Neurolymphomatosis as a late relapse of non-Hodgkin's lymphoma detected by 18F-FDG PET/CT: a case report.

Abstract:

:Neurolymphomatosis is a rare condition defined as an infiltration of nerves, nerve roots or nervous plexuses by haematological malignancy. Its diagnosis may sometimes be difficult with conventional imaging techniques. This paper aims to emphasize the importance of this entity and the role of (18)F-FDG PET/CT in this indication. We present the case of a 53-year-old male who complained of sharp pain in his right hip and right leg paresthesia after 2 years of complete remission from Non-Hodgkin's lymphoma. Physical examination and CT scan were negative and the lumbar MRI showed protrusion of L5-S1 disc. Physiotherapy, nonsteroid antiinflammatory drugs and steroids were inefficient. PET/CT was performed four months after the onset of the symptoms, revealing focal FDG uptake in the right S1 nerve root and linear FDG uptake along the right sacral plexus suggesting relapse. This was confirmed by histology.

authors

Kajáry K,Molnár Z,Mikó I,Barsi P,Lengyel Z,Szakáll S Jr

doi

10.1016/j.remn.2013.03.004

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

39-42

issue

1

eissn

2253-654X

issn

2253-8070

pii

S2253-654X(13)00043-7

journal_volume

33

pub_type

杂志文章
  • 75Se-Homocholic acid taurine scintigraphy (75SeHCAT®), a standard benchmark test in bile acid malabsorption?

    abstract::Chronic diarrhoea due to bile acid malabsorption (BAM) is an underdiagnosed pathology. Different diagnostic tools are available. However, there is currently no consensus on which of these would be the benchmark test or gold standard. This review evaluates the possibility of using 75Se-taurocholic acid (75SeHCAT®) scin...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章,评审

    doi:10.1016/j.remn.2018.12.005

    authors: Baena García A,Partida Palma F,García Martínez S,de Bonilla Candau M,Pajares Vinardell M

    更新日期:2019-01-01 00:00:00

  • Diagnostic utility and therapeutic impact of PET/CT [18F]F-Fluoromethylcholine -Choline in the biochemical recurrence of prostate cancer.

    abstract:OBJECTIVE:To assess the diagnostic capability of PET/CT with [18F]F-Fluoromethylcholine in prostate cancer (PC) with biochemical recurrence and its therapeutic impact. MATERIAL AND METHODS:We included 108 patients, diagnosed with PC with biochemical criteria for recurrence. A PET/CT Choline scan was performed by dynam...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2020.03.010

    authors: Sánchez N,Valduvieco I,Ribal MJ,Campos F,Casas F,Nicolau C,Salvador R,Mellado B,Jorcano S,Fuster D,Paredes P

    更新日期:2020-01-01 00:00:00

  • Study of factors that influence the outcome of 131I treatment in hyperthyroidism secondary to nodular goitre.

    abstract:OBJECTIVE:To assess the outcome after 131I treatment in patients with multinodular (MNG) and nodular toxic goitre (NTG) according to the administered dose and other factors related to the patient, pathology, or previous treatments. MATERIAL AND METHODS:A retrospective study was conducted on 108 patients (67 MNG and 41...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2017.03.010

    authors: Tabuenca-Dopico O,Boente-Varela R,Lamas-Ferreiro JL

    更新日期:2017-01-01 00:00:00

  • 18F-choline PET/4D CT in hyperparathyroidism: correlation between biochemical data and study parameters.

    abstract:BACKGROUND:Hyperparathyroidism (HPT) is characterised by increased levels of parathyroid hormone (HPT), surgical excision being the only definitive curative option. After establishing the need for surgery, it is essential to identify the parathyroid glands in the preoperative period to use a minimally invasive approach...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2020.03.017

    authors: Boccalatte LA,Gómez NL,Musumeci M,Galich AM,Collaud C,Figari MF

    更新日期:2020-01-01 00:00:00

  • Cardiac sympathetic innervation assessed with (123)I-MIBG retains prognostic utility in diabetic patients with severe left ventricular dysfunction evaluated for primary prevention implantable cardioverter-defibrillator.

    abstract:BACKGROUND:Scintigraphy with iodine-123-metaiodobenzylguanidine ((123)I-MIBG) is a non-invasive tool for the assessment of cardiac sympathetic innervation (CSI) that has proven to be an independent predictor of survival. Recent studies have shown that diabetic patients with heart failure (HF) have a higher deterioratio...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2015.08.002

    authors: García-González P,Fabregat-Andrés Ó,Cozar-Santiago P,Sánchez-Jurado R,Estornell-Erill J,Valle-Muñoz A,Quesada-Dorador A,Payá-Serrano R,Ferrer-Rebolleda J,Ridocci-Soriano F

    更新日期:2016-03-01 00:00:00

  • 99mTc-HMPAO brain SPECT in the monitoring of cerebral vasculitis therapy.

    abstract:OBJECTIVE:The central nervous system (CNS) may be involved in a variety of inflammatory diseases of the blood vessels, generally known as vasculitis. The clinical diagnosis of such involvement in early stages is difficult, since a mild cognitive impairment can be the only symptom. It was hypothesized that brain-perfusi...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2017.10.009

    authors: Frantellizzi V,Morreale M,Pontico M,Francia A,Drudi FM,Farcomeni A,Liberatore M

    更新日期:2018-01-01 00:00:00

  • Radioguided hepatic resection with 18F-DOPA in a patient with metastatic medullary thyroid carcinoma.

    abstract:INTRODUCTION:Medullary carcinoma accounts for 1-2% of all thyroid malignancies. 13-20% of patients present with distant metastasis, with 45% of the cases affecting the liver. CLINICAL CASE:A 50-year-old woman, diagnosed with medullary thyroid carcinoma, was treated with total thyroidectomy and a modified neck dissecti...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2017.12.003

    authors: López-Gómez J,Medina-Ornelas S,Salazar-Álvarez MA,Álvarez-Bojórquez M,Zaragoza-Cruz N,Melchor-Ruan J,Álvarez-Cano A

    更新日期:2018-01-01 00:00:00

  • Spontaneous intracranial hypotension syndrome: contribution of radioisotope cisternography.

    abstract::Spontaneous intracranial hypotension is a clinical syndrome caused by a loss of cerebrospinal fluid volume, usually secondary to leaking through structural defects of the spinal dura mater. Radioisotope cisternography (RC) can confirm the diagnosis of spontaneous intracranial hypotension, especially in doubtful or aty...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2016.05.005

    authors: Suárez JP,Domínguez ML,Gómez MA,Muñoz JL

    更新日期:2017-01-01 00:00:00

  • Hospital Radiopharmacy in Argentina during the COVID-19 pandemic. Criteria and rationale for the organization of work.

    abstract::This publication presents criteria and bases for the work organization in the safe practice of Hospital Radiopharmacy, in order to minimize the risk of viral transmission during the COVID-19 pandemic, in a reference facility of the National Energy Commission Atomic of Argentina, while continuing to perform essential s...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2020.08.015

    authors: Rabiller G,Cordoba N,Poch C,Paulo PS,Seijas M,Vazquez MF

    更新日期:2020-01-01 00:00:00

  • [Contribution of time of flight and point spread function modeling to the performance characteristics of the PET/CT Biograph mCT scanner].

    abstract:OBJECTIVE:To characterize the performance of the Biograph mCT PET/CT TrueV scanner with time of flight (TOF) and point spread function (PSF) modeling. MATERIAL AND METHODS:The PET/CT scanner combines a 64-slice CT and PET scanner that incorporates in the reconstruction the TOF and PSF information. PET operating charac...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2012.07.001

    authors: Martí-Climent JM,Prieto E,Domínguez-Prado I,García-Velloso MJ,Rodríguez-Fraile M,Arbizu J,Vigil C,Caicedo C,Peñuelas I,Richter JA

    更新日期:2013-01-01 00:00:00

  • Lymphatic drainage in prostate carcinoma assessed by lymphoscintigraphy and SPECT/CT: its importance for the sentinel node procedure.

    abstract:PURPOSE:The goal was to evaluate the sentinel node procedure in relation to different pathways of lymphatic drainage and the areas of pelvic lymphadenectomy in patients with prostate cancer assessed by lymphoscintigraphy and SPECT/CT study. METHODS:Eighteen patients with prostate cancer of intermediate prognosis were ...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.remn.2011.09.003

    authors: de Bonilla-Damiá A,Roberto Brouwer O,Meinhardt W,Valdés-Olmos RA

    更新日期:2012-03-01 00:00:00

  • Uncommon isolated distant subcutaneous tissue and skeletal muscle metastasis from oesophageal cancer diagnosed by PET/CT (18)F-FDG.

    abstract::Distant soft-tissue metastases (subcutaneous tissues and skeletal muscle) are extremely rare, particularly in oesophageal carcinoma. The case is described of a patient who was treated for oesophageal adenocarcinoma 2.5 years previously. A PET/CT was performed showing metastatic spread due to a solitary focus of increa...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2015.07.005

    authors: Domínguez ML,Rayo JI,Serrano J,Infante JR,García L,Moreno M

    更新日期:2016-01-01 00:00:00

  • Added value of the hybrid tracer indocyanine green-99mTc-nanocolloid for sentinel node biopsy in a series of patients with different lymphatic drainage patterns.

    abstract:INTRODUCTION:Indocyanine green (ICG)-(99m)Tc-nanocolloid is a novel hybrid fluorescent radioactive tracer for sentinel node (SN) biopsy. This study has aimed to evaluate the added value of this novel versatile tracer in a series of patients with different malignancies. MATERIAL AND METHODS:Twenty patients (with penile...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2013.02.004

    authors: Frontado LM,Brouwer OR,van den Berg NS,Mathéron HM,Vidal-Sicart S,van Leeuwen FW,Valdés Olmos RA

    更新日期:2013-07-01 00:00:00

  • Characterization and simulation of noise in PET images reconstructed with OSEM: Development of a method for the generation of synthetic images.

    abstract:INTRODUCTION:The goals of the study are to characterize imaging properties in 2D PET images reconstructed with the iterative algorithm ordered-subset expectation maximization (OSEM) and to propose a new method for the generation of synthetic images. MATERIAL AND METHODS:The noise is analyzed in terms of its magnitude,...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2017.10.007

    authors: Castro P,Huerga C,Chamorro P,Garayoa J,Roch M,Pérez L

    更新日期:2018-01-01 00:00:00

  • [Implementation of a quality management system according to the UNE-UN-ISO 9001:2008 standard in a nuclear medicine department].

    abstract:OBJECTIVE:To describe the process of implementing a quality management system according to UNE-EN-ISO 9001:2008 standard in a Nuclear Medicine Department. MATERIAL AND METHOD:In February 2008, the committee on internal quality of the Department was established, naming a responsible physician. The general operating pla...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2012.01.004

    authors: Poblete García VM,Talavera Rubio MP,Palomar Muñoz A,Pilkington Woll JP,Cordero García JM,García Vicente AM,Bellón Guardia M,González García B,Cañuelo Merino T,Núñez García A,Peiró Valgañón V,Soriano Castrejón AM

    更新日期:2013-01-01 00:00:00

  • False positive in fluorodeoxyglucose-F18 positron emission tomography computed tomography scan of inferior vena cava leiomyoma in patient with a suspected paraganglioma.

    abstract::Leiomyomas are benign tumors derived from smooth muscle tissue that rarely present outside the uterus. These tumors do not usually show FDG uptake. We present the case of a patient with hypertension refractory to treatment and a lesion arising from inferior vena cava, that shows intense FDG uptake in PET/CT scan, sugg...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2019.06.006

    authors: González Jiménez AD,Rodríguez Fernández A,Sánchez Sánchez R,Jaén Águila F,Mediavilla García JD,Llamas Elvira JM

    更新日期:2020-01-01 00:00:00

  • [Presence of intramammary lymph nodes in the preoperative lymphoscintigraphy to locate the sentinel lymph node. Clinical significance].

    abstract:OBJECTIVE:The routes of lymphatic drainage from a breast cancer are the axilla (the most frequent) and the extra axillary regions. Among the latter, there are the so-called intrammamary lymph nodes (IMLN). This study has aimed to assess the incidence of IMLNs in our patients and study the evolution of these cases with ...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2014.10.006

    authors: Nogareda Z,Álvarez A,Perlaza P,Caparrós FX,Alonso I,Paredes P,Vidal-Sicart S

    更新日期:2015-03-01 00:00:00

  • Estimation of the collective ionizing dose in the Portuguese population for the years 2011 and 2012, due to nuclear medicine exams.

    abstract:OBJECTIVES:In 2009-2010 a Portuguese consortium was created to implement the methodologies proposed by the Dose Datamed II (DDM2) project, aiming to collect data from diagnostic X-ray and nuclear medicine (NM) procedures, in order to determine the most frequently prescribed exams and the associated ionizing radiation d...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2014.03.009

    authors: Costa F,Teles P,Nogueira A,Barreto A,Santos AI,Carvalho A,Martins B,Oliveira C,Gaspar C,Barros C,Neves D,Costa D,Rodrigues E,Godinho F,Alves F,Cardoso G,Cantinho G,Conde I,Vale J,Santos J,Isidoro J,Pereira J,S

    更新日期:2015-01-01 00:00:00

  • Value of post-therapy 177Lu-PSMA images for accurate interpretation of therapy response with 68Ga-PSMA PET/CT.

    abstract::A 54-year-old man with progressive prostate cancer underwent a 68Ga-PSMA PET/CT, which showed lymph node and bone metastases. After 2-cycles of 177Lu-PSMA therapy, the repeated 68Ga-PSMA PET/CT showed decreased radiotracer uptake in lymph node and bones metastases, but there were new lesions which may be compatible wi...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2017.05.004

    authors: Tuncel M,Telli T

    更新日期:2018-01-01 00:00:00

  • Value of the bone scintigraphy in multiple osteochrondromatosis with sarcomatous degeneration.

    abstract::Multiple osteochondromatosis can become malignant in 20% of the cases, this being more common when the lesion is multiple than when it is solitary. A male patient with multiple osteochondromatosis who had several local recurrences of secondary chondrosarcoma and who is still under follow-up by the Nuclear Medicine Dep...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2011.10.011

    authors: Sánchez-Rodríguez V,Medina-Romero F,Gómez Rodríguez-Bethencourt MÁ,González Díaz MA,González Soto MJ,Alarcó Hernández R

    更新日期:2012-09-01 00:00:00

  • [Elaboration of the SPM template for the standardization of SPECT images with 123I-Ioflupane].

    abstract:PURPOSE:Statistical parametric mapping (SPM) is a widely used produced for normalization of functional images. This study has aimed to develop a normalization template of (123)I-Ioflupane SPECT-imaging DaTSCAN(®), GE Healthcare), not available in SPM5, and to validate it compared to other quantification methods. MATER...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2013.02.009

    authors: García-Gómez FJ,García-Solís D,Luis-Simón FJ,Marín-Oyaga VA,Carrillo F,Mir P,Vázquez-Albertino RJ

    更新日期:2013-11-01 00:00:00

  • Development of a leakage monitoring system in isolated limb perfusion with portable gamma camera.

    abstract::Isolated limb perfusion (ILP) is a method for treating unresectable lesions of limbs in patients with melanoma or sarcoma by using high doses of tumor necrosis factor alpha and melphalan. These high doses can result in high systemic toxicity if there is a drug leak from the isolated circulation of the limb to the syst...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2020.06.018

    authors: Agudo Martínez A,Calvo Morón C,Cambil Molina T,García Gómez FJ,de la Riva Pérez PA,de la Cruz Merino L,Araji Tiliani O,Terrón León JA,Castro Montaño J

    更新日期:2021-01-01 00:00:00

  • Detection of epileptogenic focus with two new methods of processing of SPECT and PET cerebral images: PET-Analysis and PISCOM.

    abstract::Functional neuroimaging with positron emission tomography with 18F-fluorodeoxyglucose (PET-18F-FDG) and perfusion single photon emission computerized tomography (SPECT) are increasingly more essential for presurgically locating the epileptogenic focus. We present the case of an 18-year-old male with epileptic seizures...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2019.01.002

    authors: Sánchez-Izquierdo N,Perissinotti A,Donaire A,Niñerola-Baizán A,Mayoral M,Setoain X

    更新日期:2019-01-01 00:00:00

  • Discordance between MRI and bone scan findings in a child with acute complicated osteomyelitis: scintigraphic features that contribute to the early diagnosis.

    abstract::Early diagnosis and prompt treatment of acute osteomyelitis are of paramount importance in children because they can prevent irreversible bone damage. Magnetic resonance imaging (MRI) with its superior spatial resolution and lack of ionizing radiation is routinely preferred over bone scan for this purpose. Increased b...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2013.06.004

    authors: Mpalaris V,Arsos G,Iakovou I,Dalpa E,Karatzas N

    更新日期:2014-03-01 00:00:00

  • Prognostic importance of 18F-fluorodeoxyglucose uptake by positron emission tomography for stage III non-small cell lung cancer treated with definitive chemoradiotherapy.

    abstract:OBJECTIVES:Survival heterogeneity exists among patients with non-small cell lung cancer (NSCLC), even within the same stage. We aimed to evaluate the prognostic role of pre-treatment maximum standardized uptake value (SUVmax) in patients treated with definitive concurrent chemoradiotherapy for stage III NSCLC. MATERIA...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2019.04.006

    authors: Kanyilmaz G,Benli Yavuz B,Aktan M,Sahin O

    更新日期:2020-01-01 00:00:00

  • Platypnea-orthodeoxia syndrome: Importance of patient position for correct diagnosis at the time of (99m)Tc-MAA injection.

    abstract::A 65-year-old male presented with unexplained hypoxia that became exacerbated by an upright posture (platypnea-orthodeoxia syndrome) secondary to hepatopulmonary syndrome (HPS). A (99m)Tc-macroaggregated albumin pulmonary perfusion scan revealed a right to left shunt of 29% in the sitting position, which had not been ...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2014.12.009

    authors: Fierro Alanis MP,Bastón Rey I,Nieves-Maldonado S,Torre Carballada JA,Domínguez-Muñoz JE,Ruibal Morell Á

    更新日期:2015-07-01 00:00:00

  • Dual time point 2-deoxy-2-[18F]fluoro-D-glucose PET/CT: nodal staging in locally advanced breast cancer.

    abstract:AIM:To assess dual time point 2-deoxy-2-[(18)F]fluoro-D-glucose (18)(F)FDG PET-CT accuracy in nodal staging and in detection of extra-axillary involvement. MATERIAL AND METHODS:Dual time point [(18)F] FDG PET/CT scan was performed in 75 patients. Visual and semiquantitative assessment of lymph nodes was performed. Sem...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/j.remn.2013.03.005

    authors: García Vicente AM,Soriano Castrejón A,Cruz Mora MÁ,Ortega Ruiperez C,Espinosa Aunión R,León Martín A,González Ageitos A,Van Gómez López O

    更新日期:2014-01-01 00:00:00

  • Reproducibility of lymphoscintigraphy before and after excisional biopsy of primary breast lesions: a study using superficial peri-areolar injection of the radiotracer.

    abstract:OBJECTIVE:A major controversial issue in the sentinel node biopsy of the breast is the applicability of sentinel node mapping in patients with the history of previous excisional biopsy of the breast lesions. In the current study, we evaluated the reproducibility of lymphoscintigraphy before and after excisional biopsy ...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2012.07.004

    authors: Asadi M,Shobeiri H,Aliakbarian M,Jangjoo A,Dabbagh Kakhki VR,Sadeghi R,Keshtgar M

    更新日期:2013-05-01 00:00:00

  • [Findings of the (18)F-FDG PET-CT in a cardiac angiosarcoma complicated by a cardiac rupture].

    abstract::Primary malignant tumors of the heart are a rare condition. The most common type is the cardiac angiosarcoma. The symptoms of this disease are very nonspecific and can be very difficult to diagnose by conventional imaging techniques. We report the case of a male patient with cardiac angiosarcoma who also had a rare co...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2013.04.006

    authors: Santiago-Chinchilla A,Ruiz-Carazo E,Moral-Ruiz A,Testart Dardel N,Martínez-Martínez A,López-Fernández S

    更新日期:2014-07-01 00:00:00

  • Contribution of 18F-sodium fluoride PET/CT to the study of the carotid atheroma calcification.

    abstract:AIM:To assess the calcification process of the carotid plaque by (18)F-sodium fluoride PET/CT imaging. MATERIAL AND METHODS:A prospectively designed study including 15 patients in whom an atheroma plaque was detected by contrast enhanced CT scan during a neurological work-up was performed. A total of 29 plaques, 19 as...

    journal_title:Revista espanola de medicina nuclear e imagen molecular

    pub_type: 杂志文章

    doi:10.1016/j.remn.2012.08.003

    authors: Quirce R,Martínez-Rodríguez I,De Arcocha Torres M,Jiménez-Bonilla JF,Banzo I,Rebollo M,Revilla MA,Palacio E,Rubio-Vassallo A,Ortega-Nava F,Del Castillo-Matos R,Carril JM

    更新日期:2013-01-01 00:00:00