当前位置： SCI文献检索 > Travel Medicine and Infectious Disease期刊下所有文献 > Neutralizing antibody persistence in pediatric travelers from non-JE-endemic countries following vaccination with IXIARO® Japanese encephalitis vaccine: An uncontrolled, open-label phase 3 follow-up study.

Neutralizing antibody persistence in pediatric travelers from non-JE-endemic countries following vaccination with IXIARO® Japanese encephalitis vaccine: An uncontrolled, open-label phase 3 follow-up study.

Abstract：

BACKGROUND:In an initial study among children from non-Japanese encephalitis (JE)-endemic countries, seroprotection rates remained high 6 months after completion of the primary series with IXIARO®. METHODS:In this open-label follow-up study, a subset of 23 children who received a 2-dose primary series of IXIARO® in the parent study, were evaluated for safety and neutralizing antibody persistence for 36 months. RESULTS:Seroprotection rates (SPRs) remained high but declined from 100% one month after primary immunization to 91.3% at month 7 and 89.5% at month 36. Geometric mean titers (GMTs) declined considerably from 384.1 by day 56-60.8 at month 36. No long-term safety concerns were identified. CONCLUSIONS:The substantial decline in GMT observed in this study, together with previously published data on children vaccinated with IXIARO® support the recommendation for a booster dose in children who remain at risk of JE from 1 year after the primary series of IXIARO®, consistent with the recommendation for adults. CLINICAL TRIAL REGISTRY NUMBER:NCT01246479.

journal_name

Travel Med Infect Dis

journal_title

Travel medicine and infectious disease

authors

Taucher C,Barnett ED,Cramer JP,Eder-Lingelbach S,Jelinek T,Kadlecek V,Kiermayr S,Mills DJ,Pandis D,Reiner D,Dubischar KL

doi

10.1016/j.tmaid.2020.101616

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

101616

eissn

1477-8939

issn

1873-0442

pii

S1477-8939(20)30084-3

journal_volume

34

pub_type

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