Abstract:
BACKGROUND:The pathogenesis of malaria is the result of complex interactions between parasites, host and environment. Several studies have assessed the role of genetic characteristics of Plasmodium falciparum infection in the clinical severity of malaria infection comparing different genotypic determinants in mild and severe cases. The genes encoding the polymorphic merozoite surface proteins 1 (msp-1) and 2 (msp-2) and the dihydrofolate reductase (dhfr) of malaria parasites have been extensively used as markers to investigate the genetic diversity and the population structure of P. falciparum. The aim of this study was to assess the epidemiological, clinical, host- and parasite-related determinant factor of the genetic diversity of P. falciparum infections in travellers returning to Italy. METHODS:Between 1998 and 2001, we have retrospectively studied 64 inpatients all returning from African malaria-endemic countries. Designation of severe malaria was determined by using the World Health Organization (WHO) definition. P. falciparum infections detected by species-specific PCR were genotyped at the msp-1 and msp-2 loci and clones were determined. PCR and enzyme-digestion methods were used to screen the mutation occurring at codon 108. RESULTS:Multiple P. falciparum genotypes were detected in 32 patients (50%). The number of genotypes was correlated to different host characteristics. No association was found between allelic number of msp-1 or msp-2 and season of travel, absence of antimalarial prophylaxis, length of stay or blood parasitemia. At multiple analysis adjusted for few confounding variables, two variables showed a significant association with multiplicity of P. falciparum genotypes: male gender (p=0.018) and severity of disease (p=0.044). CONCLUSION:In our study all but one patients with severe malaria had a infection with a multiplicity of P. falciparum clones. At multivariate analysis the male gender, and the occurrence of severe malaria were significantly more commonly detected in patients affected by imported malaria with multiple clones.
journal_name
Travel Med Infect Disjournal_title
Travel medicine and infectious diseaseauthors
Nicastri E,Paglia MG,Severini C,Ghirga P,Bevilacqua N,Narciso Pdoi
10.1016/j.tmaid.2008.01.001subject
Has Abstractpub_date
2008-07-01 00:00:00pages
205-9issue
4eissn
1477-8939issn
1873-0442pii
S1477-8939(08)00002-1journal_volume
6pub_type
杂志文章abstract::International travel is changing the epidemiology of imported malaria. Our aim was to study malaria prophylaxis administered to travellers from Greece. The study was conducted during 2008-2009. Data were collected using a standardized form. A total of 2337 travellers were studied; prophylaxis was recommended to 60.2% ...
journal_title:Travel medicine and infectious disease
pub_type: 杂志文章
doi:10.1016/j.tmaid.2011.09.005
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:The diagnosis of acute malaria in non-endemic countries is still carried out largely by microscopic examination of thick and thin smears or rapid diagnostic tests. Low-density infections might be missed, however, but the more sensitive PCR is more expensive, complex and requires considerable more time. METH...
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journal_title:Travel medicine and infectious disease
pub_type: 杂志文章
doi:10.1016/j.tmaid.2009.08.001
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journal_title:Travel medicine and infectious disease
pub_type: 杂志文章
doi:10.1016/j.tmaid.2008.07.002
更新日期:2008-11-01 00:00:00
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journal_title:Travel medicine and infectious disease
pub_type: 杂志文章
doi:10.1016/j.tmaid.2006.01.015
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:Infectious diseases are a frequent cause of morbidity in French troops deployed abroad. They are usually minor in severity and managed by field practitioners. We aimed to describe the etiological spectrum of travel-related infections in French soldiers evacuated to a level 4 military treatment facility. MET...
journal_title:Travel medicine and infectious disease
pub_type: 杂志文章
doi:10.1016/j.tmaid.2014.03.005
更新日期:2014-07-01 00:00:00
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journal_title:Travel medicine and infectious disease
pub_type: 杂志文章
doi:10.1016/j.tmaid.2016.10.005
更新日期:2016-01-01 00:00:00
abstract::A case is presented of intestinal schistosomiasis due to both Schistosoma intercalatum and Schistosoma mansoni in a 30-year-old man from Senegal with discussion of diagnostic approach, species identification and determination of the effect of treatment. The patient was admitted to hospital for investigation of renal f...
journal_title:Travel medicine and infectious disease
pub_type: 杂志文章
doi:10.1016/j.tmaid.2010.04.003
更新日期:2010-05-01 00:00:00
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journal_title:Travel medicine and infectious disease
pub_type: 杂志文章,评审
doi:10.1016/j.tmaid.2011.01.002
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abstract:BACKGROUND:In 2018, tafenoquine was approved for malaria chemoprophylaxis. We evaluated all available data on the safety and efficacy of tafenoquine chemoprophylaxis. METHODS:This systematic review followed the PRISMA guidelines and was registered on PROSPERO (CRD42019123839). We searched PubMed, Embase, Scopus, CINAH...
journal_title:Travel medicine and infectious disease
pub_type: 杂志文章
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journal_title:Travel medicine and infectious disease
pub_type: 杂志文章
doi:10.1016/j.tmaid.2007.08.004
更新日期:2008-05-01 00:00:00
abstract::A male patient developed acute pulmonary histoplasmosis 2 weeks after bathing in the water falls of Wli, Ghana. Exposure to Histoplasma capsulatum was probably mediated through inhalation of an aerosol of water and guano from the large colony of fruit bats of the falls. More cases of acute pulmonary histoplasmosis can...
journal_title:Travel medicine and infectious disease
pub_type: 杂志文章
doi:10.1016/j.tmaid.2005.10.004
更新日期:2006-09-01 00:00:00
abstract::Schistosomiasis is a common intravascular trematode infection. The snail/human lifecycle is illustrated. Travellers who acquire the infection are often asymptomatic, but nearly always give a history of fresh water exposure in endemic countries when asked. The various manifestations of symptomatic schistosomiasis are d...
journal_title:Travel medicine and infectious disease
pub_type: 杂志文章
doi:10.1016/j.tmaid.2004.02.011
更新日期:2004-02-01 00:00:00
abstract:BACKGROUND:Post-Traumatic Stress Disorder (PTSD) has been described as one of the most frequently reported mental condition among refugees and internally displaced populations (IDPs). Despite this, few has been reported about it in Latin America, even in Colombia, the country with the highest number of IDPs in the in t...
journal_title:Travel medicine and infectious disease
pub_type: 杂志文章
doi:10.1016/j.tmaid.2017.02.008
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:Among deployed U.S. military personnel, a sub-population of international travelers, acute infectious diarrhea continues to be a leading cause of morbidity and a potential threat to military effectiveness. METHODS:To assess outcomes and satisfaction of diarrhea management in the field, a systematic survey...
journal_title:Travel medicine and infectious disease
pub_type: 杂志文章
doi:10.1016/j.tmaid.2009.09.001
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:We sought to describe travel-related illness among our residents and gain insight into targeting pre-travel health advice to prevent travel-related illness. METHODS:A supplemental travel questionnaire was developed and administered for cases with a legally notifiable communicable disease reported in 2011-20...
journal_title:Travel medicine and infectious disease
pub_type: 杂志文章
doi:10.1016/j.tmaid.2014.05.005
更新日期:2014-09-01 00:00:00
abstract::Tungiasis is a parasitic skin disease caused by the penetration of female sand fleas (Tunga penetrans). It is acquired when people walk barefoot or rest on soil, where sand fleas have completed the off-host cycle. Tungiasis is a classic poverty-associated disease which belongs to the family of neglected tropical disea...
journal_title:Travel medicine and infectious disease
pub_type: 杂志文章,评审
doi:10.1016/j.tmaid.2013.10.001
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Increasing numbers of sporadic cases of melioidosis in returning travelers have been reported from non-endemic regions. METHODS:We report a new case and undertook a literature review. RESULTS:Eighty-two travelers with melioidosis infection were included. The mean age was 50.95 years, with only one case <15...
journal_title:Travel medicine and infectious disease
pub_type: 杂志文章,评审
doi:10.1016/j.tmaid.2015.08.007
更新日期:2015-09-01 00:00:00
abstract::The number of travellers returning with animal bites from rabies enzootic areas has increased in Greece. The aim of this study was to assess the knowledge of travel-associated risk and preventive measures for rabies. A questionnaire was sent to Travel Medicine consultants in all prefectures. Of 100 Travel Medicine con...
journal_title:Travel medicine and infectious disease
pub_type: 杂志文章
doi:10.1016/j.tmaid.2010.11.004
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Routine vaccination for children drastically reduces measles cases. Nonetheless, the global resurgence of measles since 2018 highlights the need for evaluating vaccine-induced immunity in an era of high vaccination coverage, especially in international travelers. This study aims to identify high-risk persons...
journal_title:Travel medicine and infectious disease
pub_type: 杂志文章
doi:10.1016/j.tmaid.2020.101804
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:The absolute number of travel-related Chlamydia cases in Sweden has consistently increased between 2000 and 2013. Given the growth in international travel, we aimed to study the trends of travel-related Chlamydia incidence to determine differences and identify high-risk groups and destinations. METHODS:For ...
journal_title:Travel medicine and infectious disease
pub_type: 杂志文章
doi:10.1016/j.tmaid.2018.02.008
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:In France, no previous studies have focused specifically on health problems among medical students during internships abroad including the clinical symptoms suggestive of infectious diseases and the acquisition of pathogen carriage. METHODS:Clinical follow up and qPCR based respiratory, gastrointestinal and...
journal_title:Travel medicine and infectious disease
pub_type: 杂志文章
doi:10.1016/j.tmaid.2019.101548
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Leptospirosis is an important zoonosis worldwide, nevertheless is often poor recognized in non tropical settings. In Thailand is becoming an emerging disease and Chiang Mai could become a popular spot to acquire the disease amongst travelers. METHODS:We describe three cases of imported leptospirosis undiffe...
journal_title:Travel medicine and infectious disease
pub_type: 杂志文章
doi:10.1016/j.tmaid.2018.02.013
更新日期:2018-01-01 00:00:00
abstract::Objectives. To examine fatal and non-fatal incidents involving tourists in Hawaii Volcanoes National Park. Methods. Official press releases from the public relations office at Hawaii Volcanoes National Park were examined for reports of fatal and non-fatal incidents involving tourists. Results. Between 1992 and 2002 th...
journal_title:Travel medicine and infectious disease
pub_type: 杂志文章
doi:10.1016/j.tmaid.2004.09.004
更新日期:2005-08-01 00:00:00
abstract::Visceral leishmaniasis (VL) serosurvey was carried out on 49 HIV/AIDS patients among 500 asymptomatic HIV/infected patients who registered in the Khorasan Razavi Province during the last 14 years. HIV infections were detected by ELISA and confirmed using western blot assay at the AIDS centre of the Khorasan Razavi Pro...
journal_title:Travel medicine and infectious disease
pub_type: 杂志文章
doi:10.1016/j.tmaid.2013.09.001
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Leprosy remains infrequent in non-endemic areas. The objective of this study was to describe the cases of leprosy reviewed at a referral unit for imported diseases in Europe and to compare these findings with published data on imported leprosy. METHODS:Cases of leprosy evaluated at a referral centre are des...
journal_title:Travel medicine and infectious disease
pub_type: 杂志文章,评审
doi:10.1016/j.tmaid.2016.06.008
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Overuse and misuse of antibiotics have been reported in Hajj. However, little is known about Knowledge, Attitude and Practice (KAP) of pilgrims themselves in relation to these agents. METHODS:Adult pilgrims from seven countries attending the 2015 Hajj were interviewed using a structured KAP questionnaire. ...
journal_title:Travel medicine and infectious disease
pub_type: 杂志文章
doi:10.1016/j.tmaid.2018.08.004
更新日期:2019-01-01 00:00:00
abstract::Adverse reactions following vaccination are rare but may include potentially fatal anaphylaxis. This audit is a retrospective review of 38 patients with a history, or potential risk, of 'vaccine allergy' referred to an Infectious Diseases Unit for vaccination over a 10 year period. A total of 59 patient encounters wer...
journal_title:Travel medicine and infectious disease
pub_type: 杂志文章
doi:10.1016/j.tmaid.2011.08.003
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:After serious epidemics of chikungunya (CHIKV) and Zika (ZIKV) in the Americas, dengue (DENV) have reemerged in most countries. We analyzed the incidence, incidence rates, and evolution of DENV cases in Honduras from 2015 to 2018 and the ongoing 2019 epidemic. METHODS:Using epidemiological weeks (EW) survei...
journal_title:Travel medicine and infectious disease
pub_type: 杂志文章
doi:10.1016/j.tmaid.2019.101517
更新日期:2019-11-09 00:00:00
abstract::Australia has a well-developed tourism industry and health care system. Despite the precautions recommended in this paper, Australia has been virtually free of local outbreaks of life threatening tropical diseases in recent decades. This paper focuses on health and safety issues for travellers to Australia, especially...
journal_title:Travel medicine and infectious disease
pub_type: 杂志文章
doi:10.1016/S1477-8939(03)00020-6
更新日期:2003-05-01 00:00:00