Abstract:
INTRODUCTION:Indocyanine green (ICG)-(99m)Tc-nanocolloid is a novel hybrid fluorescent radioactive tracer for sentinel node (SN) biopsy. This study has aimed to evaluate the added value of this novel versatile tracer in a series of patients with different malignancies. MATERIAL AND METHODS:Twenty patients (with penile carcinoma, oral cavity tumors, melanoma) were consecutively included between March-May 2012. Planar lymphoscintigraphy was performed 15 min and 2h after injection of ICG-(99m)Tc-nanocolloid followed by SPECT/CT. Blue dye (1 ml) was injected in 14 patients in surgery room. Intraoperatively, SNs were localized using a gamma probe and visualized by optical SN-detection using blue dye and fluorescence imaging. Finally, a portable gamma camera was used to confirm complete SN removal. RESULTS:At least one SN was identified by SPECT/CT in all patients. All SNs (total 68, 100%) were excised using a combination of radio- and fluorescence guidance: 89.7% were intraoperatively localized with the gamma probe. The remaining SNs, located near the injection site, were localized using fluorescence imaging. During the surgery, 97% of the SNs were fluorescent while only 39.2% were stained blue. Ex vivo, all SNs were both radioactive and fluorescent. The SN was positive in 5 patients. CONCLUSION:Synchronous radio- and fluorescence guided SN biopsy is feasible using ICG-(99m)Tc-nanocolloid. This hybrid approach combines the beneficial properties of both modalities. Adding fluorescence imaging improves optical SN detection compared to blue dye. It has been shown to be especially useful in the localization of SNs near the injection site.
journal_name
Rev Esp Med Nucl Imagen Moljournal_title
Revista espanola de medicina nuclear e imagen molecularauthors
Frontado LM,Brouwer OR,van den Berg NS,Mathéron HM,Vidal-Sicart S,van Leeuwen FW,Valdés Olmos RAdoi
10.1016/j.remn.2013.02.004subject
Has Abstractpub_date
2013-07-01 00:00:00pages
227-33issue
4eissn
2253-654Xissn
2253-8070pii
S2253-654X(13)00017-6journal_volume
32pub_type
杂志文章abstract:BACKGROUND:Scintigraphy with iodine-123-metaiodobenzylguanidine ((123)I-MIBG) is a non-invasive tool for the assessment of cardiac sympathetic innervation (CSI) that has proven to be an independent predictor of survival. Recent studies have shown that diabetic patients with heart failure (HF) have a higher deterioratio...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2015.08.002
更新日期:2016-03-01 00:00:00
abstract::Primary malignant tumors of the heart are a rare condition. The most common type is the cardiac angiosarcoma. The symptoms of this disease are very nonspecific and can be very difficult to diagnose by conventional imaging techniques. We report the case of a male patient with cardiac angiosarcoma who also had a rare co...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2013.04.006
更新日期:2014-07-01 00:00:00
abstract::Chronic diarrhoea due to bile acid malabsorption (BAM) is an underdiagnosed pathology. Different diagnostic tools are available. However, there is currently no consensus on which of these would be the benchmark test or gold standard. This review evaluates the possibility of using 75Se-taurocholic acid (75SeHCAT®) scin...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章,评审
doi:10.1016/j.remn.2018.12.005
更新日期:2019-01-01 00:00:00
abstract::A 49 year-old woman diagnosed with infiltrating lobular breast carcinoma, underwent a right mastectomy and sentinel node biopsy (SLNB). The resected sentinel lymph nodes were negative for malignancy, with an axillary lymphadenectomy not being performed. In the early post-operative period, the patient reported an axill...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2016.04.008
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVE:The central nervous system (CNS) may be involved in a variety of inflammatory diseases of the blood vessels, generally known as vasculitis. The clinical diagnosis of such involvement in early stages is difficult, since a mild cognitive impairment can be the only symptom. It was hypothesized that brain-perfusi...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2017.10.009
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVES:In 2009-2010 a Portuguese consortium was created to implement the methodologies proposed by the Dose Datamed II (DDM2) project, aiming to collect data from diagnostic X-ray and nuclear medicine (NM) procedures, in order to determine the most frequently prescribed exams and the associated ionizing radiation d...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2014.03.009
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To assess the diagnostic capability of PET/CT with [18F]F-Fluoromethylcholine in prostate cancer (PC) with biochemical recurrence and its therapeutic impact. MATERIAL AND METHODS:We included 108 patients, diagnosed with PC with biochemical criteria for recurrence. A PET/CT Choline scan was performed by dynam...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2020.03.010
更新日期:2020-01-01 00:00:00
abstract::A 54-year-old man with progressive prostate cancer underwent a 68Ga-PSMA PET/CT, which showed lymph node and bone metastases. After 2-cycles of 177Lu-PSMA therapy, the repeated 68Ga-PSMA PET/CT showed decreased radiotracer uptake in lymph node and bones metastases, but there were new lesions which may be compatible wi...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2017.05.004
更新日期:2018-01-01 00:00:00
abstract::We report a case of a patient with lung adenocarcinoma and bone and extraosseus metastases studied with (18)F-FDG PET-CT, (99m)Tc-HMDP and (18)F-fluoride PET-CT. It assesses the usefulness of (18)F-FDG PET-CT for initial staging of the disease and monitoring response to therapy. For the study of the sclerotic bone met...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2014.02.004
更新日期:2015-01-01 00:00:00
abstract::Early diagnosis and prompt treatment of acute osteomyelitis are of paramount importance in children because they can prevent irreversible bone damage. Magnetic resonance imaging (MRI) with its superior spatial resolution and lack of ionizing radiation is routinely preferred over bone scan for this purpose. Increased b...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2013.06.004
更新日期:2014-03-01 00:00:00
abstract::Functional neuroimaging with positron emission tomography with 18F-fluorodeoxyglucose (PET-18F-FDG) and perfusion single photon emission computerized tomography (SPECT) are increasingly more essential for presurgically locating the epileptogenic focus. We present the case of an 18-year-old male with epileptic seizures...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2019.01.002
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:The routes of lymphatic drainage from a breast cancer are the axilla (the most frequent) and the extra axillary regions. Among the latter, there are the so-called intrammamary lymph nodes (IMLN). This study has aimed to assess the incidence of IMLNs in our patients and study the evolution of these cases with ...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2014.10.006
更新日期:2015-03-01 00:00:00
abstract:INTRODUCTION:The goals of the study are to characterize imaging properties in 2D PET images reconstructed with the iterative algorithm ordered-subset expectation maximization (OSEM) and to propose a new method for the generation of synthetic images. MATERIAL AND METHODS:The noise is analyzed in terms of its magnitude,...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2017.10.007
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:A major controversial issue in the sentinel node biopsy of the breast is the applicability of sentinel node mapping in patients with the history of previous excisional biopsy of the breast lesions. In the current study, we evaluated the reproducibility of lymphoscintigraphy before and after excisional biopsy ...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2012.07.004
更新日期:2013-05-01 00:00:00
abstract::Multiple osteochondromatosis can become malignant in 20% of the cases, this being more common when the lesion is multiple than when it is solitary. A male patient with multiple osteochondromatosis who had several local recurrences of secondary chondrosarcoma and who is still under follow-up by the Nuclear Medicine Dep...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2011.10.011
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Hyperparathyroidism (HPT) is characterised by increased levels of parathyroid hormone (HPT), surgical excision being the only definitive curative option. After establishing the need for surgery, it is essential to identify the parathyroid glands in the preoperative period to use a minimally invasive approach...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2020.03.017
更新日期:2020-01-01 00:00:00
abstract::About one third of focal thyroid uptakes in a fluorodeoxyglucose (FDG) positron emission tomography/computerized tomography (PET/CT) study are malignant, the most frequent histological type being papillary carcinoma. Metastases to the thyroid account for approximately 7.5% of thyroid malignancies and come mainly from ...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2016.09.002
更新日期:2017-01-01 00:00:00
abstract::Neurolymphomatosis is a rare condition defined as an infiltration of nerves, nerve roots or nervous plexuses by haematological malignancy. Its diagnosis may sometimes be difficult with conventional imaging techniques. This paper aims to emphasize the importance of this entity and the role of (18)F-FDG PET/CT in this i...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2013.03.004
更新日期:2014-01-01 00:00:00
abstract::Leiomyomas are benign tumors derived from smooth muscle tissue that rarely present outside the uterus. These tumors do not usually show FDG uptake. We present the case of a patient with hypertension refractory to treatment and a lesion arising from inferior vena cava, that shows intense FDG uptake in PET/CT scan, sugg...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2019.06.006
更新日期:2020-01-01 00:00:00
abstract::(99m)Tc-tetrofosmin single photon emission computed tomography ((99m)Tc-tetrofosmin SPECT) has an important role in the assessment of coronary artery disease. Despite being its main indication, this study does not only evaluate myocardial perfusion, but much more. Moreover, during the SPECT acquisition, the field area...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2015.03.005
更新日期:2015-11-01 00:00:00
abstract::A 65-year-old male presented with unexplained hypoxia that became exacerbated by an upright posture (platypnea-orthodeoxia syndrome) secondary to hepatopulmonary syndrome (HPS). A (99m)Tc-macroaggregated albumin pulmonary perfusion scan revealed a right to left shunt of 29% in the sitting position, which had not been ...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2014.12.009
更新日期:2015-07-01 00:00:00
abstract::Moyamoya disease (MMD) is a cerebrovascular disorder involving stenosis of brain vessels. Brain perfusion SPECT in MMD demonstrates impaired perfusion in ischemic areas. We present a 6-year-old boy with MMD. The patient had numbness on the right arm and simultaneous electroencephalography changes while studying arms u...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2012.02.006
更新日期:2012-07-01 00:00:00
abstract:AIM:To assess dual time point 2-deoxy-2-[(18)F]fluoro-D-glucose (18)(F)FDG PET-CT accuracy in nodal staging and in detection of extra-axillary involvement. MATERIAL AND METHODS:Dual time point [(18)F] FDG PET/CT scan was performed in 75 patients. Visual and semiquantitative assessment of lymph nodes was performed. Sem...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.remn.2013.03.005
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:Medullary carcinoma accounts for 1-2% of all thyroid malignancies. 13-20% of patients present with distant metastasis, with 45% of the cases affecting the liver. CLINICAL CASE:A 50-year-old woman, diagnosed with medullary thyroid carcinoma, was treated with total thyroidectomy and a modified neck dissecti...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2017.12.003
更新日期:2018-01-01 00:00:00
abstract::Spontaneous intracranial hypotension is a clinical syndrome caused by a loss of cerebrospinal fluid volume, usually secondary to leaking through structural defects of the spinal dura mater. Radioisotope cisternography (RC) can confirm the diagnosis of spontaneous intracranial hypotension, especially in doubtful or aty...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2016.05.005
更新日期:2017-01-01 00:00:00
abstract:AIM:To assess the calcification process of the carotid plaque by (18)F-sodium fluoride PET/CT imaging. MATERIAL AND METHODS:A prospectively designed study including 15 patients in whom an atheroma plaque was detected by contrast enhanced CT scan during a neurological work-up was performed. A total of 29 plaques, 19 as...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2012.08.003
更新日期:2013-01-01 00:00:00
abstract::This publication presents criteria and bases for the work organization in the safe practice of Hospital Radiopharmacy, in order to minimize the risk of viral transmission during the COVID-19 pandemic, in a reference facility of the National Energy Commission Atomic of Argentina, while continuing to perform essential s...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2020.08.015
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:The goal was to evaluate the sentinel node procedure in relation to different pathways of lymphatic drainage and the areas of pelvic lymphadenectomy in patients with prostate cancer assessed by lymphoscintigraphy and SPECT/CT study. METHODS:Eighteen patients with prostate cancer of intermediate prognosis were ...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 临床试验,杂志文章
doi:10.1016/j.remn.2011.09.003
更新日期:2012-03-01 00:00:00
abstract:PURPOSE:Statistical parametric mapping (SPM) is a widely used produced for normalization of functional images. This study has aimed to develop a normalization template of (123)I-Ioflupane SPECT-imaging DaTSCAN(®), GE Healthcare), not available in SPM5, and to validate it compared to other quantification methods. MATER...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2013.02.009
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVES:Survival heterogeneity exists among patients with non-small cell lung cancer (NSCLC), even within the same stage. We aimed to evaluate the prognostic role of pre-treatment maximum standardized uptake value (SUVmax) in patients treated with definitive concurrent chemoradiotherapy for stage III NSCLC. MATERIA...
journal_title:Revista espanola de medicina nuclear e imagen molecular
pub_type: 杂志文章
doi:10.1016/j.remn.2019.04.006
更新日期:2020-01-01 00:00:00