyroid account for approximately 7.5% of thyroid malignancies and come mainly from ...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2016.09.002

    authors: Gauthé M,Testart Dardel N,Nascimento C,Trassard M,Banal A,Alberini JL

    更新日期:2017-01-01 00:00:00

  • Follow-up (99m)Tc EC renal dynamic scintigraphy and DMSA-III SPECT/CT in unmasking a masqueraded case of Horseshoe kidney.

    abstract::Hydronephrosis is a common finding in urinary tract outflow obstruction. Chronically obstructed hydronephrotic system may be associated with parenchymal changes. Ultrasound, intravenous urography, micturating cysto-urethrogram and scintigraphy are commonly performed to evaluate the cause of obstruction. In childhood, ...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2015.05.003

    authors: Jain TK,Basher RK,Mittal BR,Bhatia A,Rao KL

    更新日期:2015-11-01 00:00:00

  • Reproducibility of lymphoscintigraphy before and after excisional biopsy of primary breast lesions: a study using superficial peri-areolar injection of the radiotracer.

    abstract:OBJECTIVE:A major controversial issue in the sentinel node biopsy of the breast is the applicability of sentinel node mapping in patients with the history of previous excisional biopsy of the breast lesions. In the current study, we evaluated the reproducibility of lymphoscintigraphy before and after excisional biopsy ...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2012.07.004

    authors: Asadi M,Shobeiri H,Aliakbarian M,Jangjoo A,Dabbagh Kakhki VR,Sadeghi R,Keshtgar M

    更新日期:2013-05-01 00:00:00