Abstract：
BACKGROUND:Global travellers are increasingly at risk of contracting malaria. The increasing occurrence of drug-resistance in many endemic areas emphasizes the need for novel drug targets for antimalarial-screening. In this study, the use of pyruvate kinase as a drug-target is evaluated. The functional validation of a gene encoding pyruvate kinase (designated PK1) has previously been reported. However, alternative copies of this enzyme encoded by Plasmodium falciparum could also circumvent the role of PK1. A survey of genome data revealed a putative ORF seemingly coding for another pyruvate kinase (designated PK2). METHODS:The expression of PK1 and PK2 in in vitro cultures were investigated by RT-PCR. Biocomputational analysis was carried out to identify structural differences between the P. falciparum pyruvate kinases and the corresponding enzymes from its human host. RESULTS:Both PK1 and PK2 were indeed actively transcribed during the intraerythrocytic stages, suggesting the involvement of both enzymes during infection. A comparison of amino acid residues at the effector binding sites of PK1 and PK2, to those of the human pyruvate kinases revealed some significant differences that could serve as targets for selective inhibitors to be designed against parasitic pyruvate kinases. CONCLUSION:Experimental evidence for the expression of both PK1 and PK2 during the blood stages of malaria infection was provided. Interestingly, phylogenetic analysis revealed that the "PK2" type of enzyme appears to be confined to Apicomplexans, an important observation with respect to the assessment of PK2 as a drug-target.
journal_name
Travel Med Infect Disjournal_title
Travel medicine and infectious diseaseauthors
Chan M,Tan DS,Sim TSdoi
10.1016/j.tmaid.2006.01.015subject
Has Abstractpub_date
2007-03-01 00:00:00pages
125-31issue
2eissn
1477-8939issn
1873-0442pii
S1477-8939(06)00021-4journal_volume
5pub_type
杂志文章abstract：BACKGROUND:In France, no previous studies have focused specifically on health problems among medical students during internships abroad including the clinical symptoms suggestive of infectious diseases and the acquisition of pathogen carriage. METHODS:Clinical follow up and qPCR based respiratory, gastrointestinal and...
journal_title：Travel medicine and infectious disease
pub_type： 杂志文章
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更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:The potential for transmission of Mycobacterium tuberculosis during air travel has garnered considerable attention in the media and among public health authorities due to high-profile cases of international travelers with infectious tuberculosis (TB). METHODS:During 2007 and 2008, state and local health off...
journal_title：Travel medicine and infectious disease
pub_type： 杂志文章
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journal_title：Travel medicine and infectious disease
pub_type： 杂志文章
doi：10.1016/j.tmaid.2020.101901
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journal_title：Travel medicine and infectious disease
pub_type： 杂志文章
doi：10.1016/j.tmaid.2009.05.006
更新日期：2009-07-01 00:00:00
abstract：:Cutaneous myiasis caused by Dermatobia hominis, the human botfly, involves the infestation of human tissue with fly larvae, and is common in Central and South America. We report a case of a 57-year-old man with cutaneous myiasis imported into the US from Belize. The epidemiology, biological life cycle, clinical presen...
journal_title：Travel medicine and infectious disease
pub_type： 杂志文章
doi：10.1016/j.tmaid.2006.09.005
更新日期：2007-05-01 00:00:00
abstract：BACKGROUND:Routine vaccination for children drastically reduces measles cases. Nonetheless, the global resurgence of measles since 2018 highlights the need for evaluating vaccine-induced immunity in an era of high vaccination coverage, especially in international travelers. This study aims to identify high-risk persons...
journal_title：Travel medicine and infectious disease
pub_type： 杂志文章
doi：10.1016/j.tmaid.2020.101804
更新日期：2020-01-01 00:00:00
abstract：:Tungiasis is an endemic disease in many resource-poor communities some of which are in South America, which are visited frequently by Spanish travelers. Its diagnosis can be improved with the knowledge of the typical presentation and the correct management of its injuries. We report the first four cases identified of ...
journal_title：Travel medicine and infectious disease
pub_type： 杂志文章
doi：10.1016/j.tmaid.2011.03.005
更新日期：2011-05-01 00:00:00
abstract：BACKGROUND:From the first Zika virus (ZIKV) description, it has progressively widespread worldwide. We analyzed demographic, clinical, microbiologic and travel-related characteristic from returned patients from a ZIKV endemic country in a referral Tropical Medicine Unit. METHOD:A prospective cohort study performed in ...
journal_title：Travel medicine and infectious disease
pub_type： 杂志文章
doi：10.1016/j.tmaid.2019.101543
更新日期：2020-01-01 00:00:00
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journal_title：Travel medicine and infectious disease
pub_type： 杂志文章
doi：10.1016/j.tmaid.2019.101499
更新日期：2020-01-01 00:00:00
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journal_title：Travel medicine and infectious disease
pub_type： 杂志文章
doi：10.1016/j.tmaid.2018.04.008
更新日期：2018-01-01 00:00:00
abstract：:In the vast Travel Health literature there is still a considerable dearth on tourism's impact on local communities. This review attempts to remedy the situation. Its focus is on potential health impacts on populations living at tourist destinations outside the industrialised world. To facilitate a better understanding...
journal_title：Travel medicine and infectious disease
pub_type： 杂志文章,评审
doi：10.1016/j.tmaid.2008.05.005
更新日期：2008-09-01 00:00:00
abstract：:Influenza and meningococcal disease are two serious diseases that are especially linked. Outbreaks of influenza have been frequently associated with secondary outbreaks of meningococcal disease. Travellers such as Hajj pilgrims are at particular risk, the most recent meningococcal outbreaks being in 2000 and 2001, whi...
journal_title：Travel medicine and infectious disease
pub_type： 杂志文章
doi：10.1016/j.tmaid.2008.09.001
更新日期：2009-07-01 00:00:00
abstract：:Jet lag is a disorder in which body rhythms are out of phase with the environment because of rapid travel across time zones. Although it often produces minor symptoms it can cause serious problems in those who need to make rapid critical decisions including airline pilots and business travelers. In this article the au...
journal_title：Travel medicine and infectious disease
pub_type： 杂志文章,评审
doi：10.1016/j.tmaid.2008.09.004
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND:The absolute number of travel-related Chlamydia cases in Sweden has consistently increased between 2000 and 2013. Given the growth in international travel, we aimed to study the trends of travel-related Chlamydia incidence to determine differences and identify high-risk groups and destinations. METHODS:For ...
journal_title：Travel medicine and infectious disease
pub_type： 杂志文章
doi：10.1016/j.tmaid.2018.02.008
更新日期：2018-01-01 00:00:00
abstract：UNLABELLED:Our objective was to determine tuberculin skin test conversion rate of health care workers traveling to Botswana. The rate of tuberculin skin test conversion was 4.2% for the entire group studied or 6.87 per 1000 person weeks (95% CI, 1.87-17.60). BACKGROUND:International travel by health care workers trave...
journal_title：Travel medicine and infectious disease
pub_type： 杂志文章
doi：10.1016/j.tmaid.2013.07.002
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND:Rickettsial diseases present as acute febrile illnesses, sometimes with inoculation eschars. METHODS:We performed a systematic review of studies published between 1997 and 2017 to assess the underestimation of non-eschar rickettsial disease (NERD) relative to eschar rickettsial disease (ERD), as a cause of ...
journal_title：Travel medicine and infectious disease
pub_type： 杂志文章
doi：10.1016/j.tmaid.2018.02.006
更新日期：2018-01-01 00:00:00
abstract：:International travel is changing the epidemiology of imported malaria. Our aim was to study malaria prophylaxis administered to travellers from Greece. The study was conducted during 2008-2009. Data were collected using a standardized form. A total of 2337 travellers were studied; prophylaxis was recommended to 60.2% ...
journal_title：Travel medicine and infectious disease
pub_type： 杂志文章
doi：10.1016/j.tmaid.2011.09.005
更新日期：2011-11-01 00:00:00
abstract：:Australia has a well-developed tourism industry and health care system. Despite the precautions recommended in this paper, Australia has been virtually free of local outbreaks of life threatening tropical diseases in recent decades. This paper focuses on health and safety issues for travellers to Australia, especially...
journal_title：Travel medicine and infectious disease
pub_type： 杂志文章
doi：10.1016/S1477-8939(03)00020-6
更新日期：2003-05-01 00:00:00
abstract：:Travellers from Europe to tropical areas risk acquiring malaria against which they have no immunity. The objective of this study was to assess malaria protection measures in European travellers as a function of the risk of infection with malaria. This questionnaire-based, retrospective study evaluated 13,017 French ad...
journal_title：Travel medicine and infectious disease
pub_type： 杂志文章
doi：10.1016/j.tmaid.2009.10.005
更新日期：2010-01-01 00:00:00
abstract：:Schistosomiasis is a common intravascular trematode infection. The snail/human lifecycle is illustrated. Travellers who acquire the infection are often asymptomatic, but nearly always give a history of fresh water exposure in endemic countries when asked. The various manifestations of symptomatic schistosomiasis are d...
journal_title：Travel medicine and infectious disease
pub_type： 杂志文章
doi：10.1016/j.tmaid.2004.02.011
更新日期：2004-02-01 00:00:00
abstract：BACKGROUND:Infectious diseases are a frequent cause of morbidity in French troops deployed abroad. They are usually minor in severity and managed by field practitioners. We aimed to describe the etiological spectrum of travel-related infections in French soldiers evacuated to a level 4 military treatment facility. MET...
journal_title：Travel medicine and infectious disease
pub_type： 杂志文章
doi：10.1016/j.tmaid.2014.03.005
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND:Travellers are confronted with a variety of vector-borne threats. Is one type of repellent effective against all biting vectors? The aim of this review is to examine the literature, up to December 31st, 2012, regarding repellent efficacy. METHODS:We searched PubMed for relevant papers. Repellents of interes...
journal_title：Travel medicine and infectious disease
pub_type： 杂志文章,评审
doi：10.1016/j.tmaid.2013.10.005
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:The objective of this study was to describe the clinical pathology and seasonal variation of cutaneous larva migrans (CLM) in an impoverished community. METHOD:A representative sample of the population of a poor urban neighbourhood in Fortaleza, northeast Brazil, was examined for CLM four times during a per...
journal_title：Travel medicine and infectious disease
pub_type： 杂志文章
doi：10.1016/j.tmaid.2003.10.003
更新日期：2003-11-01 00:00:00
abstract：:A male patient developed acute pulmonary histoplasmosis 2 weeks after bathing in the water falls of Wli, Ghana. Exposure to Histoplasma capsulatum was probably mediated through inhalation of an aerosol of water and guano from the large colony of fruit bats of the falls. More cases of acute pulmonary histoplasmosis can...
journal_title：Travel medicine and infectious disease
pub_type： 杂志文章
doi：10.1016/j.tmaid.2005.10.004
更新日期：2006-09-01 00:00:00
abstract：:The number of travellers returning with animal bites from rabies enzootic areas has increased in Greece. The aim of this study was to assess the knowledge of travel-associated risk and preventive measures for rabies. A questionnaire was sent to Travel Medicine consultants in all prefectures. Of 100 Travel Medicine con...
journal_title：Travel medicine and infectious disease
pub_type： 杂志文章
doi：10.1016/j.tmaid.2010.11.004
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:Travel-related conditions have impact on the quality of oral anticoagulation therapy (OAT) with vitamin K-antagonists. No predictors for travel activity and for travel-associated haemorrhage or thromboembolic complications of patients on OAT are known. METHODS:A standardised questionnaire was sent to 2500 p...
journal_title：Travel medicine and infectious disease
pub_type： 杂志文章
doi：10.1016/j.tmaid.2014.02.006
更新日期：2014-05-01 00:00:00
abstract：:At present there are no 'high-tech' solutions to the problems that may beset intercontinental travellers. Indications for the use of drugs are limited, and their use must accord with Good Clinical Practice. Essentially, travellers must look after their sleep, as far as possible, during and after the flight. The most u...
journal_title：Travel medicine and infectious disease
pub_type： 杂志文章
doi：10.1016/j.tmaid.2006.01.009
更新日期：2006-12-01 00:00:00
abstract：:A case is presented of intestinal schistosomiasis due to both Schistosoma intercalatum and Schistosoma mansoni in a 30-year-old man from Senegal with discussion of diagnostic approach, species identification and determination of the effect of treatment. The patient was admitted to hospital for investigation of renal f...
journal_title：Travel medicine and infectious disease
pub_type： 杂志文章
doi：10.1016/j.tmaid.2010.04.003
更新日期：2010-05-01 00:00:00
abstract：BACKGROUND:The number of adolescents who travel has increased. We estimated the preparedness of adolescents (12-18 years) departing from Athens to Africa and Asia. METHODS:An airport-based survey was conducted from 2011 to 2015. RESULTS:Sixty-eight adolescents participated; 27/68 (40%) had the Greek nationality. Thei...
journal_title：Travel medicine and infectious disease
pub_type： 杂志文章
doi：10.1016/j.tmaid.2017.07.011
更新日期：2018-01-01 00:00:00
abstract：:Malaria is among the most significant travel-related infections encountered by travellers to endemic countries in terms of morbidity and mortality. The aim of this study is to assess the knowledge and practices about malaria prophylaxis of travel medicine consultants in Greece. A standardized questionnaire was sent to...
journal_title：Travel medicine and infectious disease
pub_type： 杂志文章
doi：10.1016/j.tmaid.2012.09.006
更新日期：2012-09-01 00:00:00
