Phase I trial of the MET inhibitor tepotinib in Japanese patients with solid tumors.

abstract：:Human gastrin-releasing peptide (GRP) mRNA was detected in the tumor tissues of medullary thyroid carcinomas and small cell lung carcinomas using synthetic oligodeoxyribonucleotides as hybridization probes. The amount of GRP mRNA was estimated by radiodensitometric hybridization assay. A good correlation was found bet...

journal_title：Japanese journal of clinical oncology

authors： Suzuki M,Yamaguchi K,Abe K,Adachi N,Nagasaki K,Asanuma F,Adachi I,Kimura S,Terada M,Taya Y

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND:It is common that patients with head and neck cancers have secondary malignant neoplasm of esophageal cancer. METHODS:To know the genetic background of the development of these secondary cancers, we performed microsatellite assay at six loci and immunohistochemical analysis on head and neck cancers of eight...

journal_title：Japanese journal of clinical oncology

authors： Kiriu H,Yokozaki H,Yasui W,Ito K,Tahara E

更新日期：1998-12-01 00:00:00

abstract：OBJECTIVE:There have been no previous studies about consultation of the bereaved who have lost a loved one to cancer and ask for medical help. The aim of this study was to investigate their basic characteristics and their psychiatric disorders. METHODS:A retrospective study using clinical and background data obtained ...

journal_title：Japanese journal of clinical oncology

authors： Ishida M,Onishi H,Wada M,Tada Y,Ito H,Narabayashi M,Sasaki Y,Nomura S,Uchitomi Y

更新日期：2011-03-01 00:00:00

abstract：:A Phase II trial was initiated in Japan to evaluate the efficacy and safety of preoperative chemotherapy with docetaxel, cisplatin and S-1 for gastric cancer with extensive lymph node metastasis. Patients are eligible to participate in the study if they have para-aortic lymph node metastases (stations no. 16a2/16b1) a...

journal_title：Japanese journal of clinical oncology

authors： Katayama H,Ito S,Sano T,Takahari D,Mizusawa J,Boku N,Tsuburaya A,Terashima M,Sasako M,Stomach Cancer Study Group of the Japan Clinical Oncology Group.

更新日期：2012-06-01 00:00:00

abstract：Background:Gliomas are highly malignant brain tumors. Aberrant activation of NF-κB plays a crucial role in tumor progression. Method:ELISA assay was used to detect NF-κB activity in glimoas cells with different treatments. PPP3CC expression was evaluated by qRT-PCR and western blot assay. Kaplan-Meier analysis estimat...

journal_title：Japanese journal of clinical oncology

authors： Wang H,Zhao S,Chen B,Fu C,Dang Y,Fang P,Wang J,Wang N,Liu L

更新日期：2018-02-01 00:00:00

abstract：:A combined ischiopubic rami resection is extremely rare in the field of gastroenterologic surgery. We report a case of a locally recurrent rectal cancer that was successfully treated by total pelvic exenteration with combined ischiopubic rami resection. A 58-year-old male with locally recurrent rectal cancer and liver...

journal_title：Japanese journal of clinical oncology

authors： Uehara K,Yoshioka Y,Taguchi Y,Igami T,Ebata T,Yokoyama Y,Sugawara G,Tsukushi S,Nishida Y,Yoshino Y,Nagino M

更新日期：2012-01-01 00:00:00

abstract：:Among 492 patients with esophageal carcinoma who received resective surgery, 102 survived over 5 years. These 5-year survivors were analyzed according to many factors. Females had a better prognosis than males, and patients without lymph-node metastasis had a better 5-year survival rate than those with it. Ten patient...

journal_title：Japanese journal of clinical oncology

authors： Iizuka T,Kato H,Watanabe H

更新日期：1985-06-01 00:00:00

abstract：Background:The impact of age as a prognostic factor for patients with colorectal cancer (CRC) remains controversial, possibly due to heterogeneity between studies in terms of patient numbers, percentage of patients undergoing curative resection, percentage of patients receiving neoadjuvant therapy, or failure to adjust...

journal_title：Japanese journal of clinical oncology

authors： Chou CL,Tseng CJ,Shiue YL

更新日期：2017-11-01 00:00:00

abstract：:The joint international symposium of the 22nd Hiroshima Cancer Seminar and the 4th Japanese Association for RNA Interference focused on a pivotal role of microRNAs in carcinogenesis, progression and therapy of human cancer. Mammalian immune regulator MCPIP1 (Zc3h12a) RNase acts as a novel suppressor of microRNA activi...

journal_title：Japanese journal of clinical oncology

authors： Tahara H,Kay MA,Yasui W,Tahara E

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:There are few reports of the outcomes of external beam radiotherapy in Asian males with localized prostate cancer. The aim of this study is to evaluate the long-term outcomes of external beam irradiation using three-dimensional two-dynamic conformal arc therapy, combined with neoadjuvant hormonal therapy, in ...

journal_title：Japanese journal of clinical oncology

authors： Ikeda I,Mizowaki T,Norihisa Y,Takayama K,Kamba T,Inoue T,Nakamura E,Kamoto T,Ogawa O,Hiraoka M

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:The serum erythropoietin level increases markedly during chemotherapy for leukemia. A number of hypotheses have been built for the mechanism, none of them satisfactory. Difficulty in evaluating bone marrow activity hampers the elucidation. Therefore, we focused on patients who had non-hematological cancer an...

journal_title：Japanese journal of clinical oncology

authors： Sawabe Y,Takiguchi Y,Kikuno K,Iseki T,Ito J,Iida S,Kuriyama T,Yonemitsu H

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:We evaluated whether color Doppler ultrasound (US) had diagnostic accuracy equal to dynamic computed tomography (CT) and whether performing dynamic CT and Doppler US together would be more informative in preoperative diagnosis of renal solid tumors. METHODS:A total of 110 renal solid tumors smaller than 7 c...

journal_title：Japanese journal of clinical oncology

authors： Kitamura H,Fujimoto H,Tobisu K,Mizuguchi Y,Maeda T,Matsuoka N,Komiyama M,Nakagawa T,Kakizoe T

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:Docetaxel plus cisplatin (DP) is a combination chemotherapy regimen that is active against untreated advanced gastric cancer. We evaluated the feasibility of DP treatment in patients with recurring or metastatic gastric cancer who had been previously treated with other chemotherapy regimens. PATIENTS AND ME...

journal_title：Japanese journal of clinical oncology

authors： Kim H,Park JH,Bang SJ,Kim DH,Cho HR,Kim GY,Min YJ

更新日期：2005-12-01 00:00:00

abstract：:Cancer causes profound suffering for patients, and previous reports have demonstrated that psychological distress, particularly depression, is frequently observed in advanced and/or terminally ill cancer patients. Such depression can lead to serious and far-reaching negative consequences in patients with advanced canc...

journal_title：Japanese journal of clinical oncology

authors： Akechi T

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:The majority of patients with localized and some cases of locally advanced prostate cancer undergo radical prostatectomy. However, radical prostatectomy cannot always be selected for those patients. In this situation, primary hormone therapy is an alternative treatment option. We have designed a prospective ...

journal_title：Japanese journal of clinical oncology

authors： Akaza H,Homma Y,Okada K,Yokoyama M,Moriyama N,Usami M,Hirao Y,Tsushima T,Ohashi Y,Aso Y

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVE:Second primary malignancies have become the leading cause of death in retinoblastoma survivors. Although osteosarcoma is the most common second malignancy, little is known about its clinical and therapeutic features. METHODS:We retrospectively reviewed a database of patients with retinoblastoma and osteosarc...

journal_title：Japanese journal of clinical oncology

authors： Fujiwara T,Fujiwara M,Numoto K,Ogura K,Yoshida A,Yonemoto T,Suzuki S,Kawai A

更新日期：2015-12-01 00:00:00

abstract：:Cancer is the leading cause of mortality in Singapore. The age-standardized incidence rates continue to increase as the population grows and ages, and the influence of environmental and lifestyle choices bear their consequences. The increase is most marked in colorectal, breast and prostate cancers, mirroring the most...

journal_title：Japanese journal of clinical oncology

authors： Teo MC,Soo KC

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:To assess the resectability rate of patients with initially unresectable liver-only metastases from colorectal cancer (CRC) after treatment with irinotecan/capecitabine. METHODS:Patients received irinotecan (240 mg/m(2)) as a 30 min intravenous infusion on day 1 and capecitabine (1000 mg/m(2)) orally bid for...

journal_title：Japanese journal of clinical oncology

authors： Zhao R,Zhu J,Ji X,Cai J,Wan F,Li Q,Zhong B,Tucker S,Wang D

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:To describe computed tomographic (CT) features of highly enhanced hepatic masses as seen on CT during arterial portography (CTAP) and to survey the varieties of hepatic lesions associated with such findings. METHODS:CTAP files for 400 patients were reviewed, on the basis of which six patients with highly en...

journal_title：Japanese journal of clinical oncology

authors： Onaya H,Itai Y,Satake M,Luo T,Saida Y,Haruno M,Hasebe T,Moriyama N

更新日期：2000-10-01 00:00:00

abstract：OBJECTIVE:In Japan, there had been no prospective clinical studies conducted in terms of modified FOLFOX6 + bevacizumab therapy. We performed a post-marketing Phase II multicenter clinical study to examine the efficacy and safety of this regimen as first-line therapy for Japanese patients with advanced/recurrent colore...

journal_title：Japanese journal of clinical oncology

authors： Nishina T,Takano Y,Denda T,Yasui H,Takeda K,Ura T,Esaki T,Okuyama Y,Kondo K,Takahashi Y,Sugiyama Y,Muro K

更新日期：2013-11-01 00:00:00

abstract：:The Japan Public Health Center-based prospective Study conducted a baseline survey for 140 000 registered residents aged 40-69 years within 11 public health center areas nationwide in 1990-94. Five- and 10-year follow-up surveys were conducted to update information on lifestyle habits and health conditions. In total, ...

journal_title：Japanese journal of clinical oncology

authors： Tsugane S,Sawada N

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:The outcomes of patients with localized or locally advanced prostate cancer treated with external-beam radiotherapy are not well known in Japan. METHODS:Thirty-four institutions combined data on 679 patients with localized or locally advanced prostate cancer treated with a total dose >/=60 Gy between 1995 a...

journal_title：Japanese journal of clinical oncology

authors： Nakamura K,Mizowaki T,Imada H,Karasawa K,Uno T,Onishi H,Nihei K,Sasaki S,Ogura M,Akimoto T

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:The treatment modality for desmoid-type fibromatosis has shifted from surgery to conservative treatment. This systematic review aims to evaluate the efficacy of low-dose chemotherapy with methotrexate and vinblastine for patients with extra-abdominal desmoid-type fibromatosis. METHODS:We searched the pertine...

journal_title：Japanese journal of clinical oncology

authors： Shimizu K,Hamada S,Sakai T,Koike H,Yoshida M,Nishida Y

更新日期：2020-04-07 00:00:00

abstract：:Immunohistochemical studies using antisera to keratin and secretory component (SC) and monoclonal antibody against leukocyte common antigen (LCA) were performed on 92 biopsy and autopsy specimens taken from 65 patients with nasopharyngeal carcinoma. Five biopsy specimens from malignant lymphoma of the nasopharynx and ...

journal_title：Japanese journal of clinical oncology

authors： Nomori H,Kameya T,Shimosato Y,Saito H,Ebihara S,Ono I

更新日期：1985-03-01 00:00:00

abstract：:Fibroadenoma of the breast is a common benign disease, occurring mainly in females younger than 30 years of age. Infant fibroadenoma is extremely rare. Here, we report on a 16-month-old female with a 6 month history of unilateral progressive breast enlargement. Upon clinical evaluation, a palpable mass was observed in...

journal_title：Japanese journal of clinical oncology

authors： Shi A,Li S,Xu N,Nie G,Li X,Zhang T,Fan Z

更新日期：2011-02-01 00:00:00

abstract：OBJECTIVE:The value of postmastectomy radiation therapy for breast cancer patients with T1-2 tumor and one to three positive nodes remains controversial. The purpose of this retrospective study was to compare the clinical outcomes of breast cancer patients with T1-2 and one to three positive nodes with and without post...

journal_title：Japanese journal of clinical oncology

authors： Huang CJ,Hou MF,Chuang HY,Lian SL,Huang MY,Chen FM,Fu OY,Lin SF

更新日期：2012-08-01 00:00:00

abstract：:A system for reconstructing three dimensional (3-D) images from ultrasonography using a linearly moving mirror was modified. The device could display the 3-D structure of objects in real time by employing an on-line system. In a case of hepatocellular carcinoma, structures of the tumor and blood vessels were selective...

journal_title：Japanese journal of clinical oncology

authors： Kawabata M,Mochida S,Fujiwara K,Yamanaka R,Yamamoto K,Yoshikura H

更新日期：1992-02-01 00:00:00

abstract：OBJECTIVE:This study was conducted to evaluate the efficacy and safety of pegylated liposomal doxorubicin (PLD) in Japanese patients with Müllerian carcinoma having a therapeutic history of platinum-based chemotherapy. METHODS:Patients who were diagnosed with Müllerian carcinoma (epithelial ovarian carcinoma, primary ...

journal_title：Japanese journal of clinical oncology

authors： Katsumata N,Fujiwara Y,Kamura T,Nakanishi T,Hatae M,Aoki D,Tanaka K,Tsuda H,Kamiura S,Takehara K,Sugiyama T,Kigawa J,Fujiwara K,Ochiai K,Ishida R,Inagaki M,Noda K

更新日期：2008-11-01 00:00:00

abstract：:The prognosis of multiple myeloma was quite poor in the last century, but it has significantly improved with the incorporation of novel agents, immunomodulatory drugs (IMiDs) and proteasome inhibitors. Thalidomide was first developed as a sedative in 1950s, but it was withdrawn from the market because of teratogenicit...

journal_title：Japanese journal of clinical oncology

authors： Abe Y,Ishida T

更新日期：2019-08-01 00:00:00

abstract：:A double blind study to compare the efficacy of oral UFT (400 mg Tegafur (FT) plus 896 mg uracil/day) with that of oral FT (800 mg/day) on advanced breast cancer was performed between November, 1986, and November, 1989. Sixty patients were registered for the trial and fifty-six cases were evaluated (28 for UFT and 28 ...

journal_title：Japanese journal of clinical oncology

authors： Tashiro H,Nomura Y,Ohsaki A

更新日期：1994-08-01 00:00:00