Abstract：
:Distinguishing between constitutional delay of growth and puberty (CDGP) and congenital hypogonadotropic hypogonadism (CHH) may be challenging. CDGP and CHH appear to belong to the same clinical spectrum (with low sex hormones and low LH and FSH), although one is classically transient and known as a self-limited form of delayed puberty (CDGP) while the other is permanent (CHH). Thus, the clinical history and the outcomes of these two conditions require different approaches, and an adequate and timely management for the patients is mandatory. Since the initial presentation of CDGP and CHH is almost identical and given the similarities of CDGP and partial forms of CHH (i.e. patients with partial and early interrupted pubertal development) the scientific community has been struggling to find some diagnostic tests able to allow an accurate differential diagnosis between these two conditions in delayed puberty. In this review we provide an up to date insight on the tests available, their meanings and accuracy, as well as some clues to effectively differentiate between constitutional pubertal delay and pathologic CHH.
journal_name
Minerva Pediatrjournal_title
Minerva pediatricaauthors
Bollino A,Cangiano B,Goggi G,Federici S,Duminuco P,Giovanelli L,Galazzi E,Vezzoli V,Persani L,Bonomi Mdoi
10.23736/S0026-4946.20.05860-0subject
Has Abstractpub_date
2020-08-01 00:00:00pages
278-287issue
4eissn
0026-4946issn
1827-1715pii
S0026-4946.20.05860-0journal_volume
72pub_type
杂志文章abstract：:In 1967 a baby was observed who presented post-natal progressive growth deficit, mental retardation, craniofacial dysmorphias and other malformations which didn't form part of the syndromes till then known. However the first description of patients with this combination of anomalies dates back to 1981, when Niikawa an...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：1999-07-01 00:00:00
abstract：:Sixty patients (31 male and 29 female) with thalassemia major, aged between 6 and 26 years, 18 of which were splenectomized, were observed in this study evaluating the oro-maxillo-facial alterations and correlating them to transfusion indexes, serum ferritin levels, splenectomy and age. For each patient a haematologic...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:Eosinophilic esophagitis (EoE) is a chronic disease characterized by symptoms related to esophageal dysfunction and eosinophil-predominant inflammation (≥15 eosinophils/high power field). In the last ten years, several epidemiological studies showed a significant increase in the incidence and prevalence of EoE, especi...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：10.23736/S0026-4946.20.05913-7
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:Acute gastroenteritis is responsible for dehydration in many children. The viruses like rotavirus, norovirus, and adenovirus are considered the main causative agents of gastroenteritis. The goal of this study is the evaluation of the symptoms, clinical findings and hospitalization requirements in pediatric p...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：10.23736/S0026-4946.16.04259-X
更新日期：2018-04-01 00:00:00
abstract：:The paper reports five cases of Kawasaki's syndrome diagnosed during the period 1985-89. The mean age of patients was 20 months (4/12; 4 years and 5/12). Symptomatology gradually regressed in four of these patients with a return to good health and normal cardiological controls. The fifth patient died suddenly followin...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1991-11-01 00:00:00
abstract：:One of the principal duties of a staff nurse working in a NICU is the assistance of the ventilated infants. The management of the endotracheal tube is a key moment in the neonatal care and it is fundamental to prevent the ventilator induced lung injury and the change in the perfusion (especially in the brain) that may...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：2010-06-01 00:00:00
abstract：:Aspecific chronic diarrhea is one of the most common causes of protracted diarrhea in infancy. The pathology is characterised by an increased frequency of daily bowel movement with half-formed feces; it is not associated to malabsorption syndrome or enteric infections and appears to be correlated to an unbalanced diet...
journal_title：Minerva pediatrica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1990-04-01 00:00:00
abstract：BACKGROUND:COVID-19 has quickly become a worldwide threat to health, travel, and commerce. Studies adressing the clinical-functional presentation of viral infection and physiotherapy management in children are scarce. The purpose statement was to provide current perspectives on the physiotherapy interventions for manag...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：10.23736/S0026-4946.20.06100-9
更新日期：2020-10-27 00:00:00
abstract：:Little is known about the overlapping symptoms and comorbidity of pediatric bipolar disorder (BD) and pervasive developmental disorders (PDD) in youth. The aim of this study was to clearly differentiate the symptoms, understand the prevalence and patterns of comorbid presentations, as well as to provide a summary of e...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2008-02-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to asses the validity of the TCB nomogram for the European population for predicting significant hyperbilirubinemia in healthy term and late-preterm newborns. METHODS:This observational study was conducted from February 2009 to December 2009 in the well-baby nurseries of Gemelli hos...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2010-06-01 00:00:00
abstract：:The role of etiology, pathogenesis and clinical symptoms in children with Atopic Dermatitis is evaluated. Eighteen patients with elimination diet were treated, without cow milk and egg, and with pharmacologic treatment (ketotiphene and cro molyn sodium) for two months. Dietary therapy and treatment however result in a...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1994-09-01 00:00:00
abstract：:The onset of puberty may be late - in the latter part of the predicted normal range or truly delayed - beyond this range. The latest age to start is usually regarded as 13 years in girls and 14 years in boys. There may also be a delayed completion of puberty, 16 years in girls and 17 years in boys. The initial approac...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：10.23736/S0026-4946.20.05968-X
更新日期：2020-12-01 00:00:00
abstract：:Dermatophytosis in newborns and infants has been regarded as very unusual; a case recently observed of a 2-month-old child affected by tinea faciei is described. Twenty days before, localized erythematous infiltrated patches at the upper left eyelid and eyebrows with papules and pustules, were observed. Rarefaction of...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2001-02-01 00:00:00
abstract：AIM:Aim of this study is to evaluate anxiety and temperament characteristics in developmental age subjects who practised agonistic sport (individual or team sports) in comparison with a sample group of subjects who practice no agonistic sports. METHODS:Sixty subjects aged from 10 to 16 years were enrolled in the study...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2004-02-01 00:00:00
abstract：BACKGROUND:The aim of this study is to investigate the changes of developmental and behavioral profile in a domestic adoptees sample. METHODS:Thirty-six domestic adoptive families were recruited, resulting in a sample of 39 children. Families were sent a general questionnaire for collecting data related to the childre...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2020-10-01 00:00:00
abstract：:Asthma is a condition characterised by airways inflammation and bronchial hyperresponsiveness to specific and aspecific spasmogens associated with reversible airways obstruction. The bronchomotor tone is the result of an interaction between neurotransmitter release and local mediators. The efferent neurohumoral pathwa...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：2000-11-01 00:00:00
abstract：:The development and evaluation of early preventative interventions for individuals exposed to a potentially traumatic event (PTE) have been increasing in number and sophistication over the last decade. Evaluation of early interventions for individuals who are symptomatic several weeks after exposure to a PTE have been...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：2011-06-01 00:00:00
abstract：INTRODUCTION:Chronic rhinosinusitis (CRS) is defined as an inflammatory disorder of the paranasal sinuses and of the nasal mucosa that lasts 12 weeks or longer. In CRS microbes contribute to the disease pathogenesis. Clinical microbiology is focused on finding single pathogens that causes the disease and the main goal ...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：10.23736/S0026-4946.20.05850-8
更新日期：2020-07-29 00:00:00
abstract：:Central pontine myelinolysis (CPM) is a demyelinating disease of the pons often associated with the demyelination of extrapontine areas of the central nervous system. It typically occurs 0.5-7 days after a rapid increment in serum Na level in hyponatremic patients and may lead to death. A 2.5-year-old child with a dia...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2011-02-01 00:00:00
abstract：BACKGROUND:Atopic dermatitis (AD) is a very common chronic inflammatory and eczematous skin condition characterized by flares and remissions. Skin barrier alteration or dysfunction is the most relevant patogenetic factor. Topical corticosteroids are the mainstay treatment of AD, especially during flare periods. The dai...
journal_title：Minerva pediatrica
pub_type： 临床试验,杂志文章,多中心研究
doi：10.23736/S0026-4946.17.05015-0
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:Since most of the children observed in our Centre present enuresis with voiding disturbance, we carried out a study where these patients were treated with the DDAVP + Oxybutinin association. METHODS:We have treated 89 children with enuresis and voiding disturbances (urge incontinence, voiding urgency, urina...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1999-05-01 00:00:00
abstract：BACKGROUND:The aim of this paper was to examine the present situation of adolescents admission for respiratory emergency, management of these patients, identify strategies for the best therapeutic options and better collaboration. METHODS:We have gathered data of adolescent patients who were referred to the Emergency ...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2002-12-01 00:00:00
abstract：:In the present study the authors investigated the normal range of the marker TPA in the sera of 100 children (apparently healthy) aged from 0 to 6 years. Well-defined criteria as guide-lines to the interpretation of laboratory results are a very urgent necessity for the expanding utilization of clinical laboratory dat...
journal_title：Minerva pediatrica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1994-11-01 00:00:00
abstract：BACKGROUND:A drug-related problem (DRP) may be defined as "an event or circumstance involving drug therapy that actually or potentially interferes with the desired health outcome". Our aim was to determine the frequency and characteristics of DRPs in pediatric patients admitted to a tertiary cardiac care center in the ...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2016-04-01 00:00:00
abstract：:A case of phakomatosis pigmentovascularis type IIa in a, short stature, 6-year old girl with nevus flammeus of the face and palate, bilateral ocular melanosis, aberrant mongolian spots and minor dysmorphic traits is reported. The patient has been considered at risk for glaucoma and ocular melanoma and an ophthalmologi...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1996-05-01 00:00:00
abstract：AIM:Myelomeningocele (MMC), among others functions, affects colorectal motility and bowel emptying, and often leads to constipation, faecal incontinence, or a combination of both. We investigated the benefits of transanal irrigation (TI) in children with MMC through the radiological study of intestinal transit time. M...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2013-06-01 00:00:00
abstract：:Both systolic and diastolic dysfunction in the pediatric population can be identified by bedside echocardiography and can guide therapy and evaluate response to therapy. Isolated diastolic dysfunction is rare in children; however many conditions can lead to systolic dysfunction. In this review various echocardiographi...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：2011-10-01 00:00:00
abstract：:The Femoral hypoplasia - unusual facies syndrome (FHUF) or Femoral - facial syndrome (FFS) was at first described in 1975. Up to now about 60 cases have been reported. According to our knowledge only 4 cases have had congenital central nervous system's malformations, furthermore the main stages of psychomotor developm...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2011-08-01 00:00:00
abstract：:Pharmacological profile of broxaterol, a new beta adrenergic compound, was investigated in 12 asthmatic children (6 male and 6 female with age 8-13 years). This study was performed from November to May, and venous blood was collected after 30, 45, 120, 180, 240 minutes from administration of 0.5 mg broxaterol; the uri...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1992-09-01 00:00:00
abstract：:A study was carried out to characterize in the growing skeleton the absorptiometric measurement of the ultradistal radial epiphysis where the trabecular bone is higher than at proximal scanning planes. The study showed that a radius scan, 1 to 1.4 cm proximal to the ulnar tip, and consequently 4 to 6 mm proximal to th...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1991-07-01 00:00:00
