Abstract：
INTRODUCTION:Chronic rhinosinusitis (CRS) is defined as an inflammatory disorder of the paranasal sinuses and of the nasal mucosa that lasts 12 weeks or longer. In CRS microbes contribute to the disease pathogenesis. Clinical microbiology is focused on finding single pathogens that causes the disease and the main goal is the use of antibiotics to kill bacteria. Efforts to achieve a better understanding of CRS include the study of the sinus microbiome, and to evaluate the ability of probiotics to augment homeostasis and modulate the immune response of the host mucosa. OBJECTIVE:This review provides an update on the role of the microbiome in CRS. METHODS:This review was conducted using two databases: PubMed and Science Direct. We searched for articles in English that matched the review topic. We first used the abstracts of articles to assess whether they met the inclusion criteria. We also reviewed the references of the selected articles and read those with titles that might be of interest. RESULTS:Several studies have shown that endogenous microbiome dysbiosis can impact mucosa health and disease severity. Some bacterial species presenting protective or pathogenic effect. Antimicrobial agents can create a similar disruption and impact the nasal microbiome balance. On the other hand, probiotics offers a promising avenue for developing systemic and topical therapies geared towards strategic manipulation of the biological host load, thereby augmenting immune homeostasis. CONCLUSIONS:A better comprehension of sinus-nasal microbiome in healthy and in CRS patients and the link with different CRS phenotype can help in developing new prognostics, diagnostics, and therapeutics strategies. Going forward, the use of probiotics can restore the native sinus ecology with significant therapeutic and preventive implications.
journal_name
Minerva Pediatrjournal_title
Minerva pediatricaauthors
Miraglia Del Giudice M,Parisi GF,Indolfi C,Manti S,Leonardi S,Decimo F,Ciprandi Gdoi
10.23736/S0026-4946.20.05850-8subject
Has Abstractpub_date
2020-07-29 00:00:00eissn
0026-4946issn
1827-1715pii
S0026-4946.20.05850-8pub_type
杂志文章abstract：:The authors present the developmental outcome of 16 children with congenital hypothyroidism diagnosed by screening in the neonatal period, using the Brazelton and the Dubowitz scales in the newborn and the Griffiths scale subsequently. Results are compared with those of a control group assessed at 6 and 18 months usin...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1989-04-01 00:00:00
abstract：:Syringocele is a cystic dilation of the excretory bulbourethral Cowper gland duct, and is a rather uncommon finding in pediatric age. It is frequently asymptomatic but sometimes may cause voiding symptoms and urinary tract infection (UTI). This case report describes an unusual manifestation of syringocele presenting w...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2009-02-01 00:00:00
abstract：:This is the first scientific study on Mary Sandrucci, who has been director of the Pediatric Clinic of the University of Turin from 1965-1966 up to 31 December 1989. Prof. Sandrucci led major studies on congenital heart disease, was the first Italian and among the first in Europe to describe phocomelia cases, to repor...
journal_title：Minerva pediatrica
pub_type： 传,历史文章,杂志文章
doi：
更新日期：2011-04-01 00:00:00
abstract：AIM:Optic pathway gliomas (OPG) are the predominant intracranial tumours associated with neurofibromatosis type 1 (NF1). The aim of this study was to evaluate the prevalence and the outcome of OPG in 200 NF1 patients (122 males and 78 females, aged 1-25 years) followed up to 16 years (mean of 6 years). METHODS:All chi...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2007-02-01 00:00:00
abstract：:Heart failure can be defined as the inability of the heart to sufficiently support the circulation. In the fetus, heart failure can be caused by a myriad of factors that include fetal shunting abnormalities, genetic cardiomyopathies, extracardiac malformations, arrhythmias and structural congenital heart disease. With...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：2012-10-01 00:00:00
abstract：AIM:Promoting physical activity is one of the main goals of health-promotion policies. The period of adolescence is characterised by a high rate of abandonment of any physical activity. In this age range, moreover, the risk of assuming substances in order to improve muscular-mass or athletic results is concrete. This s...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2004-06-01 00:00:00
abstract：INTRODUCTION:At present, morphine is the most commonly used first-line therapy to treat Neonatal Abstinence Syndrome (NAS). Unfortunately, there is still lack of evidence and consensus to guide pharmacologic therapy for NAS. In this review, we provide an overview on dosing regimens of morphine currently reported to tre...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：10.23736/S0026-4946.17.04928-3
更新日期：2019-06-01 00:00:00
abstract：:The care of adolescents suffering from high risk disease is a demanding challenge. At times, adolescents may well be too old for the pediatrician and Pediatric Units, and yet too young for the adult practitioner. A dedicated approach that builds on the insight deriving from special attention to, and reflection on the ...
journal_title：Minerva pediatrica
pub_type： 社论
doi：
更新日期：2011-04-01 00:00:00
abstract：AIM:This study analyses the organisational aspects and the volume of milk managed by the donated breast milk bank (banca del latte umano donato, BLUD) in Treviso. METHODS:The data gathered refer to the years 2003, 2004 and 2005. In particular the hygiene methodology is described in order to obtain a high-quality produ...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2007-08-01 00:00:00
abstract：BACKGROUND:The aim of the present study is to investigate the suicide and attempted suicide phenomenon among young people (<25 years old) in the Verbano-Cusio-Ossola province from January 1988 to December 2000. METHODS:This epidemiological-descriptive survey is based on the acquisition of data through the examination ...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2003-04-01 00:00:00
abstract：:Avascular necrosis (AN) of bone is a complication of systemic lupus erythematosus (SLE). In the present paper we describe two patients with SLE who presented an AN of femoral condyles 18 months and 2 years respectively after the diagnosis of the disease. In the second case, together with the destructive change of the ...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：BACKGROUND:Aim of study was to ascertain the possible presence of congenital dysplasia of the hip in infants (CDH) in the population immigrated from countries where the problem is surely neglected from the local health service and estimate its incidence. Moreover to observe the impact of the CDH problem on the parents ...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1997-10-01 00:00:00
abstract：:The role of etiology, pathogenesis and clinical symptoms in children with Atopic Dermatitis is evaluated. Eighteen patients with elimination diet were treated, without cow milk and egg, and with pharmacologic treatment (ketotiphene and cro molyn sodium) for two months. Dietary therapy and treatment however result in a...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1994-09-01 00:00:00
abstract：:Congenital dermal sinus represents a dysraphic state of the central nervous system. It can show up throughout a defect of the midline, of both the skull and the spine. Usually, the malformation presents a fistulous tract, connecting the skin with the underlying tissues (hypoderm, paraspinal muscles, vertebrae and, in ...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：1990-12-01 00:00:00
abstract：:A study was carried out to characterize in the growing skeleton the absorptiometric measurement of the ultradistal radial epiphysis where the trabecular bone is higher than at proximal scanning planes. The study showed that a radius scan, 1 to 1.4 cm proximal to the ulnar tip, and consequently 4 to 6 mm proximal to th...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1991-07-01 00:00:00
abstract：:Asthma is a condition characterised by airways inflammation and bronchial hyperresponsiveness to specific and aspecific spasmogens associated with reversible airways obstruction. The bronchomotor tone is the result of an interaction between neurotransmitter release and local mediators. The efferent neurohumoral pathwa...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：2000-11-01 00:00:00
abstract：BACKGROUND:The aim of our study was multifaceted neurodevelopmental examination of children born prematurely with very low birth weight (VLBW) in order to evaluate the usefulness of popularly used tests. The second aim of the study was exploration of risk and protective factors of neurodevelopmental impairment. METHOD...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：10.23736/S0026-4946.16.04513-8
更新日期：2019-08-01 00:00:00
abstract：OBJECTIVES:During a survey regarding infant health in 7 regions, diffusion and length of time of breast-feeding nowadays in Italy were studied. MATERIALS AND METHODS:By OMS Epi methodology, 210 children sampled from each area of study and specialized health workers carried out the interviews at home using a specific q...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1995-11-01 00:00:00
abstract：:Between 1973 and 1993 7 perineal testis are observed and operated on in our surgical department. The perineal testis is a rare ectopic testis probably caused by some mechanical obstacles in the entrance of the testis in the scrotum. A diagnosis is easy if also the less frequent localizations of testicular ectopia are ...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1993-11-01 00:00:00
abstract：:The introduction of the new diagnostic tools for neuroimaging has resulted in the early recognition of congenital brain tumors. In the present report we describe 39 children, in whom the diagnosis of an intracranial tumor has been obtained during the first 12 months of life. These patients represent 14.4% of a pediatr...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1990-11-01 00:00:00
abstract：:Both systolic and diastolic dysfunction in the pediatric population can be identified by bedside echocardiography and can guide therapy and evaluate response to therapy. Isolated diastolic dysfunction is rare in children; however many conditions can lead to systolic dysfunction. In this review various echocardiographi...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：2011-10-01 00:00:00
abstract：BACKGROUND:In the last years thalassemic patients gained a good improvement in prognosis and life style. However, short stature and hypogonadism are still frequent endocrine problems in this population. METHODS:In a group of eleven thalassemic males (14-18 years old), the spontaneous nocturnal endocrine patterns of LH...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1998-05-01 00:00:00
abstract：:Biliary atresia is a severe neonatal malformation in which the entire extrahepatic biliary tract or part of it is absent and replaced by fibrosclerotic tissue. Having been described for the first time by Thomson in 1891, biliary atresia has an incidence of 1:10,000-15,000 live neonates with a slight predominance in th...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2001-08-01 00:00:00
abstract：AIM:In the last few years we noted an increasing number of children with celiac disease with negative serum anti-gliadin antibodies (AGA) a useful serologic test to monitor compliance to gluten-free diet. The aim of this study was to verify diagnostic accuracy of AGA and compare clinical characteristics of AGA-negative...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2010-04-01 00:00:00
abstract：:Varicella or chickenpox is a common and highly contagious exanthematic disease caused by the varicella-zoster virus (VZV) that during primary infection has the ability to establish latency. VZV reactivation, even decades after primary infection, causes herpes zoster. In healthy immunocompetent subjects, children in pa...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：2016-06-01 00:00:00
abstract：BACKGROUND:Infections due to carbapenem resistant pathogens have become a major health threat especially for hospitalized patients. Acinetobacter baumanii (AB) and Pseudomonas aeruginosa (PA) are important pathogens causing ventilator-associated pneumonia (VAP) with a trend of high resistance to carbapenems. The aim of...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：10.23736/S0026-4946.17.04284-0
更新日期：2019-08-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to asses the validity of the TCB nomogram for the European population for predicting significant hyperbilirubinemia in healthy term and late-preterm newborns. METHODS:This observational study was conducted from February 2009 to December 2009 in the well-baby nurseries of Gemelli hos...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2010-06-01 00:00:00
abstract：:Idiopathic pulmonary fibrosis is characterized by radiographically evident interstitial infiltrates and progressive dyspnea with rapid decline of overall lung functions. The clinical course of this disease is highly variable; however, its prognosis remains poor without adequate and prompt therapeutical support. Due to...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：2004-04-01 00:00:00
abstract：:Patients with chronic kidney disease (CKD) show a broad spectrum of clinical symptoms intimately related to the disturbed mineral and bone metabolism and summarized as CKD-mineral-bone disorder (CKD-MBD). Whereas in adults an impaired bone metabolism translates mainly into an increased risk of fractures, in pediatric ...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：2010-06-01 00:00:00
abstract：AIM:The median urinary iodine concentration (UIC) for schoolchildren was 90 microg/L in Biella and 136 microg/L in Novara in survey carried out in 1995-1996. Biella resulted as iodine deficiency area and Novara as iodine sufficient area. Aim of our study was to assess goiter prevalence by ultrasonography in Biella and ...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2006-06-01 00:00:00
