Abstract:
BACKGROUND:Scintigraphy with iodine-123-metaiodobenzylguanidine ((123)I-MIBG) is a non-invasive tool for the assessment of cardiac sympathetic innervation (CSI) that has proven to be an independent predictor of survival. Recent studies have shown that diabetic patients with heart failure (HF) have a higher deterioration in CSI. It is unknown if (123)I-MIBG has the same predictive value for diabetic and non-diabetic patients with advanced HF. An analysis is performed to determine whether CSI with (123)I-MIBG retains prognostic utility in diabetic patients with HF, evaluated for a primary prevention implantable cardioverter-defibrillator (ICD). MATERIAL AND METHODS:Seventy-eight consecutive HF patients (48 diabetic) evaluated for primary prevention ICD implantation were prospectively enrolled and underwent (123)I-MIBG to assess CSI (heart-to-mediastinum ratio - HMR). A Cox proportional hazards multivariate analysis was used to determine the influence of (123)I-MIBG images for prediction of cardiac events in both diabetic and non-diabetic patients. The primary end-point was a composite of arrhythmic event, cardiac death, or admission due to HF. RESULTS:During a mean follow-up of 19.5 [9.3-29.3] months, the primary end-point occurred in 24 (31%) patients. Late HMR was significantly lower in diabetic patients (1.30 vs. 1.41, p=0.014). Late HMR≤1.30 was an independent predictor of cardiac events in diabetic (hazard ratio 4.53; p=0.012) and non-diabetic patients (hazard ratio 12.31; p=0.023). CONCLUSIONS:Diabetic patients with HF evaluated for primary prevention ICD show a higher deterioration in CSI than non-diabetics; nevertheless (123)I-MIBG imaging retained prognostic utility for both diabetic and non-diabetic patients.
journal_name
Rev Esp Med Nucl Imagen Moljournal_title
Revista espanola de medicina nuclear e imagen molecularauthors
García-González P,Fabregat-Andrés Ó,Cozar-Santiago P,Sánchez-Jurado R,Estornell-Erill J,Valle-Muñoz A,Quesada-Dorador A,Payá-Serrano R,Ferrer-Rebolleda J,Ridocci-Soriano Fdoi
10.1016/j.remn.2015.08.002subject
Has Abstractpub_date
2016-03-01 00:00:00pages
74-80issue
2eissn
2253-654Xissn
2253-8070pii
S2253-654X(15)00114-6journal_volume
35pub_type
杂志文章abstract:OBJECTIVE:To describe the process of implementing a quality management system according to UNE-EN-ISO 9001:2008 standard in a Nuclear Medicine Department. MATERIAL AND METHOD:In February 2008, the committee on internal quality of the Department was established, naming a responsible physician. The general operating pla...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2012.01.004
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Hyperparathyroidism (HPT) is characterised by increased levels of parathyroid hormone (HPT), surgical excision being the only definitive curative option. After establishing the need for surgery, it is essential to identify the parathyroid glands in the preoperative period to use a minimally invasive approach...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2020.03.017
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:The routes of lymphatic drainage from a breast cancer are the axilla (the most frequent) and the extra axillary regions. Among the latter, there are the so-called intrammamary lymph nodes (IMLN). This study has aimed to assess the incidence of IMLNs in our patients and study the evolution of these cases with ...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2014.10.006
更新日期:2015-03-01 00:00:00
abstract::Prostate tumors originate 68% in the peripheral region and 24% in the transitional region where tumors originating in the central zone are rare (8%). However, diagnosis of the tumors in the central zone is important since they exhibit greater aggressiveness conditioned by their location and different biological behavi...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2013.07.013
更新日期:2014-03-01 00:00:00
abstract:AIM:To assess the calcification process of the carotid plaque by (18)F-sodium fluoride PET/CT imaging. MATERIAL AND METHODS:A prospectively designed study including 15 patients in whom an atheroma plaque was detected by contrast enhanced CT scan during a neurological work-up was performed. A total of 29 plaques, 19 as...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2012.08.003
更新日期:2013-01-01 00:00:00
abstract::Neurolymphomatosis is a rare condition defined as an infiltration of nerves, nerve roots or nervous plexuses by haematological malignancy. Its diagnosis may sometimes be difficult with conventional imaging techniques. This paper aims to emphasize the importance of this entity and the role of (18)F-FDG PET/CT in this i...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2013.03.004
更新日期:2014-01-01 00:00:00
abstract::About one third of focal thyroid uptakes in a fluorodeoxyglucose (FDG) positron emission tomography/computerized tomography (PET/CT) study are malignant, the most frequent histological type being papillary carcinoma. Metastases to the thyroid account for approximately 7.5% of thyroid malignancies and come mainly from ...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2016.09.002
更新日期:2017-01-01 00:00:00
abstract::Isolated limb perfusion (ILP) is a method for treating unresectable lesions of limbs in patients with melanoma or sarcoma by using high doses of tumor necrosis factor alpha and melphalan. These high doses can result in high systemic toxicity if there is a drug leak from the isolated circulation of the limb to the syst...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2020.06.018
更新日期:2021-01-01 00:00:00
abstract::Primary malignant tumors of the heart are a rare condition. The most common type is the cardiac angiosarcoma. The symptoms of this disease are very nonspecific and can be very difficult to diagnose by conventional imaging techniques. We report the case of a male patient with cardiac angiosarcoma who also had a rare co...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2013.04.006
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:To characterize the performance of the Biograph mCT PET/CT TrueV scanner with time of flight (TOF) and point spread function (PSF) modeling. MATERIAL AND METHODS:The PET/CT scanner combines a 64-slice CT and PET scanner that incorporates in the reconstruction the TOF and PSF information. PET operating charac...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2012.07.001
更新日期:2013-01-01 00:00:00
abstract::A 54-year-old man with progressive prostate cancer underwent a 68Ga-PSMA PET/CT, which showed lymph node and bone metastases. After 2-cycles of 177Lu-PSMA therapy, the repeated 68Ga-PSMA PET/CT showed decreased radiotracer uptake in lymph node and bones metastases, but there were new lesions which may be compatible wi...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2017.05.004
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To assess the outcome after 131I treatment in patients with multinodular (MNG) and nodular toxic goitre (NTG) according to the administered dose and other factors related to the patient, pathology, or previous treatments. MATERIAL AND METHODS:A retrospective study was conducted on 108 patients (67 MNG and 41...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2017.03.010
更新日期:2017-01-01 00:00:00
abstract::Chronic diarrhoea due to bile acid malabsorption (BAM) is an underdiagnosed pathology. Different diagnostic tools are available. However, there is currently no consensus on which of these would be the benchmark test or gold standard. This review evaluates the possibility of using 75Se-taurocholic acid (75SeHCAT®) scin...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章,评审
doi:10.1016/j.remn.2018.12.005
更新日期:2019-01-01 00:00:00
abstract::Spontaneous intracranial hypotension is a clinical syndrome caused by a loss of cerebrospinal fluid volume, usually secondary to leaking through structural defects of the spinal dura mater. Radioisotope cisternography (RC) can confirm the diagnosis of spontaneous intracranial hypotension, especially in doubtful or aty...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2016.05.005
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:A major controversial issue in the sentinel node biopsy of the breast is the applicability of sentinel node mapping in patients with the history of previous excisional biopsy of the breast lesions. In the current study, we evaluated the reproducibility of lymphoscintigraphy before and after excisional biopsy ...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2012.07.004
更新日期:2013-05-01 00:00:00
abstract::Functional neuroimaging with positron emission tomography with 18F-fluorodeoxyglucose (PET-18F-FDG) and perfusion single photon emission computerized tomography (SPECT) are increasingly more essential for presurgically locating the epileptogenic focus. We present the case of an 18-year-old male with epileptic seizures...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2019.01.002
更新日期:2019-01-01 00:00:00
abstract:INTRODUCTION:Medullary carcinoma accounts for 1-2% of all thyroid malignancies. 13-20% of patients present with distant metastasis, with 45% of the cases affecting the liver. CLINICAL CASE:A 50-year-old woman, diagnosed with medullary thyroid carcinoma, was treated with total thyroidectomy and a modified neck dissecti...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2017.12.003
更新日期:2018-01-01 00:00:00
abstract::Multiple osteochondromatosis can become malignant in 20% of the cases, this being more common when the lesion is multiple than when it is solitary. A male patient with multiple osteochondromatosis who had several local recurrences of secondary chondrosarcoma and who is still under follow-up by the Nuclear Medicine Dep...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2011.10.011
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:The central nervous system (CNS) may be involved in a variety of inflammatory diseases of the blood vessels, generally known as vasculitis. The clinical diagnosis of such involvement in early stages is difficult, since a mild cognitive impairment can be the only symptom. It was hypothesized that brain-perfusi...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2017.10.009
更新日期:2018-01-01 00:00:00
abstract::Hydronephrosis is a common finding in urinary tract outflow obstruction. Chronically obstructed hydronephrotic system may be associated with parenchymal changes. Ultrasound, intravenous urography, micturating cysto-urethrogram and scintigraphy are commonly performed to evaluate the cause of obstruction. In childhood, ...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2015.05.003
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVES:In 2009-2010 a Portuguese consortium was created to implement the methodologies proposed by the Dose Datamed II (DDM2) project, aiming to collect data from diagnostic X-ray and nuclear medicine (NM) procedures, in order to determine the most frequently prescribed exams and the associated ionizing radiation d...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2014.03.009
更新日期:2015-01-01 00:00:00
abstract::A 65-year-old male presented with unexplained hypoxia that became exacerbated by an upright posture (platypnea-orthodeoxia syndrome) secondary to hepatopulmonary syndrome (HPS). A (99m)Tc-macroaggregated albumin pulmonary perfusion scan revealed a right to left shunt of 29% in the sitting position, which had not been ...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2014.12.009
更新日期:2015-07-01 00:00:00
abstract::We report a case of a patient with lung adenocarcinoma and bone and extraosseus metastases studied with (18)F-FDG PET-CT, (99m)Tc-HMDP and (18)F-fluoride PET-CT. It assesses the usefulness of (18)F-FDG PET-CT for initial staging of the disease and monitoring response to therapy. For the study of the sclerotic bone met...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2014.02.004
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:The goals of the study are to characterize imaging properties in 2D PET images reconstructed with the iterative algorithm ordered-subset expectation maximization (OSEM) and to propose a new method for the generation of synthetic images. MATERIAL AND METHODS:The noise is analyzed in terms of its magnitude,...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2017.10.007
更新日期:2018-01-01 00:00:00
abstract:INTRODUCTION:Indocyanine green (ICG)-(99m)Tc-nanocolloid is a novel hybrid fluorescent radioactive tracer for sentinel node (SN) biopsy. This study has aimed to evaluate the added value of this novel versatile tracer in a series of patients with different malignancies. MATERIAL AND METHODS:Twenty patients (with penile...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2013.02.004
更新日期:2013-07-01 00:00:00
abstract::Moyamoya disease (MMD) is a cerebrovascular disorder involving stenosis of brain vessels. Brain perfusion SPECT in MMD demonstrates impaired perfusion in ischemic areas. We present a 6-year-old boy with MMD. The patient had numbness on the right arm and simultaneous electroencephalography changes while studying arms u...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2012.02.006
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:To assess the diagnostic capability of PET/CT with [18F]F-Fluoromethylcholine in prostate cancer (PC) with biochemical recurrence and its therapeutic impact. MATERIAL AND METHODS:We included 108 patients, diagnosed with PC with biochemical criteria for recurrence. A PET/CT Choline scan was performed by dynam...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2020.03.010
更新日期:2020-01-01 00:00:00
abstract::(99m)Tc-tetrofosmin single photon emission computed tomography ((99m)Tc-tetrofosmin SPECT) has an important role in the assessment of coronary artery disease. Despite being its main indication, this study does not only evaluate myocardial perfusion, but much more. Moreover, during the SPECT acquisition, the field area...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2015.03.005
更新日期:2015-11-01 00:00:00
abstract::Distant soft-tissue metastases (subcutaneous tissues and skeletal muscle) are extremely rare, particularly in oesophageal carcinoma. The case is described of a patient who was treated for oesophageal adenocarcinoma 2.5 years previously. A PET/CT was performed showing metastatic spread due to a solitary focus of increa...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2015.07.005
更新日期:2016-01-01 00:00:00
abstract::Leiomyomas are benign tumors derived from smooth muscle tissue that rarely present outside the uterus. These tumors do not usually show FDG uptake. We present the case of a patient with hypertension refractory to treatment and a lesion arising from inferior vena cava, that shows intense FDG uptake in PET/CT scan, sugg...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2019.06.006
更新日期:2020-01-01 00:00:00